BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Minimal Impact of VR, Accelerated dlPFC TMS and Accelerated mPFC on Pain Interference
Background: Pain is a sensory and emotional experience, modulated by cognition and attention. Evidence of TMS efficacy targeting the related prefrontal systems is modest, so we piloted a sequence of VR mindfulness and two accelerated TMS protocols (left dorsolateral PFC and medial PFC) to explore optimization for treatment. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - July 1, 2023 Category: Neurology Authors: K.A. Johnson, M.C. Senda, I.M. Taylor, M.M. Jensen, F.A. Kozel Source Type: research

Efficacy of Transcranial Magnetic Stimulation (TMS) on cognition in psychiatric disorders: A systematic review
Background: Transcranial magnetic stimulation (TMS) is a potentially effective and safer treatment strategy for cognitive impairment. However, evidence of TMS efficacy on cognition in psychiatric disorders like depression, schizophrenia, and bipolar disorders is limited. We aimed to review the existing literature on the effects of r-TMS on cognition in psychiatric conditions. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - July 1, 2023 Category: Neurology Authors: Rakesh Kumar, Sandeep R. Pagali, Simon Kung, Paul E. Croarkin, Maria I. Lapid Source Type: research

Transcranial Magnetic Stimulation for Low Back and Radicular Pain: A Case Report
We present a case of the successful treatment of chronic low back and radicular pain using rTMS to both M1 and the dorsolateral prefrontal cortex (DLPFC) using a modified protocol. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - July 1, 2023 Category: Neurology Authors: Ali A. Farooqui, Zachary Schrodt, Azzam A. Malkawi Source Type: research

Trauma History and its Impact on Transcranial Magnetic Stimulation (TMS) Therapy Efficacy
Background: rTMS is a safe and effective treatment for MDD, however, patients often report comorbid diagnoses and other biopsychosocial factors that affect their treatment outcomes. Trauma history as a social determinant of health and lifetime trauma exposure can alter the development of psychiatric illnesses, like MDD. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - July 1, 2023 Category: Neurology Authors: Maria Cristina Davila, Amelia Hess, Monisa Saravan, Ann M. Manzardo Source Type: research

A Modified Approach of Accelerated rTMS in Combination with Ketamine Infusions for Outpatient Application: A Case Study
This study features a 28-year-old patient with TRD over the course of a modified 5-day treatment. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - July 1, 2023 Category: Neurology Authors: Maria Cristina Davila, Monisa Saravanan, Amelia Hess, Ann M. Manzardo Source Type: research

Neuro-Immunoendocrine Biomarkers of Transcranial Magnetic Stimulation Effects in Major Depressive Disorders: A Systematic Review
Background: The therapeutic effects of transcranial magnetic stimulation (rTMS) in patients with major depressive disorders (MDD) have shown promising results; however, there is a lack of mechanistic studies using neuro-immunoendocrine biological markers (BMs) as an outcome. There is a growing need for precision medicine approaches in biological psychiatry. Several studies have investigated BMs of rTMS in MDD, however, with differing results. The knowledge of BMs provides more information, guides treatment, and provides a deeper understanding of the neuro-immune endocrine effects of rTMS; therefore, we aim to review the rT...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - July 1, 2023 Category: Neurology Authors: Rakesh Kumar, Aysegul Aydogan, Anand Singh, Anita S. Kablinger, Sandeep R. Pagali Source Type: research

Accelerated theta-burst stimulation using individualized fMRI-based targets in adolescents with depression
The objective of this study was to gauge the clinical utility of fMRI-guided neuronavigation in adolescents with depression. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - July 1, 2023 Category: Neurology Authors: Erica Nakano, Peter Sedaros, Vivian Hoang, Joyce Pi, Julia Marco, Shru Shankar, Gloria Pai, Angel Luna, Shan Siddiqi, Nathan Meng, Danielle D. DeSouza, David Carreon Source Type: research

Augmenting DLPFC rTMS with Treatment at the Supplementary Motor Area: A Case Series
We present a retrospective clinical case series of patients without OCD whose depressive symptoms exhibited little-to-no improvement in response to rTMS at dlPFC but responded after the introduction of SMA treatment. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - July 1, 2023 Category: Neurology Authors: Alexander Engelbertson, Nick Weiss Source Type: research

