Single session subconvulsive electrical stimulation has rapid therapeutic effects and reduces length of hospitalization in patients in an acute manic episode

Electroconvulsive therapy (ECT) is widely regarded the most effective intervention for treatment-resistant mood disorders and some other neuropsychiatric conditions. It had long been thought that the induction of a generalized seizure was both necessary and sufficient for its antidepressant effects [1]. The claim of sufficiency was contradicted, however, by the repeated demonstrations that, contingent on electrode position and electrical dosage, generalized seizures can be routinely induced that lack efficacy [2].

Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - September 26, 2023 Category: Neurology Authors: Amilcar Silva-dos-Santos, Nagy A. Youssef, Joana Bravo, Miguel Sales, Maria Vaz Velho, F ábio Simões, Beatriz Gaspar, Maria João Gracias, Joana Lopes, Rita Duarte, Elsa Lara, Ricardo Gusmão, Harold A. Sackeim Source Type: research