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Targeted drug delivery in pulmonary therapy based on adhesion and transmission of nanocarriers designed with a metal-organic framework
This study aimed to design a magnetic field-assisted targeted drug delivery system to the lungs using three types of metal-organic frameworks (MOFs) and nanoliposomes. The optimization of the system was based on three main parameters: the surface density of the nanocarriers' (NCs) adherence to each of the lung branches, the amount of drug transferred to each branch, and the toxicity based on the rate of nanocarrier delivery to the branches. The study investigated the effect of increasing the diameter of the drug carriers and the amount of drug loaded onto the NCs in improving drug delivery to targeted areas of the lung. Re...
Source: Biomechanics and Modeling in Mechanobiology - August 25, 2023 Category: Biomedical Science Authors: Hamed Ranjbar Amirhamzeh Farajollahi Mohsen Rostami Source Type: research

The impact of vascular volume fraction and compressibility of the interstitial matrix on vascularised poroelastic tissues
Biomech Model Mechanobiol. 2023 Aug 17. doi: 10.1007/s10237-023-01742-1. Online ahead of print.ABSTRACTIn this work we address the role of the microstructural properties of a vascularised poroelastic material, characterised by the coupling between a poroelastic matrix and a viscous fluid vessels network, on its overall response in terms of pressures, velocities and stress maps. We embrace the recently developed model (Penta and Merodio in Meccanica 52(14):3321-3343, 2017) as a theoretical starting point and present the results obtained by solving the full interplay between the microscale, represented by the intervessels' d...
Source: Biomechanics and Modeling in Mechanobiology - August 16, 2023 Category: Biomedical Science Authors: Pietro Mascheroni Raimondo Penta Jos é Merodio Source Type: research

The impact of vascular volume fraction and compressibility of the interstitial matrix on vascularised poroelastic tissues
Biomech Model Mechanobiol. 2023 Aug 17. doi: 10.1007/s10237-023-01742-1. Online ahead of print.ABSTRACTIn this work we address the role of the microstructural properties of a vascularised poroelastic material, characterised by the coupling between a poroelastic matrix and a viscous fluid vessels network, on its overall response in terms of pressures, velocities and stress maps. We embrace the recently developed model (Penta and Merodio in Meccanica 52(14):3321-3343, 2017) as a theoretical starting point and present the results obtained by solving the full interplay between the microscale, represented by the intervessels' d...
Source: Biomechanics and Modeling in Mechanobiology - August 16, 2023 Category: Biomedical Science Authors: Pietro Mascheroni Raimondo Penta Jos é Merodio Source Type: research

The impact of vascular volume fraction and compressibility of the interstitial matrix on vascularised poroelastic tissues
Biomech Model Mechanobiol. 2023 Aug 17. doi: 10.1007/s10237-023-01742-1. Online ahead of print.ABSTRACTIn this work we address the role of the microstructural properties of a vascularised poroelastic material, characterised by the coupling between a poroelastic matrix and a viscous fluid vessels network, on its overall response in terms of pressures, velocities and stress maps. We embrace the recently developed model (Penta and Merodio in Meccanica 52(14):3321-3343, 2017) as a theoretical starting point and present the results obtained by solving the full interplay between the microscale, represented by the intervessels' d...
Source: Biomechanics and Modeling in Mechanobiology - August 16, 2023 Category: Biomedical Science Authors: Pietro Mascheroni Raimondo Penta Jos é Merodio Source Type: research

The impact of vascular volume fraction and compressibility of the interstitial matrix on vascularised poroelastic tissues
Biomech Model Mechanobiol. 2023 Aug 17. doi: 10.1007/s10237-023-01742-1. Online ahead of print.ABSTRACTIn this work we address the role of the microstructural properties of a vascularised poroelastic material, characterised by the coupling between a poroelastic matrix and a viscous fluid vessels network, on its overall response in terms of pressures, velocities and stress maps. We embrace the recently developed model (Penta and Merodio in Meccanica 52(14):3321-3343, 2017) as a theoretical starting point and present the results obtained by solving the full interplay between the microscale, represented by the intervessels' d...
Source: Biomechanics and Modeling in Mechanobiology - August 16, 2023 Category: Biomedical Science Authors: Pietro Mascheroni Raimondo Penta Jos é Merodio Source Type: research

