Involvement of ABC-transporters and acyltransferase 1 in intracellular cholesterol-mediated autophagy in bovine alveolar macrophages in response to the Bacillus Calmette-Guerin (BCG) infection
Understanding pathogenic mechanisms is imperative for developing novel treatment to the tuberculosis, an important public health burden worldwide. Recent studies demonstrated that host cholesterol levels have ... (Source: BMC Immunology)
Source: BMC Immunology - May 12, 2020 Category: Allergy & Immunology Authors: Jinrui Xu, Yanbing Zhou, Yi Yang, Cuiping Lv, Xiaoming Liu and Yujiong Wang Tags: Research article Source Type: research
Comparison of personal and shared frameshift neoantigen vaccines in a mouse mammary cancer model
It is widely hoped that personal cancer vaccines will extend the number of patients benefiting from checkpoint and other immunotherapies. However, it is clear creating such vaccines will be challenging. It req... (Source: BMC Immunology)
Source: BMC Immunology - May 5, 2020 Category: Allergy & Immunology Authors: Milene Peterson, Sierra Nicole Murphy, John Lainson, Jian Zhang, Luhui Shen, Chris W. Diehnelt and Stephen Albert Johnston Tags: Research article Source Type: research
Patient experience with subcutaneous immunoglobulin 20%, Ig20Gly, for primary immunodeficiency diseases: a prespecified post hoc analysis of combined data from 2 pivotal trials
Often, patients with primary immunodeficiency diseases (PID), which are marked by the absence or loss of functional antibodies, require lifelong treatment with immunoglobulin (IG) replacement therapy administe... (Source: BMC Immunology)
Source: BMC Immunology - May 4, 2020 Category: Allergy & Immunology Authors: Lisa M. Meckley, Yanyu Wu, Diane Ito, Todd Berner, Barbara McCoy and Leman Yel Tags: Research article Source Type: research
Human CD8+CD28 − T suppressor cells expanded by common gamma chain (γc) cytokines retain steady allospecific suppressive capacity in vivo
CD8+CD28 − T suppressor (Ts) cells play critical role in transplant tolerance. Our previous study has generated CD8+CD28− Ts cells in vitro which exert robust allospecific suppressive capacity in vitro. (Source: BMC Immunology)
Source: BMC Immunology - April 29, 2020 Category: Allergy & Immunology Authors: Guihuan Liu, Yuming Yu, Fu Feng, Ping Zhu, Hua Zhang, Danni Zhang, Xiaoqiang Feng, Zedan Zhang and Yanjun Liu Tags: Research article Source Type: research
Epitherapy and immune checkpoint blockade: using epigenetic reinvigoration of exhausted and dysfunctional T cells to reimburse immunotherapy response
Cancer cells subvert natural immunosuppression by upregulating the expression of checkpoint proteins and their ligands. For example, tumor cells expressing programmed death-ligand 1 (PD-L1) induce immune cell ... (Source: BMC Immunology)
Source: BMC Immunology - April 21, 2020 Category: Allergy & Immunology Authors: Isabella McGoverne, Jenny Dunn, Jacob Batham, Wen Juan Tu, Jeremy Chrisp and Sudha Rao Tags: Review Source Type: research
A regulatory role for CD72 expression on B cells and increased soluble CD72 in primary Sjogren ’s syndrome
CD72, a co-receptor of B cell receptor (BCR), has been reported to have both positive and negative effects on B cell functions in several immunological diseases. The B cell plays an important role in the patho... (Source: BMC Immunology)
Source: BMC Immunology - April 19, 2020 Category: Allergy & Immunology Authors: Yuqi Shen, Yuhua Ma, Jingyuan Xie, Li Lin, Yifan Shi, Xiao Li, Pingyan Shen, Xiaoxia Pan and Hong Ren Tags: Research article Source Type: research
Prostaglandin E2 stimulates COX-2 expression via mitogen-activated protein kinase p38 but not ERK in human follicular dendritic cell-like cells
Prostaglandin E2 (PGE2) is an endogenous lipid mediator of inflammation. Its production is regulated by the rate-limiting upstream enzyme cyclooxygenase-2 (COX-2). We have recently demonstrated that the major cel... (Source: BMC Immunology)
Source: BMC Immunology - April 17, 2020 Category: Allergy & Immunology Authors: Whajung Cho and Jongseon Choe Tags: Research article Source Type: research
Ionizing radiation modulates the phenotype and function of human CD4+ induced regulatory T cells
The use of immunotherapy strategies for the treatment of advanced cancer is rapidly increasing. Most immunotherapies rely on induction of CD8+ tumor-specific cytotoxic T cells that are capable of directly kill... (Source: BMC Immunology)
