Biomechanics and Modeling in Mechanobiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Effect of twisting of intravitreal injections on ocular bio-mechanics: a novel insight to ocular surgery
Biomech Model Mechanobiol. 2024 Feb 15. doi: 10.1007/s10237-024-01819-5. Online ahead of print.ABSTRACTAlthough intravitreal (IVT) injections provide several advantages in treating posterior segment eye diseases, several associated challenges remain. The current study uses the finite element method (FEM) to highlight the effect of IVT needle rotation along the insertion axis on the reaction forces and deformation inside the eye. A comparison of the reaction forces at the eye's key locations has been made with and without rotation. In addition, a sensitivity analysis of various parameters, such as the needle's angular speed...
Source: Biomechanics and Modeling in Mechanobiology - February 16, 2024 Category: Biomedical Science Authors: Ashish Siddharth Ajay Bhandari Sarthak S Singh Arun Dayal Udai Source Type: research

Influence of material parameter variability on the predicted coronary artery biomechanical environment via uncertainty quantification
In this study, we applied a coupled uncertainty quantification-finite element (FE) framework to understand the impact of uncertainty in vascular material properties on variability in predicted stresses. Univariate probability distributions were fit to material parameters derived from layer-specific mechanical behavior testing of human coronary tissue. Parameters were assumed to be probabilistically independent, allowing for efficient parameter ensemble sampling. In an idealized coronary artery geometry, a forward FE model for each parameter ensemble was created to predict tissue stresses under physiologic loading. An emula...
Source: Biomechanics and Modeling in Mechanobiology - February 16, 2024 Category: Biomedical Science Authors: Caleb C Berggren David Jiang Y F Jack Wang Jake A Bergquist Lindsay C Rupp Zexin Liu Rob S MacLeod Akil Narayan Lucas H Timmins Source Type: research

Correction to: A new model for evaluating pressure ‑induced vascular tone in small cerebral arteries
Biomech Model Mechanobiol. 2024 Feb 15. doi: 10.1007/s10237-023-01795-2. Online ahead of print.NO ABSTRACTPMID:38358396 | DOI:10.1007/s10237-023-01795-2 (Source: Biomechanics and Modeling in Mechanobiology)
Source: Biomechanics and Modeling in Mechanobiology - February 15, 2024 Category: Biomedical Science Authors: Alberto Coccarelli Sanjay Pant Ioannis Polydoros Osama F Harraz Source Type: research

Discrete network models of endothelial cells and their interactions with the substrate
Biomech Model Mechanobiol. 2024 Feb 14. doi: 10.1007/s10237-023-01815-1. Online ahead of print.ABSTRACTEndothelial cell monolayers line the inner surfaces of blood and lymphatic vessels. They are continuously exposed to different mechanical loads, which may trigger mechanobiological signals and hence play a role in both physiological and pathological processes. Computer-based mechanical models of cells contribute to a better understanding of the relation between cell-scale loads and cues and the mechanical state of the hosting tissue. However, the confluency of the endothelial monolayer complicates these approaches since t...
Source: Biomechanics and Modeling in Mechanobiology - February 14, 2024 Category: Biomedical Science Authors: Raphael Jakob Ben R Britt Costanza Giampietro Edoardo Mazza Alexander E Ehret Source Type: research

Effect of meniscus modelling assumptions in a static tibiofemoral finite element model: importance of geometry over material
Biomech Model Mechanobiol. 2024 Feb 13. doi: 10.1007/s10237-024-01822-w. Online ahead of print.ABSTRACTFinite element studies of the tibiofemoral joint have increased use in research, with attention often placed on the material models. Few studies assess the effect of meniscus modelling assumptions in image-based models on contact mechanics outcomes. This work aimed to assess the effect of modelling assumptions of the meniscus on knee contact mechanics and meniscus kinematics. A sensitivity analysis was performed using three specimen-specific tibiofemoral models and one generic knee model. The assumptions in representing t...
Source: Biomechanics and Modeling in Mechanobiology - February 13, 2024 Category: Biomedical Science Authors: Jiacheng Yao John Crockett Mathias D'Souza Gavin A Day Ruth K Wilcox Alison C Jones Marl ène Mengoni Source Type: research

