Biomaterial-mediated intracellular control of macrophages for cell therapy in pro-inflammatory and pro-fibrotic conditions
We present a tunable biomaterial-based strategy to control macrophages intracellularly via small molecule-releasing microparticles. Poly(lactic-co-glycolic acid) microparticles encapsulating the anti-inflammatory and anti-fibrotic drug dexamethasone were administered to macrophages in vitro, with uptake rates controlled by different loading regimes. Microparticle dose and dexamethasone content directly affected macrophage phenotype and phagocytic capacity, independent of particle content per cell, leading to an overall pro-reparative, anti-inflammatory, anti-fibrotic phenotype with increased phagocytic and ECM degrading fu...
Source: Biomaterials - March 28, 2024 Category: Materials Science Authors: Tina Tylek Joanna Wong Andrew E Vaughan Kara L Spiller Source Type: research
Overcoming antibiotic resistance caused by genetic mutations of Helicobacter pylori with mucin adhesive polymer-based therapeutics
Biomaterials. 2024 Mar 25;308:122541. doi: 10.1016/j.biomaterials.2024.122541. Online ahead of print.ABSTRACTHerein, we describe the 3'-sialyllactose-polyethyleneimine-chlorine e6 conjugate (3PC), meticulously engineered to effectively target Helicobacter bacteria (H. pylori) within the gastric environment. The composition of 3PC comprises polyethyleneimine, a cationic polymer, 3'-sialyllactose, which exhibits a specific binding affinity for H. pylori surface proteins, and a photosensitizer capable of generating oxygen radicals in response to specific wavelengths. The distinctive feature of 3PC lies in its capacity to enha...
Source: Biomaterials - March 28, 2024 Category: Materials Science Authors: Byoungjun Lim Kyoung Sub Kim Ji Yong Ahn Kun Na Source Type: research
FAK, vinculin, and talin control mechanosensitive YAP nuclear localization
Biomaterials. 2024 Mar 20;308:122542. doi: 10.1016/j.biomaterials.2024.122542. Online ahead of print.ABSTRACTFocal adhesions (FAs) are nanoscale complexes containing clustered integrin receptors and intracellular structural and signaling proteins that function as principal sites of mechanotransduction in part via promoting the nuclear translocation and activation of the transcriptional coactivator yes-associated protein (YAP). Knockdown of FA proteins such as focal adhesion kinase (FAK), talin, and vinculin can prevent YAP nuclear localization. However, the mechanism(s) of action remain poorly understood. Herein, we invest...
Source: Biomaterials - March 28, 2024 Category: Materials Science Authors: Elijah N Holland Marc A Fern ández-Yagüe Dennis W Zhou Eric B O'Neill Ayanna U Woodfolk Ana Mora-Boza Jianping Fu David D Schlaepfer Andr és J García Source Type: research
Planar amorphous silicon carbide microelectrode arrays for chronic recording in rat motor cortex
Biomaterials. 2024 Mar 21;308:122543. doi: 10.1016/j.biomaterials.2024.122543. Online ahead of print.ABSTRACTChronic implantation of intracortical microelectrode arrays (MEAs) capable of recording from individual neurons can be used for the development of brain-machine interfaces. However, these devices show reduced recording capabilities under chronic conditions due, at least in part, to the brain's foreign body response (FBR). This creates a need for MEAs that can minimize the FBR to possibly enable long-term recording. A potential approach to reduce the FBR is the use of MEAs with reduced cross-sectional geometries. Her...
Source: Biomaterials - March 28, 2024 Category: Materials Science Authors: Justin R Abbott Eleanor N Jeakle Pegah Haghighi Joshua O Usoro Brandon S Sturgill Yupeng Wu Negar Geramifard Rahul Radhakrishna Sourav Patnaik Shido Nakajima Jordan Hess Yusef Mehmood Veda Devata Gayathri Vijayakumar Armaan Sood Teresa Thuc Doan Thai Koma Source Type: research
An all-in-one therapeutic platform for the treatment of resistant Helicobacter pylori infection
Biomaterials. 2024 Mar 21;308:122540. doi: 10.1016/j.biomaterials.2024.122540. Online ahead of print.ABSTRACTHelicobacter pylori (H. pylori) infection is a major cause of gastric diseases. Currently, bismuth-based quadruple therapy is widely adopted for eradicating H. pylori infection. However, this first-line strategy faces several challenges such as drug resistance, intestinal dysbacteriosis, and patients' poor compliance. To overcome these problems, an all-in-one therapeutic platform (CLA-Bi-ZnO2@Lipo) that composed of liposomes loading clarithromycin (CLA), Bi, and ZnO2 hybrid nanoparticles was developed for eradicatin...
