A biomimetic cuproptosis amplifier for targeted NIR-II fluorescence/photoacoustic imaging-guided synergistic NIR-II photothermal immunotherapy
Biomaterials. 2023 Dec 27;305:122455. doi: 10.1016/j.biomaterials.2023.122455. Online ahead of print.ABSTRACTThe therapeutic efficacy of cuproptosis combined with phototheranostics is still hindered by easy copper efflux, nonspecific accumulation and limited light penetration depth. Here, a high-performance NIR-II semiconductor polymer was first synthesized through dual-donor engineering. Then a biomimetic cuproptosis amplifier (PCD@CM) was prepared by Cu(II)-mediated coordinative self-assembly of NIR-II ultrasmall polymer dots and the chemotherapeutic drug DOX, followed by camouflaging of tumor cell membranes. After homol...
Source: Biomaterials - December 31, 2023 Category: Materials Science Authors: Yeneng Dai Lipeng Zhu Xue Li Fengjuan Zhang Kai Chen Guanda Jiao Yu Liu Ziyi Yang Ziang Guo Baohong Zhang Qingming Shen Qi Zhao Source Type: research
Lung metastasis-Harnessed in-Situ adherent porous organic nanosponge-mediated antigen capture for A self-cascaded detained dendritic cells and T cell infiltration
Biomaterials. 2023 Dec 27;305:122443. doi: 10.1016/j.biomaterials.2023.122443. Online ahead of print.ABSTRACTThe infiltration of cytotoxic T lymphocytes promises to suppress the most irresistible metastatic tumor for immunotherapy, yet immune privilege and low immunogenic responses in these aggressive clusters often restrict lymphocyte recruitment. Here, an in situ adherent porous organic nanosponge (APON) doubles as organ selection agent and antigen captor to overcome immune privilege is developed. With selective organ targeting, the geometric effect of APON composed of disc catechol-functionalized covalent organic framew...
Source: Biomaterials - December 31, 2023 Category: Materials Science Authors: Ting-Hsien Wu Yu-Jen Lu Min-Ren Chiang Pin-Hua Chen Yu-Sheng Lee Ming-Yin Shen Wen-Hsuan Chiang Yu-Chen Liu Chun-Yu Chuang Hsiao-Chun Amy Lin Shang-Hsiu Hu Source Type: research
A carbonic anhydrase-targeted NIR-II fluorescent cisplatin theranostic nanoparticle for combined therapy of pancreatic tumors
This study demonstrates promise to fabricate NIR-II excitable nanoparticles for FLI-guided precise theranostics of pancreatic tumors.PMID:38159360 | DOI:10.1016/j.biomaterials.2023.122454 (Source: Biomaterials)
Source: Biomaterials - December 30, 2023 Category: Materials Science Authors: Yanling Yang Yili Liu Jianhui Weng Xidan Wen Ying Liu Deju Ye Source Type: research
Dual-crosslinking immunostimulatory hydrogel synchronously suppresses pancreatic fistula and pancreatic cancer relapse post-resection
Biomaterials. 2023 Dec 24;305:122453. doi: 10.1016/j.biomaterials.2023.122453. Online ahead of print.ABSTRACTIn pancreatic cancer (PC), surgical resection remains the sole curative option, albeit patients undergoing resection are susceptible to postoperative pancreatic fistula (PF) formation and tumor recurrence. An unmet need exists for a unified strategy capable of concomitantly averting PF and tumor relapse to mitigate morbidity in PC patients after surgery. Herein, an original dual crosslinked biological sealant hydrogel (methacrylate-hyaluronic acid-dopamine (MA-HA-DA) and sulfhydryl-hyaluronic acid-dopamine (SH-HA-DA...
Source: Biomaterials - December 30, 2023 Category: Materials Science Authors: Ruizhi Zhao Qiuqun Xiao Yuanyuan Wu Weiqi Zhang Jiale Liu Yinghua Zeng Jie Zhan Yanbin Cai Chihua Fang Source Type: research
Selenium promotes immunogenic radiotherapy against cervical cancer metastasis through evoking P53 activation
Biomaterials. 2023 Dec 24;305:122452. doi: 10.1016/j.biomaterials.2023.122452. Online ahead of print.ABSTRACTRadiotherapy is still the recommended treatment for cervical cancer. However, radioresistance and radiation-induced side effects remain one of the biggest clinical problems. Selenium (Se) has been confirmed to exhibit radiation-enhancing effects for cancer treatment. However, Se species dominate the biological activities and which form of Se possesses better radiosensitizing properties and radiation safety remains elusive. Here, different Se species (the valence state of Se ranged from - 2, 0, +4 to + 6) synergy scr...
