Humoral and cellular response to SARS-CoV-2 BNT162b2 mRNA vaccine in hemodialysis patients
Hemodialysis (HD) patients have an increased risk of acquiring infections due to many health care contacts and may, in addition, have a suboptimal response to vaccination and a high mortality from Covid-19 inf... (Source: BMC Immunology)
Source: BMC Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Jan Melin, Maria K. Svensson, Bo Albinsson, Ola Winqvist and Karlis Pauksens Tags: Research article Source Type: research
Soluble programmed death molecule 1 (sPD-1) as a predictor of interstitial lung disease in rheumatoid arthritis
Previous studies have indicated that the programmed death molecule 1 (PD-1) signaling pathway may play a key role in rheumatoid arthritis (RA). However, the pathogenesis of rheumatoid arthritis-related interst... (Source: BMC Immunology)
Source: BMC Immunology - October 15, 2021 Category: Allergy & Immunology Authors: Li Xu, Lichun Jiang, Liuyan Nie, Songzhao Zhang, Lei Liu, Yan Du and Jing Xue Tags: Research Source Type: research
Immunogenicity of a new enhanced tetanus-reduced dose diphtheria-acellular pertussis (Tdap) vaccine against Bordetella pertussis in a murine model
The necessity of the tetanus-reduced dose diphtheria-acellular pertussis (Tdap) vaccine in adolescence and adults has been emphasized since the resurgence of small-scale pertussis in Korea and worldwide due to... (Source: BMC Immunology)
Source: BMC Immunology - October 12, 2021 Category: Allergy & Immunology Authors: Kyu Ri Kang, Dong Ho Huh, Ji Ahn Kim and Jin Han Kang Tags: Research article Source Type: research
Activation of Toll-like receptor 2 enhances peripheral and tumor-infiltrating CD8+ T cell cytotoxicity in patients with gastric cancer
Toll-like receptors (TLRs) play central roles in the initiation of innate immune response, and also control adaptive immunity activation. Thus, the aim of the study was to investigate the regulation of TLR act... (Source: BMC Immunology)
Source: BMC Immunology - October 7, 2021 Category: Allergy & Immunology Authors: Junli Xu, Rongya Guo, Jing Jia, Yun He and Shuixiang He Tags: Research Source Type: research
Highly individual- and tissue-specific expression of glycoprotein group A and B blood antigens in the human kidney and liver
Currently, research on the quantitative distribution of ABO antigens in different organs and tissues remains limited. We aimed to examine the individual characteristics of blood group glycoprotein A and B anti... (Source: BMC Immunology)
Source: BMC Immunology - October 1, 2021 Category: Allergy & Immunology Authors: Xianding Wang, Fan Zhang, Yamei Jiang, Zilin Xu, Xiaobing Feng, Linde Li, Yu Fan, Turun Song, Yunying Shi, Zhongli Huang and Tao Lin Tags: Research Source Type: research
An efficient method to identify virus-specific TCRs for TCR-T cell immunotherapy against virus-associated malignancies
Adoptive transfer of T cells genetically engineered with a T cell receptor (TCR) is a promising cancer treatment modality that requires the identification of TCRs with good characteristics. Most T cell cloning... (Source: BMC Immunology)
Source: BMC Immunology - September 28, 2021 Category: Allergy & Immunology Authors: Lei Chen, Lianhua Dong, Yipeng Ma, Juntao Wang, Dongjuan Qiao, Geng Tian and Mingjun Wang Tags: Research Source Type: research
Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and other hematological parameters in psoriasis patients
Psoriasis is a chronic immune ‐mediated skin disorder. Systemic inflammation plays an important role in the pathogenesis of psoriasis. (Source: BMC Immunology)
Source: BMC Immunology - September 26, 2021 Category: Allergy & Immunology Authors: Wen-Ming Wang, Chao Wu, Yi-Meng Gao, Feng Li, Xiao-Ling Yu and Hong-Zhong Jin Tags: Research article Source Type: research
Analysis of multivariate longitudinal immuno-epidemiological data using a pairwise joint modelling approach
Immuno-epidemiologists are often faced with multivariate outcomes, measured repeatedly over time. Such data are characterised by complex inter- and intra-outcome relationships which must be accounted for durin... (Source: BMC Immunology)