The impact of vascular volume fraction and compressibility of the interstitial matrix on vascularised poroelastic tissues
Biomech Model Mechanobiol. 2023 Aug 17. doi: 10.1007/s10237-023-01742-1. Online ahead of print.ABSTRACTIn this work we address the role of the microstructural properties of a vascularised poroelastic material, characterised by the coupling between a poroelastic matrix and a viscous fluid vessels network, on its overall response in terms of pressures, velocities and stress maps. We embrace the recently developed model (Penta and Merodio in Meccanica 52(14):3321-3343, 2017) as a theoretical starting point and present the results obtained by solving the full interplay between the microscale, represented by the intervessels' d...
Source: Biomechanics and Modeling in Mechanobiology - August 16, 2023 Category: Biomedical Science Authors: Pietro Mascheroni Raimondo Penta Jos é Merodio Source Type: research

The impact of vascular volume fraction and compressibility of the interstitial matrix on vascularised poroelastic tissues
Biomech Model Mechanobiol. 2023 Aug 17. doi: 10.1007/s10237-023-01742-1. Online ahead of print.ABSTRACTIn this work we address the role of the microstructural properties of a vascularised poroelastic material, characterised by the coupling between a poroelastic matrix and a viscous fluid vessels network, on its overall response in terms of pressures, velocities and stress maps. We embrace the recently developed model (Penta and Merodio in Meccanica 52(14):3321-3343, 2017) as a theoretical starting point and present the results obtained by solving the full interplay between the microscale, represented by the intervessels' d...
Source: Biomechanics and Modeling in Mechanobiology - August 16, 2023 Category: Biomedical Science Authors: Pietro Mascheroni Raimondo Penta Jos é Merodio Source Type: research

The impact of vascular volume fraction and compressibility of the interstitial matrix on vascularised poroelastic tissues
Biomech Model Mechanobiol. 2023 Aug 17. doi: 10.1007/s10237-023-01742-1. Online ahead of print.ABSTRACTIn this work we address the role of the microstructural properties of a vascularised poroelastic material, characterised by the coupling between a poroelastic matrix and a viscous fluid vessels network, on its overall response in terms of pressures, velocities and stress maps. We embrace the recently developed model (Penta and Merodio in Meccanica 52(14):3321-3343, 2017) as a theoretical starting point and present the results obtained by solving the full interplay between the microscale, represented by the intervessels' d...
Source: Biomechanics and Modeling in Mechanobiology - August 16, 2023 Category: Biomedical Science Authors: Pietro Mascheroni Raimondo Penta Jos é Merodio Source Type: research

Finite element analysis of the interaction between high-compliant balloon catheters and non-cylindrical vessel structures: towards tactile sensing balloon catheters
Biomech Model Mechanobiol. 2023 Aug 13. doi: 10.1007/s10237-023-01749-8. Online ahead of print.ABSTRACTAiming for sensing balloon catheters which are able to provide intraoperative information of the vessel stiffness and shape, the present study uses finite element analysis (FEA) to evaluate the interaction between high-compliant elastomer balloon catheters with the inner wall of a non-cylindrical-shaped lumen structure. The contact simulations are based on 3D models with varying balloon thicknesses and varying tissue geometries to analyse the resulting balloon and tissue deformation as well as the inflation pressure depen...
Source: Biomechanics and Modeling in Mechanobiology - August 13, 2023 Category: Biomedical Science Authors: Ashish Bhave Benjamin Sittkus Gerald Urban Ulrich Mescheder Knut M öller Source Type: research

Computational study of the mechanical behavior of the astrocyte network and axonal compartments in the mouse optic nerve head
The objective of this study was to develop a computational modeling method to estimate the IOP-induced strains and stresses in the axonal compartments in the mouse astrocytic lamina (AL) of the ONH, and to investigate the effect of the structural features on the mechanical behavior. We developed experimentally informed finite element (FE) models of six mouse ALs to investigate the effect of structure on the strain responses of the astrocyte network and axonal compartments to pressure elevation. The specimen-specific geometries of the FE models were reconstructed from confocal fluorescent images of cryosections of the mouse...
Source: Biomechanics and Modeling in Mechanobiology - August 13, 2023 Category: Biomedical Science Authors: Yik Tung Tracy Ling Arina Korneva Harry A Quigley Thao D Nguyen Source Type: research