Source: Biomaterials - December 28, 2023 Category: Materials Science Authors: Yanchao Xu Haoqiang Lai Shuya Pan Liuliu Pan Ting Liu Ziyi Yang Tianfeng Chen Xueqiong Zhu Source Type: research
Glutathione depletion and dihydroorotate dehydrogenase inhibition actuated ferroptosis-augment to surmount triple-negative breast cancer
In this study, an albumin-based nanomedicine was developed to induce augmented ferroptosis in triple-negative breast cancer (TNBC) by depleting glutathione (GSH) and inhibiting DHODH activity. The nanomedicine (ATO/SRF@BSA) was developed by loading sorafenib (SRF) and atovaquone (ATO) into bovine serum albumin (BSA). SRF is an FDA-approved ferroptosis inducer and ATO is the only drug used in clinical that targets mitochondria. By combining the effects of SRF and ATO, ATO/SRF@BSA promoted the accumulation of lipid peroxides within mitochondria by inhibiting the glutathione peroxidase 4 (GPX4)-GSH pathway and downregulating ...
Source: Biomaterials - December 28, 2023 Category: Materials Science Authors: Tian-Jiao Zhou Meng-Meng Zhang Dan-Meng Liu Li-Ling Huang Hai-Qing Yu Yi Wang Lei Xing Hu-Lin Jiang Source Type: research
Selenium promotes immunogenic radiotherapy against cervical cancer metastasis through evoking P53 activation
Biomaterials. 2023 Dec 24;305:122452. doi: 10.1016/j.biomaterials.2023.122452. Online ahead of print.ABSTRACTRadiotherapy is still the recommended treatment for cervical cancer. However, radioresistance and radiation-induced side effects remain one of the biggest clinical problems. Selenium (Se) has been confirmed to exhibit radiation-enhancing effects for cancer treatment. However, Se species dominate the biological activities and which form of Se possesses better radiosensitizing properties and radiation safety remains elusive. Here, different Se species (the valence state of Se ranged from - 2, 0, +4 to + 6) synergy scr...
Source: Biomaterials - December 28, 2023 Category: Materials Science Authors: Yanchao Xu Haoqiang Lai Shuya Pan Liuliu Pan Ting Liu Ziyi Yang Tianfeng Chen Xueqiong Zhu Source Type: research
Glutathione depletion and dihydroorotate dehydrogenase inhibition actuated ferroptosis-augment to surmount triple-negative breast cancer
In this study, an albumin-based nanomedicine was developed to induce augmented ferroptosis in triple-negative breast cancer (TNBC) by depleting glutathione (GSH) and inhibiting DHODH activity. The nanomedicine (ATO/SRF@BSA) was developed by loading sorafenib (SRF) and atovaquone (ATO) into bovine serum albumin (BSA). SRF is an FDA-approved ferroptosis inducer and ATO is the only drug used in clinical that targets mitochondria. By combining the effects of SRF and ATO, ATO/SRF@BSA promoted the accumulation of lipid peroxides within mitochondria by inhibiting the glutathione peroxidase 4 (GPX4)-GSH pathway and downregulating ...
Source: Biomaterials - December 28, 2023 Category: Materials Science Authors: Tian-Jiao Zhou Meng-Meng Zhang Dan-Meng Liu Li-Ling Huang Hai-Qing Yu Yi Wang Lei Xing Hu-Lin Jiang Source Type: research
Selenium promotes immunogenic radiotherapy against cervical cancer metastasis through evoking P53 activation
Biomaterials. 2023 Dec 24;305:122452. doi: 10.1016/j.biomaterials.2023.122452. Online ahead of print.ABSTRACTRadiotherapy is still the recommended treatment for cervical cancer. However, radioresistance and radiation-induced side effects remain one of the biggest clinical problems. Selenium (Se) has been confirmed to exhibit radiation-enhancing effects for cancer treatment. However, Se species dominate the biological activities and which form of Se possesses better radiosensitizing properties and radiation safety remains elusive. Here, different Se species (the valence state of Se ranged from - 2, 0, +4 to + 6) synergy scr...
Source: Biomaterials - December 28, 2023 Category: Materials Science Authors: Yanchao Xu Haoqiang Lai Shuya Pan Liuliu Pan Ting Liu Ziyi Yang Tianfeng Chen Xueqiong Zhu Source Type: research
Glutathione depletion and dihydroorotate dehydrogenase inhibition actuated ferroptosis-augment to surmount triple-negative breast cancer
In this study, an albumin-based nanomedicine was developed to induce augmented ferroptosis in triple-negative breast cancer (TNBC) by depleting glutathione (GSH) and inhibiting DHODH activity. The nanomedicine (ATO/SRF@BSA) was developed by loading sorafenib (SRF) and atovaquone (ATO) into bovine serum albumin (BSA). SRF is an FDA-approved ferroptosis inducer and ATO is the only drug used in clinical that targets mitochondria. By combining the effects of SRF and ATO, ATO/SRF@BSA promoted the accumulation of lipid peroxides within mitochondria by inhibiting the glutathione peroxidase 4 (GPX4)-GSH pathway and downregulating ...
