Nail Lichen Planus in a Patient with Cogan Syndrome: Report of a Case and Discussion
Cogan syndrome and lichen planus represent two autoimmune disorders. Cogan syndrome is a very rare type of ANCA-negative vasculitis affecting the eyes and vestibulocochlear system. It has been associated with other autoimmune disorders, none of them showing any lichenoid inflammation. We herein report the first case of a patient that suffered from Cogan disease and developed isolated lichen planus on all nails a few years after the first diagnosis. The combination of two autoimmune disorders is not unusual and raises the question of common immunogenetic pathomechanisms.Case Rep Dermatol 2019;11:175 –179 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - June 26, 2019 Category: Dermatology Source Type: research
Severe Cutaneous Adverse Reactions during Tapering of High-Dose Systemic Steroid Therapy for Autoimmune Diseases: Implications for Non-HIV Immune Reconstitution Inflammatory Syndrome
We present 2 cases of severe cutaneous adverse reactions (SCARs) during the tapering of corticosteroids, following several courses of high-dose pulse therapy for Vogt-Koyanagi-Harada disease. Their general symptoms and mucous membrane lesions, including those of the eye, were milder than those usually seen in Stevens-Johnson syndrome/toxic epidermal necrolysis. Based on their initial presentation, these cases were not initially identified as SCARs, but continued to progress over the course of a few days. The mechanism underlying the paradoxical response to steroid administration seen in these patients can be interpreted as...
Source: Case Reports in Dermatology - June 13, 2019 Category: Dermatology Source Type: research
Linear and Annular Lupus Panniculitis of the Scalp: Case Report with Emphasis on Trichoscopic Findings and Review of the Literature
Linear and annular lupus panniculitis of the scalp (LALPS) is a unique subset of lupus panniculitis, which results in non-scarring alopecia along the Blaschko line of the scalp in an otherwise healthy young patient. Numerous cases have been reported around the world, but data on their trichoscopic findings and correlations with the underlying pathology is sparse. We hereby present a case of 23-year-old male with LALPS and further describe his trichoscopic findings as well as their correlations with histopathological features.Case Rep Dermatol 2019;11:157 –165 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - June 6, 2019 Category: Dermatology Source Type: research
Alopecia Induced by Autologous Fat Injection into the Temporal Area: Case Report and Review of the Literature
Alopecia secondary to facial filler injections is a highly unusual sequela. Only 2 cases of hyaluronic acid-induced alopecia have been reported to date. Accumulating evidence suggests vascular compromise as its etiology, which can be accidental intravascular injection or external compression by overfilled materials. We hereby present, to the best of our knowledge, the first case of localized nonscarring and scarring alopecia secondary to autologous fat grafting and review the literature regarding filler-induced alopecia.Case Rep Dermatol 2019;11:150 –156 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - June 5, 2019 Category: Dermatology Source Type: research
Spontaneous Regression of Annular Basal Cell Carcinoma: A Case Report
We herein present a case of annular basal cell carcinoma (BCC) with spontaneous regression on the right temporal region of a 56-year-old Japanese male. Histopathological examination revealed that the central section had no tumor cells. The sweat glands, follicles, and other cutaneous appendages were also absent. This pattern of spontaneous regression is quite uncommon, and understanding the histopathology may be important for future approaches to BCC.Case Rep Dermatol 2019;11:145 –149 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - June 4, 2019 Category: Dermatology Source Type: research
Original Method to Repigment Achromic Laser Tattoo Removal Scars
Laser tattoo removal is expensive, painful, and time-consuming. Even with the use of the right laser equipment, it is often impossible to eliminate all pigments. Incomplete tattoo removal, one of the undesired effects of laser treatment, is widely disseminated in the media and accepted by most patients. However, few patients know that laser tattoo removal can cause permanent scars. Some patients who develop achromic scars can feel disappointed with the results of laser tattoo removal and take legal action against the physician responsible for the treatment. This paper describes our experience with a drug delivery treatment...
Source: Case Reports in Dermatology - May 23, 2019 Category: Dermatology Source Type: research
Successful Treatment with Topical Diphenylcyclopropenone for Three Cases of Anogenital Warts in Children
Anogenital warts are caused by human papillomavirus types 6 and 11. They are rare in children, and treatment is difficult since conventional treatments are generally painful and require the patient to be anesthetized. Topical diphenylcyclopropenone (DPCP) is a contact immunotherapy used for treatments of recalcitrant warts and alopecia areata. We herein report 3 cases of anogenital warts in children successfully treated with topical DPCP. Our results suggest that topical DPCP may be a valuable option for the treatment of anogenital warts in children who have difficulty with painful destructive therapy.Case Rep Dermatol 201...
Source: Case Reports in Dermatology - May 21, 2019 Category: Dermatology Source Type: research
Bullous Pemphigoid Associated with Acquired Hemophilia A: A Case Report and Review of the Literature
We report a 68-year-old Thai woman diagnosed and treated for bullous pemphigoid (BP) for 11 months who recently presented with a 3-day history of extensive hemorrhagic bullae and large intra-oral buccal hematoma. Laboratory investigations confirmed a prolonged activated partial thromboplastin time, a low factor VIII level, a high factor VIII inhibitor level, and elevated anti-BPAG180 and anti-BPAG230 titers, confirming the diagnosis of BP associated with AHA. Immunosuppressive therapy with systemic corticosteroids and cyclophosphamide combined with bypassing agents for bleeding control resulted in significant clinical impr...