A fast in silico model for preoperative risk assessment of paravalvular leakage
Biomech Model Mechanobiol. 2024 Feb 11. doi: 10.1007/s10237-024-01816-8. Online ahead of print.ABSTRACTIn silico simulations can be used to evaluate and optimize the safety, quality, efficacy and applicability of medical devices. Furthermore, in silico modeling is a powerful tool in therapy planning to optimally tailor treatment for each patient. For this purpose, a workflow to perform fast preoperative risk assessment of paravalvular leakage (PVL) after transcatheter aortic valve replacement (TAVR) is presented in this paper. To this end, a novel, efficient method is introduced to calculate the regurgitant volume in a sim...
Source: Biomechanics and Modeling in Mechanobiology - February 11, 2024 Category: Biomedical Science Authors: Michelle Spanjaards Finja Borowski Laura Supp Ren é Ubachs Valentina Lavezzo Olaf van der Sluis Source Type: research

Uniaxial mechanical stretch properties correlated with three-dimensional microstructure of human dermal skin
Biomech Model Mechanobiol. 2024 Feb 7. doi: 10.1007/s10237-023-01813-3. Online ahead of print.ABSTRACTThe intact and healthy skin forms a barrier to the outside world and protects the body from mechanical impact. The skin is a complex structure with unique mechano-elastic properties. To better direct the design of biomimetic materials and induce skin regeneration in wounds with optimal outcome, more insight is required in how the mechano-elastic properties emerge from the skin's main constituents, collagen and elastin fibers. Here, we employed two-photon excited autofluorescence and second harmonic generation microscopy to...
Source: Biomechanics and Modeling in Mechanobiology - February 7, 2024 Category: Biomedical Science Authors: Mengyao Zhou Patrick Jos é González Ludo Van Haasterecht Alperen Soylu Maria Mihailovski Paul Van Zuijlen Marie Louise Groot Source Type: research

A molecular arm: the molecular bending-unbending mechanism of integrin
This study provides new insights into the mechanism of how the integrin secures in the bent inactivated state and sheds light on how the integrin could achieve a stable extended state.PMID:38308770 | DOI:10.1007/s10237-023-01805-3 (Source: Biomechanics and Modeling in Mechanobiology)
Source: Biomechanics and Modeling in Mechanobiology - February 3, 2024 Category: Biomedical Science Authors: Zhenhai Li Source Type: research

Effect of collagen fibril orientation on the anisotropic properties of peri-implant bone
Biomech Model Mechanobiol. 2024 Feb 1. doi: 10.1007/s10237-023-01811-5. Online ahead of print.ABSTRACTIn orthopedic and dental surgery, the implantation of biomaterials within the bone to restore the integrity of the treated organ has become a standard procedure. Their long-term stability relies on the osseointegration phenomena, where bone grows onto and around metallic implants, creating a bone-implant interface. Bone is a highly hierarchical material that evolves spatially and temporally during this healing phase. A deeper understanding of its biomechanical characteristics is needed, as they are determinants for surgica...
Source: Biomechanics and Modeling in Mechanobiology - February 1, 2024 Category: Biomedical Science Authors: Lucas Colabella Salah Naili Sophie Le Cann Guillaume Haiat Source Type: research

Bone turnover and mineralisation kinetics control trabecular BMDD and apparent bone density: insights from a discrete statistical bone remodelling model
Biomech Model Mechanobiol. 2024 Jan 27. doi: 10.1007/s10237-023-01812-4. Online ahead of print.ABSTRACTThe mechanical quality of trabecular bone is influenced by its mineral content and spatial distribution, which is controlled by bone remodelling and mineralisation. Mineralisation kinetics occur in two phases: a fast primary mineralisation and a secondary mineralisation that can last from several months to years. Variations in bone turnover and mineralisation kinetics can be observed in the bone mineral density distribution (BMDD). Here, we propose a statistical spatio-temporal bone remodelling model to study the effects ...
Source: Biomechanics and Modeling in Mechanobiology - January 27, 2024 Category: Biomedical Science Authors: Natalia M Castoldi Edmund Pickering Vittorio Sansalone David Cooper Peter Pivonka Source Type: research

