Biomechanics and Modeling in Mechanobiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Modeling the effects of external oscillations on mucus clearance in obstructed airways
In this study, the effectiveness of this treatment method was investigated numerically using computational fluid dynamics (CFD) on the generated mucus-obstructed bronchial geometry. The conducted analyses compared the effects of vibrations acting in the axial, radial, and tangential directions on the clearance of mucus, which exhibits non-Newtonian flow behavior with shear-thinning properties. Simultaneously, the effects of changes in vibration amplitude and frequency, pressure differentials, fluid properties, and ciliary movements on the flow were separately examined and interpreted. The findings demonstrate that ciliary ...
Source: Biomechanics and Modeling in Mechanobiology - October 20, 2023 Category: Biomedical Science Authors: Yusuf Hamida El Naser Durmu ş Karayel Source Type: research

Cortical bone adaptation response is region specific, but not peak load dependent: insights from [Formula: see text]CT image analysis and mechanostat simulations of the mouse tibia loading model
Biomech Model Mechanobiol. 2023 Oct 18. doi: 10.1007/s10237-023-01775-6. Online ahead of print.ABSTRACTThe two major aims of the present study were: (i) quantify localised cortical bone adaptation at the surface level using contralateral endpoint imaging data and image analysis techniques, and (ii) investigate whether cortical bone adaptation responses are universal or region specific and dependent on the respective peak load. For this purpose, we re-analyse previously published [Formula: see text]CT data of the mouse tibia loading model that investigated bone adaptation in response to sciatic neurectomy and various peak l...
Source: Biomechanics and Modeling in Mechanobiology - October 18, 2023 Category: Biomedical Science Authors: Corey J Miller Edmund Pickering Saulo Martelli Enrico Dall'Ara Peter Delisser Peter Pivonka Source Type: research

Study on the flow mechanism and frequency characteristics of rales in lower respiratory tract
Biomech Model Mechanobiol. 2023 Oct 13. doi: 10.1007/s10237-023-01769-4. Online ahead of print.ABSTRACTThe frequency characteristics of lung sounds have great significance for noninvasive diagnosis of respiratory diseases. The rales in the lower respiratory tract region that can provide rich information about symptoms of respiratory diseases are not clear. In this paper, a three-dimensional idealized bifurcated lower respiratory tract geometric model, which contains 3rd to 13th generation (G3-G13) bronchi is constructed, where [Formula: see text], and then the large eddy simulation and volume of fluid are used to study the...
Source: Biomechanics and Modeling in Mechanobiology - October 13, 2023 Category: Biomedical Science Authors: Yongjun Jin Zhijian Liu Chenxing Hu Zhijian Dong Rui Rong Haiyang Liu Zhenyu Liang Jingwei Liu Li Chen Minghua Huang Haihang Cui Yan Shen Source Type: research

The impact of actuator nozzle and surroundings condition on drug delivery using pressurized-metered dose inhalers
Biomech Model Mechanobiol. 2023 Oct 10. doi: 10.1007/s10237-023-01754-x. Online ahead of print.ABSTRACTThe most commonly used method to deliver aerosolized drugs to the lung is with pressurized metered-dose inhalers (pMDIs). The spray actuator is a critical component of pMDI, since it controls the atomization process by forming aerosol plumes and determining droplet size distribution. Through computational fluid dynamics (CFD) simulations, this study investigated the effect of two different nozzle types (single conventional and twin nozzles) on drug deposition in the mouth-throat (MT) region. We also studied the behavior o...
Source: Biomechanics and Modeling in Mechanobiology - October 10, 2023 Category: Biomedical Science Authors: Mahsa Jahed Janusz Kozinski Leila Pakzad Source Type: research

Comparison of computational fluid dynamics with transcranial Doppler ultrasound in response to physiological stimuli
Biomech Model Mechanobiol. 2023 Oct 8. doi: 10.1007/s10237-023-01772-9. Online ahead of print.ABSTRACTCerebrovascular haemodynamics are sensitive to multiple physiological stimuli that require synergistic response to maintain adequate perfusion. Understanding haemodynamic changes within cerebral arteries is important to inform how the brain regulates perfusion; however, methods for direct measurement of cerebral haemodynamics in these environments are challenging. The aim of this study was to assess velocity waveform metrics obtained using transcranial Doppler (TCD) with flow-conserving subject-specific three-dimensional (...
Source: Biomechanics and Modeling in Mechanobiology - October 8, 2023 Category: Biomedical Science Authors: Harrison T Caddy Hannah J Thomas Lachlan J Kelsey Kurt J Smith Barry J Doyle Daniel J Green Source Type: research

Analyzing force measurements of multi-cellular clusters comprising indeterminate geometries
Biomech Model Mechanobiol. 2023 Sep 28. doi: 10.1007/s10237-023-01764-9. Online ahead of print.ABSTRACTMulti-cellular biomimetic models often comprise heterogenic geometries. Therefore, quantification of their mechanical properties-which is crucial for various biomedical applications-is a challenge. Due to its simplicity, linear fitting is traditionally used in analyzing force-displacement data of parallel compression measurements of multi-cellular clusters, such as tumor spheroids. However, the linear assumption would be artificial when the contact geometry is not planar. We propose here the integrated elasticity (IE) reg...
Source: Biomechanics and Modeling in Mechanobiology - September 28, 2023 Category: Biomedical Science Authors: Yifat Brill-Karniely Katerina Tischenko Ofra Benny Source Type: research