Biomechanics and Modeling in Mechanobiology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Finite element model of ocular adduction with unconstrained globe translation
Biomech Model Mechanobiol. 2024 Feb 28. doi: 10.1007/s10237-023-01794-3. Online ahead of print.ABSTRACTDetails of the anatomy and behavior of the structures responsible for human eye movements have been extensively elaborated since the first modern biomechanical models were introduced. Based on these findings, a finite element model of human ocular adduction is developed based on connective anatomy and measured optic nerve (ON) properties, as well as active contractility of bilaminar extraocular muscles (EOMs), but incorporating the novel feature that globe translation is not otherwise constrained so that realistic kinemat...
Source: Biomechanics and Modeling in Mechanobiology - February 28, 2024 Category: Biomedical Science Authors: Somaye Jafari Joseph Park Yongtao Lu Joseph L Demer Source Type: research
An explainable machine learning-based probabilistic framework for the design of scaffolds in bone tissue engineering
Biomech Model Mechanobiol. 2024 Feb 28. doi: 10.1007/s10237-024-01817-7. Online ahead of print.ABSTRACTRecently, 3D-printed biodegradable scaffolds have shown great potential for bone repair in critical-size fractures. The differentiation of the cells on a scaffold is impacted among other factors by the surface deformation of the scaffold due to mechanical loading and the wall shear stresses imposed by the interstitial fluid flow. These factors are in turn significantly affected by the material properties, the geometry of the scaffold, as well as the loading and flow conditions. In this work, a numerical framework is propo...
Source: Biomechanics and Modeling in Mechanobiology - February 28, 2024 Category: Biomedical Science Authors: George Drakoulas Theodore Gortsas Efstratios Polyzos Stephanos Tsinopoulos Lincy Pyl Demosthenes Polyzos Source Type: research
Finite element model of ocular adduction with unconstrained globe translation
Biomech Model Mechanobiol. 2024 Feb 28. doi: 10.1007/s10237-023-01794-3. Online ahead of print.ABSTRACTDetails of the anatomy and behavior of the structures responsible for human eye movements have been extensively elaborated since the first modern biomechanical models were introduced. Based on these findings, a finite element model of human ocular adduction is developed based on connective anatomy and measured optic nerve (ON) properties, as well as active contractility of bilaminar extraocular muscles (EOMs), but incorporating the novel feature that globe translation is not otherwise constrained so that realistic kinemat...
Source: Biomechanics and Modeling in Mechanobiology - February 28, 2024 Category: Biomedical Science Authors: Somaye Jafari Joseph Park Yongtao Lu Joseph L Demer Source Type: research
An explainable machine learning-based probabilistic framework for the design of scaffolds in bone tissue engineering
Biomech Model Mechanobiol. 2024 Feb 28. doi: 10.1007/s10237-024-01817-7. Online ahead of print.ABSTRACTRecently, 3D-printed biodegradable scaffolds have shown great potential for bone repair in critical-size fractures. The differentiation of the cells on a scaffold is impacted among other factors by the surface deformation of the scaffold due to mechanical loading and the wall shear stresses imposed by the interstitial fluid flow. These factors are in turn significantly affected by the material properties, the geometry of the scaffold, as well as the loading and flow conditions. In this work, a numerical framework is propo...
Source: Biomechanics and Modeling in Mechanobiology - February 28, 2024 Category: Biomedical Science Authors: George Drakoulas Theodore Gortsas Efstratios Polyzos Stephanos Tsinopoulos Lincy Pyl Demosthenes Polyzos Source Type: research
Finite element model of ocular adduction with unconstrained globe translation
Biomech Model Mechanobiol. 2024 Feb 28. doi: 10.1007/s10237-023-01794-3. Online ahead of print.ABSTRACTDetails of the anatomy and behavior of the structures responsible for human eye movements have been extensively elaborated since the first modern biomechanical models were introduced. Based on these findings, a finite element model of human ocular adduction is developed based on connective anatomy and measured optic nerve (ON) properties, as well as active contractility of bilaminar extraocular muscles (EOMs), but incorporating the novel feature that globe translation is not otherwise constrained so that realistic kinemat...
