Sweet Syndrome and Secondary Syphilis in a Person with Acute Necrotizing Tonsillitis
Syphilis has received its classical designation as one of “the great imitators,” reflecting a wide variety of symptoms and presentations, which can cause difficulties in diagnosis. Here we report an unusual case of secondary syphilis in a person with acute necrotizing tonsillitis and Sweet syndrome. A 33-year-old female presented with fever, bilateral cervical lymphadenopathy, tonsillar enlargements with ulcerated pus-filled lesions on the right tonsil, and multiple pseudovesicular, mammillated, edematous plaques on her neck, face, and extremities. Syphilis serology was positive and a skin biopsy demonstrated a neutrop...
Source: Case Reports in Dermatology - April 15, 2021 Category: Dermatology Source Type: research
Vitiligo with Progressive Repigmentation during Secukinumab Treatment in a Patient with Psoriatic Arthritis: A Case Report
The proposed role of interleukin (IL)-17 in vitiligo pathogenesis, as well as the possible action of anti-IL-17A drugs on vitiligo, are not fully understood. The appearance of vitiligo as a paradoxical effect of treatment with anti-tumor necrosis factor- α drugs is an event well known in the literature, but is rarely described with anti-IL-17A drugs. In this case report, we describe a 42-year-old woman who developed new-onset vitiligo with repigmentation during successful secukinumab therapy for psoriatic arthritis. After 1 year of secukinumab ther apy, vitiligo affecting #x3e;85% of the skin was evident on clinical and d...
Source: Case Reports in Dermatology - April 12, 2021 Category: Dermatology Source Type: research
Successful Treatment of Recurrent Dermatitis after < b > < i > Physalia physalis < /i > < /b > (Portuguese Man O ’ War) Envenomation with Extracorporeal Shock Wave Therapy
For more than 3 decades, extracorporeal shock wave therapy (ESWT) has been clinically implemented in urologic and orthopaedic indications. Here, we present the case of a patient with envenomation from a highly toxic jellyfish-like siphonophore (Physalia physalis) with a toxic contact dermatitis resulting in chronic eruptive skin lesions. The skin lesions on the dorsal right hand lasted more than 16 weeks and were refractive to local cortisone treatment. They finally healed after 8 applications of low-energy planar/defocused ESWT over 4 weeks. In detail, the clinical course, ESWT specifications and the possible mechanisms o...
Source: Case Reports in Dermatology - April 7, 2021 Category: Dermatology Source Type: research
Lymphatic Malformation Responsive to Sirolimus in Keratinocytic Epidermal Nevus Syndrome with KRAS Mutation: A Case and Brief Literature Discussion
We present a rare case of KRAS keratinocytic epidermal nevus syndrome with lymphatic malformation, responsive to treatment with sirolimus, an mTOR inhibitor. A brief review of the current literature regarding sirolimus use in vascular malformations, lymphatic malformations, regional overgrowth syndromes, and RASopathies is discussed.Case Rep Dermatol 2021;13:195 –201 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - April 1, 2021 Category: Dermatology Source Type: research
Topical Tofacitinib: A Janus Kinase Inhibitor for the Treatment of Vitiligo in an Adolescent Patient
Vitiligo is an autoimmune skin disease presenting with areas of depigmentation. Recent reports suggest that Janus kinase (JAK) inhibitors may be an effective therapy. In this case report, we show our experience with an adolescent patient with a long history of generalized and refractory vitiligo, for which treatment with topical tofacitinib, a JAK inhibitor, associated with phototherapy for 9 months, resulted in near complete repigmentation.Case Rep Dermatol 2021;13:190 –194 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - April 1, 2021 Category: Dermatology Source Type: research
Erythema Ab Igne with Histological Features of Keratosis Lichenoides Chronica
Erythema ab igne (EAI) is a localized, hyperpigmented and reticulated dermatosis at sites of chronic heat exposure. Within longstanding skin lesions of EAI, hyperkeratotic lesions may emerge and can potentially transform into pre-malignant or malignant skin lesions. A 55-year-old woman presented for the evaluation of multiple hyperkeratotic lesions along with a reticular patterned hyperpigmentation on her right knee, an area that had repeated and prolonged exposure to a heat source over a period of several months. Based on her clinical history and the physical examination of her lesions, she was diagnosed as having a hyper...