Treatment Tolerance and Depression Improvement in the Elderly > 70 Years Old with Transcranial Magnetic Stimulation (TMS)
Background: Currently, TMS is FDA-cleared for those 18 to 70 years of age. Our study looked at those above 70 years of age. Eighteen patients over 70 (averaging 74.6 years old), all with resistant depression, were studied using Transcranial Magnetic Stimulation (TMS). Two were males. Our findings demonstrated improvement in mood, with minimal side effects and no seizures in those>70, and suggest the age limit guidelines could be higher, allowing TMS treatment to more people with difficult-to-treat depression. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - July 1, 2023 Category: Neurology Authors: Debra J. Stultz, Savanna Osburn, Tyler Burns, Thomas M. Gills, Christina Shafer, Robin Walton, Star Michelle Roe Source Type: research

Neuronavigated 20hz theta burst TMS for OCD comorbid with depression and anxiety sequentially targeting RDLPFC, LDLPFC, and ROFC
Background: Preliminary studies using neuronavigated TBS-50Hz (50Hz pulse frequency theta burst stimulation) and neuronavigated TBS-30Hz have shown promise for the treatment of obsessive-compulsive disorder (OCD), but neuronavigated TBS-20Hz has not been tested for OCD or for OCD with depression and anxiety. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - July 1, 2023 Category: Neurology Authors: William F. Stubbeman, Julianne Converse, Melodi Gencosmanoglu, Daisy Morales Ortega, Jordyn Morris, Raya Khairkhah Source Type: research

Doubling Down On The “Fast-On, Fast-Off” Phenomenon With Accelerated iTBS X2
Background: Accelerated iTBS showed high efficacy in depression treatment. A higher response rate was reported in SAINT and SNT. Results of both SAINT and SNT hinted at less-than-optimal durability after 4 to 5 weeks. This “fast-on, fast-off” phenomenon has been a concern for accelerated iTBS. Here we report on the durability of dual courses of accelerated intermittent theta burst stimulation. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - July 1, 2023 Category: Neurology Authors: Aliaa Al-Sabbagh, Daeya Alhadid, Alexis Solly, Taylor Craford, Baseeruddin Qazi, Mhd Khaled Bowarshi Source Type: research

Comparison of Modified Beam F3 with Scalp Geometry-Based Parameter (SGP) for Locating the DLPFC
Background: As the field of transcranial magnetic stimulation (TMS) evolves, there is still debate over the optimal therapeutic target for the effective treatment of depression. Over time, it has become elucidated that the left dorsolateral prefrontal cortex (DLPFC) is highly heterogenous, and response rates may depend on the precise location of where in the DLPFC rTMS is administered. DLPFC targeting approaches have ranged from a variety of scalp measurement techniques, such as the 5-cm rule or the Beam F3 method, to neuroimaging and neuronavigation. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - July 1, 2023 Category: Neurology Authors: Bob Sammons, Sabrina K. Segal Source Type: research

Ensuring most optimal C3
Background: Finding the motor threshold over the right motor hand area is an integral part of cortical mapping and is conducted at approximately C3 on the motor strip. Two different scalp-based techniques have been taught frequently to find the position of maximal C3 stimulation. At Harvard, C3 was found by measuring from the 5 cm from the vertex on a line from vertex to tragus The second measurement is based on the 10-20 International System where C3 is found by calculating 20% of the distance from tragus to tragus and measured from vertex to tragus marking this value. (Source: BRAIN STIMULATION: Basic, Translational, and...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - July 1, 2023 Category: Neurology Authors: Robert A. Sammons, Paige Gwaltney, Katherine O ’Hara Source Type: research

Retrospective comparison of response rates in extended rTMS courses between age groups
Background: In this retrospective analysis of naturalistic clinical data, response rates were assessed for patients diagnosed with MDD (N=166, nmales=55), who received>36 sessions of an acute course of rTMS, in an effort to increase response. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - July 1, 2023 Category: Neurology Authors: Victoria Middleton Source Type: research

Across-Scale Depression Severity Ratings in Transcranial Magnetic Stimulation Treatment
Background: The Hamilton Depression Rating Scale (HAMD-17), Beck Depression Inventory (BDI), and Patient Health Questionnaire (PHQ9) are commonly-used scales to classify Transcranial Magnetic Stimulation (TMS) response and remission. In the absence of a standard scale, it is critical to know whether classifications vary across scales. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - July 1, 2023 Category: Neurology Authors: Kevin Kinback, Sean P. Johnson, Christina Sun, Alyssa Estrada, Anh Nguyen, Mark G. Haviland Source Type: research