The decreased of peripheral blood natural killer cell is associated with serum IL-2 level in the renal tubular acidosis in patients with primary sjogren ’s syndrome
Primary Sjogren ’s Syndrome (pSS) is a lymphoproliferative disease with autoimmune characteristics, which is characterized by lymphocyte infiltration of exocrine glands and involvement and dysfunction of extrag... (Source: BMC Immunology)
Source: BMC Immunology - June 30, 2023 Category: Allergy & Immunology Authors: Liyun Cheng, Lu Liu, Ronghui Su, Huanhuan Yan, Xiaoyu Zi, Chong Gao, Xiaofeng Li and Caihong Wang Tags: Research Source Type: research
CD40 ligand stimulation affects the number and memory phenotypes of human peripheral CD8+ T cells
CD40L is primarily expressed on activated CD4+ T cells and binds to CD40 which is expressed by various cells including dendritic cells, macrophages and B lymphocytes. While CD40-CD40L interaction is known to be d... (Source: BMC Immunology)
Source: BMC Immunology - June 30, 2023 Category: Allergy & Immunology Authors: Haeyoun Choi, Hyun-Joo Lee, Hyun-Jung Sohn and Tai-Gyu Kim Tags: Research Source Type: research
Optimizing tumor-associated antigen-stimulated autologous dendritic cell and cytokine-induced killer cell coculture to enhance cytotoxicity for cancer immunotherapy in manufacturing
Dendritic Cell Cytokine-induced killer cell (DC-CIK) coculture treatment in cancer immunotherapy has been shown to be effective. However, the cost of DC- CIK therapy is prohibitive for many patients, and the l... (Source: BMC Immunology)
Source: BMC Immunology - June 29, 2023 Category: Allergy & Immunology Authors: Yi-Yen Lee, Shao-Ciao Luo, Chung-Hsin Lee, Chien-Lun Tang, Chiung-Chyi Shen, Wen-Yu Cheng, Yi-Chin Yang, Meng-Yin Yang and Chun-Ming Yen Tags: Research Source Type: research
Immunoprofiling of cytokines, chemokines, and growth factors in female patients with systemic lupus erythematosus – a pilot study
This study aimed to determine the concentrations of 30 different human cytokines, chemokines, and growth fa... (Source: BMC Immunology)
Source: BMC Immunology - June 27, 2023 Category: Allergy & Immunology Authors: Laila A. Damiati, Iuliana Denetiu, Sami Bahlas, Samar Damiati and Peter Natesan Pushparaj Tags: Research Source Type: research
Prevention of M2 polarization and temporal limitation of differentiation in monocytes by extracellular ATP
Elevated levels of extracellular adenosine triphosphate (ATP) modulate immunologic pathways and are considered to be a danger signal in inflammation, lung fibrosis and cancer. Macrophages can be classified int... (Source: BMC Immunology)
Source: BMC Immunology - June 23, 2023 Category: Allergy & Immunology Authors: Benedikt F. Scherr, Martin F. Reiner, Flavia Baumann, Kerstin H öhne, Tobias Müller, Korcan Ayata, Joachim Müller-Quernheim, Marco Idzko and Gernot Zissel Tags: Research Source Type: research
Unsolved mystery of Fas: mononuclear cells may have trouble dying in patients with Sj ögren’s syndrome
Patients with Sj ögren’s syndrome, like other patients with autoimmune disorders, display dysregulation in the function of their immune system. Fas and Fas Ligand (FasL) are among the dysregulated proteins. (Source: BMC Immunology)
Source: BMC Immunology - June 23, 2023 Category: Allergy & Immunology Authors: Irena Lindrova, Martina Kolackova, Tereza Svadlakova, Radka Vankova, Marcela Chmelarova, Michaela Rosecka, Eva Jozifkova, Martin Sembera, Jan Krejsek and Radovan Slezak Tags: Research article Source Type: research
Investigation of KIR/HLA relationship and other clinical variables after T-cell-replete haploidentical bone marrow transplantation in patients with acute myeloid leukemia (AML)
KIR/HLA mismatch in hematopoietic stem cell transplantation (HSCT), particularly in patients with acute myeloid leukemia (AML), was related to decreased recurrence rates, improved engraftment, and a reduction ... (Source: BMC Immunology)
Source: BMC Immunology - June 20, 2023 Category: Allergy & Immunology Authors: Tahereh Bakhtiari, Mohammad Ahmadvand, Marjan Yaghmaie, Alireza Sadeghi, Seied Asadollah Mousavi, Tahereh Rostami and Mazdak Ganjalikhani-Hakemi Tags: Research Source Type: research
Assessment of the first presentations of common variable immunodeficiency in a large cohort of patients
Common Variable Immunodeficiency (CVID) is a primary immunodeficiency syndrome resulting in recurrent infections, autoimmunity, and granulomatous manifestations. (Source: BMC Immunology)
