The relationship between symptom burden and systemic inflammation differs between male and female athletes following concussion
Inflammation appears to be an important component of concussion pathophysiology. However, its relationship to symptom burden is unclear. Therefore, the purpose of this study was to evaluate the relationship be... (Source: BMC Immunology)
Source: BMC Immunology - March 12, 2020 Category: Allergy & Immunology Authors: Alex P. Di Battista, Nathan Churchill, Shawn G. Rhind, Doug Richards and Michael G. Hutchison Tags: Research article Source Type: research
Positive staining of the immunoligand B7-H6 in abnormal/transformed keratinocytes consistently accompanies the progression of cervical cancer
B7-H6 has been revealed as an endogenous immunoligand expressed in a variety of tumors, but not expressed in healthy tissues. Heretofore, no studies have been reported describing B7-H6 in women with cervical c... (Source: BMC Immunology)
Source: BMC Immunology - March 6, 2020 Category: Allergy & Immunology Authors: Gloria Yareli Gutierrez-Silerio, Ramon Antonio Franco-Topete, Jesse Haramati, Eduardo Miguel Navarrete-Medina, Jorge Gutierrez-Franco, Miriam Ruth Bueno-Topete, Blanca Estela Bastidas-Ramirez, Martha Eloisa Ramos-Marquez and Susana del Toro-Arreola Tags: Research article Source Type: research
Allo-HSCT compared with immunosuppressive therapy for acquired aplastic anemia: a system review and meta-analysis
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) and immunosuppressive therapy (IST) are two major competing treatment strategies for acquired aplastic anemia (AA). Whether allo-HSCT is superior ... (Source: BMC Immunology)
Source: BMC Immunology - March 6, 2020 Category: Allergy & Immunology Authors: Yangmin Zhu, Qingyan Gao, Jing Hu, Xu Liu, Dongrui Guan and Fengkui Zhang Tags: Research article Source Type: research
The DNA methyltransferase inhibitor, guadecitabine, targets tumor-induced myelopoiesis and recovers T cell activity to slow tumor growth in combination with adoptive immunotherapy in a mouse model of breast cancer
Myeloid derived suppressor cells (MDSCs) present a significant obstacle to cancer immunotherapy because they dampen anti-tumor cytotoxic T cell responses. Previous groups, including our own, have reported on t... (Source: BMC Immunology)
Source: BMC Immunology - February 27, 2020 Category: Allergy & Immunology Authors: Andrea J. Luker, Laura J. Graham, Timothy M. Smith Jr, Carmen Camarena, Matt P. Zellner, Jamie-Jean S. Gilmer, Sheela R. Damle, Daniel H. Conrad, Harry D. Bear and Rebecca K. Martin Tags: Research article Source Type: research
Inducible nitric oxide synthase and systemic lupus erythematosus: a systematic review and meta-analysis
There is a growing body of evidences indicating iNOS has involved in the pathogenesis of SLE. However, the role of iNOS in SLE is inconsistency. This systematic review was designed to evaluate the association ... (Source: BMC Immunology)
Source: BMC Immunology - February 17, 2020 Category: Allergy & Immunology Authors: Lu Pan, Sirui Yang, Jinghua Wang, Meng Xu, Shaofeng Wang and Huanfa Yi Tags: Research article Source Type: research
The impact of Clonorchis sinensis infection on immune response in mice with type II collagen-induced arthritis
Clonorchis sinensis infection could trigger strong immune responses in mice and humans. However, whether the C.sinensis infection has an impact on arthritis is unknown. Here we investigated the effect of C.sinens... (Source: BMC Immunology)
Source: BMC Immunology - February 17, 2020 Category: Allergy & Immunology Authors: Xiangyang Li, Ying Yang, Suping Qin, Fanyun Kong, Chao Yan, Wanpeng Cheng, Wei Pan, Qian Yu, Hui Hua, Kuiyang Zheng and Renxian Tang Tags: Research article Source Type: research
Dysregulation of TNF- α and IFN-γ expression is a common host immune response in a chronically infected mouse model of melioidosis when comparing multiple human strains of Burkholderia pseudomallei
Melioidosis is endemic in Southeast Asia and Northern Australia and is caused by the Gram-negative, facultative intracellular pathogen Burkholderia pseudomallei. Diagnosis of melioidosis is often difficult becaus... (Source: BMC Immunology)
Source: BMC Immunology - February 3, 2020 Category: Allergy & Immunology Authors: Kei Amemiya, Jennifer L. Dankmeyer, Jeremy J. Bearss, Xiankun Zeng, Spencer W. Stonier, Carl Soffler, Christopher K. Cote, Susan L. Welkos, David P. Fetterer, Taylor B. Chance, Sylvia R. Trevino, Patricia L. Worsham and David M. Waag Tags: Research article Source Type: research