Source: Case Reports in Dermatology - May 21, 2019 Category: Dermatology Source Type: research
Merkel Cell Carcinoma of the Head in a Young African Albino Woman with HIV/HTLV-1 Coinfection Associated with Multiple Squamous Cell Carcinomas
We report a case of MCC of the head in a young albino woman with a HIV/HTLV-1 coinfection. The patient also suffered from multiple squamous cell carcinomas of the scalp, face, lip, and ears, suggesting an UV carcinogenesis of MCC. The purpose of this case report is to emphasize the relationship between immunosuppression (HIV/HTLV-1 coinfection, chronic sun exposure, ocular-cutaneous albinism, pregnancy) and MCC. It highlights the importance of early diagnosis, dermatological screening with a risk-stratified surveillance, particularly in immunosuppressed albino patients in sub-Saharan Africa, and multidisciplinary managemen...
Source: Case Reports in Dermatology - May 5, 2019 Category: Dermatology Source Type: research
Terra Firme-Forme Dermatosis Diagnostic Sign and Treatment: A Case Report
Terra firma-forme dermatosis (TFFD) is a little-known disease of unknown etiology that clinically presents with asymptomatic brown to black plaques and resembles dirty skin. Here, we report the case of a 38-year-old woman with skin changes on her areolae that were mistakenly diagnosed as “dermatitis neglecta” by several physicians. Cleansing with water and soap had no impact on the skin appearance. But a swab of 70% isopropyl alcohol removed the plaques immediately, which confirmed the diagnosis of TFFD. Only a few cases of TFFD have been published, and this skin condition is no t mentioned in many textbooks. Given the...
Source: Case Reports in Dermatology - April 24, 2019 Category: Dermatology Source Type: research
Granulomatous Reactions from Tattoos Following BRAF Inhibitor Therapy
BRAF inhibitors may present several cutaneous adverse effects, including actinic keratosis, squamous cell carcinoma, keratoacanthoma, rashes, increased photosensitivity, panniculitis, palmoplantar and capillary involvement, pruritus and xerosis as well as granulomatous reactions. A 30-year-old patient with multiple tattoos received dabrafenib and trametinib for metastatic melanoma. After 4 months, he developed an induration and thickening strictly limited to several tattoos. Histopathology revealed nonnecrotizing granulomas in the dermis. Topical steroids relieved pruritus but not the granulomatous aspect of the tattoos. A...
Source: Case Reports in Dermatology - April 18, 2019 Category: Dermatology Source Type: research
< b > < i > Vibrio parahaemolyticus < /i > < /b > Induced Cellulitis and Septic Shock after a Sea Beach Holiday in a Patient with Leg Ulcers
We report the case of an 85-year-old patient who developed lower limb cellulitis caused byV. parahaemolyticus, originating from leg ulcers and complicated by septicaemia and septic shock, after a sea beach holiday. We discuss the epidemiology, pathogenesis, clinical manifestations and treatment ofV. parahaemolyticus infections.Case Rep Dermatol 2019;11:94 –100 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - April 16, 2019 Category: Dermatology Source Type: research
Hidradenitis Suppurativa is a Diagnosis to be Discussed
One of the values of case reports is that they foster communication between the involved parties. The cases included in this mini-review all underline different aspects of communication: between peers but also between physicians and patients. Few things, if any, can equal the concrete occasion to discuss empirical data. Among physicians, communication can not only create awareness but just as importantly provide solutions or suggest perspective to problems, while communication with patients is at the very core of medicine. These aspects are demonstrated in four cases dealing with the disease hidradenitis suppurativa.Case R...
Source: Case Reports in Dermatology - April 15, 2019 Category: Dermatology Source Type: research
Acral Amelanotic Melanoma Mimicking a Non-Healing Arterial Ulcer
Acral melanomas contribute to approximately 2 –3% of melanomas but are commonly misdiagnosed due to their rarity, subtlety at onset and tendency to display amelanotic features. This case report describes a 70-year-old male with an amelanotic melanoma misdiagnosed as a non-healing arterial ulcer. Histopathology demonstrated a Breslow 2.3 mm, C lark level IV acral lentiginous melanoma, which was definitively managed with surgical intervention. This case report highlights the importance of considering melanoma in the differential diagnosis of non-healing ulcers.Case Rep Dermatol 2019;11:77 –81 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - March 31, 2019 Category: Dermatology Source Type: research
Alopecia Diffusa while Using Interleukin-17 Inhibitors against Psoriasis Vulgaris
We report two cases of alopecia diffusa during the treatment of psoriasis vulgaris with interleukin (IL)-17 inhibitors. Psoriasis is one of the most common immune-mediated chronic skin diseases, strongly associated with IL-17A. Clinically, the monoclonal antibodies to IL-17A or its receptor, IL-17R, show a dramatic effect against psoriasis. Alopecia is also an IL-17-mediated autoimmune disease, and IL-17 inhibitors have been expected to be the gold standard for the treatment of alopecia; therefore, the complication of alopecia while using IL-17 may be regarded as an unexpected “paradoxical reaction.” T helper (Th)17 ce...
Source: Case Reports in Dermatology - March 31, 2019 Category: Dermatology Source Type: research
