Phenotypic and immune functional profiling of patients with suspected Mendelian Susceptibility to Mycobacterial Disease in South Africa
Mendelian Susceptibility to Mycobacterial Disease (MSMD) is a primary immunodeficiency (PID) characterised by a predisposition to infection by weakly-pathogenic mycobacteria. In countries with a high prevalenc... (Source: BMC Immunology)
Source: BMC Immunology - September 13, 2021 Category: Allergy & Immunology Authors: Ansia van Coller, Brigitte Glanzmann, Helena Cornelissen, Marlo M öller, Craig Kinnear, Monika Esser and Richard Glashoff Tags: Research Source Type: research
Association between serum markers of the humoral immune system and inflammation in the Swedish AMORIS study
Although the onset of inflammatory cascades may profoundly influence the nature of antibody responses, the interplay between inflammatory and humoral (antibody) immune markers remains unclear. Thus, we explore... (Source: BMC Immunology)
Source: BMC Immunology - September 6, 2021 Category: Allergy & Immunology Authors: Aida Santaolalla, Sam Sollie, Ali Rislan, Debra H. Josephs, Niklas Hammar, Goran Walldius, Hans Garmo, Sophia N. Karagiannis and Mieke Van Hemelrijck Tags: Research article Source Type: research
The augment of regulatory T cells undermines the efficacy of anti-PD-L1 treatment in cervical cancer
Immune checkpoint inhibitors have aroused great expectation of tumor eradication. However, the effect of anti-PD-L1 treatment for cervical cancer is unsatisfactory and the underlying antagonist to anti-PD-L1 e... (Source: BMC Immunology)
Source: BMC Immunology - September 3, 2021 Category: Allergy & Immunology Authors: Fengying Xu, Fengying Zhang, Qian Wang, Ying Xu, Shuifang Xu, Caihong Zhang and Lihua Wang Tags: Research Source Type: research
Innate lymphoid cell dysfunction during long-term suppressive antiretroviral therapy in an African cohort
Innate lymphoid cells (ILC) are lymphoid lineage innate immune cells that do not mount antigen-specific responses due to their lack of B and T-cell receptors. ILCs are predominantly found at mucosal surfaces, ... (Source: BMC Immunology)
Source: BMC Immunology - August 26, 2021 Category: Allergy & Immunology Authors: Rose Nabatanzi, Lois Bayigga, Stephen Cose, Glenda Canderan, Sarah Rowland Jones, Moses Joloba and Damalie Nakanjako Tags: Research Source Type: research
Intratumoral regulatory T cells from colon cancer patients comprise several activated effector populations
Intratumoral regulatory T cells (Treg) in colon cancer are a heterogeneous cell population, with potential impact on patient outcome. Generally, a high Treg infiltration has been correlated to a worse patient ... (Source: BMC Immunology)
Source: BMC Immunology - August 19, 2021 Category: Allergy & Immunology Authors: Louis Szeponik, Filip Ahlmanner, Patrik Sundstr öm, William Rodin, Bengt Gustavsson, Elinor Bexe Lindskog, Yvonne Wettergren and Marianne Quiding-Järbrink Tags: Research Source Type: research
Pharmacological activation of rev-erb α suppresses LPS-induced macrophage M1 polarization and prevents pregnancy loss
Circadian rhythm is an important player for reproduction. Rev-erb α, a significant clock gene, is involved in regulating cell differentiation, inflammation and metabolism. Macrophage polarization plays crucial ... (Source: BMC Immunology)
Source: BMC Immunology - August 16, 2021 Category: Allergy & Immunology Authors: Liyuan Cui, Feng Xu, Songcun Wang, Xinyi Li, Haiyan Lin, Yan Ding and Meirong Du Tags: Research Source Type: research
The transmembrane domain and luminal C-terminal region independently support invariant chain trimerization and assembly with MHCII into nonamers
Invariant chain (CD74, Ii) is a multifunctional protein expressed in antigen presenting cells. It assists the ER exit of various cargos and serves as a receptor for the macrophage migration inhibitory factor. ... (Source: BMC Immunology)
Source: BMC Immunology - August 12, 2021 Category: Allergy & Immunology Authors: Maryse Cloutier, Jean-Simon Fortin and Jacques Thibodeau Tags: Research article Source Type: research
Critical role of triglycerides for adiponectin levels in hepatitis C: a joint study of human and HCV core transgenic mice
Both hepatitis C virus (HCV) infection and adiponectin are critically involved in metabolism. The reversal and associations of altering adiponectin levels after sustained virological responses (SVRs) following... (Source: BMC Immunology)
