Biomechanics and Modeling in Mechanobiology 
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Biomech Model Mechanobiol. 2024 Jan 13. doi: 10.1007/s10237-023-01779-2. Online ahead of print.ABSTRACTFrom biological organs to soft robotics, highly deformable materials are essential components of natural and engineered systems. These highly deformable materials can have heterogeneous material properties, and can experience heterogeneous deformations with or without underlying material heterogeneity. Many recent works have established that computational modeling approaches are well suited for understanding and predicting the consequences of material heterogeneity and for interpreting observed heterogeneous strain fields...
Source: Biomechanics and Modeling in Mechanobiology - January 13, 2024 Category: Biomedical Science Authors: Quan Nguyen Emma Lejeune Source Type: research
Multiscale mechanical characterisation of the craniofacial system under external forces
Biomech Model Mechanobiol. 2024 Jan 13. doi: 10.1007/s10237-023-01799-y. Online ahead of print.ABSTRACTPremature fusion of craniofacial joints, i.e. sutures, is a major clinical condition. This condition affects children and often requires numerous invasive surgeries to correct. Minimally invasive external loading of the skull has shown some success in achieving therapeutic effects in a mouse model of this condition, promising a new non-invasive treatment approach. However, our fundamental understanding of the level of deformation that such loading has induced across the sutures, leading to the effects observed is severely...
Source: Biomechanics and Modeling in Mechanobiology - January 13, 2024 Category: Biomedical Science Authors: Marius Didziokas Dominic Jones Ali Alazmani Miranda Steacy Erwin Pauws Mehran Moazen Source Type: research
Investigation of direction- and age-dependent prestretch in mouse cranial dura mater
Biomech Model Mechanobiol. 2024 Jan 11. doi: 10.1007/s10237-023-01802-6. Online ahead of print.ABSTRACTCranial dura mater is a dense interwoven vascularized connective tissue that helps regulate neurocranial remodeling by responding to strains from the growing brain. Previous ex vivo experimentation has failed to account for the role of prestretch in the mechanical behavior of the dura. Here we aim to estimate the prestretch in mouse cranial dura mater and determine its dependency on direction and age. We performed transverse and longitudinal incisions in parietal dura excised from newborn (day [Formula: see text]4) and ma...
Source: Biomechanics and Modeling in Mechanobiology - January 11, 2024 Category: Biomedical Science Authors: Jack Consolini Alyssa G Oberman John Sayut Frederick W Damen Craig J Goergen Matthew J Ravosa Maria A Holland Source Type: research
Nonlocal damage evaluation of a sigmoid-based damage model for fibrous biological soft tissues
Biomech Model Mechanobiol. 2023 Dec 29. doi: 10.1007/s10237-023-01798-z. Online ahead of print.ABSTRACTThe comprehension and modeling of the mechanical behavior of soft biological tissues are essential due to their clinical applications. This knowledge is essential for predicting tissue responses accurately and enhancing our ability to compute the behavior of biological structures and bio-prosthetic devices under specific loading conditions. The current research is centered on modeling the initiation and progression of soft tissues damage, which typically exhibit intricate anisotropic and nonlinear elastic characteristics....
Source: Biomechanics and Modeling in Mechanobiology - December 29, 2023 Category: Biomedical Science Authors: Sof ía Suárez Jose A L ópez-Campos Jose R Fern ández Abraham Segade Source Type: research
Nonlocal damage evaluation of a sigmoid-based damage model for fibrous biological soft tissues
Biomech Model Mechanobiol. 2023 Dec 29. doi: 10.1007/s10237-023-01798-z. Online ahead of print.ABSTRACTThe comprehension and modeling of the mechanical behavior of soft biological tissues are essential due to their clinical applications. This knowledge is essential for predicting tissue responses accurately and enhancing our ability to compute the behavior of biological structures and bio-prosthetic devices under specific loading conditions. The current research is centered on modeling the initiation and progression of soft tissues damage, which typically exhibit intricate anisotropic and nonlinear elastic characteristics....
