Biomechanics and Modeling in Mechanobiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Analyzing force measurements of multi-cellular clusters comprising indeterminate geometries
Biomech Model Mechanobiol. 2023 Sep 28. doi: 10.1007/s10237-023-01764-9. Online ahead of print.ABSTRACTMulti-cellular biomimetic models often comprise heterogenic geometries. Therefore, quantification of their mechanical properties-which is crucial for various biomedical applications-is a challenge. Due to its simplicity, linear fitting is traditionally used in analyzing force-displacement data of parallel compression measurements of multi-cellular clusters, such as tumor spheroids. However, the linear assumption would be artificial when the contact geometry is not planar. We propose here the integrated elasticity (IE) reg...
Source: Biomechanics and Modeling in Mechanobiology - September 28, 2023 Category: Biomedical Science Authors: Yifat Brill-Karniely Katerina Tischenko Ofra Benny Source Type: research

A new look at an old problem: 3D modeling of accommodation reveals how age-related biomechanical changes contribute to dysfunction in presbyopia
Biomech Model Mechanobiol. 2023 Sep 21. doi: 10.1007/s10237-023-01767-6. Online ahead of print.ABSTRACTPresbyopia is an age-related ocular disorder where accommodative ability declines so that an individual's focusing range is insufficient to provide visual clarity for near and distance vision tasks without corrective measures. With age, the eye exhibits changes in biomechanical properties of many components involved in accommodation, including the lens, sclera, and ciliary muscle. Changes occur at different rates, affecting accommodative biomechanics differently, but individual contributions to presbyopia are unknown. We ...
Source: Biomechanics and Modeling in Mechanobiology - September 21, 2023 Category: Biomedical Science Authors: Katherine R Knaus AnnMarie Hipsley Silvia S Blemker Source Type: research

Biomechanical characterization of tissue types in murine dissecting aneurysms based on histology and 4D ultrasound-derived strain
Biomech Model Mechanobiol. 2023 Oct;22(5):1773-1788. doi: 10.1007/s10237-023-01759-6. Epub 2023 Sep 14.ABSTRACTAbdominal aortic aneurysm disease is the local enlargement of the aorta, typically in the infrarenal section, causing up to 200,000 deaths/year. In vivo information to characterize the individual elastic properties of the aneurysm wall in terms of rupture risk is lacking. We used a method that combines 4D ultrasound and direct deformation estimation to compute in vivo 3D Green-Lagrange strain in murine angiotensin II-induced dissecting aortic aneurysms, a commonly used mouse model. After euthanasia, histological s...
Source: Biomechanics and Modeling in Mechanobiology - September 14, 2023 Category: Biomedical Science Authors: Achim Hegner Hannah L Cebull Antonio J G ámez Christopher Blase Craig J Goergen Andreas Wittek Source Type: research

Foreword to the special issue entitled "Progress and future directions in soft tissue mechanics" in the Journal Biomechanics and Modeling in Mechanobiology
Biomech Model Mechanobiol. 2023 Oct;22(5):1461-1464. doi: 10.1007/s10237-023-01770-x. Epub 2023 Sep 14.NO ABSTRACTPMID:37707686 | DOI:10.1007/s10237-023-01770-x (Source: Biomechanics and Modeling in Mechanobiology)
Source: Biomechanics and Modeling in Mechanobiology - September 14, 2023 Category: Biomedical Science Authors: St éphane Avril Gerhard A Holzapfel Source Type: research

Impact of disturbed flow and arterial stiffening on mechanotransduction in endothelial cells
Biomech Model Mechanobiol. 2023 Sep 14. doi: 10.1007/s10237-023-01743-0. Online ahead of print.ABSTRACTDisturbed flow promotes progression of atherosclerosis at particular regions of arteries where the recent studies show the arterial wall becomes stiffer. Objective of this study is to show how mechanotransduction in subcellular organelles of endothelial cells (ECs) will alter with changes in blood flow profiles applied on ECs surface and mechanical properties of arterial wall where ECs are attached to. We will examine the exposure of ECs to atherogenic flow profiles (disturbed flow) and non-atherogenic flow profiles (pure...
Source: Biomechanics and Modeling in Mechanobiology - September 14, 2023 Category: Biomedical Science Authors: Andrea Alonso Alessandra Ebben Mahsa Dabagh Source Type: research

Biomechanical characterization of tissue types in murine dissecting aneurysms based on histology and 4D ultrasound-derived strain
Biomech Model Mechanobiol. 2023 Sep 14. doi: 10.1007/s10237-023-01759-6. Online ahead of print.ABSTRACTAbdominal aortic aneurysm disease is the local enlargement of the aorta, typically in the infrarenal section, causing up to 200,000 deaths/year. In vivo information to characterize the individual elastic properties of the aneurysm wall in terms of rupture risk is lacking. We used a method that combines 4D ultrasound and direct deformation estimation to compute in vivo 3D Green-Lagrange strain in murine angiotensin II-induced dissecting aortic aneurysms, a commonly used mouse model. After euthanasia, histological staining ...
Source: Biomechanics and Modeling in Mechanobiology - September 14, 2023 Category: Biomedical Science Authors: Achim Hegner Hannah L Cebull Antonio J G ámez Christopher Blase Craig J Goergen Andreas Wittek Source Type: research