Finite element analysis of the interaction between high-compliant balloon catheters and non-cylindrical vessel structures: towards tactile sensing balloon catheters
Biomech Model Mechanobiol. 2023 Aug 13. doi: 10.1007/s10237-023-01749-8. Online ahead of print.ABSTRACTAiming for sensing balloon catheters which are able to provide intraoperative information of the vessel stiffness and shape, the present study uses finite element analysis (FEA) to evaluate the interaction between high-compliant elastomer balloon catheters with the inner wall of a non-cylindrical-shaped lumen structure. The contact simulations are based on 3D models with varying balloon thicknesses and varying tissue geometries to analyse the resulting balloon and tissue deformation as well as the inflation pressure depen...
Source: Biomechanics and Modeling in Mechanobiology - August 13, 2023 Category: Biomedical Science Authors: Ashish Bhave Benjamin Sittkus Gerald Urban Ulrich Mescheder Knut M öller Source Type: research

Computational study of the mechanical behavior of the astrocyte network and axonal compartments in the mouse optic nerve head
The objective of this study was to develop a computational modeling method to estimate the IOP-induced strains and stresses in the axonal compartments in the mouse astrocytic lamina (AL) of the ONH, and to investigate the effect of the structural features on the mechanical behavior. We developed experimentally informed finite element (FE) models of six mouse ALs to investigate the effect of structure on the strain responses of the astrocyte network and axonal compartments to pressure elevation. The specimen-specific geometries of the FE models were reconstructed from confocal fluorescent images of cryosections of the mouse...
Source: Biomechanics and Modeling in Mechanobiology - August 13, 2023 Category: Biomedical Science Authors: Yik Tung Tracy Ling Arina Korneva Harry A Quigley Thao D Nguyen Source Type: research

Finite element analysis of the interaction between high-compliant balloon catheters and non-cylindrical vessel structures: towards tactile sensing balloon catheters
Biomech Model Mechanobiol. 2023 Aug 13. doi: 10.1007/s10237-023-01749-8. Online ahead of print.ABSTRACTAiming for sensing balloon catheters which are able to provide intraoperative information of the vessel stiffness and shape, the present study uses finite element analysis (FEA) to evaluate the interaction between high-compliant elastomer balloon catheters with the inner wall of a non-cylindrical-shaped lumen structure. The contact simulations are based on 3D models with varying balloon thicknesses and varying tissue geometries to analyse the resulting balloon and tissue deformation as well as the inflation pressure depen...
Source: Biomechanics and Modeling in Mechanobiology - August 13, 2023 Category: Biomedical Science Authors: Ashish Bhave Benjamin Sittkus Gerald Urban Ulrich Mescheder Knut M öller Source Type: research

Computational study of the mechanical behavior of the astrocyte network and axonal compartments in the mouse optic nerve head
The objective of this study was to develop a computational modeling method to estimate the IOP-induced strains and stresses in the axonal compartments in the mouse astrocytic lamina (AL) of the ONH, and to investigate the effect of the structural features on the mechanical behavior. We developed experimentally informed finite element (FE) models of six mouse ALs to investigate the effect of structure on the strain responses of the astrocyte network and axonal compartments to pressure elevation. The specimen-specific geometries of the FE models were reconstructed from confocal fluorescent images of cryosections of the mouse...
Source: Biomechanics and Modeling in Mechanobiology - August 13, 2023 Category: Biomedical Science Authors: Yik Tung Tracy Ling Arina Korneva Harry A Quigley Thao D Nguyen Source Type: research

A numerical study of the effect of thrombus breakdown on predicted thrombus formation and growth
In conclusion, the effect of thrombus breakdown is not negligible and should be included in computational models of thrombosis.PMID:37566172 | DOI:10.1007/s10237-023-01757-8 (Source: Biomechanics and Modeling in Mechanobiology)
Source: Biomechanics and Modeling in Mechanobiology - August 11, 2023 Category: Biomedical Science Authors: Kaihong Wang Chl öe H Armour Richard G J Gibbs Xiao Yun Xu Source Type: research