BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Resting-state background features demonstrate multidien cycles in long-term EEG device recordings
Longitudinal EEG recorded by implanted devices is critical for understanding and managing epilepsy. Recent research reports patient-specific, multi-day cycles in device-detected epileptiform events that coincide with increased likelihood of clinical seizures. Understanding these cycles could elucidate mechanisms generating seizures and advance drug and neurostimulation therapies. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - November 15, 2023 Category: Neurology Authors: William K.S. Ojemann, Brittany H. Scheid, Sofia Mouchtaris, Alfredo Lucas, Joshua J. LaRocque, Carlos Aguila, Arian Ashourvan, Lorenzo Caciagli, Kathryn A. Davis, Erin C. Conrad, Brian Litt Source Type: research

Intersession reliability of fast motor mapping using TMS
The organization of the primary motor cortex (M1) can be non-invasively assessed using transcranial magnetic stimulation (TMS) combined with frameless neuro-navigation. By delivering single pulses of TMS over M1 and recording the motor evoked potentials (MEP) from target muscles, the location and size of muscle representations can be obtained to create a “motor map” [1]. Characteristics such as area, volume, and center of gravity (CoG) are quantified from motor maps. Motor mapping typically requires upwards of 30 minutes to complete which reduces its utility in time-sensitive contexts. (Source: BRAIN STIMULATION: Basic...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - November 15, 2023 Category: Neurology Authors: Faith C. Adams, Stevie D. Foglia, Chloe C. Drapeau, Claudia V. Turco, Karishma R. Ramdeo, Aimee J. Nelson Source Type: research

Electroconvulsive therapy improves somatic symptoms before mood in patients with depression: A directed network analysis
The recent network perspective of depression conceptualizes depression as a dynamic network of causally related symptoms, that contrasts with the traditional view of depression as a discrete latent entity that causes all symptoms. Electroconvulsive therapy (ECT) is an effective treatment for severe depression, but little is known about the temporal trajectories of symptom improvement during a course of ECT. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - November 10, 2023 Category: Neurology Authors: Emma De Schuyteneer, Erik Giltay, Kristof Vansteelandt, Jasmien Obbels, Liese Van den Eynde, Shauni Verspecht, Chelsea Verledens, Kaat Hebbrecht, Pascal Sienaert Source Type: research

Subjective states induced by intracranial electrical stimulation matches the cytoarchitectonic organization of the human insula
Functions of the human insula have been explored extensively with neuroimaging methods and intracranial electrical stimulation studies that have highlighted a functional segregation across its subregions. A recently developed cytoarchitectonic map of the human insula has also segregated this brain region into various areas. Our knowledge of the functional organization of this brain region at the level of these fine-parceled microstructural areas remains only partially understood. We address this gap of knowledge by applying a multimodal approach linking direct electrical stimulation and task-evoked intracranial EEG recordi...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - November 8, 2023 Category: Neurology Authors: Anna Duong, Julian Quabs, Aaron Kucyi, Zoe Lusk, Vivek Buch, Svenja Caspers, Josef Parvizi Source Type: research

Alpha transcranial alternating current stimulation modulates auditory perception
Studies using transcranial alternating current stimulation (tACS), a type of non-invasive brain stimulation, have demonstrated a relationship between the positive versus negative phase of both alpha and delta/theta oscillations with variable near-threshold auditory perception. These findings have not been directly compared before. Furthermore, as perception was better in the positive versus negative phase of two different frequencies, it is unclear whether changes in polarity (independent of a specific frequency) could also modulate auditory perception. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Researc...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - November 7, 2023 Category: Neurology Authors: Sreekari Vogeti, Maryam Faramarzi, Christoph S. Herrmann Source Type: research

Rethinking NBM DBS: Intermittent stimulation improves sustained attention in Parkinson's disease
Degeneration of the Nucleus Basalis of Meynert (NBM) has been implicated in the cognitive decline in Parkinson's disease (PD) [1] and has therefore been a target of interest for deep brain stimulation (DBS). We have previously published on the feasibility and safety of NBM and globus pallidus interna stimulation in PD with advanced cognitive impairment [2]. The NBM was programmed to performance on sustained attention as it is a sensitive marker of cholinergic activity [3] and is crucial to several activities of daily living [4]. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - November 5, 2023 Category: Neurology Authors: Sanskriti Sasikumar, Melanie Cohn, Ariana Youm, Katherine Duncan, Alexandra Boogers, Antonio P. Strafella, David T. Blake, Alfonso Fasano Source Type: research

