Ultrasound-augmented enzyodynamic-Ca < sup > 2+ < /sup > overload synergetic tumor nanotherapy
This study highlights the role of ultrasound coupled with functional nanozyme in the homeostasis imbalance and function disorder of mitochondria for highly efficient tumor treatment.PMID:38432005 | DOI:10.1016/j.biomaterials.2024.122513 (Source: Biomaterials)
Source: Biomaterials - March 3, 2024 Category: Materials Science Authors: Meiqi Chang Lu Zhang Tingting Zhang Yanqiu Duan Wei Feng Shaoling Yang Yu Chen Zeyu Wang Source Type: research
An ATPase-Mimicking MXene nanozyme pharmacologically breaks the ironclad defense system for ferroptosis cancer therapy
This study provides a paradigm for the use of pharmacologically active nanozymes to moderate specific cellular signals and elicit desirable pharmacological activities for therapeutic applications.PMID:38432004 | DOI:10.1016/j.biomaterials.2024.122523 (Source: Biomaterials)
Source: Biomaterials - March 3, 2024 Category: Materials Science Authors: Huan Wang Xinchen Liu Xiangyu Yan Yong Du Fang Pu Jinsong Ren Xiaogang Qu Source Type: research
Ultrasound-augmented enzyodynamic-Ca < sup > 2+ < /sup > overload synergetic tumor nanotherapy
This study highlights the role of ultrasound coupled with functional nanozyme in the homeostasis imbalance and function disorder of mitochondria for highly efficient tumor treatment.PMID:38432005 | DOI:10.1016/j.biomaterials.2024.122513 (Source: Biomaterials)
Source: Biomaterials - March 3, 2024 Category: Materials Science Authors: Meiqi Chang Lu Zhang Tingting Zhang Yanqiu Duan Wei Feng Shaoling Yang Yu Chen Zeyu Wang Source Type: research
Cuproptotic nanoinducer-driven proteotoxic stress potentiates cancer immunotherapy by activating the mtDNA-cGAS-STING signaling
This study proposes an anti-tumor immunotherapy through mitochondrial proteotoxicity.PMID:38430646 | DOI:10.1016/j.biomaterials.2024.122512 (Source: Biomaterials)
Source: Biomaterials - March 2, 2024 Category: Materials Science Authors: Xinying Yu Bei Li Jie Yan Wenxi Li Hao Tian Guohao Wang Songtao Zhou Yunlu Dai Source Type: research
Development of pluripotent stem cell-derived epidermal organoids that generate effective extracellular vesicles in skin regeneration
Biomaterials. 2024 Feb 23;307:122522. doi: 10.1016/j.biomaterials.2024.122522. Online ahead of print.ABSTRACTCellular skin substitutes such as epidermal constructs have been developed for various applications, including wound healing and skin regeneration. These cellular models are mostly derived from primary cells such as keratinocytes and fibroblasts in a two-dimensional (2D) state, and further development of three-dimensional (3D) cultured organoids is needed to provide insight into the in vivo epidermal phenotype and physiology. Here, we report the development of epidermal organoids (EpiOs) generated from induced pluri...
Source: Biomaterials - March 1, 2024 Category: Materials Science Authors: Sojung Kwak Cho Lok Song Jinhyuk Lee Sungyeon Kim Seungyoon Nam Young-Jun Park Jungwoon Lee Source Type: research
Mild magnetic hyperthermia-activated immuno-responses for primary bladder cancer therapy
This study uncovers the potential immune-activating mechanism of mild MHT in the treatment of bladder cancer and confirms the effectiveness and safety of this strategy, indicating its promising potential for the clinical management of bladder cancer with a high tendency for relapse.PMID:38428093 | DOI:10.1016/j.biomaterials.2024.122514 (Source: Biomaterials)
Source: Biomaterials - March 1, 2024 Category: Materials Science Authors: Fenggang Qi Qunqun Bao Ping Hu Yuedong Guo Yang Yan Xudong Yao Jianlin Shi Source Type: research
Development of pluripotent stem cell-derived epidermal organoids that generate effective extracellular vesicles in skin regeneration
Biomaterials. 2024 Feb 23;307:122522. doi: 10.1016/j.biomaterials.2024.122522. Online ahead of print.ABSTRACTCellular skin substitutes such as epidermal constructs have been developed for various applications, including wound healing and skin regeneration. These cellular models are mostly derived from primary cells such as keratinocytes and fibroblasts in a two-dimensional (2D) state, and further development of three-dimensional (3D) cultured organoids is needed to provide insight into the in vivo epidermal phenotype and physiology. Here, we report the development of epidermal organoids (EpiOs) generated from induced pluri...