Source: Case Reports in Dermatology - March 29, 2021 Category: Dermatology Source Type: research
A Case Report of Familial Extramammary Paget's Disease in Female Siblings
This article reports two cases of familial extramammary Paget’s disease in female siblings.Case Rep Dermatol 2021;13:176 –183 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - March 22, 2021 Category: Dermatology Source Type: research
A Case of Epidermal Cyst with Underlying Lipoma on the Back: A Rare Presentation
We present a rare case of an epidermal cyst with underlying lipoma on the back. This case report may simply be a result of coincidence, but the possibility of underlying subcutaneous tumors should be considered before epidermal cyst surgery.Case Rep Dermatol 2021;13:171 –175 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - March 18, 2021 Category: Dermatology Source Type: research
Schwannoma of the Lower Lip: A Case Report of an Unusual Presentation
This article describes the first case in the Eastern Mediterranean region of a lower lip schwannoma in a 17-year-old male patient.Case Rep Dermatol 2021;13:164 –170 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - March 3, 2021 Category: Dermatology Source Type: research
Severe Generalized Bullous Fixed Drug Eruption Treated with Cyclosporine: A Case Report and Literature Review
We present the case of a 7-year-old girl with GBFDE believed to be secondary to oral ibuprofen, who experienced rapid resolution of lesions and cessation of blistering with a 3-week course of oral cyclosporine. To the best of our knowledge, this is the first report of a paediatric case of GBFDE treated with cyclosporine. In our report, we review published cases of GBFDE in children, and all adult cases managed with cyclosporine.Case Rep Dermatol 2021;13:154 –163 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - March 3, 2021 Category: Dermatology Source Type: research
Varicella Zoster Virus-Associated Meningitis as a Rebound Varicella Zoster Disease after Antiviral Discontinuation
In this report, we describe an unusual case of herpes zoster (HZ) in a young woman who was first diagnosed during tapering of prednisone for dermatomyositis. The skin lesions affected the left L2 and L3 dermatomes, which is unusual in VZV-associated meningitis. Despite showing a good rapid response to antivirals, she developed VZV-associated meningitis immediately after discontinuation of ACV. This phenomenon is often called rebound VZV reactivation disease and occurs after discontinuation of antivirals. This case was notable in that the affected dermatomes were distant from the cranial nerves. Thus, progression of HZ to V...
Source: Case Reports in Dermatology - February 26, 2021 Category: Dermatology Source Type: research
Development of Dermatitis Herpetiformis in Chronic Plaque Psoriasis
We report a case of chronic plaque psoriasis complicated by DH in a 60-year-old patient with no known history of CD or associated symptoms. In our patient, DH presented atypically as multiple vesicles along the edges of psoriatic plaques located on the back and hips, and as vesiculobullous eruptions on the fingers. The patient was successfully treated with a combination of dapsone and a gluten-free diet for DH, and secukinumab for psoriasis. This case highlights the importance of screening for CD in patients with psoriasis, as well as other concomitant autoimmune diseases. A gluten-free diet should be trialled in psoriatic...
Source: Case Reports in Dermatology - February 24, 2021 Category: Dermatology Source Type: research
Recurrent Erythema Annulare Centrifugum due to Influenza Type A
We present a 42-year-old dark-skinned woman affected by recurrent EAC that appeared secondary to influenza type A (H1N1). Histopathology showed a superficial form of EAC. In our case, a previous cytomegalovirus and Epstein-Barr virus (EBV) infection were identified and no underlying other diseases were found. Clarithromycin with calcipotriol betamethasone treatment was temporarily efficacious. In the last 3 years, the lesions started to appear every 2 weeks and tended to regress with local treatment after a variable period. We believe that the latent cytomegalovirus and the reactivity induced by EBV combined with influenza...
Source: Case Reports in Dermatology - February 18, 2021 Category: Dermatology Source Type: research
A Low-Grade Trichoblastic Carcinoma Treated with Mohs Micrographic Surgery
Trichoblastomas are rare dermal neoplasms usually found on the scalp and face. Histology shows a proliferation of small basaloid cells arranged in cords or fields surrounded by cellular stroma. Trichoblastomas are usually not aggressive, but trichoblastic carcinomas arising from preexisting trichoblastomas have been described and have been linked to basal cell carcinoma. We found a tumor with features of trichoblastoma with presence of Merkel cells, but with a deeply infiltrative growth pattern into the fat and muscle tissue, without significant architectural or cellular atypia. Tumors with similar growth patterns were pre...
Source: Case Reports in Dermatology - February 18, 2021 Category: Dermatology Source Type: research
Subtype-Specific Off-Label Treatment of Rosacea
We present 2 cases of rosacea that were successfully managed with off-label treatment. The first is a case of painful, exuding papulopustular lesions of the nose treated with rifaximin, and the other is a case of severe, debilitating and painful flushing treated with sumatriptan. The cases support previous notions that gastrointestinal comorbidities may be related to papulopustular lesions and that flushing may be related to neurogenic inflammation and migraine. The cases also imply that a new approach to rosacea management, based on endotypes and comorbidities, may be warranted.Case Rep Dermatol 2021;13:121 –128 (Source...
Source: Case Reports in Dermatology - February 16, 2021 Category: Dermatology Source Type: research
