Prognostic role of red blood cell distribution width in patients with sepsis: a systematic review and meta-analysis
Outcome prediction for patients with sepsis may be conductive to early aggressive interventions. Numerous biomarkers and multiple scoring systems have been utilized in predicting outcomes, however, these tools... (Source: BMC Immunology)
Source: BMC Immunology - July 6, 2020 Category: Allergy & Immunology Authors: Lin Zhang, Cui-hua Yu, Kuan-peng Guo, Cai-zhi Huang and Li-ya Mo Tags: Research article Source Type: research

Health status and infections in patients with symptomatic primary and secondary immunoglobulin G (IgG) deficiencies receiving intravenous IgG replacement
The effects of intravenous immunoglobulin G replacement on perceived health and infection susceptibility of patients suffering from immunoglobulin G (IgG) deficiencies should be evaluated in a prospective anal... (Source: BMC Immunology)
Source: BMC Immunology - June 29, 2020 Category: Allergy & Immunology Authors: Rudolf Weide, Roland Schnell, Christof Schardt, Michael Koenigsmann, Burkhard Otremba, Mark-Oliver Zahn, Jan Wierecky, Ute Braun, Manfred Hensel, Martine Klausmann, Doris Fleckenstein, Peter Ehscheidt and Stefan Feiten Tags: Research article Source Type: research

What is the response profile of deciduous pulp fibroblasts stimulated with E. coli LPS and E. faecalis LTA?
Oral fibroblast immunological responses to bacterial stimuli are well known. However, there are few studies about pulp fibroblasts from deciduous teeth (HDPF) responses, which are important for the treatment o... (Source: BMC Immunology)
Source: BMC Immunology - June 22, 2020 Category: Allergy & Immunology Authors: Bella Luna Colombini-Ishikiriama, Thiago Jose Dionisio, Thais Francini Garbieri, Rafaela Alves da Silva, Maria Aparecida Andrade Moreira Machado, Sandra Helena Penha de Oliveira, Vanessa Soares Lara, Andrew Seth Greene and Carlos Ferreira Santos Tags: Research article Source Type: research

RelB regulates the homeostatic proliferation but not the function of Tregs
RelB, a member of the NF- κB family, plays a critical role in the development of T cells. However, the role of RelB in Foxp3+ regulatory T cells (Tregs) remains controversial. (Source: BMC Immunology)
Source: BMC Immunology - June 18, 2020 Category: Allergy & Immunology Authors: Shuping Zhou, Weiwei Wu, Zhaoxia Wang, Zhaopeng Wang, Qinghong Su, Xiaofan Li, Yong Yu, Weidong Zhang, Mingzhao Zhu and Wei Lin Tags: Research article Source Type: research

JAK inhibitors impair GM-CSF-mediated signaling in innate immune cells
Innate immune cells play a crucial role in the pathophysiology of rheumatoid arthritis (RA) via release of cytokines. Small-molecule inhibitors of Janus kinases (JAKi) are clinically efficacious in patients wi... (Source: BMC Immunology)
Source: BMC Immunology - June 15, 2020 Category: Allergy & Immunology Authors: Yuya Fujita, Naoki Matsuoka, Jumpei Temmoku, Makiko Furuya-Yashiro, Tomoyuki Asano, Shuzo Sato, Haruki Matsumoto, Hiroshi Watanabe, Hideko Kozuru, Hiroshi Yatsuhashi, Atsushi Kawakami and Kiyoshi Migita Tags: Research article Source Type: research

Correction to: Ionizing radiation modulates the phenotype and function of human CD4+ induced regulatory T cells
An amendment to this paper has been published and can be accessed via the original article. (Source: BMC Immunology)
Source: BMC Immunology - June 15, 2020 Category: Allergy & Immunology Authors: Samantha S. Beauford, Anita Kumari and Charlie Garnett-Benson Tags: Correction Source Type: research

Phosphate starvation enhances phagocytosis of Mycobacterium bovis/BCG by macrophages
Tuberculosis is an important health problem worldwide. The only available vaccine is M. bovis/BCG, an attenuated mycobacterium that activates the innate and the acquired immune system after being phagocytosed by ... (Source: BMC Immunology)
Source: BMC Immunology - June 9, 2020 Category: Allergy & Immunology Authors: Patricia Espinosa-Cueto, Alejandro Magallanes-Puebla and Raul Mancilla Tags: Research article Source Type: research

Progranulin inhibits LPS-induced macrophage M1 polarization via NF- кB and MAPK pathways
Macrophage M1 polarization plays a pivotal role in inflammatory diseases. Progranulin (PGRN) has potential anti-inflammation action, however, the effect of PGRN on macrophage M1 polarization has been poorly st... (Source: BMC Immunology)
Source: BMC Immunology - June 5, 2020 Category: Allergy & Immunology Authors: Lianlian Liu, Hongmei Guo, Aimei Song, Jiahui Huang, Yu Zhang, Shanshan Jin, Shutong Li, Liguo Zhang, Chengzhe Yang and Pishan Yang Tags: Research article Source Type: research

