Biomechanics and Modeling in Mechanobiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Computational fluid dynamic modeling of the lymphatic system: a review of existing models and future directions
This article reviews existing computational fluid dynamic models of the lymphatics covering each structural component including the initial lymphatics, pre-collecting and collecting vessels, and lymph nodes. This is followed by a summary of limitations and gaps in existing computational models and reasons that development in this field has been hindered to date. Over the next decade, efforts to further characterize lymphatic anatomy and physiology are anticipated to provide key data to further inform and validate lymphatic fluid dynamic models. Development of more comprehensive multiscale- and multi-physics computational m...
Source: Biomechanics and Modeling in Mechanobiology - October 30, 2023 Category: Biomedical Science Authors: Tharanga D Jayathungage Don Soroush Safaei Gonzalo D Maso Talou Peter S Russell Anthony R J Phillips Hayley M Reynolds Source Type: research

Dynamic strain fields of the mouse brain during rotation
Biomech Model Mechanobiol. 2023 Oct 28. doi: 10.1007/s10237-023-01781-8. Online ahead of print.ABSTRACTMouse models are used to better understand brain injury mechanisms in humans, yet there is a limited understanding of biomechanical relevance, beginning with how the murine brain deforms when the head undergoes rapid rotation from blunt impact. This problem makes it difficult to translate some aspects of diffuse axonal injury from mouse to human. To address this gap, we present the two-dimensional strain field of the mouse brain undergoing dynamic rotation in the sagittal plane. Using a high-speed camera with digital imag...
Source: Biomechanics and Modeling in Mechanobiology - October 27, 2023 Category: Biomedical Science Authors: Connor Bradfield Liming Voo David Drewry Vassilis Koliatsos K T Ramesh Source Type: research

In silico analysis shows that dynamic changes in curvature guide cell migration over long distances
This study extends a previous in-silico model to explore the effects over time of changing the substrate curvature on cell migration guidance. By simulating a dynamic surface curvature using traveling wave patterns, we investigate the influence of wave height and speed, and find that long-distance cell migration guidance can be achieved on specific wave patterns. We propose a mechanistic explanation of what we call dynamic curvotaxis and highlight those cellular features that may be involved. Our results open a new area of study for understanding cell mobility in dynamic environments, from single-cell in vitro experiments ...
Source: Biomechanics and Modeling in Mechanobiology - October 24, 2023 Category: Biomedical Science Authors: Ian Manifacier Gildas Carlin Dongshu Liu Maxime Vassaux Laurent Pieuchot Valeriy Luchnikov Karine Anselme Jean-Louis Milan Source Type: research

Mechanical behavior and microstructure of porcine brain tissues under pulsed electric fields
This study revealed the effect of pulsed electric fields on the mechanical properties and microstructure of ex vivo brain tissue, providing essential information to promote the advancement of brain tissue electrotherapy in clinical settings.PMID:37861916 | DOI:10.1007/s10237-023-01771-w (Source: Biomechanics and Modeling in Mechanobiology)
Source: Biomechanics and Modeling in Mechanobiology - October 20, 2023 Category: Biomedical Science Authors: Yiqiang Li Qixun Zhang Jiucheng Zhao Zhaoxin Wang Xiangyu Zong Li Yang Chi Zhang Hongwei Zhao Source Type: research

Modeling the effects of external oscillations on mucus clearance in obstructed airways
In this study, the effectiveness of this treatment method was investigated numerically using computational fluid dynamics (CFD) on the generated mucus-obstructed bronchial geometry. The conducted analyses compared the effects of vibrations acting in the axial, radial, and tangential directions on the clearance of mucus, which exhibits non-Newtonian flow behavior with shear-thinning properties. Simultaneously, the effects of changes in vibration amplitude and frequency, pressure differentials, fluid properties, and ciliary movements on the flow were separately examined and interpreted. The findings demonstrate that ciliary ...
Source: Biomechanics and Modeling in Mechanobiology - October 20, 2023 Category: Biomedical Science Authors: Yusuf Hamida El Naser Durmu ş Karayel Source Type: research