Macrophage-derived biomimetic nanoparticles enhanced SDT combined with immunotherapy inhibited tumor growth and metastasis
Biomaterials. 2024 Jan 5;305:122456. doi: 10.1016/j.biomaterials.2023.122456. Online ahead of print.ABSTRACTCombination therapy based on sonodynamic therapy (SDT) combined with immune checkpoint blockers anti-PD-L1 provides effective anti-tumor effects. We designed a combination therapy based on M1/PLGA@IR780/CAT NPs of SDT-enhanced immunity combined with immune checkpoint blockers against PD-L1, which was based on M1 macrophage membrane-encapsulated poly (lactic-co-glycolic acid) (PLGA) nanoparticles loaded with the acoustic sensitizer IR780 and catalase (CAT) to successfully realize it. SDT based on M1/PLGA@IR780/CAT NPs...
Source: Biomaterials - January 7, 2024 Category: Materials Science Authors: Sijie Chen Tianliang Ma Jiahao Wang Shuailong Liang Haiqin Liao Wanlin Tan Mingyu Chen Xiaohui Zhou Yan Xu Long Wang Chengcheng Niu Source Type: research
Protein-based nanoparticles for therapeutic nucleic acid delivery
Biomaterials. 2024 Jan 2;305:122464. doi: 10.1016/j.biomaterials.2023.122464. Online ahead of print.ABSTRACTTo realize the full potential of emerging nucleic acid therapies, there is a need for effective delivery agents to transport cargo to cells of interest. Protein materials exhibit several unique properties, including biodegradability, biocompatibility, ease of functionalization via recombinant and chemical modifications, among other features, which establish a promising basis for therapeutic nucleic acid delivery systems. In this review, we highlight progress made in the use of non-viral protein-based nanoparticles fo...
Source: Biomaterials - January 5, 2024 Category: Materials Science Authors: Feyisayo Eweje Michelle L Walsh Kiran Ahmad Vanessa Ibrahim Assma Alrefai Jiaxuan Chen Elliot L Chaikof Source Type: research
Protein-based nanoparticles for therapeutic nucleic acid delivery
Biomaterials. 2024 Jan 2;305:122464. doi: 10.1016/j.biomaterials.2023.122464. Online ahead of print.ABSTRACTTo realize the full potential of emerging nucleic acid therapies, there is a need for effective delivery agents to transport cargo to cells of interest. Protein materials exhibit several unique properties, including biodegradability, biocompatibility, ease of functionalization via recombinant and chemical modifications, among other features, which establish a promising basis for therapeutic nucleic acid delivery systems. In this review, we highlight progress made in the use of non-viral protein-based nanoparticles fo...
Source: Biomaterials - January 5, 2024 Category: Materials Science Authors: Feyisayo Eweje Michelle L Walsh Kiran Ahmad Vanessa Ibrahim Assma Alrefai Jiaxuan Chen Elliot L Chaikof Source Type: research
RNA four-way junction (4WJ) for spontaneous cancer-targeting, effective tumor-regression, metastasis suppression, fast renal excretion and undetectable toxicity
Biomaterials. 2023 Dec 21;305:122432. doi: 10.1016/j.biomaterials.2023.122432. Online ahead of print.ABSTRACTThe field of RNA therapeutics has been emerging as the third milestone in pharmaceutical drug development. RNA nanoparticles have displayed motile and deformable properties to allow for high tumor accumulation with undetectable healthy organ accumulation. Therefore, RNA nanoparticles have the potential to serve as potent drug delivery vehicles with strong anti-cancer responses. Herein, we report the physicochemical basis for the rational design of a branched RNA four-way junction (4WJ) nanoparticle that results in a...
Source: Biomaterials - January 4, 2024 Category: Materials Science Authors: Xin Li Kai Jin Tzu-Chun Cheng You-Cheng Liao Wen-Jui Lee Abhjeet S Bhullar Li-Ching Chen Piotr Rychahou Mitch A Phelps Yuan Soon Ho Peixuan Guo Source Type: research
Retraction notice to "Viability and proliferation of rat MSCs on adhesion protein-modified PET and PU scaffolds" [Biomaterials 33/12 (2012) 8094-8103]
Biomaterials. 2024 Jan 3:122445. doi: 10.1016/j.biomaterials.2023.122445. Online ahead of print.NO ABSTRACTPMID:38176982 | DOI:10.1016/j.biomaterials.2023.122445 (Source: Biomaterials)
Source: Biomaterials - January 4, 2024 Category: Materials Science Authors: Ylva Gustafsson Johannes Haag Philipp Jungebluth Vanessa Lundin Mei Ling Lim Silvia Baiguera Fatemeh Ajalloueian Costantino Del Gaudio Alessandra Bianco Guido Moll Sebastian Sj öqvist Greg Lemon Ana Isabel Teixeira Paolo Macchiarini Source Type: research
RNA four-way junction (4WJ) for spontaneous cancer-targeting, effective tumor-regression, metastasis suppression, fast renal excretion and undetectable toxicity
Biomaterials. 2023 Dec 21;305:122432. doi: 10.1016/j.biomaterials.2023.122432. Online ahead of print.ABSTRACTThe field of RNA therapeutics has been emerging as the third milestone in pharmaceutical drug development. RNA nanoparticles have displayed motile and deformable properties to allow for high tumor accumulation with undetectable healthy organ accumulation. Therefore, RNA nanoparticles have the potential to serve as potent drug delivery vehicles with strong anti-cancer responses. Herein, we report the physicochemical basis for the rational design of a branched RNA four-way junction (4WJ) nanoparticle that results in a...