Can presepsin uniformly respond to various pathogens? - an in vitro assay of new sepsis marker -
Presepsin (soluble CD14 subtype) is a novel biomarker of sepsis used for early diagnosis. Originally, CD14 is known as the pattern recognition receptor for the lipopolysaccharide (LPS)/LBP complexes, and the d... (Source: BMC Immunology)
Source: BMC Immunology - June 5, 2020 Category: Allergy & Immunology Authors: Yusuke Koizumi, Daisuke Sakanashi, Tetsuo Mohri, Hiroki Watanabe, Arufumi Shiota, Nobuhiro Asai, Hideo Kato, Mao Hagihara, Kenta Murotani, Yuka Yamagishi, Hiroyuki Suematsu and Hiroshige Mikamo Tags: Research article Source Type: research

Formation of ultralong DH regions through genomic rearrangement
Cow antibodies are very unusual in having exceptionally long CDR H3 regions. The genetic basis for this length largely derives from long heavy chain diversity (DH) regions, with a single “ultralong” DH, IGHD8–... (Source: BMC Immunology)
Source: BMC Immunology - June 2, 2020 Category: Allergy & Immunology Authors: Brevin A. Smider and Vaughn V. Smider Tags: Research article Source Type: research

Association of circulating SLAMF7+Tfh1 cells with IgG4 levels in patients with IgG4-related disease
Follicular helper CD4+ T (Tfh) cells have a critical role in IgG4 production by B cells in IgG4-related disease (IgG4-RD). Recent studies including ours showed that SLAMF7+CD4+ T cells are an important pathologic... (Source: BMC Immunology)
Source: BMC Immunology - June 1, 2020 Category: Allergy & Immunology Authors: Kazuhiko Higashioka, Yuri Ota, Takashi Maehara, Masafumi Moriyama, Masahiro Ayano, Hiroki Mitoma, Mitsuteru Akahoshi, Yojiro Arinobu, Takahiko Horiuchi, Seiji Nakamura, Koichi Akashi and Hiroaki Niiro Tags: Research article Source Type: research

Immunogenicity and protective efficacy of a live, oral cholera vaccine formulation stored outside-the-cold-chain for 140  days
Cholera, an acute watery diarrhoeal disease caused by Vibrio cholerae serogroup O1 and O139 across the continents. Replacing the existing WHO licensed killed multiple-dose oral cholera vaccines that demand ‘cold ... (Source: BMC Immunology)
Source: BMC Immunology - May 25, 2020 Category: Allergy & Immunology Authors: Tew Hui Xian, Kurunathan Sinniah, Chan Yean Yean, Venkateskumar Krishnamoorthy, Mohd Baidi Bahari, Manickam Ravichandran and Guruswamy Prabhakaran Tags: Research article Source Type: research

Anti-inflammatory activity of berberine in non-alcoholic fatty liver disease via the Angptl2 pathway
Nonalcoholic fatty liver disease (NAFLD) has become the most common liver disease worldwide. Recent studies have shown that the Angptl2 pathway mediated hepatic inflammatory response plays an important role in... (Source: BMC Immunology)
Source: BMC Immunology - May 19, 2020 Category: Allergy & Immunology Authors: Zengsheng Lu, Beihui He, Zhiyun Chen, Maoxiang Yan and Liyan Wu Tags: Research article Source Type: research

Multi-HLA class II tetramer analyses of citrulline-reactive T cells and early treatment response in rheumatoid arthritis
HLA class II tetramers can be used for ex vivo enumeration and phenotypic characterisation of antigen-specific CD4+ T cells. They are increasingly applied in settings like allergy, vaccination and autoimmune d... (Source: BMC Immunology)
Source: BMC Immunology - May 18, 2020 Category: Allergy & Immunology Authors: Christina Gerstner, Sara Turcinov, Aase H. Hensvold, Karine Chemin, Hannes Uchtenhagen, Tamara H. Ramwadhdoebe, Anatoly Dubnovitsky, Genadiy Kozhukh, Lars R önnblom, William W. Kwok, Adnane Achour, Anca I. Catrina, Lisa G. M. van Baarsen and Vivianne Mal Tags: Research article Source Type: research

Involvement of ABC-transporters and acyltransferase 1 in intracellular cholesterol-mediated autophagy in bovine alveolar macrophages in response to the Bacillus Calmette-Guerin (BCG) infection
Understanding pathogenic mechanisms is imperative for developing novel treatment to the tuberculosis, an important public health burden worldwide. Recent studies demonstrated that host cholesterol levels have ... (Source: BMC Immunology)
Source: BMC Immunology - May 12, 2020 Category: Allergy & Immunology Authors: Jinrui Xu, Yanbing Zhou, Yi Yang, Cuiping Lv, Xiaoming Liu and Yujiong Wang Tags: Research article Source Type: research