Source: Biomaterials - March 27, 2024 Category: Materials Science Authors: Chao Sun Jia Huang Xiaoqian Guo Chenli Zhang Li Wei Ka Ioi Wong Ziyun Yang Gang Zhao Min Lu Weiyan Yao Source Type: research
Multi-step strategies for synergistic treatment of urinary tract infections based on D-xylose-decorated antimicrobial peptide carbon dots
Biomaterials. 2024 Mar 22;308:122547. doi: 10.1016/j.biomaterials.2024.122547. Online ahead of print.ABSTRACTUrinary tract infections (UTIs) caused by Uropathogenic Escherichia coli (UPEC), often reoccur due to the formation of intracellular bacterial colonies (IBCs) and antibiotic resistance. Given the significance of YadC for UPEC infection in our previous study, we developed D-xylose-decorated ɛ-poly-L-lysine (εPL)-based carbon dots (D-xyl@εPLCDs) that can be traced, and employed multi-step approaches to elucidate the functional roles of D-xyl@εPLCDs in UPEC infection. Compared to undecorated particles, D-xyl@εPLCD...
Source: Biomaterials - March 27, 2024 Category: Materials Science Authors: Chunhui Miao Yajie Zhang Guowen Liu Jianming Yang Kaiyuan Yu Junqiang Lv Ran Liu Zhi Yao Yuanjie Niu Xiaojuan Wang Quan Wang Source Type: research
An all-in-one therapeutic platform for the treatment of resistant Helicobacter pylori infection
Biomaterials. 2024 Mar 21;308:122540. doi: 10.1016/j.biomaterials.2024.122540. Online ahead of print.ABSTRACTHelicobacter pylori (H. pylori) infection is a major cause of gastric diseases. Currently, bismuth-based quadruple therapy is widely adopted for eradicating H. pylori infection. However, this first-line strategy faces several challenges such as drug resistance, intestinal dysbacteriosis, and patients' poor compliance. To overcome these problems, an all-in-one therapeutic platform (CLA-Bi-ZnO2@Lipo) that composed of liposomes loading clarithromycin (CLA), Bi, and ZnO2 hybrid nanoparticles was developed for eradicatin...
Source: Biomaterials - March 27, 2024 Category: Materials Science Authors: Chao Sun Jia Huang Xiaoqian Guo Chenli Zhang Li Wei Ka Ioi Wong Ziyun Yang Gang Zhao Min Lu Weiyan Yao Source Type: research
Multi-step strategies for synergistic treatment of urinary tract infections based on D-xylose-decorated antimicrobial peptide carbon dots
Biomaterials. 2024 Mar 22;308:122547. doi: 10.1016/j.biomaterials.2024.122547. Online ahead of print.ABSTRACTUrinary tract infections (UTIs) caused by Uropathogenic Escherichia coli (UPEC), often reoccur due to the formation of intracellular bacterial colonies (IBCs) and antibiotic resistance. Given the significance of YadC for UPEC infection in our previous study, we developed D-xylose-decorated ɛ-poly-L-lysine (εPL)-based carbon dots (D-xyl@εPLCDs) that can be traced, and employed multi-step approaches to elucidate the functional roles of D-xyl@εPLCDs in UPEC infection. Compared to undecorated particles, D-xyl@εPLCD...
Source: Biomaterials - March 27, 2024 Category: Materials Science Authors: Chunhui Miao Yajie Zhang Guowen Liu Jianming Yang Kaiyuan Yu Junqiang Lv Ran Liu Zhi Yao Yuanjie Niu Xiaojuan Wang Quan Wang Source Type: research
Mammary tissue-derived extracellular matrix hydrogels reveal the role of irradiation in driving a pro-tumor and immunosuppressive microenvironment
In this study, we evaluated the structure, molecular composition, and mechanical properties of irradiated murine mammary fat pads (MFPs) and developed ECM hydrogels from decellularized tissues (dECM) to assess the effects of RT-induced ECM changes on breast cancer cell behavior. Irradiated MFPs were characterized by increased ECM deposition and fiber density compared to unirradiated controls, which may provide a platform for cell invasion and proliferation. ECM component changes in collagens I, IV, and VI, and fibronectin were observed following irradiation in both MFPs and dECM hydrogels. Encapsulated TNBC cell proliferat...
Source: Biomaterials - March 26, 2024 Category: Materials Science Authors: Tian Zhu Steven M Alves Arianna Adamo Xiaona Wen Kevin C Corn Anastasia Shostak Shereena Johnson Nicholas D Shaub Shannon E Martello Benjamin C Hacker Antonio D'Amore Rizia Bardhan Marjan Rafat Source Type: research
Mammary tissue-derived extracellular matrix hydrogels reveal the role of irradiation in driving a pro-tumor and immunosuppressive microenvironment
In this study, we evaluated the structure, molecular composition, and mechanical properties of irradiated murine mammary fat pads (MFPs) and developed ECM hydrogels from decellularized tissues (dECM) to assess the effects of RT-induced ECM changes on breast cancer cell behavior. Irradiated MFPs were characterized by increased ECM deposition and fiber density compared to unirradiated controls, which may provide a platform for cell invasion and proliferation. ECM component changes in collagens I, IV, and VI, and fibronectin were observed following irradiation in both MFPs and dECM hydrogels. Encapsulated TNBC cell proliferat...
