Biomechanics and Modeling in Mechanobiology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Mechano-chemo-biological model of atherosclerosis formation based on the outside-in theory
Biomech Model Mechanobiol. 2023 Dec 23. doi: 10.1007/s10237-023-01790-7. Online ahead of print.ABSTRACTAtherosclerosis is a disease in blood vessels that often results in plaque formation and lumen narrowing. It is an inflammatory response of the tissue caused by disruptions in the vessel wall nourishment. Blood vessels are nourished by nutrients originating from the blood of the lumen. In medium-sized and larger vessels, nutrients are additionally provided from outside through a network of capillaries called vasa vasorum. It has recently been hypothesized (Haverich in Circulation 135:205-207, 2017) that the root of athero...
Source: Biomechanics and Modeling in Mechanobiology - December 23, 2023 Category: Biomedical Science Authors: Meike Gierig Alexandros Tragoudas Axel Haverich Peter Wriggers Source Type: research
Mechano-chemo-biological model of atherosclerosis formation based on the outside-in theory
Biomech Model Mechanobiol. 2023 Dec 23. doi: 10.1007/s10237-023-01790-7. Online ahead of print.ABSTRACTAtherosclerosis is a disease in blood vessels that often results in plaque formation and lumen narrowing. It is an inflammatory response of the tissue caused by disruptions in the vessel wall nourishment. Blood vessels are nourished by nutrients originating from the blood of the lumen. In medium-sized and larger vessels, nutrients are additionally provided from outside through a network of capillaries called vasa vasorum. It has recently been hypothesized (Haverich in Circulation 135:205-207, 2017) that the root of athero...
Source: Biomechanics and Modeling in Mechanobiology - December 23, 2023 Category: Biomedical Science Authors: Meike Gierig Alexandros Tragoudas Axel Haverich Peter Wriggers Source Type: research
Mechano-chemo-biological model of atherosclerosis formation based on the outside-in theory
Biomech Model Mechanobiol. 2023 Dec 23. doi: 10.1007/s10237-023-01790-7. Online ahead of print.ABSTRACTAtherosclerosis is a disease in blood vessels that often results in plaque formation and lumen narrowing. It is an inflammatory response of the tissue caused by disruptions in the vessel wall nourishment. Blood vessels are nourished by nutrients originating from the blood of the lumen. In medium-sized and larger vessels, nutrients are additionally provided from outside through a network of capillaries called vasa vasorum. It has recently been hypothesized (Haverich in Circulation 135:205-207, 2017) that the root of athero...
Source: Biomechanics and Modeling in Mechanobiology - December 23, 2023 Category: Biomedical Science Authors: Meike Gierig Alexandros Tragoudas Axel Haverich Peter Wriggers Source Type: research
The role of interface geometry and appendages on the mesoscale mechanics of the skin
This study highlights the importance of skin heterogeneities, particularly its potential mechanophysiological role in the sense of touch and the prevention of skin delamination.PMID:38129671 | DOI:10.1007/s10237-023-01791-6 (Source: Biomechanics and Modeling in Mechanobiology)
Source: Biomechanics and Modeling in Mechanobiology - December 22, 2023 Category: Biomedical Science Authors: Omar Moreno-Flores Manuel K Rausch Adrian B Tepole Source Type: research
The inclusion of the epithelium in numerical models of the human cornea
In this study, we want to assess the relevance of the inclusion of the epithelium in the model of the cornea, by analyzing the effects in terms of uncertainties of the mechanical properties, stress distribution across the thickness, and numerical discretization. We conclude that if the epithelium is modeled as stroma, the material properties should be reduced by 10%. While this choice represents a sufficiently good approximation for the simulation of in vivo mechanical tests, it might result into an under-estimation of the postoperative stress in the simulation of refractive surgery.PMID:38129672 | DOI:10.1007/s10237-023-0...
