BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

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(Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 1, 2024 Category: Neurology Source Type: research

Deep brain stimulation with short versus conventional pulse width in Parkinson's disease and essential tremor: A systematic review and meta-analysis
To maximize clinical benefit and minimize stimulation-induced side effects, optimising deep brain stimulation (DBS) parameters is paramount. Recent literature suggests a potential benefit of short pulse width DBS (spDBS; ≤40 μs) over conventional pulse width DBS (cDBS; ≥60 μs) in movement disorders. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - December 29, 2023 Category: Neurology Authors: Sara Smeets, Alexandra Boogers, Tine Van Bogaert, Jana Peeters, Myles McLaughlin, Bart Nuttin, Tom Theys, Wim Vandenberghe, Philippe De Vloo Source Type: research

Medial forebrain bundle stimulation after failed subcallosal cingulate deep brain stimulation for treatment-resistant depression: Efficacy of a dual deep brain stimulation system for depression
Treatment-resistant depression (TRD) occurs in up to one-third of patients with major depressive disorder (MDD) [1]. Several DBS targets have been identified, including the subcallosal cingulate cortex (SCC), nucleus accumbens, anterior limb of internal capsule, lateral habenula, red nucleus of the stria terminalis and medial forebrain bundle (MFB) [2]. MFB is an emerging target showing efficacy for stimulation in TRD6-8 and might be the best target for anhedonic depression [3]. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - December 28, 2023 Category: Neurology Authors: Amit R. Persad, Nicole R. Coote, Karen Waterhouse, Sara McLeod, Jonathan A. Norton, Layla Gould, Aleksander M. Vitali Source Type: research

Conversion of a medical implant into a versatile computer-brain interface
Information transmission into the human nervous system is the basis for a variety of prosthetic applications. Spinal cord stimulation (SCS) systems are widely available, have a well documented safety record, can be implanted minimally invasively, and are known to stimulate afferent pathways. Nonetheless, SCS devices are not yet used for computer-brain- interfacing applications. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - December 23, 2023 Category: Neurology Authors: B álint Várkuti, László Halász, Saman Hagh Gooie, Gabriella Miklós, Ricardo Smits Serena, Gijs van Elswijk, Cameron C. McIntyre, Scott F. Lempka, Andres M. Lozano, Loránd Erōss Source Type: research

Locus coeruleus tyrosine hydroxylase positive neurons mediated the peripheral and central therapeutic effects of transcutaneous auricular vagal nerve stimulation (taVNS) in MRL/lpr mice
This study aims to investigate the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on the development of systemic lupus erythematosus (SLE) in MRL/lpr mice. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - December 23, 2023 Category: Neurology Authors: Hongjie Lv, Xiu Yu, Ping Wang, Mengxian Luo, Yijun Luo, Haimei Lu, Keer Wang, Anran Xi, Chengping Wen, Zhenghao Xu Source Type: research

Pulse-width modulated temporal interference (PWM-TI) brain stimulation
Electrical stimulation involving temporal interference of two different kHz frequency sinusoidal electric fields (temporal interference (TI)) enables non-invasive deep brain stimulation by creating an electric field that is amplitude modulated at the slow difference frequency within the neural range at the target brain region. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - December 22, 2023 Category: Neurology Authors: Charlotte E. Luff, Patrycja Dzialecka, Emma Acerbo, Adam Williamson, Nir Grossman Source Type: research

Hearing safety of accelerated TMS: Calculating daily noise dose of the SAINT protocol for depression
The FDA recently approved the SAINT protocol, an accelerated transcranial magnetic stimulation (TMS) protocol, for depression. 10 intermittent theta burst (iTBS) TMS sessions are administered per day to condense the 90,000 pulse treatment into 5 days [1]. Each TMS pulse generates a loud impulse noise caused by rapid expansion of the coil. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - December 21, 2023 Category: Neurology Authors: Bianca N. De, Brent R. Carr Source Type: research

Transcranial focused ultrasound for the treatment of tremor: A preliminary case series
Essential tremor (ET) can be debilitating. Treatments for ET include beta-blockers and surgical interventions. Low-intensity focused ultrasound (LIFU) may offer an office-based non-invasive alternative. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - December 18, 2023 Category: Neurology Authors: Deveney C.M., Surya J.R, J.M. Haroon, K.D. Mahdavi, K.R. Hoffman, K.C. Enemuo, K.G. Jordan, S.A. Becerra, T. Kuhn, A. Bystristky, S.E. Jordan Tags: Techniques and Methods Source Type: research

