Plant mucus-derived microgels: Blood-triggered gelation and strong hemostatic adhesion
Biomaterials. 2024 Mar 16;307:122535. doi: 10.1016/j.biomaterials.2024.122535. Online ahead of print.ABSTRACTArrest of bleeding usually applies clotting agents to trigger coagulation procedures or adhesives to interrupt blood flow through sealing the vessel; however, the efficiency is compromised. Here, we propose a concept of integration of hemostasis and adhesion via yam mucus's microgels. The mucus microgels exhibit attractive attributes of hydrogel with uniform size and shape. Their shear-thinning, self-healing and strong adhesion make them feasible as injectable bioadhesion. Exceptionally, the blood can trigger the mi...
Source: Biomaterials - March 22, 2024 Category: Materials Science Authors: Yu Huang Weichao Hu Kaige Xu Ruijue Dan Shali Tan Zhenzhen Shu Xin Li Hangzong Liu Chaoqiang Fan Malcolm Xing Shiming Yang Source Type: research
A neoteric antibacterial ceria-silver nanozyme for abiotic surfaces
Biomaterials. 2024 Mar 18;307:122527. doi: 10.1016/j.biomaterials.2024.122527. Online ahead of print.ABSTRACTCommunity-associated and hospital-acquired infections caused by bacteria continue to yield major global challenges to human health. Bacterial contamination on abiotic surfaces is largely spread via high-touch surfaces and contemporary standard disinfection practices show limited efficacy, resulting in unsatisfactory therapeutic outcomes. New strategies that offer non-specific and broad protection are urgently needed. Herein, we report our novel ceria-silver nanozyme engineered at a molar ratio of 5:1 and with a high...
Source: Biomaterials - March 22, 2024 Category: Materials Science Authors: Abinaya Sindu Pugazhendhi Craig J Neal Khoa Minh Ta Marco Molinari Udit Kumar Fei Wei Elayaraja Kolanthai Andrew Ady Christina Drake Megan Hughes Shibu Yooseph Sudipta Seal Melanie J Coathup Source Type: research
ROS-responsive drug-releasing injectable microgels for ameliorating myocardial infarction
Biomaterials. 2024 Mar 16;307:122534. doi: 10.1016/j.biomaterials.2024.122534. Online ahead of print.ABSTRACTDespite of the recent advances in regulatory T cell (Treg) therapy, a limited number of available cells and specificity at the desired tissue site have severely compromised their efficacy. Herein, an injectable drug-releasing (MTK-TK-drug) microgel system in response to in situ stimulation by reactive oxygen species (ROS) was constructed with a coaxial capillary microfluidic system and UV curing. The spherical microgels with a size of 150 μm were obtained. The MTK-TK-drug microgels efficiently converted the pro-inf...
Source: Biomaterials - March 22, 2024 Category: Materials Science Authors: Shuqin Wang Yuejun Yao Liang Song Zihe Zhai Shifen Li Zhaolong Wang Liyin Shen Yang Zhu Wenxing Liu Changyou Gao Source Type: research
Plant mucus-derived microgels: Blood-triggered gelation and strong hemostatic adhesion
Biomaterials. 2024 Mar 16;307:122535. doi: 10.1016/j.biomaterials.2024.122535. Online ahead of print.ABSTRACTArrest of bleeding usually applies clotting agents to trigger coagulation procedures or adhesives to interrupt blood flow through sealing the vessel; however, the efficiency is compromised. Here, we propose a concept of integration of hemostasis and adhesion via yam mucus's microgels. The mucus microgels exhibit attractive attributes of hydrogel with uniform size and shape. Their shear-thinning, self-healing and strong adhesion make them feasible as injectable bioadhesion. Exceptionally, the blood can trigger the mi...