Reliable reference genes for the quantification of mRNA in human T-cells and PBMCs stimulated with live influenza virus
Quantitative PCR (qPCR) is a powerful tool that is particularly well-suited to measure mRNA levels in clinical samples, especially those with relatively low cell counts. However, a caveat of this approach is t... (Source: BMC Immunology)
Source: BMC Immunology - January 31, 2020 Category: Allergy & Immunology Authors: Justin G. Roy, Janet E. McElhaney and Chris P. Verschoor Tags: Research article Source Type: research
miR32-5p promoted vascular smooth muscle cell calcification by upregulating TNF α in the microenvironment
Vascular calcification is often associated with chronic inflammation and is a risk factor for brain arterial stiffness. Our previous results showed that miR32-5p was positively correlated with vascular smooth ... (Source: BMC Immunology)
Source: BMC Immunology - January 17, 2020 Category: Allergy & Immunology Authors: Jingsong Cao, Ling Chen, Xiaoling Zhong, Yingying Shen, Yan Gao, Qian Chen, Xuyu Zu and Jianghua Liu Tags: Research article Source Type: research
Diagnostic value of serum soluble triggering expressed receptor on myeloid cells 1 (sTREM-1) in suspected sepsis: a meta-analysis
We aim to synthesize the up-to-date studies to investigate the diagnostic value of serum soluble triggering expressed receptor on myeloid cells 1 (sTREM-1) in suspected sepsis. (Source: BMC Immunology)
Source: BMC Immunology - January 13, 2020 Category: Allergy & Immunology Authors: Wei Chang, Fei Peng, Shan-Shan Meng, Jing-Yuan Xu and Yi Yang Tags: Research article Source Type: research
A software package for immunologists to learn simulation modeling
As immunology continues to become more quantitative, increasingly sophisticated computational tools are commonly used. One useful toolset are simulation models. Becoming familiar with such models and their use... (Source: BMC Immunology)
Source: BMC Immunology - January 2, 2020 Category: Allergy & Immunology Authors: Andreas Handel Tags: Software Source Type: research
Amentoflavone ameliorates cold stress-induced inflammation in lung by suppression of C3/BCR/NF- κB pathways
Cold stress, which may lead to local and systemic injury, is reported to be related to the immune system, especially the complement system. At present, the lack of effective treatment is a critical issue. Amen... (Source: BMC Immunology)
Source: BMC Immunology - December 30, 2019 Category: Allergy & Immunology Authors: Jiayi Cai, Chunyang Zhao, Yajie Du, Yuan Huang and Qingchun Zhao Tags: Research article Source Type: research
Interactions between Yersinia pestis V-antigen (LcrV) and human Toll-like receptor 2 (TLR2) in a modelled protein complex and potential mechanistic insights
Yersinia pestis, the etiological pathogen of plague, is capable of repressing the immune response of white blood cells to evade phagocytosis. The V-antigen (LcrV) was found to be involved in this process by bindi... (Source: BMC Immunology)
Source: BMC Immunology - December 16, 2019 Category: Allergy & Immunology Authors: Tiandi Wei, Jing Gong, Guojing Qu, Mingyu Wang and Hai Xu Tags: Research article Source Type: research
ILC2 transfers to apolipoprotein E deficient mice reduce the lipid content of atherosclerotic lesions
Expansion of type 2 innate lymphoid cells (ILC2s) in hypercholesterolaemic mice protects against atherosclerosis while different ILC2 subsets have been described (natural, inflammatory) based on their suppress... (Source: BMC Immunology)
Source: BMC Immunology - December 10, 2019 Category: Allergy & Immunology Authors: Polyxeni T. Mantani, Pontus Dun ér, Irena Ljungcrantz, Jan Nilsson, Harry Björkbacka and Gunilla Nordin Fredrikson Tags: Research article Source Type: research
NK cell predicts the severity of acute graft-versus-host disease in patients after allogeneic stem cell transplantation using antithymocyte globulin (ATG) in pretreatment scheme
Graft-versus-host disease (GVHD) is one of the most complex complications after allogeneic stem cell transplantation. Current standard of grading system is based on clinical symptoms in skin, liver and intesti... (Source: BMC Immunology)
Source: BMC Immunology - December 9, 2019 Category: Allergy & Immunology Authors: Ping Zhang, Shujun Yang, Yujing Zou, Xiao Yan, Hao Wu, Miao Zhou, Yong Cheng Sun, Yi Zhang, Huiling Zhu, Kaihong Xu, Yi Wang, Li Xia Sheng, Qitian Mu, Liguang Sun and Guifang Ouyang Tags: Research article Source Type: research
