Single-cell analysis of immune cell transcriptome during HIV-1 infection and therapy
Cellular immune responses are phenotypically and functionally perturbed during HIV-1 infection, with the majority of function restored upon antiretroviral therapy (ART). Despite ART, residual inflammation rema... (Source: BMC Immunology)
Source: BMC Immunology - September 29, 2022 Category: Allergy & Immunology Authors: Justin Pollara, Santosh Khanal, R. Whitney Edwards, Bhavna Hora, Guido Ferrari, Barton F. Haynes and Todd Bradley Tags: Research Source Type: research
Gentamicin promoted the production of CD4+CD25+ Tregs via the STAT5 signaling pathway in mice sepsis
In this study, we investigated the mechanism of GNT in sepsis. (Source: BMC Immunology)
Source: BMC Immunology - September 26, 2022 Category: Allergy & Immunology Authors: Jinfeng Li, Fengdan Xu, Song Li, Mingyu Xie and Ning Li Tags: Research Source Type: research
The immune subtypes and landscape of sarcomas
Considering the molecular heterogeneity of sarcomas and their immunologically quiet character, immunotherapy (e.g., immune checkpoint inhibitors) plays a viable role in only a subset of these tumors. This stud... (Source: BMC Immunology)
Source: BMC Immunology - September 24, 2022 Category: Allergy & Immunology Authors: Weiwei Weng, Lin Yu, Zhang Li, Cong Tan, Jiaojie Lv, I. Weng Lao, Wenhuo Hu, Zhenzhong Deng, Zebing Liu, Jian Wang and Midie Xu Tags: Research Source Type: research
Interleukin-22 protects from endotoxemia by inducing suppressive F4/80+Ly6GhiLy6Chi cells population
Excessive inflammatory response is the primary cause of early death in patients with endotoxemia. Interleukin 22 (IL-22) has been shown to play critical roles in the modulation of infectious diseases, but its ... (Source: BMC Immunology)
Source: BMC Immunology - September 19, 2022 Category: Allergy & Immunology Authors: Chang Yu, Qihua Ling, Junzhe Jiao, Juhong Liu, Zhihua Huang, Fang Wang, Xuehua Sun and Xiaoni Kong Tags: Research Source Type: research
GBP2 acts as a member of the interferon signalling pathway in lupus nephritis
Lupus nephritis (LN) is a common and serious clinical manifestation of systemic lupus erythematosus. However, the pathogenesis of LN is not fully understood. The currently available treatments do not cure the ... (Source: BMC Immunology)
Source: BMC Immunology - September 17, 2022 Category: Allergy & Immunology Authors: Yuan Zhang, Yinping Liao, Qing Hang, Dong Sun and Ya Liu Tags: Research Source Type: research
Reversing BCG-mediated autophagy inhibition and mycobacterial survival to improve vaccine efficacy
Autophagy is an important mechanism for promoting Mycobacterium clearance from macrophages. Pathogenic and non-pathogenic mycobacterium can activate the mTOR pathway while simultaneously inducing autophagy. M. tu... (Source: BMC Immunology)
Source: BMC Immunology - September 14, 2022 Category: Allergy & Immunology Authors: Maria Gonzalez-Orozco, Emily J. Strong, Ruchi Paroha and Sunhee Lee Tags: Research Source Type: research
The potential pathogenic roles of S100A8/A9 and S100A12 in patients with MPO-ANCA-positive vasculitis
This study was dedicated to exploring the potential pathogenic roles... (Source: BMC Immunology)
Source: BMC Immunology - September 10, 2022 Category: Allergy & Immunology Authors: Xue Bai, Peng-Cheng Xu, Tong Chen, Hao-Miao Zhang, Si-Jing Wu, Xia Yang, Shan Gao, Jun-Ya Jia, Jian-Qing Jiang and Tie-Kun Yan Tags: Research Source Type: research
The proportion and phenotypic changes of CD4+CD25 −Foxp3+ T cells in patients with untreated rheumatoid arthritis
CD4+CD25+Foxp3+ regulatory T (Treg) cell-mediated immunosuppression is an essential mechanism of rheumatoid arthritis (RA). However, little is known regarding the specific role of CD4+CD25 −Foxp3+ Treg cells in RA... (Source: BMC Immunology)
