Bone turnover and mineralisation kinetics control trabecular BMDD and apparent bone density: insights from a discrete statistical bone remodelling model

Biomech Model Mechanobiol. 2024 Jan 27. doi: 10.1007/s10237-023-01812-4. Online ahead of print.ABSTRACTThe mechanical quality of trabecular bone is influenced by its mineral content and spatial distribution, which is controlled by bone remodelling and mineralisation. Mineralisation kinetics occur in two phases: a fast primary mineralisation and a secondary mineralisation that can last from several months to years. Variations in bone turnover and mineralisation kinetics can be observed in the bone mineral density distribution (BMDD). Here, we propose a statistical spatio-temporal bone remodelling model to study the effects of bone turnover (associated with the activation frequency [Formula: see text]) and mineralisation kinetics (associated with secondary mineralisation [Formula: see text]) on BMDD. In this model, individual basic multicellular units (BMUs) are activated discretely on trabecular surfaces that undergo typical bone remodelling periods. Our results highlight that trabecular BMDD is strongly regulated by [Formula: see text] and [Formula: see text] in a coupled way. Ca wt% increases with lower [Formula: see text] and short [Formula: see text]. For example, a [Formula: see text] 4 BMU/year/mm[Formula: see text] and [Formula: see text] = 8 years result in a mean Ca wt% of 25, which is in accordance with Ca wt% values reported in quantitative backscattered electron imaging (qBEI) experiments. However, for lower [Formula: see text] and shorter [Formula: see text] (from...
Source: Biomechanics and Modeling in Mechanobiology - Category: Biomedical Science Authors: Source Type: research