Source: Biomechanics and Modeling in Mechanobiology - December 22, 2023 Category: Biomedical Science Authors: Andrea Montanino Anna Pandolfi Source Type: research
The role of interface geometry and appendages on the mesoscale mechanics of the skin
This study highlights the importance of skin heterogeneities, particularly its potential mechanophysiological role in the sense of touch and the prevention of skin delamination.PMID:38129671 | DOI:10.1007/s10237-023-01791-6 (Source: Biomechanics and Modeling in Mechanobiology)
Source: Biomechanics and Modeling in Mechanobiology - December 22, 2023 Category: Biomedical Science Authors: Omar Moreno-Flores Manuel K Rausch Adrian B Tepole Source Type: research
The inclusion of the epithelium in numerical models of the human cornea
In this study, we want to assess the relevance of the inclusion of the epithelium in the model of the cornea, by analyzing the effects in terms of uncertainties of the mechanical properties, stress distribution across the thickness, and numerical discretization. We conclude that if the epithelium is modeled as stroma, the material properties should be reduced by 10%. While this choice represents a sufficiently good approximation for the simulation of in vivo mechanical tests, it might result into an under-estimation of the postoperative stress in the simulation of refractive surgery.PMID:38129672 | DOI:10.1007/s10237-023-0...
Source: Biomechanics and Modeling in Mechanobiology - December 22, 2023 Category: Biomedical Science Authors: Andrea Montanino Anna Pandolfi Source Type: research
Multiscale computational modeling of aortic valve calcification
In this study, we developed a multiscale computational model for TGF[Formula: see text]-stimulated CAVD. The model framework comprises cellular behavior dynamics, subcellular signaling pathways, and tissue-level diffusion fields of pertinent chemical species, where information is shared among different scales. Processes such as endothelial to mesenchymal transition (EndMT), fibrosis, and calcification are incorporated. The results indicate that the majority of myofibroblasts and osteoblast-like cells ultimately die due to lack of nutrients as they become trapped in areas with higher levels of fibrosis or calcification, and...
Source: Biomechanics and Modeling in Mechanobiology - December 13, 2023 Category: Biomedical Science Authors: Javid Azimi-Boulali Gretchen J Mahler Bruce T Murray Peter Huang Source Type: research
Multiscale computational modeling of aortic valve calcification
In this study, we developed a multiscale computational model for TGF[Formula: see text]-stimulated CAVD. The model framework comprises cellular behavior dynamics, subcellular signaling pathways, and tissue-level diffusion fields of pertinent chemical species, where information is shared among different scales. Processes such as endothelial to mesenchymal transition (EndMT), fibrosis, and calcification are incorporated. The results indicate that the majority of myofibroblasts and osteoblast-like cells ultimately die due to lack of nutrients as they become trapped in areas with higher levels of fibrosis or calcification, and...
Source: Biomechanics and Modeling in Mechanobiology - December 13, 2023 Category: Biomedical Science Authors: Javid Azimi-Boulali Gretchen J Mahler Bruce T Murray Peter Huang Source Type: research
Multiscale computational modeling of aortic valve calcification
In this study, we developed a multiscale computational model for TGF[Formula: see text]-stimulated CAVD. The model framework comprises cellular behavior dynamics, subcellular signaling pathways, and tissue-level diffusion fields of pertinent chemical species, where information is shared among different scales. Processes such as endothelial to mesenchymal transition (EndMT), fibrosis, and calcification are incorporated. The results indicate that the majority of myofibroblasts and osteoblast-like cells ultimately die due to lack of nutrients as they become trapped in areas with higher levels of fibrosis or calcification, and...
Source: Biomechanics and Modeling in Mechanobiology - December 13, 2023 Category: Biomedical Science Authors: Javid Azimi-Boulali Gretchen J Mahler Bruce T Murray Peter Huang Source Type: research
Multiscale computational modeling of aortic valve calcification
In this study, we developed a multiscale computational model for TGF[Formula: see text]-stimulated CAVD. The model framework comprises cellular behavior dynamics, subcellular signaling pathways, and tissue-level diffusion fields of pertinent chemical species, where information is shared among different scales. Processes such as endothelial to mesenchymal transition (EndMT), fibrosis, and calcification are incorporated. The results indicate that the majority of myofibroblasts and osteoblast-like cells ultimately die due to lack of nutrients as they become trapped in areas with higher levels of fibrosis or calcification, and...
