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Subject-specific one-dimensional fluid dynamics model of chronic thromboembolic pulmonary hypertension
Biomech Model Mechanobiol. 2023 Nov 29. doi: 10.1007/s10237-023-01786-3. Online ahead of print.ABSTRACTChronic thromboembolic pulmonary hypertension (CTEPH) develops due to the accumulation of blood clots in the lung vasculature that obstructs flow and increases pressure. The mechanobiological factors that drive progression of CTEPH are not understood, in part because mechanical and hemodynamic changes in the small pulmonary arteries due to CTEPH are not easily measurable. Using previously published hemodynamic measurements and imaging from a large animal model of CTEPH, we applied a subject-specific one-dimensional (1D) c...
Source: Biomechanics and Modeling in Mechanobiology - November 28, 2023 Category: Biomedical Science Authors: Amirreza Kachabi Mitchel J Colebank Naomi C Chesler Source Type: research

Subject-specific one-dimensional fluid dynamics model of chronic thromboembolic pulmonary hypertension
Biomech Model Mechanobiol. 2023 Nov 29. doi: 10.1007/s10237-023-01786-3. Online ahead of print.ABSTRACTChronic thromboembolic pulmonary hypertension (CTEPH) develops due to the accumulation of blood clots in the lung vasculature that obstructs flow and increases pressure. The mechanobiological factors that drive progression of CTEPH are not understood, in part because mechanical and hemodynamic changes in the small pulmonary arteries due to CTEPH are not easily measurable. Using previously published hemodynamic measurements and imaging from a large animal model of CTEPH, we applied a subject-specific one-dimensional (1D) c...
Source: Biomechanics and Modeling in Mechanobiology - November 28, 2023 Category: Biomedical Science Authors: Amirreza Kachabi Mitchel J Colebank Naomi C Chesler Source Type: research

Subject-specific one-dimensional fluid dynamics model of chronic thromboembolic pulmonary hypertension
Biomech Model Mechanobiol. 2023 Nov 29. doi: 10.1007/s10237-023-01786-3. Online ahead of print.ABSTRACTChronic thromboembolic pulmonary hypertension (CTEPH) develops due to the accumulation of blood clots in the lung vasculature that obstructs flow and increases pressure. The mechanobiological factors that drive progression of CTEPH are not understood, in part because mechanical and hemodynamic changes in the small pulmonary arteries due to CTEPH are not easily measurable. Using previously published hemodynamic measurements and imaging from a large animal model of CTEPH, we applied a subject-specific one-dimensional (1D) c...
Source: Biomechanics and Modeling in Mechanobiology - November 28, 2023 Category: Biomedical Science Authors: Amirreza Kachabi Mitchel J Colebank Naomi C Chesler Source Type: research

Subject-specific one-dimensional fluid dynamics model of chronic thromboembolic pulmonary hypertension
Biomech Model Mechanobiol. 2023 Nov 29. doi: 10.1007/s10237-023-01786-3. Online ahead of print.ABSTRACTChronic thromboembolic pulmonary hypertension (CTEPH) develops due to the accumulation of blood clots in the lung vasculature that obstructs flow and increases pressure. The mechanobiological factors that drive progression of CTEPH are not understood, in part because mechanical and hemodynamic changes in the small pulmonary arteries due to CTEPH are not easily measurable. Using previously published hemodynamic measurements and imaging from a large animal model of CTEPH, we applied a subject-specific one-dimensional (1D) c...
Source: Biomechanics and Modeling in Mechanobiology - November 28, 2023 Category: Biomedical Science Authors: Amirreza Kachabi Mitchel J Colebank Naomi C Chesler Source Type: research

Subject-specific one-dimensional fluid dynamics model of chronic thromboembolic pulmonary hypertension
Biomech Model Mechanobiol. 2023 Nov 29. doi: 10.1007/s10237-023-01786-3. Online ahead of print.ABSTRACTChronic thromboembolic pulmonary hypertension (CTEPH) develops due to the accumulation of blood clots in the lung vasculature that obstructs flow and increases pressure. The mechanobiological factors that drive progression of CTEPH are not understood, in part because mechanical and hemodynamic changes in the small pulmonary arteries due to CTEPH are not easily measurable. Using previously published hemodynamic measurements and imaging from a large animal model of CTEPH, we applied a subject-specific one-dimensional (1D) c...
Source: Biomechanics and Modeling in Mechanobiology - November 28, 2023 Category: Biomedical Science Authors: Amirreza Kachabi Mitchel J Colebank Naomi C Chesler Source Type: research