Source: BMC Immunology - April 16, 2020 Category: Allergy & Immunology Authors: Samantha S. Beauford, Anita Kumari and Charlie Garnett-Benson Tags: Research article Source Type: research
Thalidomide with blockade of co-stimulatory molecules prolongs the survival of alloantigen-primed mice with cardiac allografts
Miscellaneous memory cell populations that exist before organ transplantation are crucial barriers to transplantation. In the present study, we used a skin-primed heart transplantation model in mouse to evalua... (Source: BMC Immunology)
Source: BMC Immunology - April 16, 2020 Category: Allergy & Immunology Authors: Maoshu Zhu, Yunhan Ma, Kai Tan, Liyi Zhang, Zhaowei Wang, Yongsheng Li, Yingyu Chen, Junjun Guo, Guoliang Yan and Zhongquan Qi Tags: Research article Source Type: research
Increased Interleukin-35 suppresses peripheral CD14+ monocytes function in patients with Kawasaki disease
Interleukin-35 (IL-35) is a newly identified IL-12 cytokine family member, which regulates the activity of immune cells in infectious diseases and autoimmune disorders. However, the regulatory function of IL-3... (Source: BMC Immunology)
Source: BMC Immunology - April 10, 2020 Category: Allergy & Immunology Authors: Haijian Xing and Gang Tian Tags: Research article Source Type: research
Identification of differentially expressed circulating exosomal lncRNAs in IgA nephropathy patients
Although immunoglobulin A nephropathy (IgAN) is one of the foremost primary glomerular disease, treatment of IgAN is still in infancy. Non-invasive biomarkers are urgently needed for IgAN diagnosis. We investi... (Source: BMC Immunology)
Source: BMC Immunology - March 31, 2020 Category: Allergy & Immunology Authors: Na Guo, Qin Zhou, Xiang Huang, Jianwen Yu, Qianqian Han, Baoting Nong, Yuanyan Xiong, Peifen Liang, Jiajia Li, Min Feng, Jun Lv and Qiongqiong Yang Tags: Research article Source Type: research
Functional comparison of PBMCs isolated by Cell Preparation Tubes (CPT) vs. Lymphoprep Tubes
Cryopreserved human peripheral blood mononuclear cells (PBMCs) are a commonly used sample type for a variety of immunological assays. Many factors can affect the quality of PBMCs, and careful consideration and... (Source: BMC Immunology)
Source: BMC Immunology - March 30, 2020 Category: Allergy & Immunology Authors: Han Chen, Christian M. Sch ürch, Kevin Noble, Kenneth Kim, Peter O. Krutzik, Erika O’Donnell, Jason Vander Tuig, Garry P. Nolan and David R. McIlwain Tags: Methodology article Source Type: research
A combination of the activation marker CD86 and the immune checkpoint marker B and T lymphocyte attenuator (BTLA) indicates a putative permissive activation state of B cell subtypes in healthy blood donors independent of age and sex
The use of anti-B cell based therapies in immune-mediated diseases targeting general B cell markers or molecules important for B cell function has increased the clinical needs of monitoring B cell subpopulations. (Source: BMC Immunology)
Source: BMC Immunology - March 20, 2020 Category: Allergy & Immunology Authors: Susanne Axelsson, Anders Magnuson, Anna Lange, Aseel Alshamari, Elisabeth Hultgren H örnquist and Olof Hultgren Tags: Research article Source Type: research
Cyclosporine a directly affects human and mouse b cell migration in vitro by disrupting a hIF-1 αdependent, o2 sensing, molecular switch
Hypoxia is a potent molecular signal for cellular metabolism, mitochondrial function, and migration. Conditions of low oxygen tension trigger regulatory cascades mediated via the highly conserved HIF-1 α post-tra... (Source: BMC Immunology)
Source: BMC Immunology - March 18, 2020 Category: Allergy & Immunology Authors: Shannon P Hilchey, Mukta G Palshikar, Jason A Emo, Dongmei Li, Jessica Garigen, Jiong Wang, Eric S Mendelson, Valentina Cipolla, Juilee Thakar and Martin S Zand Tags: Research Article Source Type: research
Specific humoral response in cancer patients treated with a VEGF-specific active immunotherapy procedure within a compassionate use program
CIGB-247 is a cancer therapeutic vaccine that uses as antigen a variant of human vascular endothelial growth factor (VEGF) mixed with the bacterially-derived adjuvant VSSP. CIGB-247 has been already evaluated ... (Source: BMC Immunology)
Source: BMC Immunology - March 14, 2020 Category: Allergy & Immunology Authors: Javier S ánchez Ramírez, Yanelys Morera Díaz, Mónica Bequet-Romero, Francisco Hernández-Bernal, Yenima Martín Bauta, Katty-Hind Selman-Housein Bernal, Ana Victoria de la Torre Santos, Mariela Pérez de la Iglesia, Lian Trimiño Lorenzo and Marta Aya Tags: Research article Source Type: research
