Interleukin 4 gene polymorphism ( −589C/T) and the risk of asthma: a meta-analysis and met-regression based on 55 studies
Numerous investigations have previously evaluated the association of interleukin (IL) 4 gene polymorphisms and the risk of asthma, conferring inconsistent results. To resolve the incongruent outcomes yielded from... (Source: BMC Immunology)
Source: BMC Immunology - October 21, 2020 Category: Allergy & Immunology Authors: Ahmad Kousha, Armita Mahdavi Gorabi, Mehdi Forouzesh, Mojgan Hosseini, Markov Alexander, Danyal Imani, Bahman Razi, Mohammad Javad Mousavi, Saeed Aslani and Haleh Mikaeili Tags: Research article Source Type: research

Comparative efficacy of glucocorticoid receptor agonists on Th2 cell function and attenuation by progesterone
Corticosteroids (CS)s suppress cytokine production and induce apoptosis of inflammatory cells. Prednisone and dexamethasone are oral CSs prescribed for treating asthma exacerbations. While prednisone is more c... (Source: BMC Immunology)
Source: BMC Immunology - October 19, 2020 Category: Allergy & Immunology Authors: Alexander Luchak, Lauren A. Solomon, Tharsan Kanagalingam, Meerah Vijeyakumaran, Brian H. Rowe and Lisa Cameron Tags: Research article Source Type: research

Decreased glycolysis induced dysfunction of NK cells in Henoch-Schonlein purpura patients
Henoch-Schonlein purpura (HSP) is the most common systemic vasculitis of the childhood. However, its mechanisms and pathogenesis still need more exploration. Natural killer (NK) cells are innate lymphocytes, a... (Source: BMC Immunology)
Source: BMC Immunology - October 9, 2020 Category: Allergy & Immunology Authors: Wenjia Chai, Xiaolin Wang, Wei Wang, Hui Wang, Wenjun Mou and Jingang Gui Tags: Research article Source Type: research

Cytokine profile in the sputum of subjects with post-tuberculosis airflow obstruction and in those with tobacco related chronic obstructive pulmonary disease
Previous studies have shown that tuberculosis (TB) is a risk factor for chronic airflow limitation. Chronic obstructive pulmonary disease (COPD) is recognized as the result of chronic inflammation, usually rel... (Source: BMC Immunology)
Source: BMC Immunology - October 1, 2020 Category: Allergy & Immunology Authors: Elise Guiedem, Eric Walter Pefura-Yone, George Mondinde Ikomey, C éline Nguefeu Nkenfou, Martha Mesembe, Mbanyamsig Mispa Yivala, Bih Hycenta Chendi, Graeme Brendon Jacobs, Novel Njweipi Chegou and Marie Claire Assoumou Okomo Tags: Research article Source Type: research

Natural killer cell levels in adults living with type 2 diabetes: a systematic review and meta-analysis of clinical studies
Chronic immune activation and hyperglycaemia are a hallmark of type 2 diabetes mellitus (T2D) while natural killer (NK) cells are involved in the pathogenesis of T2D. Dysregulated NK cell responses are associa... (Source: BMC Immunology)
Source: BMC Immunology - September 9, 2020 Category: Allergy & Immunology Authors: Vuyolwethu Mxinwa, Phiwayinkosi V. Dludla, Tawanda M. Nyambuya, Kabelo Mokgalaboni, Sithandiwe E. Mazibuko-Mbeje and Bongani B. Nkambule Tags: Research article Source Type: research

Genomic, microbial and environmental standardization in animal experimentation limiting immunological discovery
The use of inbred mice housed under standardized environmental conditions has been critical in identifying immuno-pathological mechanisms in different infectious and inflammatory diseases as well as revealing ... (Source: BMC Immunology)
Source: BMC Immunology - September 2, 2020 Category: Allergy & Immunology Authors: Josue Enriquez, Brianyell Mc Daniel Mims, Scott Trasti, Kathryn L. Furr and Matthew B. Grisham Tags: Review Source Type: research

Elevated expansion of follicular helper T cells in peripheral blood from children with acute measles infection
Measles outbreaks have threatened the global elimination and eradication of measles in recent years. Measles virus (MeV)-specific antibodies are successful in clearing MeV infection. Follicular helper T (Tfh) ... (Source: BMC Immunology)
Source: BMC Immunology - September 1, 2020 Category: Allergy & Immunology Authors: Weiyun Shen, Hongzhou Ye, Xilin Zhang, Lixia Huo, Jingli Shen, Li Zhu, Xiang Wang and Dawei Cui Tags: Research article Source Type: research

