Bioactive nanomaterials kickstart early repair processes and potentiate temporally modulated healing of healthy and diabetic wounds
Biomaterials. 2024 Jan 30;306:122496. doi: 10.1016/j.biomaterials.2024.122496. Online ahead of print.ABSTRACTSlow-healing and chronic wounds represent a major global economic and medical burden, and there is significant unmet need for novel therapies which act to both accelerate wound closure and enhance biomechanical recovery of the skin. Here, we report a new approach in which bioactives that augment early stages of wound healing can kickstart and engender effective wound closure in healthy and diabetic, obese animals, and set the stage for subsequent tissue repair processes. We demonstrate that a nanomaterial dressing m...
Source: Biomaterials - February 19, 2024 Category: Materials Science Authors: Deepanjan Ghosh Jordan R Yaron Muhammad Raisul Abedin Sudhakar Godeshala Suneel Kumar Jacquelyn Kilbourne Francois Berthiaume Kaushal Rege Source Type: research
Bioactive nanomaterials kickstart early repair processes and potentiate temporally modulated healing of healthy and diabetic wounds
Biomaterials. 2024 Jan 30;306:122496. doi: 10.1016/j.biomaterials.2024.122496. Online ahead of print.ABSTRACTSlow-healing and chronic wounds represent a major global economic and medical burden, and there is significant unmet need for novel therapies which act to both accelerate wound closure and enhance biomechanical recovery of the skin. Here, we report a new approach in which bioactives that augment early stages of wound healing can kickstart and engender effective wound closure in healthy and diabetic, obese animals, and set the stage for subsequent tissue repair processes. We demonstrate that a nanomaterial dressing m...
Source: Biomaterials - February 19, 2024 Category: Materials Science Authors: Deepanjan Ghosh Jordan R Yaron Muhammad Raisul Abedin Sudhakar Godeshala Suneel Kumar Jacquelyn Kilbourne Francois Berthiaume Kaushal Rege Source Type: research
Small-diameter vascular graft composing of core-shell structured micro-nanofibers loaded with heparin and VEGF for endothelialization and prevention of neointimal hyperplasia
This study aims to design and fabricate a core-shell fibrous small-diameter vascular graft by co-axial electrospinning process, which will mechanically and biologically meet the benchmarks for blood vessel replacement. The presented graft (PGHV) comprised polycaprolactone/gelatin (shell) loaded with heparin-VEGF and polycaprolactone (core). This study hypothesized that the shell structure of the fibers would allow rapid degradation to release heparin-VEGF, and the core would provide mechanical strength for long-term application. Physico-mechanical evaluation, in vitro biocompatibility, and hemocompatibility assays were per...
Source: Biomaterials - February 17, 2024 Category: Materials Science Authors: Md Abdullah Al Fahad Hyun-Yong Lee Seongsu Park Minji Choi Prayas Chakma Shanto Myeongki Park Sang Ho Bae Byong-Taek Lee Source Type: research
Small-diameter vascular graft composing of core-shell structured micro-nanofibers loaded with heparin and VEGF for endothelialization and prevention of neointimal hyperplasia
This study aims to design and fabricate a core-shell fibrous small-diameter vascular graft by co-axial electrospinning process, which will mechanically and biologically meet the benchmarks for blood vessel replacement. The presented graft (PGHV) comprised polycaprolactone/gelatin (shell) loaded with heparin-VEGF and polycaprolactone (core). This study hypothesized that the shell structure of the fibers would allow rapid degradation to release heparin-VEGF, and the core would provide mechanical strength for long-term application. Physico-mechanical evaluation, in vitro biocompatibility, and hemocompatibility assays were per...
Source: Biomaterials - February 17, 2024 Category: Materials Science Authors: Md Abdullah Al Fahad Hyun-Yong Lee Seongsu Park Minji Choi Prayas Chakma Shanto Myeongki Park Sang Ho Bae Byong-Taek Lee Source Type: research
Biomimetic nanodrug targets inflammation and suppresses YAP/TAZ to ameliorate atherosclerosis
Biomaterials. 2024 Feb 7;306:122505. doi: 10.1016/j.biomaterials.2024.122505. Online ahead of print.ABSTRACTAtherosclerosis, a chronic inflammatory disease, is the primary cause of myocardial infarction and ischemic stroke. Recent studies have demonstrated that dysregulation of yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding domain (TAZ) contributes to plaque development, making YAP/TAZ potential therapeutic targets. However, systemic modulation of YAP/TAZ expression or activities risks serious off-target effects, limiting clinical applicability. To address the challenge, this study develops m...