Source: Biomechanics and Modeling in Mechanobiology - February 28, 2024 Category: Biomedical Science Authors: Somaye Jafari Joseph Park Yongtao Lu Joseph L Demer Source Type: research
An explainable machine learning-based probabilistic framework for the design of scaffolds in bone tissue engineering
Biomech Model Mechanobiol. 2024 Feb 28. doi: 10.1007/s10237-024-01817-7. Online ahead of print.ABSTRACTRecently, 3D-printed biodegradable scaffolds have shown great potential for bone repair in critical-size fractures. The differentiation of the cells on a scaffold is impacted among other factors by the surface deformation of the scaffold due to mechanical loading and the wall shear stresses imposed by the interstitial fluid flow. These factors are in turn significantly affected by the material properties, the geometry of the scaffold, as well as the loading and flow conditions. In this work, a numerical framework is propo...
Source: Biomechanics and Modeling in Mechanobiology - February 28, 2024 Category: Biomedical Science Authors: George Drakoulas Theodore Gortsas Efstratios Polyzos Stephanos Tsinopoulos Lincy Pyl Demosthenes Polyzos Source Type: research
Finite element model of ocular adduction with unconstrained globe translation
Biomech Model Mechanobiol. 2024 Feb 28. doi: 10.1007/s10237-023-01794-3. Online ahead of print.ABSTRACTDetails of the anatomy and behavior of the structures responsible for human eye movements have been extensively elaborated since the first modern biomechanical models were introduced. Based on these findings, a finite element model of human ocular adduction is developed based on connective anatomy and measured optic nerve (ON) properties, as well as active contractility of bilaminar extraocular muscles (EOMs), but incorporating the novel feature that globe translation is not otherwise constrained so that realistic kinemat...
Source: Biomechanics and Modeling in Mechanobiology - February 28, 2024 Category: Biomedical Science Authors: Somaye Jafari Joseph Park Yongtao Lu Joseph L Demer Source Type: research
An explainable machine learning-based probabilistic framework for the design of scaffolds in bone tissue engineering
Biomech Model Mechanobiol. 2024 Feb 28. doi: 10.1007/s10237-024-01817-7. Online ahead of print.ABSTRACTRecently, 3D-printed biodegradable scaffolds have shown great potential for bone repair in critical-size fractures. The differentiation of the cells on a scaffold is impacted among other factors by the surface deformation of the scaffold due to mechanical loading and the wall shear stresses imposed by the interstitial fluid flow. These factors are in turn significantly affected by the material properties, the geometry of the scaffold, as well as the loading and flow conditions. In this work, a numerical framework is propo...
Source: Biomechanics and Modeling in Mechanobiology - February 28, 2024 Category: Biomedical Science Authors: George Drakoulas Theodore Gortsas Efstratios Polyzos Stephanos Tsinopoulos Lincy Pyl Demosthenes Polyzos Source Type: research
Finite element model of ocular adduction with unconstrained globe translation
Biomech Model Mechanobiol. 2024 Feb 28. doi: 10.1007/s10237-023-01794-3. Online ahead of print.ABSTRACTDetails of the anatomy and behavior of the structures responsible for human eye movements have been extensively elaborated since the first modern biomechanical models were introduced. Based on these findings, a finite element model of human ocular adduction is developed based on connective anatomy and measured optic nerve (ON) properties, as well as active contractility of bilaminar extraocular muscles (EOMs), but incorporating the novel feature that globe translation is not otherwise constrained so that realistic kinemat...
Source: Biomechanics and Modeling in Mechanobiology - February 28, 2024 Category: Biomedical Science Authors: Somaye Jafari Joseph Park Yongtao Lu Joseph L Demer Source Type: research
An explainable machine learning-based probabilistic framework for the design of scaffolds in bone tissue engineering
Biomech Model Mechanobiol. 2024 Feb 28. doi: 10.1007/s10237-024-01817-7. Online ahead of print.ABSTRACTRecently, 3D-printed biodegradable scaffolds have shown great potential for bone repair in critical-size fractures. The differentiation of the cells on a scaffold is impacted among other factors by the surface deformation of the scaffold due to mechanical loading and the wall shear stresses imposed by the interstitial fluid flow. These factors are in turn significantly affected by the material properties, the geometry of the scaffold, as well as the loading and flow conditions. In this work, a numerical framework is propo...
