Linking myosin heavy chain isoform shift to mechanical properties and fracture modes in skeletal muscle tissue
In this study, the shift of myosin heavy chain (MHC) isoforms is used for the first time to establish a linkage between tissue histological variation and passive mechanical properties. The shift of MHC isoform is found not only to induce significant differences in skeletal muscle passive mechanical properties, but also to lead to differences in strain rate responses. Non-negligible rate dependence is observed even in the conventionally defined quasi-static regime. Fidelity in the estimated constitutive parameters, which can be impacted due to variation in MHC isoforms and hence in rate sensitivity, is enhanced using a Baye...
Source: Biomechanics and Modeling in Mechanobiology - August 11, 2023 Category: Biomedical Science Authors: Jiabao Tang Wenyang Liu Xuhong Li Yun Peng Yingchun Zhang Shujuan Hou Source Type: research

A numerical study of the effect of thrombus breakdown on predicted thrombus formation and growth
In conclusion, the effect of thrombus breakdown is not negligible and should be included in computational models of thrombosis.PMID:37566172 | DOI:10.1007/s10237-023-01757-8 (Source: Biomechanics and Modeling in Mechanobiology)
Source: Biomechanics and Modeling in Mechanobiology - August 11, 2023 Category: Biomedical Science Authors: Kaihong Wang Chl öe H Armour Richard G J Gibbs Xiao Yun Xu Source Type: research

Linking myosin heavy chain isoform shift to mechanical properties and fracture modes in skeletal muscle tissue
In this study, the shift of myosin heavy chain (MHC) isoforms is used for the first time to establish a linkage between tissue histological variation and passive mechanical properties. The shift of MHC isoform is found not only to induce significant differences in skeletal muscle passive mechanical properties, but also to lead to differences in strain rate responses. Non-negligible rate dependence is observed even in the conventionally defined quasi-static regime. Fidelity in the estimated constitutive parameters, which can be impacted due to variation in MHC isoforms and hence in rate sensitivity, is enhanced using a Baye...
Source: Biomechanics and Modeling in Mechanobiology - August 11, 2023 Category: Biomedical Science Authors: Jiabao Tang Wenyang Liu Xuhong Li Yun Peng Yingchun Zhang Shujuan Hou Source Type: research

A numerical study of the effect of thrombus breakdown on predicted thrombus formation and growth
In conclusion, the effect of thrombus breakdown is not negligible and should be included in computational models of thrombosis.PMID:37566172 | DOI:10.1007/s10237-023-01757-8 (Source: Biomechanics and Modeling in Mechanobiology)
Source: Biomechanics and Modeling in Mechanobiology - August 11, 2023 Category: Biomedical Science Authors: Kaihong Wang Chl öe H Armour Richard G J Gibbs Xiao Yun Xu Source Type: research

Mathematical modeling and numerical simulation of arterial dissection based on a novel surgeon's view
The objective here is to extend that model by incorporating a damage mechanism in order to capture the tearing (rupture) in the artery wall as a result of micro-injuries in VV. Unlike the existing damage-based model of the dissection in the literature, here the damage is driven by the internal bleeding (hematoma) rather than purely mechanical external loading. The numerical implementation is carried out using finite element method (FEM).PMID:37552344 | DOI:10.1007/s10237-023-01753-y (Source: Biomechanics and Modeling in Mechanobiology)
Source: Biomechanics and Modeling in Mechanobiology - August 8, 2023 Category: Biomedical Science Authors: Meisam Soleimani Rohan Deo Blaz Hudobivnik Reza Poyanmehr Axel Haverich Peter Wriggers Source Type: research