Source: Biomaterials - February 15, 2024 Category: Materials Science Authors: Hui-Chun Huang Ting-Yun Wang Joshua Rousseau Mark Orlando Michelle Mungaray Chamonix Michaud Christopher Plaisier Zhen Bouman Chen Kuei-Chun Wang Source Type: research
Phospholipid-inspired alkoxylation induces crystallization and cellular uptake of luminescent COF nanocarriers
Biomaterials. 2024 Feb 7;306:122503. doi: 10.1016/j.biomaterials.2024.122503. Online ahead of print.ABSTRACTThe porous nature and structural variability of covalent organic frameworks (COFs) make them preferred for drug loading and delivery applications. However, most COF materials suffer from poor luminescent properties and inefficiency for cell uptake. Herein, we experimentally demonstrate the crucial role of long alkoxy chains in the synthesis of crystalline COF nanostructures with high cellular uptake efficiency. After luminescence integration through band engineering, the semiconducting COF exhibits an optical bandgap...
Source: Biomaterials - February 15, 2024 Category: Materials Science Authors: Wei Zhang Shuo Xiang Yuxin Han Haiyan Wang Yuxian Deng Panpan Bian Yoshio Bando Dmitri Golberg Qunhong Weng Source Type: research
Biomimetic nanodrug targets inflammation and suppresses YAP/TAZ to ameliorate atherosclerosis
Biomaterials. 2024 Feb 7;306:122505. doi: 10.1016/j.biomaterials.2024.122505. Online ahead of print.ABSTRACTAtherosclerosis, a chronic inflammatory disease, is the primary cause of myocardial infarction and ischemic stroke. Recent studies have demonstrated that dysregulation of yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding domain (TAZ) contributes to plaque development, making YAP/TAZ potential therapeutic targets. However, systemic modulation of YAP/TAZ expression or activities risks serious off-target effects, limiting clinical applicability. To address the challenge, this study develops m...
Source: Biomaterials - February 15, 2024 Category: Materials Science Authors: Hui-Chun Huang Ting-Yun Wang Joshua Rousseau Mark Orlando Michelle Mungaray Chamonix Michaud Christopher Plaisier Zhen Bouman Chen Kuei-Chun Wang Source Type: research
Phospholipid-inspired alkoxylation induces crystallization and cellular uptake of luminescent COF nanocarriers
Biomaterials. 2024 Feb 7;306:122503. doi: 10.1016/j.biomaterials.2024.122503. Online ahead of print.ABSTRACTThe porous nature and structural variability of covalent organic frameworks (COFs) make them preferred for drug loading and delivery applications. However, most COF materials suffer from poor luminescent properties and inefficiency for cell uptake. Herein, we experimentally demonstrate the crucial role of long alkoxy chains in the synthesis of crystalline COF nanostructures with high cellular uptake efficiency. After luminescence integration through band engineering, the semiconducting COF exhibits an optical bandgap...
Source: Biomaterials - February 15, 2024 Category: Materials Science Authors: Wei Zhang Shuo Xiang Yuxin Han Haiyan Wang Yuxian Deng Panpan Bian Yoshio Bando Dmitri Golberg Qunhong Weng Source Type: research
Biomimetic nanodrug targets inflammation and suppresses YAP/TAZ to ameliorate atherosclerosis
Biomaterials. 2024 Feb 7;306:122505. doi: 10.1016/j.biomaterials.2024.122505. Online ahead of print.ABSTRACTAtherosclerosis, a chronic inflammatory disease, is the primary cause of myocardial infarction and ischemic stroke. Recent studies have demonstrated that dysregulation of yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding domain (TAZ) contributes to plaque development, making YAP/TAZ potential therapeutic targets. However, systemic modulation of YAP/TAZ expression or activities risks serious off-target effects, limiting clinical applicability. To address the challenge, this study develops m...
Source: Biomaterials - February 15, 2024 Category: Materials Science Authors: Hui-Chun Huang Ting-Yun Wang Joshua Rousseau Mark Orlando Michelle Mungaray Chamonix Michaud Christopher Plaisier Zhen Bouman Chen Kuei-Chun Wang Source Type: research
Phospholipid-inspired alkoxylation induces crystallization and cellular uptake of luminescent COF nanocarriers
Biomaterials. 2024 Feb 7;306:122503. doi: 10.1016/j.biomaterials.2024.122503. Online ahead of print.ABSTRACTThe porous nature and structural variability of covalent organic frameworks (COFs) make them preferred for drug loading and delivery applications. However, most COF materials suffer from poor luminescent properties and inefficiency for cell uptake. Herein, we experimentally demonstrate the crucial role of long alkoxy chains in the synthesis of crystalline COF nanostructures with high cellular uptake efficiency. After luminescence integration through band engineering, the semiconducting COF exhibits an optical bandgap...