Source: Biomaterials - March 26, 2024 Category: Materials Science Authors: Tian Zhu Steven M Alves Arianna Adamo Xiaona Wen Kevin C Corn Anastasia Shostak Shereena Johnson Nicholas D Shaub Shannon E Martello Benjamin C Hacker Antonio D'Amore Rizia Bardhan Marjan Rafat Source Type: research
Progress in the development of piezoelectric biomaterials for tissue remodeling
Biomaterials. 2024 Mar 11;307:122528. doi: 10.1016/j.biomaterials.2024.122528. Online ahead of print.ABSTRACTPiezoelectric biomaterials have demonstrated significant potential in the past few decades to heal damaged tissue and restore cellular functionalities. Herein, we discuss the role of bioelectricity in tissue remodeling and explore ways to mimic such tissue-like properties in synthetic biomaterials. In the past decade, biomedical engineers have adopted emerging functional biomaterials-based tissue engineering approaches using innovative bioelectronic stimulation protocols based on dynamic stimuli to direct cellular a...
Source: Biomaterials - March 24, 2024 Category: Materials Science Authors: Amit Nain Srishti Chakraborty Snigdha Roy Barman Pratik Gavit Sushma Indrakumar Akhilesh Agrawal Zong-Hong Lin Kaushik Chatterjee Source Type: research
Membrane-anchoring selenophene viologens for antibacterial photodynamic therapy against periodontitis via restoring subgingival flora and alleviating inflammation
Biomaterials. 2024 Mar 21;307:122536. doi: 10.1016/j.biomaterials.2024.122536. Online ahead of print.ABSTRACTAntibacterial photodynamic therapy (aPDT) has emerged as a promising strategy for treating periodontitis. However, the weak binding of most photosensitizers to bacteria and the hypoxic environment of periodontal pockets severely hamper the therapeutic efficacy. Herein, two novel oxygen-independent photosensitizers are developed by introducing selenophene into viologens and modifying with hexane chains (HASeV) or quaternary ammonium chains (QASeV), which improve the adsorption to bacteria through anchoring to the neg...
Source: Biomaterials - March 24, 2024 Category: Materials Science Authors: Rui Ding Xu Liu Xiaodan Zhao Qi Sun Yilong Cheng Ang Li Dandan Pei Gang He Source Type: research
Progress in the development of piezoelectric biomaterials for tissue remodeling
Biomaterials. 2024 Mar 11;307:122528. doi: 10.1016/j.biomaterials.2024.122528. Online ahead of print.ABSTRACTPiezoelectric biomaterials have demonstrated significant potential in the past few decades to heal damaged tissue and restore cellular functionalities. Herein, we discuss the role of bioelectricity in tissue remodeling and explore ways to mimic such tissue-like properties in synthetic biomaterials. In the past decade, biomedical engineers have adopted emerging functional biomaterials-based tissue engineering approaches using innovative bioelectronic stimulation protocols based on dynamic stimuli to direct cellular a...
Source: Biomaterials - March 24, 2024 Category: Materials Science Authors: Amit Nain Srishti Chakraborty Snigdha Roy Barman Pratik Gavit Sushma Indrakumar Akhilesh Agrawal Zong-Hong Lin Kaushik Chatterjee Source Type: research
Membrane-anchoring selenophene viologens for antibacterial photodynamic therapy against periodontitis via restoring subgingival flora and alleviating inflammation
Biomaterials. 2024 Mar 21;307:122536. doi: 10.1016/j.biomaterials.2024.122536. Online ahead of print.ABSTRACTAntibacterial photodynamic therapy (aPDT) has emerged as a promising strategy for treating periodontitis. However, the weak binding of most photosensitizers to bacteria and the hypoxic environment of periodontal pockets severely hamper the therapeutic efficacy. Herein, two novel oxygen-independent photosensitizers are developed by introducing selenophene into viologens and modifying with hexane chains (HASeV) or quaternary ammonium chains (QASeV), which improve the adsorption to bacteria through anchoring to the neg...
Source: Biomaterials - March 24, 2024 Category: Materials Science Authors: Rui Ding Xu Liu Xiaodan Zhao Qi Sun Yilong Cheng Ang Li Dandan Pei Gang He Source Type: research
ROS-responsive drug-releasing injectable microgels for ameliorating myocardial infarction
Biomaterials. 2024 Mar 16;307:122534. doi: 10.1016/j.biomaterials.2024.122534. Online ahead of print.ABSTRACTDespite of the recent advances in regulatory T cell (Treg) therapy, a limited number of available cells and specificity at the desired tissue site have severely compromised their efficacy. Herein, an injectable drug-releasing (MTK-TK-drug) microgel system in response to in situ stimulation by reactive oxygen species (ROS) was constructed with a coaxial capillary microfluidic system and UV curing. The spherical microgels with a size of 150 μm were obtained. The MTK-TK-drug microgels efficiently converted the pro-inf...
Source: Biomaterials - March 22, 2024 Category: Materials Science Authors: Shuqin Wang Yuejun Yao Liang Song Zihe Zhai Shifen Li Zhaolong Wang Liyin Shen Yang Zhu Wenxing Liu Changyou Gao Source Type: research