Source: BMC Immunology - August 11, 2021 Category: Allergy & Immunology Authors: Ming-Ling Chang, Jing-Hong Hu, Li-Heng Pao, Ming-Shyan Lin, Chia-Jung Kuo, Shiang-Chi Chen, Chun-Ming Fan, Ming-Yu Chang and Rong-Nan Chien Tags: Research article Source Type: research
Identification of active small-molecule modulators targeting the novel immune checkpoint VISTA
Cancer immunotherapy has gained increasing popularity as a novel approach to treat cancer. A member of the B7 family, V-domain immunoglobulin suppressor of T-cell activation (VISTA) is a novel immune checkpoin... (Source: BMC Immunology)
Source: BMC Immunology - August 11, 2021 Category: Allergy & Immunology Authors: Ting-ting Li, Jing-wei Jiang, Chen-xin Qie, Chun-xiao Xuan, Xin-lei Hu, Wan-mei Liu, Wen-ting Chen and Jun Liu Tags: Research article Source Type: research
Factors associated with IgG levels in adults with IgG subclass deficiency
(IgGSD) are incompletely understood. We studied adults with IgGSD with subnormal IgG1 only, subnormal IgG1/IgG3, or subnormal IgG3 only... (Source: BMC Immunology)
Source: BMC Immunology - August 9, 2021 Category: Allergy & Immunology Authors: James C. Barton, Jackson Clayborn Barton, Luigi F. Bertoli and Ronald T. Acton Tags: Research Source Type: research
Anti-inflammatory protein TNF α-stimulated gene-6 (TSG-6) reduces inflammatory response after brain injury in mice
Current research suggests that the glial scar surrounding penetrating brain injuries is instrumental in preserving the surrounding uninjured tissue by limiting the inflammatory response to the injury site. We ... (Source: BMC Immunology)
Source: BMC Immunology - August 4, 2021 Category: Allergy & Immunology Authors: Kazadi Nadine Mutoji, Mingxia Sun, Amanda Nash, Sudan Puri, Vincent Hascall and Vivien J. Coulson-Thomas Tags: Research article Source Type: research
Angiopoietin 1 release from human neutrophils is independent from neutrophil extracellular traps (NETs)
Neutrophils induce the synthesis and release of angiopoietin 1 (Ang1), a cytosolic growth factor involved in angiogenesis and capable of inducing several pro-inflammatory activities in neutrophils. Neutrophils... (Source: BMC Immunology)
Source: BMC Immunology - August 3, 2021 Category: Allergy & Immunology Authors: Elcha Charles, Benjamin L. Dumont, Steven Bonneau, Paul-Eduard Neagoe, Louis Villeneuve, Agn ès Räkel, Michel White and Martin G. Sirois Tags: Research Source Type: research
Variable clinical characteristics and laboratory results in five patients with Chinese Good's syndrome (thymoma and hypogammaglobulinemia): an 8-year retrospective analysis in a university hospital in China
Good's syndrome (GS) is a rare secondary immunodeficiency disease presenting as thymoma and hypogammaglobulinemia. Due to its rarity, the diagnosis of GS is often missed. (Source: BMC Immunology)
Source: BMC Immunology - August 3, 2021 Category: Allergy & Immunology Authors: Jinyao Ni, Junwu Zhang, Yanxia Chen, Weizhong Wang and Jinlin Liu Tags: Research Source Type: research
Targeted immune epitope prediction to HHLA2 and MAGEB5 protein variants as therapeutic approach to related viral diseases
Targeted immunotherapy is mostly associated with cancer treatment wherein designed molecules engage signaling pathways and mutant proteins critical to the survival of the cell. One of several genetic approache... (Source: BMC Immunology)
Source: BMC Immunology - July 28, 2021 Category: Allergy & Immunology Authors: Daniel A. Achinko, Anton Dormer, Mahesh Narayanan and Elton F. Norman Tags: Research Source Type: research
Prevalence of human leukocyte antigen HLA-B*57:01 in individuals with HIV in West and Central Africa
The presence of the human leukocyte antigen HLA-B*57:01 is associated with the development of a hypersensitivity reaction to abacavir (ABC). Limited data exist on HLA-B*57:01 prevalence in individuals with HIV... (Source: BMC Immunology)
Source: BMC Immunology - July 22, 2021 Category: Allergy & Immunology Authors: Malewe Kolou, Armel Poda, Zelica Diallo, Esther Konou, Tatiana Dokpomiwa, Jacques Zoungrana, Mounerou Salou, Lion èle Mba-Tchounga, André Bigot, Abdoul-Salam Ouedraogo, Marielle Bouyout-Akoutet, Didier K. Ekouevi and Serge P. Eholie Tags: Research Source Type: research