Source: Biomechanics and Modeling in Mechanobiology - December 29, 2023 Category: Biomedical Science Authors: Sof ía Suárez Jose A L ópez-Campos Jose R Fern ández Abraham Segade Source Type: research
Nonlocal damage evaluation of a sigmoid-based damage model for fibrous biological soft tissues
Biomech Model Mechanobiol. 2023 Dec 29. doi: 10.1007/s10237-023-01798-z. Online ahead of print.ABSTRACTThe comprehension and modeling of the mechanical behavior of soft biological tissues are essential due to their clinical applications. This knowledge is essential for predicting tissue responses accurately and enhancing our ability to compute the behavior of biological structures and bio-prosthetic devices under specific loading conditions. The current research is centered on modeling the initiation and progression of soft tissues damage, which typically exhibit intricate anisotropic and nonlinear elastic characteristics....
Source: Biomechanics and Modeling in Mechanobiology - December 29, 2023 Category: Biomedical Science Authors: Sof ía Suárez Jose A L ópez-Campos Jose R Fern ández Abraham Segade Source Type: research
Nonlocal damage evaluation of a sigmoid-based damage model for fibrous biological soft tissues
Biomech Model Mechanobiol. 2023 Dec 29. doi: 10.1007/s10237-023-01798-z. Online ahead of print.ABSTRACTThe comprehension and modeling of the mechanical behavior of soft biological tissues are essential due to their clinical applications. This knowledge is essential for predicting tissue responses accurately and enhancing our ability to compute the behavior of biological structures and bio-prosthetic devices under specific loading conditions. The current research is centered on modeling the initiation and progression of soft tissues damage, which typically exhibit intricate anisotropic and nonlinear elastic characteristics....
Source: Biomechanics and Modeling in Mechanobiology - December 29, 2023 Category: Biomedical Science Authors: Sof ía Suárez Jose A L ópez-Campos Jose R Fern ández Abraham Segade Source Type: research
Nonlocal damage evaluation of a sigmoid-based damage model for fibrous biological soft tissues
Biomech Model Mechanobiol. 2023 Dec 29. doi: 10.1007/s10237-023-01798-z. Online ahead of print.ABSTRACTThe comprehension and modeling of the mechanical behavior of soft biological tissues are essential due to their clinical applications. This knowledge is essential for predicting tissue responses accurately and enhancing our ability to compute the behavior of biological structures and bio-prosthetic devices under specific loading conditions. The current research is centered on modeling the initiation and progression of soft tissues damage, which typically exhibit intricate anisotropic and nonlinear elastic characteristics....
Source: Biomechanics and Modeling in Mechanobiology - December 29, 2023 Category: Biomedical Science Authors: Sof ía Suárez Jose A L ópez-Campos Jose R Fern ández Abraham Segade Source Type: research
Nonlocal damage evaluation of a sigmoid-based damage model for fibrous biological soft tissues
Biomech Model Mechanobiol. 2023 Dec 29. doi: 10.1007/s10237-023-01798-z. Online ahead of print.ABSTRACTThe comprehension and modeling of the mechanical behavior of soft biological tissues are essential due to their clinical applications. This knowledge is essential for predicting tissue responses accurately and enhancing our ability to compute the behavior of biological structures and bio-prosthetic devices under specific loading conditions. The current research is centered on modeling the initiation and progression of soft tissues damage, which typically exhibit intricate anisotropic and nonlinear elastic characteristics....
Source: Biomechanics and Modeling in Mechanobiology - December 29, 2023 Category: Biomedical Science Authors: Sof ía Suárez Jose A L ópez-Campos Jose R Fern ández Abraham Segade Source Type: research
Nonlocal damage evaluation of a sigmoid-based damage model for fibrous biological soft tissues
Biomech Model Mechanobiol. 2023 Dec 29. doi: 10.1007/s10237-023-01798-z. Online ahead of print.ABSTRACTThe comprehension and modeling of the mechanical behavior of soft biological tissues are essential due to their clinical applications. This knowledge is essential for predicting tissue responses accurately and enhancing our ability to compute the behavior of biological structures and bio-prosthetic devices under specific loading conditions. The current research is centered on modeling the initiation and progression of soft tissues damage, which typically exhibit intricate anisotropic and nonlinear elastic characteristics....
