Macrophage-derived biomimetic nanoparticles enhanced SDT combined with immunotherapy inhibited tumor growth and metastasis

Biomaterials. 2024 Jan 5;305:122456. doi: 10.1016/j.biomaterials.2023.122456. Online ahead of print.ABSTRACTCombination therapy based on sonodynamic therapy (SDT) combined with immune checkpoint blockers anti-PD-L1 provides effective anti-tumor effects. We designed a combination therapy based on M1/PLGA@IR780/CAT NPs of SDT-enhanced immunity combined with immune checkpoint blockers against PD-L1, which was based on M1 macrophage membrane-encapsulated poly (lactic-co-glycolic acid) (PLGA) nanoparticles loaded with the acoustic sensitizer IR780 and catalase (CAT) to successfully realize it. SDT based on M1/PLGA@IR780/CAT NPs could induce tumor cell death by promoting dendritic cell (DC) maturation and modulating the tumor immune microenvironment. In particular, the systemic anti-tumor immune response and potent immune memory induced upon combination with anti-PD-L1 checkpoint blockade not only alleviated the progression of mammary cancer in 4T1 mice and effectively blocked distant metastasis, but also prevented tumor recurrence, providing a promising new therapeutic strategy for clinical tumor therapy.PMID:38184961 | DOI:10.1016/j.biomaterials.2023.122456

Source: Biomaterials - January 7, 2024 Category: Materials Science Authors: Sijie Chen Tianliang Ma Jiahao Wang Shuailong Liang Haiqin Liao Wanlin Tan Mingyu Chen Xiaohui Zhou Yan Xu Long Wang Chengcheng Niu Source Type: research