Source: Biomechanics and Modeling in Mechanobiology - December 13, 2023 Category: Biomedical Science Authors: Javid Azimi-Boulali Gretchen J Mahler Bruce T Murray Peter Huang Source Type: research
Multiscale computational modeling of aortic valve calcification
In this study, we developed a multiscale computational model for TGF[Formula: see text]-stimulated CAVD. The model framework comprises cellular behavior dynamics, subcellular signaling pathways, and tissue-level diffusion fields of pertinent chemical species, where information is shared among different scales. Processes such as endothelial to mesenchymal transition (EndMT), fibrosis, and calcification are incorporated. The results indicate that the majority of myofibroblasts and osteoblast-like cells ultimately die due to lack of nutrients as they become trapped in areas with higher levels of fibrosis or calcification, and...
Source: Biomechanics and Modeling in Mechanobiology - December 13, 2023 Category: Biomedical Science Authors: Javid Azimi-Boulali Gretchen J Mahler Bruce T Murray Peter Huang Source Type: research
Multiscale computational modeling of aortic valve calcification
In this study, we developed a multiscale computational model for TGF[Formula: see text]-stimulated CAVD. The model framework comprises cellular behavior dynamics, subcellular signaling pathways, and tissue-level diffusion fields of pertinent chemical species, where information is shared among different scales. Processes such as endothelial to mesenchymal transition (EndMT), fibrosis, and calcification are incorporated. The results indicate that the majority of myofibroblasts and osteoblast-like cells ultimately die due to lack of nutrients as they become trapped in areas with higher levels of fibrosis or calcification, and...
Source: Biomechanics and Modeling in Mechanobiology - December 13, 2023 Category: Biomedical Science Authors: Javid Azimi-Boulali Gretchen J Mahler Bruce T Murray Peter Huang Source Type: research
Mechanical properties of human hepatic tissues to develop liver-mimicking phantoms for medical applications
Biomech Model Mechanobiol. 2023 Dec 10. doi: 10.1007/s10237-023-01785-4. Online ahead of print.ABSTRACTUsing liver phantoms for mimicking human tissue in clinical training, disease diagnosis, and treatment planning is a common practice. The fabrication material of the liver phantom should exhibit mechanical properties similar to those of the real liver organ in the human body. This tissue-equivalent material is essential for qualitative and quantitative investigation of the liver mechanisms in producing nutrients, excretion of waste metabolites, and tissue deformity at mechanical stimulus. This paper reviews the mechanical...
Source: Biomechanics and Modeling in Mechanobiology - December 10, 2023 Category: Biomedical Science Authors: Aicha S Lemine Zubair Ahmad Noora J Al-Thani Anwarul Hasan Jolly Bhadra Source Type: research
Mechanical properties of human hepatic tissues to develop liver-mimicking phantoms for medical applications
Biomech Model Mechanobiol. 2023 Dec 10. doi: 10.1007/s10237-023-01785-4. Online ahead of print.ABSTRACTUsing liver phantoms for mimicking human tissue in clinical training, disease diagnosis, and treatment planning is a common practice. The fabrication material of the liver phantom should exhibit mechanical properties similar to those of the real liver organ in the human body. This tissue-equivalent material is essential for qualitative and quantitative investigation of the liver mechanisms in producing nutrients, excretion of waste metabolites, and tissue deformity at mechanical stimulus. This paper reviews the mechanical...
Source: Biomechanics and Modeling in Mechanobiology - December 10, 2023 Category: Biomedical Science Authors: Aicha S Lemine Zubair Ahmad Noora J Al-Thani Anwarul Hasan Jolly Bhadra Source Type: research