Source: BMC Immunology - June 13, 2023 Category: Allergy & Immunology Authors: Hossein Esmaeilzadeh, Armita Jokar-Derisi, Amir Hossein Hassani, Reza Yazdani, Samaneh Delavari, Hassan Abolhassani, Negar Mortazavi and Aida Askarisarvestani Tags: Research Source Type: research
Assessment of autoantibodies in paediatric population with primary immunodeficiencies: a pilot study
The correlation between primary immunodeficiencies (PIDs) and autoimmunity shows ethnic and geographical diversity. The aim of our study was to accumulate more data in paediatric PID population. (Source: BMC Immunology)
Source: BMC Immunology - June 3, 2023 Category: Allergy & Immunology Authors: Karolina Pieniawska- Śmiech, Aleksandra Lewandowicz-Uszyńska, Magdalena Zemelka-Wiacek and Marek Jutel Tags: Research Source Type: research
Transcriptomic responses of bat cells to European bat lyssavirus 1 infection under conditions simulating euthermia and hibernation
Coevolution between pathogens and their hosts decreases host morbidity and mortality. Bats host and can tolerate viruses which can be lethal to other vertebrate orders, including humans. Bat adaptations to inf... (Source: BMC Immunology)
Source: BMC Immunology - April 21, 2023 Category: Allergy & Immunology Authors: Mark éta Harazim, Juliette Perrot, Hugo Varet, Hervé Bourhy, Julien Lannoy, Jiri Pikula, Veronika Seidlová, Laurent Dacheux and Natália Martínková Tags: Research article Source Type: research
Proinflammatory plasticity towards Th17 paradigm of regulatory T cells consistent with elevated prevalence of TGFBR2 variants in elderly patients with primary immune thrombocytopenia
Primary immune thrombocytopenia (ITP) is characterized for the skewed Th differentiation towards Th1 and Th17 cells as well as the impaired number and function of regulatory T cells (Tregs). Tregs are capable ... (Source: BMC Immunology)
Source: BMC Immunology - April 7, 2023 Category: Allergy & Immunology Authors: Jingjing Cao, Yanxia Zhan, Lili Ji, Pu Chen, Luya Cheng, Feng Li, Xibing Zhuang, Zhihui Min, Lihua Sun, Fanli Hua, Hao Chen, Boting Wu and Yunfeng Cheng Tags: Research article Source Type: research
Optimized workflow to modify microRNA expression in primary human intravascular cells
A comprehensive dissection of the role of microRNAs (miRNAs) in gene regulation and subsequent cell functions requires a specific and efficient knockdown or overexpression of the miRNA of interest; these are a... (Source: BMC Immunology)
Source: BMC Immunology - February 15, 2023 Category: Allergy & Immunology Authors: Safak Caglayan, John-Bjarne Hansen and Omri Snir Tags: Research Source Type: research
PU.1-CD23 signaling mediates pulmonary innate immunity against Aspergillus fumigatus infection by driving inflammatory response
Aspergillosis is a common cause of morbidity and mortality in immunocompromised populations. PU.1 is critical for innate immunity against Aspergillus fumigatus (AF) in macrophages. However, the molecular mechanis... (Source: BMC Immunology)
Source: BMC Immunology - January 17, 2023 Category: Allergy & Immunology Authors: Min Wang, Ming Zhang, Jiayong Qiu, Chenyang Liu, Yao Lou, Tongsheng Wang, Yingmin Zhang and Yimin Mao Tags: Research Source Type: research
CTLA4+CD4+CXCR5 −FOXP3+ T cells associate with unfavorable outcome in patients with chronic HBV infection
A major barrier to achieving a favorable outcome of chronic HBV infection is a dysregulated HBV-specific immune response resulting from immunosuppressive features of FOXP3+ T cells. A better definition of FOXP3+ ... (Source: BMC Immunology)
Source: BMC Immunology - January 12, 2023 Category: Allergy & Immunology Authors: Chunhua Wen, Zheyu Dong, Yiyue Wang, Guofu Ye, Yanchen Ma, Xuan Yi, Yang Zhou, Xiaoyi Li, Xinchun Zheng, Jinlin Hou, Yongyin Li and Libo Tang Tags: Research Source Type: research
Patients with indolent lymphomas are at high risk of infections: experience from a German outpatient clinic
Patients with indolent B-cell non-Hodgkin lymphomas (B-NHLs) have an increased risk of infections which is caused by pathomechanisms of the diseases itself but also as a result of anti-tumor therapy. Especiall... (Source: BMC Immunology)
Source: BMC Immunology - January 11, 2023 Category: Allergy & Immunology Authors: Christoph Lutz, Stefan Feiten, Geothy Chakupurakal, Jochen Heymanns, J örg Thomalla, Christoph van Roye and Rudolf Weide Tags: Research Source Type: research