Source: Biomaterials - December 28, 2023 Category: Materials Science Authors: Tian-Jiao Zhou Meng-Meng Zhang Dan-Meng Liu Li-Ling Huang Hai-Qing Yu Yi Wang Lei Xing Hu-Lin Jiang Source Type: research
Selenium promotes immunogenic radiotherapy against cervical cancer metastasis through evoking P53 activation
Biomaterials. 2023 Dec 24;305:122452. doi: 10.1016/j.biomaterials.2023.122452. Online ahead of print.ABSTRACTRadiotherapy is still the recommended treatment for cervical cancer. However, radioresistance and radiation-induced side effects remain one of the biggest clinical problems. Selenium (Se) has been confirmed to exhibit radiation-enhancing effects for cancer treatment. However, Se species dominate the biological activities and which form of Se possesses better radiosensitizing properties and radiation safety remains elusive. Here, different Se species (the valence state of Se ranged from - 2, 0, +4 to + 6) synergy scr...
Source: Biomaterials - December 28, 2023 Category: Materials Science Authors: Yanchao Xu Haoqiang Lai Shuya Pan Liuliu Pan Ting Liu Ziyi Yang Tianfeng Chen Xueqiong Zhu Source Type: research
Glutathione depletion and dihydroorotate dehydrogenase inhibition actuated ferroptosis-augment to surmount triple-negative breast cancer
In this study, an albumin-based nanomedicine was developed to induce augmented ferroptosis in triple-negative breast cancer (TNBC) by depleting glutathione (GSH) and inhibiting DHODH activity. The nanomedicine (ATO/SRF@BSA) was developed by loading sorafenib (SRF) and atovaquone (ATO) into bovine serum albumin (BSA). SRF is an FDA-approved ferroptosis inducer and ATO is the only drug used in clinical that targets mitochondria. By combining the effects of SRF and ATO, ATO/SRF@BSA promoted the accumulation of lipid peroxides within mitochondria by inhibiting the glutathione peroxidase 4 (GPX4)-GSH pathway and downregulating ...
Source: Biomaterials - December 28, 2023 Category: Materials Science Authors: Tian-Jiao Zhou Meng-Meng Zhang Dan-Meng Liu Li-Ling Huang Hai-Qing Yu Yi Wang Lei Xing Hu-Lin Jiang Source Type: research
Eyedrop delivery of therapeutic proteins with zwitterionic polymers to treat dry age-related macular degeneration
In this study, zwitterion-grafted chitosan (CS-ZW) was developed and then self-assembled with protein therapeutics including adalimumab (ADA) or catalase (CAT) for the treatment of dry age-related macular degeneration (dAMD) via topical eyedrops. Since CS-ZW can cross the mucus layer and open the tight junctions between epithelial cells, their delivered therapeutic proteins can be shuttled across the ocular barriers to reach the diseased site in the fundus. CS-ZW/ADA eyedrops delivering ADA to bind TNF-α in the fundus achieved a similar therapeutic effect to intravitreal ADA injection in a mouse dAMD model. In addition, t...
Source: Biomaterials - December 27, 2023 Category: Materials Science Authors: Yutong Jiang Xuehui Fu Ming Shao Wanwan Chang Han Zhang Zhuang Liu Source Type: research
A facile boronophenylalanine modified polydopamine dual drug-loaded nanoparticles for enhanced anti-tumor immune response in hepatocellular carcinoma comprehensive treatment
Biomaterials. 2023 Dec 21;305:122435. doi: 10.1016/j.biomaterials.2023.122435. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) has an insidious onset and high malignancy. Most patients have progressed to intermediate and advanced stages by the time of diagnosis, and the long-term efficacy of traditional treatments is not satisfactory. Immunotherapy has shown great promise in the treatment of HCC in recent years; however, the low immunogenicity and severe immunosuppressive tumor microenvironment result in a low response rate to immunotherapy in HCC patients. Therefore, it is of great significance to improve the...
Source: Biomaterials - December 27, 2023 Category: Materials Science Authors: Fan Yang Liqun Dai Kun Shi Qingya Liu Meng Pan Dong Mo Hanzhi Deng Liping Yuan Yi Lu Lili Pan Tingyu Yang Zhiyong Qian Source Type: research
Nitrogen vacancy-rich carbon nitride anchored with iron atoms for efficient redox dyshomeostasis under ultrasound actuation
Biomaterials. 2023 Dec 23;305:122446. doi: 10.1016/j.biomaterials.2023.122446. Online ahead of print.ABSTRACTTraditional Fe-based Fenton reaction for inducing oxidative stress is restricted by random charge transfer without oriental delivery, and the resultant generation of reactive oxygen species (ROS) is always too simplistic to realize a satisfactory therapeutic outcome. Herein, FeNv/CN nanosheets rich in nitrogen vacancies are developed for high-performance redox dyshomeostasis therapy after surface conjugation with polyethylene glycol (PEG) and cyclic Arg-Gly-Asp (cRGD). Surface defects in FeNv/CN serve as electron tr...
Source: Biomaterials - December 27, 2023 Category: Materials Science Authors: Mengting He Xiaoqin Wang Honglian Yu Yinmin Zhao Lei Zhang Zhigang Xu Yuejun Kang Peng Xue Source Type: research
