BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Meniere Disease treated with transcutaneous auricular vagus nerve stimulation combined with betahistine Mesylate: A randomized controlled trial
Meniere Disease is a clinical condition defined by hearing loss, tinnitus, and aural fullness symptoms, there are currently no any medications approved for its treatment. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - October 12, 2023 Category: Neurology Authors: Dong Wu, Bo Liu, Yunqing Wu, Yu Wang, Jingyi Sun, Jun Yang, Jinping Duan, Gang Liu, Kai Cao, Yi Zhang, Peijing Rong Source Type: research

Dosing transcranial magnetic stimulation in major depressive disorder: Relations between number of treatment sessions and effectiveness in a large patient registry
The number of sessions in an acute TMS course for major depressive disorder (MDD) is greater than in the earlier randomized controlled trials. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - October 10, 2023 Category: Neurology Authors: Todd M. Hutton, Scott T. Aaronson, Linda L. Carpenter, Kenneth Pages, David Krantz, Lindsay Lucas, Bing Chen, Harold A. Sackeim Source Type: research

Causal influence of brainstem response to transcutaneous vagus nerve stimulation on cardiovagal outflow
The autonomic response to transcutaneous auricular vagus nerve stimulation (taVNS) has been linked to the engagement of brainstem circuitry modulating autonomic outflow. However, the physiological mechanisms supporting such efferent vagal responses are not well understood, particularly in humans. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - October 10, 2023 Category: Neurology Authors: Nicola Toschi, Andrea Duggento, Riccardo Barbieri, Ronald G. Garcia, Harrison P. Fisher, Norman W. Kettner, Vitaly Napadow, Roberta Sclocco Source Type: research

TMS of parietal and occipital cortex locked to spontaneous transient large-scale brain states enhances natural oscillations in EEG
Fluctuating neuronal network states influence brain responses to transcranial magnetic stimulation (TMS). Our previous studies revealed that transient spontaneous bihemispheric brain states in the EEG, driven by oscillatory power, information flow and regional domination, modify cortical EEG responses to TMS. However, the impact of ongoing fluctuations of large-scale brain network states on TMS-EEG responses has not been explored. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - October 10, 2023 Category: Neurology Authors: Yang Bai, Jie Xuan, Shihang Jia, Ulf Ziemann Source Type: research

Efficacy of insula deep repetitive transcranial magnetic stimulation combined with varenicline for smoking cessation: A randomized, double-blind, sham controlled trial
Current smoking cessation treatments are limited in terms of efficacy, particularly with regards to long term abstinence. There is a large amount of evidence implicating the insula in nicotine addiction. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - October 6, 2023 Category: Neurology Authors: Christine Ibrahim, Victor M. Tang, Daniel M. Blumberger, Saima Malik, Rachel Tyndale, Allison Trevizol, Mera S. Barr, Zafiris J. Daskalakis, Abraham Zangen, Bernard Le Foll Source Type: research

Corrigendum to “Characterization of vagus nerve stimulation-induced pupillary responses in epileptic patients” [Brain Stimul. 15 (2022) 1498–1507]
The authors of the above paper would like to point out an omission in the ‘Funding Sources’ section of their paper. The sentence, ”and by the Queen Elisabeth Medical Foundation for Neurosciences (F.M.R.E.-G.S.K.E.), which is a Belgian non-profit organization that support clinical research in the field of neurosciences (https://www.fmre-gske.be/pages/en/actual.html)” was mistakenly omitted from the end of this section. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - October 2, 2023 Category: Neurology Authors: Simone Vespa, Lars Stumpp, Giulia Liberati, Jean Delbeke, Antoine Nonclercq, Andr é Mouraux, Riëm El Tahry Source Type: research

Devising a framework of optogenetic coding in the auditory pathway: Insights from auditory midbrain recordings
Cochlear implants (CIs) restore activity in the deafened auditory system via electrical stimulation of the auditory nerve. As the spread of electric current in biological tissues is rather broad, the spectral information provided by electrical CIs is limited. Optogenetic stimulation of the auditory nerve has been suggested for artificial sound coding with improved spectral selectivity, as light can be conveniently confined in space. Yet, the foundations for optogenetic sound coding strategies remain to be established. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - September 29, 2023 Category: Neurology Authors: Maria Michael, Bettina Julia Wolf, Astrid Klinge-Strahl, Marcus Jeschke, Tobias Moser, Alexander Dieter Source Type: research

Electrophysiological characteristics of CM-pf in diagnosis and outcome of patients with disorders of consciousness
Deep brain stimulation (DBS) in the centromedian-parafascicular complex (CM-pf) has been reported as a potential therapeutic option for disorders of consciousness (DoC). However, the lack of understanding of its electrophysiological characteristics limits the improvement of therapeutic effect. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - September 28, 2023 Category: Neurology Authors: Jianghong He, Haoran Zhang, Yuanyuan Dang, Yutong Zhuang, Qianqian Ge, Yi Yang, Long Xu, Xiaoyu Xia, Steven Laureys, Shan Yu, Wangming Zhang Source Type: research