Stereo-EEG-guided network modulation for psychiatric disorders: Surgical considerations
Deep brain stimulation (DBS) and other neuromodulatory techniques are being increasingly utilized to treat refractory neurologic and psychiatric disorders. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - November 1, 2023 Category: Neurology Authors: Sameer A. Sheth, Ben Shofty, Anusha Allawala, Jiayang Xiao, Joshua A. Adkinson, Raissa K. Mathura, Victoria Pirtle, John Myers, Denise Oswalt, Nicole R. Provenza, Nisha Giridharan, Angela M. Noecker, Garrett P. Banks, Ron Gadot, Ricardo A. Najera, Adrish Source Type: research

Stereo-EEG-guided network modulation for psychiatric disorders: Interactive holographic planning
Connectomic modeling studies are expanding understanding of the brain networks that are modulated by deep brain stimulation (DBS) therapies. However, explicit integration of these modeling results into prospective neurosurgical planning is only beginning to evolve. One challenge of employing connectomic models in patient-specific surgical planning is the inherent 3D nature of the results, which can make clinically useful data integration and visualization difficult. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - November 1, 2023 Category: Neurology Authors: Angela M. Noecker, Jeffrey Mlakar, Kelly R. Bijanki, Mark A. Griswold, Nader Pouratian, Sameer A. Sheth, Cameron C. McIntyre Source Type: research

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Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - November 1, 2023 Category: Neurology Source Type: research

Masthead
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Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - November 1, 2023 Category: Neurology Source Type: research

Editorial Board
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Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - November 1, 2023 Category: Neurology Source Type: research

Table of Contents
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Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - November 1, 2023 Category: Neurology Source Type: research

Effects of multisession cathodal transcranial direct current stimulation with cognitive training on sociocognitive functioning and brain dynamics in ASD: A double-blind, sham-controlled, randomized EEG study
Few treatment options are available for targeting core symptoms of autism spectrum disorder (ASD). The development of treatments that target common neural circuit dysfunctions caused by known genetic defects, namely, disruption of the excitation/inhibition (E/I) balance, is promising. Transcranial direct current stimulation (tDCS) is capable of modulating the E/I balance in healthy individuals, yet its clinical and neurobiological effects in ASD remain elusive. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - October 31, 2023 Category: Neurology Authors: Melody M.Y. Chan, Coco X.T. Choi, Tom C.W. Tsoi, Caroline K.S. Shea, Klaire W.K. Yiu, Yvonne M.Y. Han Source Type: research

The effects of STN-DBS on motor speech: A longitudinal articulographic study
Speech deficits in Parkinson's disease (PD) manifest as hypokinetic dysarthria comprising reduced ability to modulate speech melody and loudness, and imprecise articulation [1]. The latter results from smaller, slower, and less precise articulatory movements further leading to reduced intelligibility [1]. The effect of deep brain stimulation of the subthalamic nucleus (STN-DBS) on speech is under debate. Whereas some studies report improvement, e.g. Refs. [2 –4], others report a deterioration of speech functions, e.g. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - October 28, 2023 Category: Neurology Authors: Tabea Thies, Hannah Jergas, Doris M ücke, Gregor Brandt, Veerle Visser-Vandewalle, Serge Pinto, Michael T. Barbe Source Type: research

Toward a neurocircuit-based sequential bilateral transcranial magnetic stimulation for treatment of obsessive-compulsive disorder
Individuals diagnosed with obsessive-compulsive disorder (OCD) present a substantial demand for innovative therapeutic interventions, given that they often endure significant residual symptoms despite undergoing treatment [1]. The prevailing body of research has predominantly explored the utility of repetitive transcranial magnetic stimulation (rTMS) as a non-invasive cerebral stimulation technique for alternative interventions. High frequency rTMS (HF-rTMS; ≥5 Hz) can produce a local increase in cortical excitability, whereas low frequency rTMS (LF-rTMS; ≤1 Hz) can produce decreases in local cortical excitability [2]....
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - October 27, 2023 Category: Neurology Authors: Kun Wei, Yange Luo, Yuyin Bai, Titi Chen, Bo Bi Source Type: research