Source: Biomechanics and Modeling in Mechanobiology - December 29, 2023 Category: Biomedical Science Authors: Sof ía Suárez Jose A L ópez-Campos Jose R Fern ández Abraham Segade Source Type: research
Multiscale insights into postnatal aortic development
Biomech Model Mechanobiol. 2023 Dec 27. doi: 10.1007/s10237-023-01800-8. Online ahead of print.ABSTRACTDespite its vital importance for establishing proper cardiovascular function, the process through which the vasculature develops and matures postnatally remains poorly understood. From a clinical perspective, an ability to mechanistically model the developmental time course in arteries and veins, as well as to predict how various pathologies and therapeutic interventions alter the affected vessels, promises to improve treatment strategies and long-term clinical outcomes, particularly in pediatric patients suffering from c...
Source: Biomechanics and Modeling in Mechanobiology - December 27, 2023 Category: Biomedical Science Authors: Bruno V Rego Sae-Il Murtada Guangxin Li George Tellides Jay D Humphrey Source Type: research
Multiscale insights into postnatal aortic development
Biomech Model Mechanobiol. 2023 Dec 27. doi: 10.1007/s10237-023-01800-8. Online ahead of print.ABSTRACTDespite its vital importance for establishing proper cardiovascular function, the process through which the vasculature develops and matures postnatally remains poorly understood. From a clinical perspective, an ability to mechanistically model the developmental time course in arteries and veins, as well as to predict how various pathologies and therapeutic interventions alter the affected vessels, promises to improve treatment strategies and long-term clinical outcomes, particularly in pediatric patients suffering from c...
Source: Biomechanics and Modeling in Mechanobiology - December 27, 2023 Category: Biomedical Science Authors: Bruno V Rego Sae-Il Murtada Guangxin Li George Tellides Jay D Humphrey Source Type: research
Multiscale insights into postnatal aortic development
Biomech Model Mechanobiol. 2023 Dec 27. doi: 10.1007/s10237-023-01800-8. Online ahead of print.ABSTRACTDespite its vital importance for establishing proper cardiovascular function, the process through which the vasculature develops and matures postnatally remains poorly understood. From a clinical perspective, an ability to mechanistically model the developmental time course in arteries and veins, as well as to predict how various pathologies and therapeutic interventions alter the affected vessels, promises to improve treatment strategies and long-term clinical outcomes, particularly in pediatric patients suffering from c...
Source: Biomechanics and Modeling in Mechanobiology - December 27, 2023 Category: Biomedical Science Authors: Bruno V Rego Sae-Il Murtada Guangxin Li George Tellides Jay D Humphrey Source Type: research
Multiscale insights into postnatal aortic development
Biomech Model Mechanobiol. 2023 Dec 27. doi: 10.1007/s10237-023-01800-8. Online ahead of print.ABSTRACTDespite its vital importance for establishing proper cardiovascular function, the process through which the vasculature develops and matures postnatally remains poorly understood. From a clinical perspective, an ability to mechanistically model the developmental time course in arteries and veins, as well as to predict how various pathologies and therapeutic interventions alter the affected vessels, promises to improve treatment strategies and long-term clinical outcomes, particularly in pediatric patients suffering from c...
Source: Biomechanics and Modeling in Mechanobiology - December 27, 2023 Category: Biomedical Science Authors: Bruno V Rego Sae-Il Murtada Guangxin Li George Tellides Jay D Humphrey Source Type: research
Multiscale insights into postnatal aortic development
Biomech Model Mechanobiol. 2023 Dec 27. doi: 10.1007/s10237-023-01800-8. Online ahead of print.ABSTRACTDespite its vital importance for establishing proper cardiovascular function, the process through which the vasculature develops and matures postnatally remains poorly understood. From a clinical perspective, an ability to mechanistically model the developmental time course in arteries and veins, as well as to predict how various pathologies and therapeutic interventions alter the affected vessels, promises to improve treatment strategies and long-term clinical outcomes, particularly in pediatric patients suffering from c...
Source: Biomechanics and Modeling in Mechanobiology - December 27, 2023 Category: Biomedical Science Authors: Bruno V Rego Sae-Il Murtada Guangxin Li George Tellides Jay D Humphrey Source Type: research