Source: Biomaterials - March 22, 2024 Category: Materials Science Authors: Yu Huang Weichao Hu Kaige Xu Ruijue Dan Shali Tan Zhenzhen Shu Xin Li Hangzong Liu Chaoqiang Fan Malcolm Xing Shiming Yang Source Type: research
A neoteric antibacterial ceria-silver nanozyme for abiotic surfaces
Biomaterials. 2024 Mar 18;307:122527. doi: 10.1016/j.biomaterials.2024.122527. Online ahead of print.ABSTRACTCommunity-associated and hospital-acquired infections caused by bacteria continue to yield major global challenges to human health. Bacterial contamination on abiotic surfaces is largely spread via high-touch surfaces and contemporary standard disinfection practices show limited efficacy, resulting in unsatisfactory therapeutic outcomes. New strategies that offer non-specific and broad protection are urgently needed. Herein, we report our novel ceria-silver nanozyme engineered at a molar ratio of 5:1 and with a high...
Source: Biomaterials - March 22, 2024 Category: Materials Science Authors: Abinaya Sindu Pugazhendhi Craig J Neal Khoa Minh Ta Marco Molinari Udit Kumar Fei Wei Elayaraja Kolanthai Andrew Ady Christina Drake Megan Hughes Shibu Yooseph Sudipta Seal Melanie J Coathup Source Type: research
Local delivery of stem cell spheroids with protein/polyphenol self-assembling armor to improve myocardial infarction treatment via immunoprotection and immunoregulation
Biomaterials. 2024 Mar 8;307:122526. doi: 10.1016/j.biomaterials.2024.122526. Online ahead of print.ABSTRACTStem cell therapies have shown great potential for treating myocardial infarction (MI) but are limited by low cell survival and compromised functionality due to the harsh microenvironment at the disease site. Here, we presented a Mesenchymal stem cell (MSC) spheroid-based strategy for MI treatment by introducing a protein/polyphenol self-assembling armor coating on the surface of cell spheroids, which showed significantly enhanced therapeutic efficacy by actively manipulating the hostile pathological MI microenvironm...
Source: Biomaterials - March 21, 2024 Category: Materials Science Authors: Chuanfeng An Fei Shao Canling Long Yujie Zhang Wen Nie Rui Zeng Zhenzhen Dou Yuan Zhao Yuanyuan Lin Shiying Zhang Lijun Zhang Changle Ren Yang Zhang Guangqian Zhou Huanan Wang Jia Liu Source Type: research
Degradation-controlled tissue extracellular sponge for rapid hemostasis and wound repair after kidney injury
Biomaterials. 2024 Mar 11;307:122524. doi: 10.1016/j.biomaterials.2024.122524. Online ahead of print.ABSTRACTPatients diagnosed with T1a cancer undergo partial nephrectomy to remove the tumors. In the process of removing the tumors, loss of kidney volume is inevitable, and current surgical methods focus solely on hemostasis and wound closure. Here, we developed an implantable form of decellularized extracellular matrix sponge to target both hemostasis and wound healing at the lesion site. A porous form of kidney decellularized matrix was achieved by fabricating a chemically cross-linked cryogel followed by lyophilization. ...
Source: Biomaterials - March 21, 2024 Category: Materials Science Authors: Jae Yun Kim Tugce Sen Jae Yeon Lee Dong-Woo Cho Source Type: research
Ultrasound-driven radical chain reaction and immunoregulation of piezoelectric-based hybrid coating for treating implant infection
Biomaterials. 2024 Mar 14;307:122532. doi: 10.1016/j.biomaterials.2024.122532. Online ahead of print.ABSTRACTThe poor efficiency of US-responsive coatings on implants restricts their practical application. Immunotherapy that stimulates immune cells to enhance their antibacterial activity is expected to synergize with sonodynamic therapy for treating implant infection effectively and safely. Herein, US-responsive hybrid coatings composed of the oxygen-deficient BaTiO3 nanorod arrays and l-arginine (BaTiO3-x/LA) are designed and prepared on titanium implants for sonocatalytic therapy-cooperated immunotherapy to treat Methici...
