Biomechanics and Modeling in Mechanobiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Inverse identification of region-specific hyperelastic material parameters for human brain tissue
Biomech Model Mechanobiol. 2023 Sep 7. doi: 10.1007/s10237-023-01739-w. Online ahead of print.ABSTRACTThe identification of material parameters accurately describing the region-dependent mechanical behavior of human brain tissue is crucial for computational models used to assist, e.g., the development of safety equipment like helmets or the planning and execution of brain surgery. While the division of the human brain into different anatomical regions is well established, knowledge about regions with distinct mechanical properties remains limited. Here, we establish an inverse parameter identification scheme using a hypere...
Source: Biomechanics and Modeling in Mechanobiology - September 7, 2023 Category: Biomedical Science Authors: Jan Hinrichsen Nina Reiter Lars Br äuer Friedrich Paulsen Stefan Kaessmair Silvia Budday Source Type: research

Interstitial flow, pressure and residual stress in the aging carotid artery model in FEBio
Biomech Model Mechanobiol. 2023 Sep 5. doi: 10.1007/s10237-023-01766-7. Online ahead of print.ABSTRACTVascular smooth muscle cells (VSMCs) are subject to interstitial flow-induced shear stress, which is a critical parameter in cardiovascular disease progression. Transmural pressure loading and residual stresses alter the hydraulic conductivity of the arterial layers and modulate the interstitial fluid flux through the arterial wall. In this paper, a biphasic multilayer model of a common carotid artery (CCA) with anisotropic fiber-reinforced soft tissue and strain-dependent permeability is developed in FEBio software. After...
Source: Biomechanics and Modeling in Mechanobiology - September 5, 2023 Category: Biomedical Science Authors: Sercan Altundemir S Samaneh Lashkarinia Kerem Pekkan A Kerem U ğuz Source Type: research

A computational growth and remodeling framework for adaptive and maladaptive pulmonary arterial hemodynamics
Biomech Model Mechanobiol. 2023 Sep 2. doi: 10.1007/s10237-023-01744-z. Online ahead of print.ABSTRACTHemodynamic loading is known to contribute to the development and progression of pulmonary arterial hypertension (PAH). This loading drives changes in mechanobiological stimuli that affect cellular phenotypes and lead to pulmonary vascular remodeling. Computational models have been used to simulate mechanobiological metrics of interest, such as wall shear stress, at single time points for PAH patients. However, there is a need for new approaches that simulate disease evolution to allow for prediction of long-term outcomes....
Source: Biomechanics and Modeling in Mechanobiology - September 2, 2023 Category: Biomedical Science Authors: Jason M Szafron Weiguang Yang Jeffrey A Feinstein Marlene Rabinovitch Alison L Marsden Source Type: research

Prediction of skull fractures in blunt force head traumas using finite element head models
Biomech Model Mechanobiol. 2023 Sep 1. doi: 10.1007/s10237-023-01768-5. Online ahead of print.ABSTRACTTraumatic head injuries remain a leading cause of death and disability worldwide. Although skull fractures are one of the most common head injuries, the fundamental mechanics of cranial bone and its impact tolerance are still uncertain. In the present study, a strain-rate-dependent material model for cranial bone has been proposed and implemented in subject-specific Finite Element (FE) head models in order to predict skull fractures in five real-world fall accidents. The subject-specific head models were developed followin...
Source: Biomechanics and Modeling in Mechanobiology - September 1, 2023 Category: Biomedical Science Authors: Natalia Lindgren Mikkel J Henningsen Christina Jacobsen Chiara Villa Svein Kleiven Xiaogai Li Source Type: research

Computational modeling based on confocal imaging predicts changes in osteocyte and dendrite shear stress due to canalicular loss with aging
In this study, we used computational modeling to predict the effect of canalicular density, the number of fluid inlets, and load direction on fluid flow shear stress (FFSS) and bone strains and how these might change following the microstructural deterioration of the lacunar-canalicular network that occurs with aging. Four distinct computational models were initially generated of osteocytes with either ten or eighteen dendrites using a fluid-structure interaction method with idealized geometries. Next, a young and a simulated aged osteocyte were developed from confocal images after FITC staining of the femur of a 4-month-o...
Source: Biomechanics and Modeling in Mechanobiology - August 29, 2023 Category: Biomedical Science Authors: Mohammad Niroobakhsh Loretta E Laughrey Sarah L Dallas Mark L Johnson Thiagarajan Ganesh Source Type: research

Targeted drug delivery in pulmonary therapy based on adhesion and transmission of nanocarriers designed with a metal-organic framework
This study aimed to design a magnetic field-assisted targeted drug delivery system to the lungs using three types of metal-organic frameworks (MOFs) and nanoliposomes. The optimization of the system was based on three main parameters: the surface density of the nanocarriers' (NCs) adherence to each of the lung branches, the amount of drug transferred to each branch, and the toxicity based on the rate of nanocarrier delivery to the branches. The study investigated the effect of increasing the diameter of the drug carriers and the amount of drug loaded onto the NCs in improving drug delivery to targeted areas of the lung. Re...
Source: Biomechanics and Modeling in Mechanobiology - August 25, 2023 Category: Biomedical Science Authors: Hamed Ranjbar Amirhamzeh Farajollahi Mohsen Rostami Source Type: research