Frequency-specific modulation of oscillatory activity in the rat auditory cortex by vagus nerve stimulation
We previously found that vagus nerve stimulation (VNS) strengthened stimulus-evoked activity in the superficial layer of the sensory cortex but not in the deep layer, suggesting that VNS altered the balance between the feedforward (FF) and feedback (FB) pathways. Band-specific oscillatory activities in the cortex could serve as an index of the FF-FB balance, but whether VNS affects cortical oscillations along sensory pathways through neuromodulators remains unclear. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - September 28, 2023 Category: Neurology Authors: Shinichi Kumagai, Tomoyo Isoguchi Shiramatsu, Akane Matsumura, Yohei Ishishita, Kenji Ibayashi, Yoshiyuki Onuki, Kensuke Kawai, Hirokazu Takahashi Source Type: research

The intracortical excitability changes underlying the enhancing effects of rewards and punishments on motor performance
Monetary rewards and punishments enhance motor performance and are associated with corticospinal excitability (CSE) increases within the motor cortex (M1) during movement preparation. However, such CSE changes have unclear origins. Based on converging evidence, one possibility is that they stem from increased glutamatergic (GLUTergic) facilitation and/or decreased type A gamma-aminobutyric acid (GABAA)-mediated inhibition within M1. To investigate this, paired-pulse transcranial magnetic stimulation was used over the left M1 to evaluate intracortical facilitation (ICF) and short intracortical inhibition (SICI), indirect as...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - September 28, 2023 Category: Neurology Authors: R. Hamel, J. Pearson, L. Sifi, D. Patel, M.R. Hinder, N. Jenkinson, J.M. Galea Source Type: research

Personalized 7T fMRI-Guided navigation TMS targeting: Preliminary data of speech-motor cortex in speech perception
Transcranial magnetic stimulation (TMS) is a valuable tool in human cognitive neuroscience studies investigating the organization and function of the motor cortex. Nevertheless, stimulation targeting remains imprecise in TMS studies regardless of design, and many studies rely on navigation systems to enhance precision. While measuring motor-evoked potentials (MEPs) from the relevant muscle provides evidence that the intended brain area is stimulated, the possibility of strong modulations in other nearby areas cannot be excluded. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - September 27, 2023 Category: Neurology Authors: Mohammad Daneshzand, Kaisu Lankinen, Jyrki Ahveninen, Qing Mei Wang, Jordan R. Green, Teresa J. Kimberley, Shasha Li Source Type: research

Comparison of GPi-DBS, STN-DBS, and pallidotomy in primary Meige syndrome
Primary Meige syndrome (PMS) is a rare movement disorder characterized by blepharospasm, oromandibular dystonia, and cervical dystonia [1]. Blepharospasm, the most prevalent and debilitating manifestation, has a significant impact on motor function and social functioning, even though cognitive function remains intact. Dystonic symptoms typically worsen and show resistance to oral medication and botulinum toxin injections (BTXs) [2]. Deep brain nucleus lesions (DBNLs) and deep brain stimulation (DBS) have emerged as innovative and promising therapeutic approaches, heralding a new era in the treatment of neurological disorde...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - September 27, 2023 Category: Neurology Authors: Qingpei Hao, Gaoquan Lv, Wentao Zheng, Zihao Zhang, Hu Ding, Jia OuYang, Gang Wu, Fanding Xiang, Yao Tan, Guangyong Wu, Ruen Liu Source Type: research

Single session subconvulsive electrical stimulation has rapid therapeutic effects and reduces length of hospitalization in patients in an acute manic episode
Electroconvulsive therapy (ECT) is widely regarded the most effective intervention for treatment-resistant mood disorders and some other neuropsychiatric conditions. It had long been thought that the induction of a generalized seizure was both necessary and sufficient for its antidepressant effects [1]. The claim of sufficiency was contradicted, however, by the repeated demonstrations that, contingent on electrode position and electrical dosage, generalized seizures can be routinely induced that lack efficacy [2]. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - September 26, 2023 Category: Neurology Authors: Amilcar Silva-dos-Santos, Nagy A. Youssef, Joana Bravo, Miguel Sales, Maria Vaz Velho, F ábio Simões, Beatriz Gaspar, Maria João Gracias, Joana Lopes, Rita Duarte, Elsa Lara, Ricardo Gusmão, Harold A. Sackeim Source Type: research

Transcranial direct current stimulation to the left angular gyrus improves verbal learning in amnestic mild cognitive impairment: A case report
Here we report the behavioral and neuroimaging outcomes of a novel transcranial direct current stimulation (tDCS) treatment of a participant with amnestic mild cognitive impairment (aMCI). Almost all non-invasive neuromodulation studies on aMCI/AD to date targeted the dorsal lateral prefrontal cortex (DLPFC, see recent reviews of [1,2]), a region that is part of the Frontoparietal Central Executive Network. Meanwhile, dysfunction of the default-mode network (DMN), including reduced metabolism and connectivity, has been increasingly recognized as another hallmark of AD pathology besides hippocampal atrophy [3,4]. (Source: B...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - September 26, 2023 Category: Neurology Authors: Yuan Tao, Alexandros Afthinos, Jessica Gallegos, Olivia Herrmann, Constantine Frangakis, Kyrana Tsapkini Source Type: research

Moderators of stimulation-induced neural excitability in the left DLPFC: A concurrent iTBS/fNIRS case study
The abstract of this study was presented at the 34th CINP World Congress of Neuropsychopharmacology (CINP 2023). (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - September 24, 2023 Category: Neurology Authors: Rebecca L.D. Kan, Tim T.Z. Lin, Bella B.B. Zhang, Cristian G. Giron, Minxia Jin, Penny P.I. Qin, Adam W.L. Xia, Sherry K.W. Chan, Bolton K.H. Chau, Georg S. Kranz Source Type: research