Association of TIM-3 expression with glucose metabolism in Jurkat T cells
T cell activation is associated with increase in glycolysis and glutaminolysis. T cell immunoglobulin and mucin domain containing protein-3 (TIM-3), a T cell surface molecule, downregulates T cell activation a... (Source: BMC Immunology)
Source: BMC Immunology - August 20, 2020 Category: Allergy & Immunology Authors: Mi Jin Lee, Su Jin Yun, Bokyoung Lee, Eun Jeong, Gyesoon Yoon, Kyongmin Kim and Sun Park Tags: Research article Source Type: research

Subcutaneous immunoglobulin in primary immunodeficiency – impact of training and infusion characteristics on patient-reported outcomes
Subcutaneous immunoglobulin (SCIG) is increasingly utilized in primary immunodeficiency (PI). Understanding factors associated with treatment experience and satisfaction can optimize patient outcomes. We analy... (Source: BMC Immunology)
Source: BMC Immunology - August 10, 2020 Category: Allergy & Immunology Authors: R. Mallick, T. Henderson, B. J. Lahue, A. Kafal, P. Bassett and C. Scalchunes Tags: Research article Source Type: research

CD16 expression on neutrophils predicts treatment efficacy of capecitabine in colorectal cancer patients
Early detection of capecitabine-resistance could largely increase overall survival of colorectal cancer (CRC) patients. Previous studies suggested examination of immune cells in peripheral blood would help to ... (Source: BMC Immunology)
Source: BMC Immunology - August 8, 2020 Category: Allergy & Immunology Authors: Yu Lu, Yizhou Huang, Lei Huang, Yanjie Xu, Zien Wang, Han Li, Ting Zhang, Ming Zhong, Wei-qiang Gao and Yan Zhang Tags: Research article Source Type: research

Tertiary lymphoid structure related B-cell IgE isotype switching and secondary lymphoid organ linked IgE production in mouse allergy model
Numerous data obtained by different research laboratories indicate that specific IgE production is triggered independently of specific IgG or IgA ones and so it is not linked to fully matured germinal centers ... (Source: BMC Immunology)
Source: BMC Immunology - August 7, 2020 Category: Allergy & Immunology Authors: Dmitrii Borisovich Chudakov, Dmitrii Yuryevich Ryasantsev, Daria Sergeevna Tsaregorotseva, Olga Dmitrievna Kotsareva, Gulnar Vaisovna Fattakhova and Elena Viktorovna Svirshchevskaya Tags: Research article Source Type: research

Characteristics and reference ranges of CD4+T cell subpopulations among healthy adult Han Chinese in Shanxi Province, North China
Immunophenotyping of blood lymphocytes is an essential tool to evaluate the immune function of patients with immunodeficiency or autoimmunity. Predominately identified CD4+T cell subsets, Th1, Th2, Th17, as well ... (Source: BMC Immunology)
Source: BMC Immunology - August 3, 2020 Category: Allergy & Immunology Authors: Hong-Qing Niu, Xiang-Cong Zhao, Wei Li, Jian-Fang Xie, Xiao-Qing Liu, Jing Luo, Wen-Peng Zhao and Xiao-Feng Li Tags: Research article Source Type: research

Reduced polyfunctional T cells and increased cellular activation markers in adult allergy patients reporting adverse reactions to food
The underlying cellular mechanisms causing adverse reactions to food are complex and still not fully understood. Therefore, in this study we aimed to identify functional and/or phenotypical immune cell signatu... (Source: BMC Immunology)
Source: BMC Immunology - July 22, 2020 Category: Allergy & Immunology Authors: Friederike Sonnet, Ellen Namork, Eva Stylianou, Ingvild Gaare-Olstad, Kanutte Huse, Sandra Andorf, Siri Mjaaland, Hubert Dirven and Unni Nygaard Tags: Research article Source Type: research

Assessment of weight and height of patients with primary immunodeficiency disorders and group of children with recurrent respiratory tract infections
Primary immunodeficiences (PIDs) are a group of chronic, serious disorders in which the immune response is insufficient. In consequence, it leads to an increased susceptibility to infections. Up to date, there... (Source: BMC Immunology)
Source: BMC Immunology - July 16, 2020 Category: Allergy & Immunology Authors: Karolina Pieniawska- Śmiech, Kamil Bar, Mateusz Babicki, Karol Śmiech and Aleksandra Lewandowicz-Uszyńska Tags: Research article Source Type: research

EGR2 is elevated and positively regulates inflammatory IFN γ production in lupus CD4+ T cells
Recent studies have shown that early growth response 2 (EGR2) is highly induced in activated T cells and regulates T cell functions. In normal C57BL/6 (B6) mice, deletion of EGR2 in lymphocytes results in the ... (Source: BMC Immunology)
Source: BMC Immunology - July 9, 2020 Category: Allergy & Immunology Authors: Rujuan Dai, Bettina Heid, Xiguang Xu, Hehuang Xie, Christopher M. Reilly and S. Ansar Ahmed Tags: Research article Source Type: research