Source: Biomaterials - March 17, 2024 Category: Materials Science Authors: Menglin Sun Jiameng Wang Xiaobo Huang Ruiqiang Hang Peide Han Jiqiang Guo Xiaohong Yao Paul K Chu Xiangyu Zhang Source Type: research
MDSC-targeting gold nanoparticles enhance PD-1 tumor immunotherapy by inhibiting NLRP3 inflammasomes
In this study, we revealed that gold nanoparticles (Au NPs) with a size of 30 nm disrupted NLRP3 inflammasome, but not other inflammasomes, in bone marrow-derived macrophages through abrogating NLRP3-NEK7 interactions mediated by reactive oxygen species (ROS). Density functional theory (DFT) calculations provided insights into the mechanism underlying the exceptional ROS scavenging capabilities of Au NPs. Additionally, when coupled with H6, a small peptide targeting MDSCs, Au NPs demonstrated the capacity to effectively reduce IL-1β levels and diminish the MDSCs population in tumor microenvironment, leading to enhanced T ...
Source: Biomaterials - March 17, 2024 Category: Materials Science Authors: Yangyang Zhu Pin Chen Bochuan Hu Suqin Zhong Kai Yan Yu Wu Shanshan Li Yinyin Yang Zexin Xu Yutong Lu Ying Ouyang Hui Bao Weiguang Gu Longping Wen Yunjiao Zhang Source Type: research
Magnetic natural lipid nanoparticles for oral treatment of colorectal cancer through potentiated antitumor immunity and microbiota metabolite regulation
Biomaterials. 2024 Mar 11;307:122530. doi: 10.1016/j.biomaterials.2024.122530. Online ahead of print.ABSTRACTThe therapeutic efficacy of oral nanotherapeutics against colorectal cancer (CRC) is restricted by inadequate drug accumulation, immunosuppressive microenvironment, and intestinal microbiota imbalance. To overcome these challenges, we elaborately constructed 6-gingerol (Gin)-loaded magnetic mesoporous silicon nanoparticles and functionalized their surface with mulberry leaf-extracted lipids (MLLs) and Pluronic F127 (P127). In vitro experiments revealed that P127 functionalization and alternating magnetic fields (AMF...
Source: Biomaterials - March 17, 2024 Category: Materials Science Authors: Baoyi Li Menghang Zu Aodi Jiang Yingui Cao Jiaxue Wu Mohammad-Ali Shahbazi Xiaoxiao Shi Rui L Reis Subhas C Kundu Bo Xiao Source Type: research
Ultrasound-driven radical chain reaction and immunoregulation of piezoelectric-based hybrid coating for treating implant infection
Biomaterials. 2024 Mar 14;307:122532. doi: 10.1016/j.biomaterials.2024.122532. Online ahead of print.ABSTRACTThe poor efficiency of US-responsive coatings on implants restricts their practical application. Immunotherapy that stimulates immune cells to enhance their antibacterial activity is expected to synergize with sonodynamic therapy for treating implant infection effectively and safely. Herein, US-responsive hybrid coatings composed of the oxygen-deficient BaTiO3 nanorod arrays and l-arginine (BaTiO3-x/LA) are designed and prepared on titanium implants for sonocatalytic therapy-cooperated immunotherapy to treat Methici...
Source: Biomaterials - March 17, 2024 Category: Materials Science Authors: Menglin Sun Jiameng Wang Xiaobo Huang Ruiqiang Hang Peide Han Jiqiang Guo Xiaohong Yao Paul K Chu Xiangyu Zhang Source Type: research
MDSC-targeting gold nanoparticles enhance PD-1 tumor immunotherapy by inhibiting NLRP3 inflammasomes
In this study, we revealed that gold nanoparticles (Au NPs) with a size of 30 nm disrupted NLRP3 inflammasome, but not other inflammasomes, in bone marrow-derived macrophages through abrogating NLRP3-NEK7 interactions mediated by reactive oxygen species (ROS). Density functional theory (DFT) calculations provided insights into the mechanism underlying the exceptional ROS scavenging capabilities of Au NPs. Additionally, when coupled with H6, a small peptide targeting MDSCs, Au NPs demonstrated the capacity to effectively reduce IL-1β levels and diminish the MDSCs population in tumor microenvironment, leading to enhanced T ...