Longitudinal resting-state network connectivity changes in electroconvulsive therapy patients compared to healthy controls
In this study, we investigated changes in resting-state networks after ECT in a multicenter study. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - December 13, 2023 Category: Neurology Authors: Joey P.A.J. Verdijk, Laurens A. van de Mortel, Freek ten Doesschate, Julia C.M. Pottk ämper, Sven Stuiver, Willem B. Bruin, Christopher C. Abbott, Miklos Argyelan, Olga T. Ousdal, Hauke Bartsch, Katherine Narr, Indira Tendolkar, Vince Calhoun, Joshua Luk Source Type: research

Altered In vivo early neurogenesis traits in patients with depression: Evidence from neuron-derived extracellular vesicles and electroconvulsive therapy
The neurogenesis hypothesis is a promising candidate etiologic hypothesis for depression, and it is associated with electroconvulsive therapy (ECT). However, human in vivo molecular-level evidence is lacking. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - December 13, 2023 Category: Neurology Authors: Xin-hui Xie, Shu-xian Xu, Lihua Yao, Mian-mian Chen, Honghan Zhang, Chao Wang, Corina Nagy, Zhongchun Liu Source Type: research

Intracranial beta activity is a biomarker of circadian and stimulation-induced arousal in obsessive compulsive disorder
Deep brain stimulation (DBS) has been investigated as therapy for treatment-resistant neuropsychiatric disorders, such as obsessive-compulsive disorder (OCD) [1] and major depressive disorder (MDD) [2]. However, side effects associated with increased arousal, such as insomnia and manic symptoms [3,4], can limit the efficacy of therapy. Manic symptoms, which include a decreased need for sleep, have been reported in up to 30 –45 % of individuals receiving anterior limb of internal capsule (ALIC) stimulation [3] and require urgent care. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - December 12, 2023 Category: Neurology Authors: Joline M. Fan, Bianca De, Adam Frank, Genevieve Basich-Pease, Tenzin Norbu, Melanie A. Morrison, Paul Larson, Philip A. Starr, Andrew D. Krystal, A Moses Lee Source Type: research

The importance of acoustic output measurement and monitoring for the replicability of transcranial ultrasound stimulation studies
We are writing about what we believe are important considerations for ensuring high standards and replicability of experiments using transcranial ultrasonic stimulation (TUS). TUS is a technique in its infancy, yet its potential is widely recognized. For the first time in humans, neural activity can be modulated non-invasively and with millimetre precision in deep brain regions. This opens up possibilities for therapeutic interventions in psychiatric and neurological brain disorders where current treatments include invasive deep brain stimulation or ablation. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical R...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - December 11, 2023 Category: Neurology Authors: Miriam Klein-Fl ügge, Elsa Fouragnan, Eleanor Martin Source Type: research

Measuring the accuracy of ICA-based artifact removal from TMS-evoked potentials
The analysis and interpretation of transcranial magnetic stimulation (TMS)-evoked potentials (TEPs) relies on successful cleaning of the artifacts, which typically mask the early (0 –30 ms) TEPs. Independent component analysis (ICA) is possibly the single most utilized methodology to clean these signals. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - December 8, 2023 Category: Neurology Authors: Iiris Atti, Paolo Belardinelli, Risto J. Ilmoniemi, Johanna Metsomaa Source Type: research

Transcranial ultrasound neuromodulation for epilepsy: A pilot safety trial
We report our experience, a first-in-human pilot safety trial using serial TUS treatments to the hippocampus in mesial temporal lobe epilepsy (mTLE) (Fig. 1a). (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - December 7, 2023 Category: Neurology Authors: Ellen J. Bubrick, Nathan J. McDannold, Janet Orozco, Timothy Y. Mariano, Laura Rigolo, Alexandra J. Golby, Yanmei Tie, Philip J. White Source Type: research

Oscillatory network markers of subcallosal cingulate deep brain stimulation for depression
Identifying functional biomarkers related to treatment success can aid in expediting therapy optimization, as well as contribute to a better understanding of the neural mechanisms of the treatment-resistant depression (TRD) and subcallosal cingulate deep brain stimulation (SCC-DBS).Magnetoencephalography data were obtained from 16 individuals with SCC-DBS for TRD and 25 healthy subjects. The first objective of the study was to identify region-specific oscillatory modulations that both (i) discriminate individuals with TRD (with SCC-DBS OFF) from healthy controls, and (ii) discriminate TRD treatment responders from non-resp...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - December 5, 2023 Category: Neurology Authors: M. Scherer, I.E. Harmsen, N. Samuel, G.J.B. Elias, J. Germann, A. Boutet, C.E. MacLeod, P. Giacobbe, N.C. Rowland, A.M. Lozano, L. Milosevic Source Type: research