Source: Biomaterials - February 15, 2024 Category: Materials Science Authors: Wei Zhang Shuo Xiang Yuxin Han Haiyan Wang Yuxian Deng Panpan Bian Yoshio Bando Dmitri Golberg Qunhong Weng Source Type: research
Targeted platelet with hydrogen peroxide responsive behavior for non-alcoholic steatohepatitis detection
Biomaterials. 2024 Feb 8;306:122506. doi: 10.1016/j.biomaterials.2024.122506. Online ahead of print.ABSTRACTThe most common chronic liver illness, non-alcoholic fatty liver disease (NAFLD), refers to a range of abnormalities of the liver with varying degrees of steatosis. When the clinical symptoms including liver damage, inflammation, and fibrosis, are added to the initial steatosis, NAFLD becomes non-alcoholic steatohepatitis (NASH), the problematic and severe stage. The diagnosis of NASH at the right time could therefore effectively prevent deterioration of the disease. Considering that platelets (PLTs) could migrate to...
Source: Biomaterials - February 14, 2024 Category: Materials Science Authors: Jingjing Liu Xingang Liu Yi Shan Hui Jun Ting Xiaodong Yu Jiong-Wei Wang Bin Liu Source Type: research
Extracellular vesicles purified from serum-converted human platelet lysates offer strong protection after cardiac ischaemia/reperfusion injury
Biomaterials. 2024 Feb 6;306:122502. doi: 10.1016/j.biomaterials.2024.122502. Online ahead of print.ABSTRACTExtracellular vesicles (EVs) from cultured cells or bodily fluids have been demonstrated to show therapeutic value following myocardial infarction. However, challenges in donor variation, EV generation and isolation methods, and material availability have hindered their therapeutic use. Here, we show that human clinical-grade platelet concentrates from a blood establishment can be used to rapidly generate high concentrations of high purity EVs from sero-converted platelet lysate (SCPL-EVs) with minimal processing, us...
Source: Biomaterials - February 14, 2024 Category: Materials Science Authors: Dora Livkisa Tzu-Hsin Chang Thierry Burnouf Andreas Czosseck Nhi Thao Ngoc Le Gleb Shamrin Wei-Ting Yeh Masao Kamimura David J Lundy Source Type: research
Corrigendum to "Self-assembling peptide hydrogel enables instant epicardial coating of the heart with mesenchymal stromal cells for the treatment of heart failure" [Biomaterials 154 (2018) 12-23]
Biomaterials. 2024 Feb 9:122500. doi: 10.1016/j.biomaterials.2024.122500. Online ahead of print.NO ABSTRACTPMID:38341294 | DOI:10.1016/j.biomaterials.2024.122500 (Source: Biomaterials)
Source: Biomaterials - February 10, 2024 Category: Materials Science Authors: Yuki Ichihara Masahiro Kaneko Kenichi Yamahara Marinos Koulouroudias Nobuhiko Sato Rakesh Uppal Kenji Yamazaki Satoshi Saito Ken Suzuki Source Type: research
Stiffness assisted cell-matrix remodeling trigger 3D mechanotransduction regulatory programs
Biomaterials. 2024 Jan 18;306:122473. doi: 10.1016/j.biomaterials.2024.122473. Online ahead of print.ABSTRACTEngineered matrices provide a valuable platform to understand the impact of biophysical factors on cellular behavior such as migration, proliferation, differentiation, and tissue remodeling, through mechanotransduction. While recent studies have identified some mechanisms of 3D mechanotransduction, there is still a critical knowledge gap in comprehending the interplay between 3D confinement, ECM properties, and cellular behavior. Specifically, the role of matrix stiffness in directing cellular fate in 3D microenviro...
Source: Biomaterials - February 9, 2024 Category: Materials Science Authors: Anna L Kersey Daniel Y Cheng Kaivalya A Deo Christina R Dubell Ting-Ching Wang Manish K Jaiswal Min Hee Kim Aparna Murali Sarah E Hargett Sumana Mallick Tanmay P Lele Irtisha Singh Akhilesh K Gaharwar Source Type: research
Corrigendum to "On-site fabrication of bi-layered adhesive mesenchymal stromal cell dressings for the treatment of heart failure" [Biomaterials 209 (2019) 41-53]
Biomaterials. 2024 Feb 8:122499. doi: 10.1016/j.biomaterials.2024.122499. Online ahead of print.NO ABSTRACTPMID:38336538 | DOI:10.1016/j.biomaterials.2024.122499 (Source: Biomaterials)
Source: Biomaterials - February 9, 2024 Category: Materials Science Authors: Kazuya Kobayashi Yuki Ichihara Nobuhiko Sato Nobuyoshi Umeda Laura Fields Masafumi Fukumitsu Yoshiyuki Tago Tomoya Ito Satoshi Kainuma Mihai Podaru Fiona Lewis-McDougall Kenichi Yamahara Rakesh Uppal Ken Suzuki Source Type: research
