Transcranial direct current stimulation to the left angular gyrus improves verbal learning in amnestic mild cognitive impairment: A case report

Here we report the behavioral and neuroimaging outcomes of a novel transcranial direct current stimulation (tDCS) treatment of a participant with amnestic mild cognitive impairment (aMCI). Almost all non-invasive neuromodulation studies on aMCI/AD to date targeted the dorsal lateral prefrontal cortex (DLPFC, see recent reviews of [1,2]), a region that is part of the Frontoparietal Central Executive Network. Meanwhile, dysfunction of the default-mode network (DMN), including reduced metabolism and connectivity, has been increasingly recognized as another hallmark of AD pathology besides hippocampal atrophy [3,4].
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - Category: Neurology Authors: Source Type: research