Source: BMC Immunology - September 6, 2022 Category: Allergy & Immunology Authors: Bomiao Ju, Li Zhu, Jing Wang, Jian Zheng, Zhiming Hao, Jing Luo, Jing Zhang, Nan Hu, Qi An, Xiuyuan Feng, Yongwei Huo and Lan He Tags: Research Source Type: research
Cycling and activated CD8+ T lymphocytes and their association with disease severity in influenza patients
T cell lymphopenia was a significant characteristic of severe influenza infection and it was associated with the functional changes of T cells. It is necessary to clarify the T cells characteristics of kinetic... (Source: BMC Immunology)
Source: BMC Immunology - September 5, 2022 Category: Allergy & Immunology Authors: Shuai Liu, Zhisheng Huang, Ruyue Fan, Ju Jia, Xiaoyan Deng, Xiaohui Zou, Hui Li and Bin Cao Tags: Research Source Type: research
NLRP3 inflammasome up-regulates major histocompatibility complex class I expression and promotes inflammatory infiltration in polymyositis
This study was designed to investigate the role of the nucleotide-binding-domain -and leucine-rich repeat -containing (NLR) family, pyrin-domain-containing 3 (NLRP3) inflammasome in the pathogenesis of polymyo... (Source: BMC Immunology)
Source: BMC Immunology - August 14, 2022 Category: Allergy & Immunology Authors: Ping Xia, Yu-Quan Shao, Cong-Cong Yu, Yu Xie and Zhi-Jie Zhou Tags: Research Source Type: research
Correction: Thalidomide with blockade of costimulatory molecules prolongs the survival of alloantigen-primed mice with cardiac allografts
(Source: BMC Immunology)
Source: BMC Immunology - August 9, 2022 Category: Allergy & Immunology Authors: Maoshu Zhu, Yunhan Ma, Kai Tan, Liyi Zhang, Zhaowei Wang, Yongsheng Li, Yingyu Chen, Junjun Guo, Guoliang Yan and Zhongquan Qi Tags: Correction Source Type: research
Blockade of exosome generation by GW4869 inhibits the education of M2 macrophages in prostate cancer
Tumor-associated macrophages are considered to be a major contributor affecting the development of tumors. Recently, numerous studies have shown that tumor cells were able to educate their microenvironment by ... (Source: BMC Immunology)
Source: BMC Immunology - August 8, 2022 Category: Allergy & Immunology Authors: Yilin Peng, Min Zhao, Yinying Hu, Hongyan Guo, Yanyan Zhang, Yanqin Huang, Lin Zhao, Yong Chai and Zhigang Wang Tags: Research Source Type: research
Conformational flexibility of a free and TCR-bound pMHC-I protein investigated by long-term molecular dynamics simulations
Major histocompatibility complexes (MHCs) play a crucial role in the cell-mediated adaptive immune response as they present antigenic peptides (p) which are recognized by host T cells through a complex formati... (Source: BMC Immunology)
Source: BMC Immunology - July 29, 2022 Category: Allergy & Immunology Authors: Lisa Tomasiak, Rudolf Karch and Wolfgang Schreiner Tags: Research Source Type: research
Interleukin-7 regulates CD127 expression and promotes CD8+ T cell activity in patients with primary cutaneous melanoma
Interleukin (IL)-7 signaling through CD127 is impaired in lymphocytes in cancers and chronic infections, resulting in CD8+ T cell exhaustion. The mechanisms underlying CD8+ T cell responses to IL-7 in melanoma re... (Source: BMC Immunology)
Source: BMC Immunology - July 18, 2022 Category: Allergy & Immunology Authors: Hongxia He, Binjun Qiao, Shuping Guo, Hongzhou Cui, Ziyan Zhang and Junxia Qin Tags: Research Source Type: research
The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) within human lymph nodes
HIV eradication efforts have been unsuccessful partly due to virus persistence in immune sanctuary sites such as germinal centres within lymph node (LN) tissues. Recent evidence suggests that LNs harbour a nov... (Source: BMC Immunology)
Source: BMC Immunology - July 1, 2022 Category: Allergy & Immunology Authors: Bongiwe Mahlobo, Faatima Laher, Werner Smidt, Funsho Ogunshola, Trevor Khaba, Thandeka Nkosi, Anele Mbatha, Thandekile Ngubane, Krista Dong, Ismail Jajbhay, Johan Pansegrouw and Zaza M. Ndhlovu Tags: Research Source Type: research