Subject-specific one-dimensional fluid dynamics model of chronic thromboembolic pulmonary hypertension
Biomech Model Mechanobiol. 2023 Nov 29. doi: 10.1007/s10237-023-01786-3. Online ahead of print.ABSTRACTChronic thromboembolic pulmonary hypertension (CTEPH) develops due to the accumulation of blood clots in the lung vasculature that obstructs flow and increases pressure. The mechanobiological factors that drive progression of CTEPH are not understood, in part because mechanical and hemodynamic changes in the small pulmonary arteries due to CTEPH are not easily measurable. Using previously published hemodynamic measurements and imaging from a large animal model of CTEPH, we applied a subject-specific one-dimensional (1D) c...
Source: Biomechanics and Modeling in Mechanobiology - November 28, 2023 Category: Biomedical Science Authors: Amirreza Kachabi Mitchel J Colebank Naomi C Chesler Source Type: research

Physical biology of cell-substrate interactions under cyclic stretch
Biomech Model Mechanobiol. 2023 Nov 27. doi: 10.1007/s10237-023-01783-6. Online ahead of print.ABSTRACTMechanosensitive focal adhesion (FA) complexes mediate dynamic interactions between cells and substrates and regulate cellular function. Integrins in FA complexes link substrate ligands to stress fibers (SFs) and aid load transfer and traction generation. We developed a one-dimensional, multi-scale, stochastic finite element model of a fibroblast on a substrate that includes calcium signaling, SF remodeling, and FA dynamics. We linked stochastic dynamics, describing the formation and clustering of integrins to substrate l...
Source: Biomechanics and Modeling in Mechanobiology - November 27, 2023 Category: Biomedical Science Authors: Siddhartha Jaddivada Namrata Gundiah Source Type: research

Physical biology of cell-substrate interactions under cyclic stretch
Biomech Model Mechanobiol. 2023 Nov 27. doi: 10.1007/s10237-023-01783-6. Online ahead of print.ABSTRACTMechanosensitive focal adhesion (FA) complexes mediate dynamic interactions between cells and substrates and regulate cellular function. Integrins in FA complexes link substrate ligands to stress fibers (SFs) and aid load transfer and traction generation. We developed a one-dimensional, multi-scale, stochastic finite element model of a fibroblast on a substrate that includes calcium signaling, SF remodeling, and FA dynamics. We linked stochastic dynamics, describing the formation and clustering of integrins to substrate l...
Source: Biomechanics and Modeling in Mechanobiology - November 27, 2023 Category: Biomedical Science Authors: Siddhartha Jaddivada Namrata Gundiah Source Type: research

Potential of computational models in personalized treatment of obstructive sleep apnea: a patient-specific partial 3D finite element study
Biomech Model Mechanobiol. 2023 Nov 17. doi: 10.1007/s10237-023-01788-1. Online ahead of print.ABSTRACTThe upper airway experiences mechanical loads during breathing. Obstructive sleep apnea is a very common sleep disorder, in which the normal function of the airway is compromised, enabling its collapse. Its treatment remains unsatisfactory with variable efficacy in the case of many surgeries. Finite element models of the upper airway to simulate the effects of various anatomic and physiologic manipulations on its mechanics could be helpful in predicting surgical success. Partial 3D finite element models based on patient-s...
Source: Biomechanics and Modeling in Mechanobiology - November 17, 2023 Category: Biomedical Science Authors: Venkat Ayyalasomayajula Mads Moxness Bj ørn Skallerud Source Type: research

Potential of computational models in personalized treatment of obstructive sleep apnea: a patient-specific partial 3D finite element study
Biomech Model Mechanobiol. 2023 Nov 17. doi: 10.1007/s10237-023-01788-1. Online ahead of print.ABSTRACTThe upper airway experiences mechanical loads during breathing. Obstructive sleep apnea is a very common sleep disorder, in which the normal function of the airway is compromised, enabling its collapse. Its treatment remains unsatisfactory with variable efficacy in the case of many surgeries. Finite element models of the upper airway to simulate the effects of various anatomic and physiologic manipulations on its mechanics could be helpful in predicting surgical success. Partial 3D finite element models based on patient-s...
Source: Biomechanics and Modeling in Mechanobiology - November 17, 2023 Category: Biomedical Science Authors: Venkat Ayyalasomayajula Mads Moxness Bj ørn Skallerud Source Type: research