Source: BMC Immunology - September 17, 2021 Category: Allergy & Immunology Authors: Lawrence Lubyayi, Patrice A. Mawa, Stephen Cose, Alison M. Elliott, Jonathan Levin and Emily L. Webb Tags: Methodology article Source Type: research
Phenotypic and immune functional profiling of patients with suspected Mendelian Susceptibility to Mycobacterial Disease in South Africa
Mendelian Susceptibility to Mycobacterial Disease (MSMD) is a primary immunodeficiency (PID) characterised by a predisposition to infection by weakly-pathogenic mycobacteria. In countries with a high prevalenc... (Source: BMC Immunology)
Source: BMC Immunology - September 13, 2021 Category: Allergy & Immunology Authors: Ansia van Coller, Brigitte Glanzmann, Helena Cornelissen, Marlo M öller, Craig Kinnear, Monika Esser and Richard Glashoff Tags: Research Source Type: research
Association between serum markers of the humoral immune system and inflammation in the Swedish AMORIS study
Although the onset of inflammatory cascades may profoundly influence the nature of antibody responses, the interplay between inflammatory and humoral (antibody) immune markers remains unclear. Thus, we explore... (Source: BMC Immunology)
Source: BMC Immunology - September 6, 2021 Category: Allergy & Immunology Authors: Aida Santaolalla, Sam Sollie, Ali Rislan, Debra H. Josephs, Niklas Hammar, Goran Walldius, Hans Garmo, Sophia N. Karagiannis and Mieke Van Hemelrijck Tags: Research article Source Type: research
The augment of regulatory T cells undermines the efficacy of anti-PD-L1 treatment in cervical cancer
Immune checkpoint inhibitors have aroused great expectation of tumor eradication. However, the effect of anti-PD-L1 treatment for cervical cancer is unsatisfactory and the underlying antagonist to anti-PD-L1 e... (Source: BMC Immunology)
Source: BMC Immunology - September 3, 2021 Category: Allergy & Immunology Authors: Fengying Xu, Fengying Zhang, Qian Wang, Ying Xu, Shuifang Xu, Caihong Zhang and Lihua Wang Tags: Research Source Type: research
Innate lymphoid cell dysfunction during long-term suppressive antiretroviral therapy in an African cohort
Innate lymphoid cells (ILC) are lymphoid lineage innate immune cells that do not mount antigen-specific responses due to their lack of B and T-cell receptors. ILCs are predominantly found at mucosal surfaces, ... (Source: BMC Immunology)
Source: BMC Immunology - August 26, 2021 Category: Allergy & Immunology Authors: Rose Nabatanzi, Lois Bayigga, Stephen Cose, Glenda Canderan, Sarah Rowland Jones, Moses Joloba and Damalie Nakanjako Tags: Research Source Type: research
Intratumoral regulatory T cells from colon cancer patients comprise several activated effector populations
Intratumoral regulatory T cells (Treg) in colon cancer are a heterogeneous cell population, with potential impact on patient outcome. Generally, a high Treg infiltration has been correlated to a worse patient ... (Source: BMC Immunology)
Source: BMC Immunology - August 19, 2021 Category: Allergy & Immunology Authors: Louis Szeponik, Filip Ahlmanner, Patrik Sundstr öm, William Rodin, Bengt Gustavsson, Elinor Bexe Lindskog, Yvonne Wettergren and Marianne Quiding-Järbrink Tags: Research Source Type: research
Pharmacological activation of rev-erb α suppresses LPS-induced macrophage M1 polarization and prevents pregnancy loss
Circadian rhythm is an important player for reproduction. Rev-erb α, a significant clock gene, is involved in regulating cell differentiation, inflammation and metabolism. Macrophage polarization plays crucial ... (Source: BMC Immunology)
Source: BMC Immunology - August 16, 2021 Category: Allergy & Immunology Authors: Liyuan Cui, Feng Xu, Songcun Wang, Xinyi Li, Haiyan Lin, Yan Ding and Meirong Du Tags: Research Source Type: research
The transmembrane domain and luminal C-terminal region independently support invariant chain trimerization and assembly with MHCII into nonamers
Invariant chain (CD74, Ii) is a multifunctional protein expressed in antigen presenting cells. It assists the ER exit of various cargos and serves as a receptor for the macrophage migration inhibitory factor. ... (Source: BMC Immunology)
Source: BMC Immunology - August 12, 2021 Category: Allergy & Immunology Authors: Maryse Cloutier, Jean-Simon Fortin and Jacques Thibodeau Tags: Research article Source Type: research