Source: Biomechanics and Modeling in Mechanobiology - February 28, 2024 Category: Biomedical Science Authors: George Drakoulas Theodore Gortsas Efstratios Polyzos Stephanos Tsinopoulos Lincy Pyl Demosthenes Polyzos Source Type: research
Mechanical complexity of living cells can be mapped onto simple homogeneous equivalents
Biomech Model Mechanobiol. 2024 Feb 27. doi: 10.1007/s10237-024-01823-9. Online ahead of print.ABSTRACTBiological cells are built up from different constituents of varying size and stiffness which all contribute to the cell's mechanical properties. Despite this heterogeneity, in the analysis of experimental measurements one often assumes a strongly simplified homogeneous cell and thus a single elastic modulus is assigned to the entire cell. This ad-hoc simplification has so far mostly been used without proper justification. Here, we use computer simulations to show that indeed a mechanically heterogeneous cell can effectiv...
Source: Biomechanics and Modeling in Mechanobiology - February 27, 2024 Category: Biomedical Science Authors: Sebastian Wohlrab Sebastian Mueller Stephan Gekle Source Type: research
Quantifying fat zonation in liver lobules: an integrated multiscale in silico model combining disturbed microperfusion and fat metabolism via a continuum biomechanical bi-scale, tri-phasic approach
Biomech Model Mechanobiol. 2024 Feb 25. doi: 10.1007/s10237-023-01797-0. Online ahead of print.ABSTRACTMetabolic zonation refers to the spatial separation of metabolic functions along the sinusoidal axes of the liver. This phenomenon forms the foundation for adjusting hepatic metabolism to physiological requirements in health and disease (e.g., metabolic dysfunction-associated steatotic liver disease/MASLD). Zonated metabolic functions are influenced by zonal morphological abnormalities in the liver, such as periportal fibrosis and pericentral steatosis. We aim to analyze the interplay between microperfusion, oxygen gradie...
Source: Biomechanics and Modeling in Mechanobiology - February 24, 2024 Category: Biomedical Science Authors: Lena Lambers Navina Waschinsky Jana Schleicher Matthias K önig Hans-Michael Tautenhahn Mohamed Albadry Uta Dahmen Tim Ricken Source Type: research
Quantifying fat zonation in liver lobules: an integrated multiscale in silico model combining disturbed microperfusion and fat metabolism via a continuum biomechanical bi-scale, tri-phasic approach
Biomech Model Mechanobiol. 2024 Feb 25. doi: 10.1007/s10237-023-01797-0. Online ahead of print.ABSTRACTMetabolic zonation refers to the spatial separation of metabolic functions along the sinusoidal axes of the liver. This phenomenon forms the foundation for adjusting hepatic metabolism to physiological requirements in health and disease (e.g., metabolic dysfunction-associated steatotic liver disease/MASLD). Zonated metabolic functions are influenced by zonal morphological abnormalities in the liver, such as periportal fibrosis and pericentral steatosis. We aim to analyze the interplay between microperfusion, oxygen gradie...
Source: Biomechanics and Modeling in Mechanobiology - February 24, 2024 Category: Biomedical Science Authors: Lena Lambers Navina Waschinsky Jana Schleicher Matthias K önig Hans-Michael Tautenhahn Mohamed Albadry Uta Dahmen Tim Ricken Source Type: research
Quantifying fat zonation in liver lobules: an integrated multiscale in silico model combining disturbed microperfusion and fat metabolism via a continuum biomechanical bi-scale, tri-phasic approach
Biomech Model Mechanobiol. 2024 Feb 25. doi: 10.1007/s10237-023-01797-0. Online ahead of print.ABSTRACTMetabolic zonation refers to the spatial separation of metabolic functions along the sinusoidal axes of the liver. This phenomenon forms the foundation for adjusting hepatic metabolism to physiological requirements in health and disease (e.g., metabolic dysfunction-associated steatotic liver disease/MASLD). Zonated metabolic functions are influenced by zonal morphological abnormalities in the liver, such as periportal fibrosis and pericentral steatosis. We aim to analyze the interplay between microperfusion, oxygen gradie...
Source: Biomechanics and Modeling in Mechanobiology - February 24, 2024 Category: Biomedical Science Authors: Lena Lambers Navina Waschinsky Jana Schleicher Matthias K önig Hans-Michael Tautenhahn Mohamed Albadry Uta Dahmen Tim Ricken Source Type: research
Thanks to our reviewers
Biomech Model Mechanobiol. 2024 Feb 21. doi: 10.1007/s10237-024-01824-8. Online ahead of print.NO ABSTRACTPMID:38381239 | DOI:10.1007/s10237-024-01824-8 (Source: Biomechanics and Modeling in Mechanobiology)
Source: Biomechanics and Modeling in Mechanobiology - February 21, 2024 Category: Biomedical Science Source Type: research