Source: Biomaterials - March 1, 2024 Category: Materials Science Authors: Sojung Kwak Cho Lok Song Jinhyuk Lee Sungyeon Kim Seungyoon Nam Young-Jun Park Jungwoon Lee Source Type: research
Mild magnetic hyperthermia-activated immuno-responses for primary bladder cancer therapy
This study uncovers the potential immune-activating mechanism of mild MHT in the treatment of bladder cancer and confirms the effectiveness and safety of this strategy, indicating its promising potential for the clinical management of bladder cancer with a high tendency for relapse.PMID:38428093 | DOI:10.1016/j.biomaterials.2024.122514 (Source: Biomaterials)
Source: Biomaterials - March 1, 2024 Category: Materials Science Authors: Fenggang Qi Qunqun Bao Ping Hu Yuedong Guo Yang Yan Xudong Yao Jianlin Shi Source Type: research
Multichannel-optical imaging for in vivo evaluating the safety and therapeutic efficacy of stem cells in tumor model in terms of cell tropism, proliferation and NF- κB activity
Biomaterials. 2024 Feb 23;307:122510. doi: 10.1016/j.biomaterials.2024.122510. Online ahead of print.ABSTRACTStem cell-based cancer treatment has garnered significant attention, yet its safety and efficacy remain incompletely understood. The nuclear factor-kappa B (NF-κB) pathway, a critical signaling mechanism involved in tumor growth, angiogenesis, and invasion, serves as an essential metric for evaluating the behavior of stem cells in tumor models. Herein, we report the development of a triple-channel imaging system capable of simultaneously monitoring the tropism of stem cells towards tumors, assessing tumor prolifera...
Source: Biomaterials - February 29, 2024 Category: Materials Science Authors: Dehua Huang Xue Yang Zhao Peng Hongqiang Yin Yongyang Liu Yejun Zhang Chunyan Li Guangcun Chen Qiangbin Wang Source Type: research
Multichannel-optical imaging for in vivo evaluating the safety and therapeutic efficacy of stem cells in tumor model in terms of cell tropism, proliferation and NF- κB activity
Biomaterials. 2024 Feb 23;307:122510. doi: 10.1016/j.biomaterials.2024.122510. Online ahead of print.ABSTRACTStem cell-based cancer treatment has garnered significant attention, yet its safety and efficacy remain incompletely understood. The nuclear factor-kappa B (NF-κB) pathway, a critical signaling mechanism involved in tumor growth, angiogenesis, and invasion, serves as an essential metric for evaluating the behavior of stem cells in tumor models. Herein, we report the development of a triple-channel imaging system capable of simultaneously monitoring the tropism of stem cells towards tumors, assessing tumor prolifera...