Source: Biomaterials - January 4, 2024 Category: Materials Science Authors: Xin Li Kai Jin Tzu-Chun Cheng You-Cheng Liao Wen-Jui Lee Abhjeet S Bhullar Li-Ching Chen Piotr Rychahou Mitch A Phelps Yuan Soon Ho Peixuan Guo Source Type: research
Retraction notice to "Viability and proliferation of rat MSCs on adhesion protein-modified PET and PU scaffolds" [Biomaterials 33/12 (2012) 8094-8103]
Biomaterials. 2024 Jan 3:122445. doi: 10.1016/j.biomaterials.2023.122445. Online ahead of print.NO ABSTRACTPMID:38176982 | DOI:10.1016/j.biomaterials.2023.122445 (Source: Biomaterials)
Source: Biomaterials - January 4, 2024 Category: Materials Science Authors: Ylva Gustafsson Johannes Haag Philipp Jungebluth Vanessa Lundin Mei Ling Lim Silvia Baiguera Fatemeh Ajalloueian Costantino Del Gaudio Alessandra Bianco Guido Moll Sebastian Sj öqvist Greg Lemon Ana Isabel Teixeira Paolo Macchiarini Source Type: research
Emergence of nanoscale viscoelasticity from single cancer cells to established tumors
Biomaterials. 2023 Dec 22;305:122431. doi: 10.1016/j.biomaterials.2023.122431. Online ahead of print.ABSTRACTTumors are complex materials whose physical properties dictate growth and treatment outcomes. Recent evidence suggests time-dependent physical properties, such as viscoelasticity, are crucial, distinct mechanical regulators of cancer progression and malignancy, yet the genesis and consequences of tumor viscoelasticity are poorly understood. Here, using Wide-bandwidth AFM-based ViscoElastic Spectroscopy (WAVES) coupled with mathematical modeling, we probe the origins of tumor viscoelasticity. From single carcinoma ce...
Source: Biomaterials - January 3, 2024 Category: Materials Science Authors: Muhamed Hadzipasic Sue Zhang Zhuoying Huang Rachel Passaro Margaret S Sten Ganesh M Shankar Hadi T Nia Source Type: research
Injectable microcapillary network hydrogels engineered by liquid-liquid phase separation for stem cell transplantation
Biomaterials. 2023 Dec 28;305:122451. doi: 10.1016/j.biomaterials.2023.122451. Online ahead of print.ABSTRACTInjectable hydrogels are promising carriers for cell delivery in regenerative medicine. However, injectable hydrogels composed of crosslinked polymer networks are often non-microporous and prevent biological communication with host tissues through signals, nutrients, oxygen, and cells, thereby limiting graft survival and tissue integration. Here we report injectable hydrogels with liquid-liquid phase separation-induced microcapillary networks (μCN) as stem cell-delivering scaffolds. The molecular modification of ge...
Source: Biomaterials - January 3, 2024 Category: Materials Science Authors: Akihiro Nishiguchi Shima Ito Kazuhiro Nagasaka Hiyori Komatsu Koichiro Uto Tetsushi Taguchi Source Type: research
Atherosclerotic three-layer nanomatrix vascular sheets for high-throughput therapeutic evaluation
Biomaterials. 2023 Dec 27;305:122450. doi: 10.1016/j.biomaterials.2023.122450. Online ahead of print.ABSTRACTIn vitro atherosclerosis models are essential to evaluate therapeutics before in vivo and clinical studies, but significant limitations remain, such as the lack of three-layer vascular architecture and limited atherosclerotic features. Moreover, no scalable 3D atherosclerosis model is available for making high-throughput assays for therapeutic evaluation. Herein, we report an in vitro 3D three-layer nanomatrix vascular sheet with critical atherosclerosis multi-features (VSA), including endothelial dysfunction, monoc...
