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Biomechanical characterization of tissue types in murine dissecting aneurysms based on histology and 4D ultrasound-derived strain
Biomech Model Mechanobiol. 2023 Sep 14. doi: 10.1007/s10237-023-01759-6. Online ahead of print.ABSTRACTAbdominal aortic aneurysm disease is the local enlargement of the aorta, typically in the infrarenal section, causing up to 200,000 deaths/year. In vivo information to characterize the individual elastic properties of the aneurysm wall in terms of rupture risk is lacking. We used a method that combines 4D ultrasound and direct deformation estimation to compute in vivo 3D Green-Lagrange strain in murine angiotensin II-induced dissecting aortic aneurysms, a commonly used mouse model. After euthanasia, histological staining ...
Source: Biomechanics and Modeling in Mechanobiology - September 14, 2023 Category: Biomedical Science Authors: Achim Hegner Hannah L Cebull Antonio J G ámez Christopher Blase Craig J Goergen Andreas Wittek Source Type: research

Foreword to the special issue entitled "Progress and future directions in soft tissue mechanics" in the Journal Biomechanics and Modeling in Mechanobiology
Biomech Model Mechanobiol. 2023 Sep 14. doi: 10.1007/s10237-023-01770-x. Online ahead of print.NO ABSTRACTPMID:37707686 | DOI:10.1007/s10237-023-01770-x (Source: Biomechanics and Modeling in Mechanobiology)
Source: Biomechanics and Modeling in Mechanobiology - September 14, 2023 Category: Biomedical Science Authors: St éphane Avril Gerhard A Holzapfel Source Type: research

Impact of disturbed flow and arterial stiffening on mechanotransduction in endothelial cells
Biomech Model Mechanobiol. 2023 Sep 14. doi: 10.1007/s10237-023-01743-0. Online ahead of print.ABSTRACTDisturbed flow promotes progression of atherosclerosis at particular regions of arteries where the recent studies show the arterial wall becomes stiffer. Objective of this study is to show how mechanotransduction in subcellular organelles of endothelial cells (ECs) will alter with changes in blood flow profiles applied on ECs surface and mechanical properties of arterial wall where ECs are attached to. We will examine the exposure of ECs to atherogenic flow profiles (disturbed flow) and non-atherogenic flow profiles (pure...
Source: Biomechanics and Modeling in Mechanobiology - September 14, 2023 Category: Biomedical Science Authors: Andrea Alonso Alessandra Ebben Mahsa Dabagh Source Type: research

A computational investigation of occlusive arterial thrombosis
Biomech Model Mechanobiol. 2023 Sep 13. doi: 10.1007/s10237-023-01765-8. Online ahead of print.ABSTRACTThe generation of occlusive thrombi in stenotic arteries involves the rapid deposition of millions of circulating platelets under high shear flow. The process is mediated by the formation of molecular bonds of several distinct types between platelets; the bonds capture the moving platelets and stabilize the growing thrombi under flow. We investigated the mechanisms behind occlusive thrombosis in arteries with a two-phase continuum model. The model explicitly tracks the formation and rupture of the two types of interplatel...
Source: Biomechanics and Modeling in Mechanobiology - September 13, 2023 Category: Biomedical Science Authors: Jian Du Aaron L Fogelson Source Type: research

Can a bulky glycocalyx promote catch bonding in early integrin adhesion? Perhaps a bit
Biomech Model Mechanobiol. 2023 Sep 13. doi: 10.1007/s10237-023-01762-x. Online ahead of print.ABSTRACTMany types of cancer cells overexpress bulky glycoproteins to form a thick glycocalyx layer. The glycocalyx physically separates the cell from its surroundings, but recent work has shown that the glycocalyx can paradoxically increase adhesion to soft tissues and therefore promote the metastasis of cancer cells. This surprising phenomenon occurs because the glycocalyx forces adhesion molecules (called integrins) on the cell's surface into clusters. These integrin clusters have cooperative effects that allow them to form st...
Source: Biomechanics and Modeling in Mechanobiology - September 13, 2023 Category: Biomedical Science Authors: Aaron T Blanchard Source Type: research

Inverse identification of region-specific hyperelastic material parameters for human brain tissue
Biomech Model Mechanobiol. 2023 Sep 7. doi: 10.1007/s10237-023-01739-w. Online ahead of print.ABSTRACTThe identification of material parameters accurately describing the region-dependent mechanical behavior of human brain tissue is crucial for computational models used to assist, e.g., the development of safety equipment like helmets or the planning and execution of brain surgery. While the division of the human brain into different anatomical regions is well established, knowledge about regions with distinct mechanical properties remains limited. Here, we establish an inverse parameter identification scheme using a hypere...
Source: Biomechanics and Modeling in Mechanobiology - September 7, 2023 Category: Biomedical Science Authors: Jan Hinrichsen Nina Reiter Lars Br äuer Friedrich Paulsen Stefan Kaessmair Silvia Budday Source Type: research