Source: Biomaterials - February 29, 2024 Category: Materials Science Authors: Dehua Huang Xue Yang Zhao Peng Hongqiang Yin Yongyang Liu Yejun Zhang Chunyan Li Guangcun Chen Qiangbin Wang Source Type: research
Corrigendum to "Selective binding of C-6OH sulfated hyaluronic acid to the angiogenic isoform of VEGF < sub > 165 < /sub > " [Biomaterials 77(2016) 130-138]
Biomaterials. 2024 Feb 27:122501. doi: 10.1016/j.biomaterials.2024.122501. Online ahead of print.NO ABSTRACTPMID:38418279 | DOI:10.1016/j.biomaterials.2024.122501 (Source: Biomaterials)
Source: Biomaterials - February 28, 2024 Category: Materials Science Authors: Dong-Kwon Lim Ryan G Wylie Robert S Langer Daniel S Kohane Source Type: research
Corrigendum to "Selective binding of C-6OH sulfated hyaluronic acid to the angiogenic isoform of VEGF < sub > 165 < /sub > " [Biomaterials 77(2016) 130-138]
Biomaterials. 2024 Feb 27:122501. doi: 10.1016/j.biomaterials.2024.122501. Online ahead of print.NO ABSTRACTPMID:38418279 | DOI:10.1016/j.biomaterials.2024.122501 (Source: Biomaterials)
Source: Biomaterials - February 28, 2024 Category: Materials Science Authors: Dong-Kwon Lim Ryan G Wylie Robert S Langer Daniel S Kohane Source Type: research
Honeycomb-inspired ZIF-sealed interface enhances osseointegration via anti-infection and osteoimmunomodulation
Biomaterials. 2024 Feb 21;307:122515. doi: 10.1016/j.biomaterials.2024.122515. Online ahead of print.ABSTRACTImplant-associated infections (IAIs) pose a significant threat to orthopedic surgeries. Bacteria colonizing the surface of implants disrupt bone formation-related cells and interfere with the osteoimmune system, resulting in an impaired immune microenvironment and osteogenesis disorders. Inspired by nature, a zeolitic imidazolate framework (ZIF)-sealed smart drug delivery system on Ti substrates (ZSTG) was developed for the "natural-artificial dual-enzyme intervention (NADEI)" strategy to address these challenges. T...
Source: Biomaterials - February 24, 2024 Category: Materials Science Authors: Jiale Dong Wei Zhou Xianli Hu Jiaxiang Bai Siming Zhang Xianzuo Zhang Lei Yu Peng Yang Lingtong Kong Mingkai Liu Xifu Shang Zheng Su Dechun Geng Chen Zhu Source Type: research
Smart composite scaffold to synchronize magnetic hyperthermia and chemotherapy for efficient breast cancer therapy
Biomaterials. 2024 Feb 20;307:122511. doi: 10.1016/j.biomaterials.2024.122511. Online ahead of print.ABSTRACTCombination of different therapies is an attractive approach for cancer therapy. However, it is a challenge to synchronize different therapies for maximization of therapeutic effects. In this work, a smart composite scaffold that could synchronize magnetic hyperthermia and chemotherapy was prepared by hybridization of magnetic Fe3O4 nanoparticles and doxorubicin (Dox)-loaded thermosensitive liposomes with biodegradable polymers. Irradiation of alternating magnetic field (AMF) could not only increase the scaffold tem...
Source: Biomaterials - February 24, 2024 Category: Materials Science Authors: Rui Sun Huajian Chen Man Wang Toru Yoshitomi Masaki Takeguchi Naoki Kawazoe Yingnan Yang Guoping Chen Source Type: research
Honeycomb-inspired ZIF-sealed interface enhances osseointegration via anti-infection and osteoimmunomodulation
Biomaterials. 2024 Feb 21;307:122515. doi: 10.1016/j.biomaterials.2024.122515. Online ahead of print.ABSTRACTImplant-associated infections (IAIs) pose a significant threat to orthopedic surgeries. Bacteria colonizing the surface of implants disrupt bone formation-related cells and interfere with the osteoimmune system, resulting in an impaired immune microenvironment and osteogenesis disorders. Inspired by nature, a zeolitic imidazolate framework (ZIF)-sealed smart drug delivery system on Ti substrates (ZSTG) was developed for the "natural-artificial dual-enzyme intervention (NADEI)" strategy to address these challenges. T...
Source: Biomaterials - February 24, 2024 Category: Materials Science Authors: Jiale Dong Wei Zhou Xianli Hu Jiaxiang Bai Siming Zhang Xianzuo Zhang Lei Yu Peng Yang Lingtong Kong Mingkai Liu Xifu Shang Zheng Su Dechun Geng Chen Zhu Source Type: research