Potential of computational models in personalized treatment of obstructive sleep apnea: a patient-specific partial 3D finite element study
Biomech Model Mechanobiol. 2023 Nov 17. doi: 10.1007/s10237-023-01788-1. Online ahead of print.ABSTRACTThe upper airway experiences mechanical loads during breathing. Obstructive sleep apnea is a very common sleep disorder, in which the normal function of the airway is compromised, enabling its collapse. Its treatment remains unsatisfactory with variable efficacy in the case of many surgeries. Finite element models of the upper airway to simulate the effects of various anatomic and physiologic manipulations on its mechanics could be helpful in predicting surgical success. Partial 3D finite element models based on patient-s...
Source: Biomechanics and Modeling in Mechanobiology - November 17, 2023 Category: Biomedical Science Authors: Venkat Ayyalasomayajula Mads Moxness Bj ørn Skallerud Source Type: research

Potential of computational models in personalized treatment of obstructive sleep apnea: a patient-specific partial 3D finite element study
Biomech Model Mechanobiol. 2023 Nov 17. doi: 10.1007/s10237-023-01788-1. Online ahead of print.ABSTRACTThe upper airway experiences mechanical loads during breathing. Obstructive sleep apnea is a very common sleep disorder, in which the normal function of the airway is compromised, enabling its collapse. Its treatment remains unsatisfactory with variable efficacy in the case of many surgeries. Finite element models of the upper airway to simulate the effects of various anatomic and physiologic manipulations on its mechanics could be helpful in predicting surgical success. Partial 3D finite element models based on patient-s...
Source: Biomechanics and Modeling in Mechanobiology - November 17, 2023 Category: Biomedical Science Authors: Venkat Ayyalasomayajula Mads Moxness Bj ørn Skallerud Source Type: research

Potential of computational models in personalized treatment of obstructive sleep apnea: a patient-specific partial 3D finite element study
Biomech Model Mechanobiol. 2023 Nov 17. doi: 10.1007/s10237-023-01788-1. Online ahead of print.ABSTRACTThe upper airway experiences mechanical loads during breathing. Obstructive sleep apnea is a very common sleep disorder, in which the normal function of the airway is compromised, enabling its collapse. Its treatment remains unsatisfactory with variable efficacy in the case of many surgeries. Finite element models of the upper airway to simulate the effects of various anatomic and physiologic manipulations on its mechanics could be helpful in predicting surgical success. Partial 3D finite element models based on patient-s...
Source: Biomechanics and Modeling in Mechanobiology - November 17, 2023 Category: Biomedical Science Authors: Venkat Ayyalasomayajula Mads Moxness Bj ørn Skallerud Source Type: research

Potential of computational models in personalized treatment of obstructive sleep apnea: a patient-specific partial 3D finite element study
Biomech Model Mechanobiol. 2023 Nov 17. doi: 10.1007/s10237-023-01788-1. Online ahead of print.ABSTRACTThe upper airway experiences mechanical loads during breathing. Obstructive sleep apnea is a very common sleep disorder, in which the normal function of the airway is compromised, enabling its collapse. Its treatment remains unsatisfactory with variable efficacy in the case of many surgeries. Finite element models of the upper airway to simulate the effects of various anatomic and physiologic manipulations on its mechanics could be helpful in predicting surgical success. Partial 3D finite element models based on patient-s...
Source: Biomechanics and Modeling in Mechanobiology - November 17, 2023 Category: Biomedical Science Authors: Venkat Ayyalasomayajula Mads Moxness Bj ørn Skallerud Source Type: research

Potential of computational models in personalized treatment of obstructive sleep apnea: a patient-specific partial 3D finite element study
Biomech Model Mechanobiol. 2023 Nov 17. doi: 10.1007/s10237-023-01788-1. Online ahead of print.ABSTRACTThe upper airway experiences mechanical loads during breathing. Obstructive sleep apnea is a very common sleep disorder, in which the normal function of the airway is compromised, enabling its collapse. Its treatment remains unsatisfactory with variable efficacy in the case of many surgeries. Finite element models of the upper airway to simulate the effects of various anatomic and physiologic manipulations on its mechanics could be helpful in predicting surgical success. Partial 3D finite element models based on patient-s...
Source: Biomechanics and Modeling in Mechanobiology - November 17, 2023 Category: Biomedical Science Authors: Venkat Ayyalasomayajula Mads Moxness Bj ørn Skallerud Source Type: research