Source: Biomaterials - January 3, 2024 Category: Materials Science Authors: Jun Chen Xixi Zhang Robbie Cross Yujin Ahn Gillian Huskin Will Evans Patrick Taejoon Hwang Jeong-A Kim Brigitta C Brott Hanjoong Jo Young-Sup Yoon Ho-Wook Jun Source Type: research
Self-controllable proteinic antibacterial coating with bacteria-triggered antibiotic release for prevention of periprosthetic infection
Biomaterials. 2023 Dec 30;305:122457. doi: 10.1016/j.biomaterials.2023.122457. Online ahead of print.ABSTRACTPeriprosthetic infection is a devastating postimplantation complication in which a biofilm layer harboring invasive microorganisms forms around orthopedic implants, leading to severe implant failure and patient morbidity. Despite the development of several infection-triggered antibiotic release approaches, most current antibacterial coatings are susceptible to undesired antibiotic leakage or mechanical disintegration during prosthesis installation. Herein, we propose a self-controllable proteinic antibacterial coati...
Source: Biomaterials - January 3, 2024 Category: Materials Science Authors: Hyun Sun Choi Jinyoung Yun Yeonsu Jeong Yun Kee Jo Hyung Joon Cha Source Type: research
FAK-p38 signaling serves as a potential target for reverting matrix stiffness-modulated liver sinusoidal endothelial cell defenestration
Biomaterials. 2024 Jan 1;305:122462. doi: 10.1016/j.biomaterials.2023.122462. Online ahead of print.ABSTRACTLiver sinusoidal endothelial cells (LSECs) are highly specific endothelial cells which play an essential role in the maintenance of liver homeostasis. During the progression of liver fibrosis, matrix stiffening promotes LSEC defenestration, however, the underlying mechanotransduction mechanism remains poorly understood. Here, we applied stiffness-tunable hydrogels to assess the matrix stiffening-induced phenotypic changes in primary mouse LSECs. Results indicated that increased stiffness promoted LSEC defenestration ...
Source: Biomaterials - January 3, 2024 Category: Materials Science Authors: Xiaoyu Zhang Peiwen Li Jin Zhou Ziliang Zhang Huan Wu Xinyu Shu Wang Li Yi Wu Yu Du Dongyuan L ü Shouqin L ü Ning Li Mian Long Source Type: research
Macrophage-mediated fracture healing: Unraveling molecular mechanisms and therapeutic implications using hydrogel-based interventions
Biomaterials. 2024 Jan 1;305:122461. doi: 10.1016/j.biomaterials.2023.122461. Online ahead of print.ABSTRACTFracture healing is a complex biological process that involves the orchestrated interplay of various cells and molecular signaling pathways. Among the key players, macrophages have emerged as critical regulators of fracture repair, influencing inflammation, tissue remodeling, and angiogenesis. Recent advances in hydrogel-based therapeutics have provided exciting opportunities to leverage the modulatory effects of macrophages for improving fracture healing outcomes. In the present study, we review the importance of ma...
Source: Biomaterials - January 3, 2024 Category: Materials Science Authors: Bobin Mi Yuan Xiong Li Lu Jiewen Liao Guohui Liu Yanli Zhao Source Type: research
Emergence of nanoscale viscoelasticity from single cancer cells to established tumors
Biomaterials. 2023 Dec 22;305:122431. doi: 10.1016/j.biomaterials.2023.122431. Online ahead of print.ABSTRACTTumors are complex materials whose physical properties dictate growth and treatment outcomes. Recent evidence suggests time-dependent physical properties, such as viscoelasticity, are crucial, distinct mechanical regulators of cancer progression and malignancy, yet the genesis and consequences of tumor viscoelasticity are poorly understood. Here, using Wide-bandwidth AFM-based ViscoElastic Spectroscopy (WAVES) coupled with mathematical modeling, we probe the origins of tumor viscoelasticity. From single carcinoma ce...
Source: Biomaterials - January 3, 2024 Category: Materials Science Authors: Muhamed Hadzipasic Sue Zhang Zhuoying Huang Rachel Passaro Margaret S Sten Ganesh M Shankar Hadi T Nia Source Type: research
Injectable microcapillary network hydrogels engineered by liquid-liquid phase separation for stem cell transplantation
Biomaterials. 2023 Dec 28;305:122451. doi: 10.1016/j.biomaterials.2023.122451. Online ahead of print.ABSTRACTInjectable hydrogels are promising carriers for cell delivery in regenerative medicine. However, injectable hydrogels composed of crosslinked polymer networks are often non-microporous and prevent biological communication with host tissues through signals, nutrients, oxygen, and cells, thereby limiting graft survival and tissue integration. Here we report injectable hydrogels with liquid-liquid phase separation-induced microcapillary networks (μCN) as stem cell-delivering scaffolds. The molecular modification of ge...
Source: Biomaterials - January 3, 2024 Category: Materials Science Authors: Akihiro Nishiguchi Shima Ito Kazuhiro Nagasaka Hiyori Komatsu Koichiro Uto Tetsushi Taguchi Source Type: research