Source: Biomaterials - March 17, 2024 Category: Materials Science Authors: Yangyang Zhu Pin Chen Bochuan Hu Suqin Zhong Kai Yan Yu Wu Shanshan Li Yinyin Yang Zexin Xu Yutong Lu Ying Ouyang Hui Bao Weiguang Gu Longping Wen Yunjiao Zhang Source Type: research
Magnetic natural lipid nanoparticles for oral treatment of colorectal cancer through potentiated antitumor immunity and microbiota metabolite regulation
Biomaterials. 2024 Mar 11;307:122530. doi: 10.1016/j.biomaterials.2024.122530. Online ahead of print.ABSTRACTThe therapeutic efficacy of oral nanotherapeutics against colorectal cancer (CRC) is restricted by inadequate drug accumulation, immunosuppressive microenvironment, and intestinal microbiota imbalance. To overcome these challenges, we elaborately constructed 6-gingerol (Gin)-loaded magnetic mesoporous silicon nanoparticles and functionalized their surface with mulberry leaf-extracted lipids (MLLs) and Pluronic F127 (P127). In vitro experiments revealed that P127 functionalization and alternating magnetic fields (AMF...
Source: Biomaterials - March 17, 2024 Category: Materials Science Authors: Baoyi Li Menghang Zu Aodi Jiang Yingui Cao Jiaxue Wu Mohammad-Ali Shahbazi Xiaoxiao Shi Rui L Reis Subhas C Kundu Bo Xiao Source Type: research
Ultrasound-driven radical chain reaction and immunoregulation of piezoelectric-based hybrid coating for treating implant infection
Biomaterials. 2024 Mar 14;307:122532. doi: 10.1016/j.biomaterials.2024.122532. Online ahead of print.ABSTRACTThe poor efficiency of US-responsive coatings on implants restricts their practical application. Immunotherapy that stimulates immune cells to enhance their antibacterial activity is expected to synergize with sonodynamic therapy for treating implant infection effectively and safely. Herein, US-responsive hybrid coatings composed of the oxygen-deficient BaTiO3 nanorod arrays and l-arginine (BaTiO3-x/LA) are designed and prepared on titanium implants for sonocatalytic therapy-cooperated immunotherapy to treat Methici...
Source: Biomaterials - March 17, 2024 Category: Materials Science Authors: Menglin Sun Jiameng Wang Xiaobo Huang Ruiqiang Hang Peide Han Jiqiang Guo Xiaohong Yao Paul K Chu Xiangyu Zhang Source Type: research
MDSC-targeting gold nanoparticles enhance PD-1 tumor immunotherapy by inhibiting NLRP3 inflammasomes
In this study, we revealed that gold nanoparticles (Au NPs) with a size of 30 nm disrupted NLRP3 inflammasome, but not other inflammasomes, in bone marrow-derived macrophages through abrogating NLRP3-NEK7 interactions mediated by reactive oxygen species (ROS). Density functional theory (DFT) calculations provided insights into the mechanism underlying the exceptional ROS scavenging capabilities of Au NPs. Additionally, when coupled with H6, a small peptide targeting MDSCs, Au NPs demonstrated the capacity to effectively reduce IL-1β levels and diminish the MDSCs population in tumor microenvironment, leading to enhanced T ...
Source: Biomaterials - March 17, 2024 Category: Materials Science Authors: Yangyang Zhu Pin Chen Bochuan Hu Suqin Zhong Kai Yan Yu Wu Shanshan Li Yinyin Yang Zexin Xu Yutong Lu Ying Ouyang Hui Bao Weiguang Gu Longping Wen Yunjiao Zhang Source Type: research