Research on ultrasonic bone cutting mechanism based on extended finite element method
Biomech Model Mechanobiol. 2024 Jan 23. doi: 10.1007/s10237-023-01810-6. Online ahead of print.ABSTRACTThe research on the crack propagation mechanism of bone has important research significance and clinical medical value for the selection of cutting parameters and the development of new surgical tools. In this paper, an extended finite element method (X-FEM) model of ultrasonic bone cutting considering microstructure was developed to further study the ultrasonic bone cutting mechanism and to quantitatively analyze the effects of cutting direction, ultrasonic parameters, and cutting parameters on the mechanism of ultrasoni...
Source: Biomechanics and Modeling in Mechanobiology - January 23, 2024 Category: Biomedical Science Authors: Linwei Wang Yu Liu Shiwei Wang Jinguang Li Yumeng Sun Jingyu Wang Qilei Zou Source Type: research

A new method to design energy-conserving surrogate models for the coupled, nonlinear responses of intervertebral discs
Biomech Model Mechanobiol. 2024 Jan 20. doi: 10.1007/s10237-023-01804-4. Online ahead of print.ABSTRACTThe aim of this study was to design physics-preserving and precise surrogate models of the nonlinear elastic behaviour of an intervertebral disc (IVD). Based on artificial force-displacement data sets from detailed finite element (FE) disc models, we used greedy kernel and polynomial approximations of second, third and fourth order to train surrogate models for the scalar force-torque -potential. Doing so, the resulting models of the elastic IVD responses ensured the conservation of mechanical energy through their structu...
Source: Biomechanics and Modeling in Mechanobiology - January 20, 2024 Category: Biomedical Science Authors: Maria Hammer Tizian Wenzel Gabriele Santin Laura Meszaros-Beller Judith Paige Little Bernard Haasdonk Syn Schmitt Source Type: research

A physics-informed deep learning framework for modeling of coronary in-stent restenosis
Biomech Model Mechanobiol. 2024 Jan 18. doi: 10.1007/s10237-023-01796-1. Online ahead of print.ABSTRACTMachine learning (ML) techniques have shown great potential in cardiovascular surgery, including real-time stenosis recognition, detection of stented coronary anomalies, and prediction of in-stent restenosis (ISR). However, estimating neointima evolution poses challenges for ML models due to limitations in manual measurements, variations in image quality, low data availability, and the difficulty of acquiring biological quantities. An effective in silico model is necessary to accurately capture the mechanisms leading to n...
Source: Biomechanics and Modeling in Mechanobiology - January 18, 2024 Category: Biomedical Science Authors: Jianye Shi Kiran Manjunatha Marek Behr Felix Vogt Stefanie Reese Source Type: research

Numerical study of ultra-large von Willebrand factor multimers in coagulopathy
In this study, using a computational model based on first principles, we quantitatively show how the uncleaved UL-VWF multimers interact with the blood cells to initiate microthrombosis. We observed that platelets first adhere to unfolded and stretched uncleaved UL-VWF multimers anchored to the microvessel wall. By the end of this initial adhesion phase, the UL-VWF multimers and platelets make a mesh-like trap in which the red blood cells increasingly accumulate to initiate a gradually growing microthrombosis. Although high-shear rate and blood flow velocity are required to activate platelets and unfold the UL-VWFs, during...
Source: Biomechanics and Modeling in Mechanobiology - January 13, 2024 Category: Biomedical Science Authors: Nahid Rahmati Pouyan Keshavarz Motamed Nima Maftoon Source Type: research