Systemic peptide amphiphile nanofiber delivery following subcutaneous injection
Biomaterials. 2023 Nov 18;303:122401. doi: 10.1016/j.biomaterials.2023.122401. Online ahead of print.ABSTRACTPeptide amphiphile (PA) nanofibers have been shown to target and deliver drugs when administered via an intravenous (IV) injection. Subcutaneous administration can broaden the applicability of PA nanofibers in the medical field. The ability of PA nanofibers to be absorbed into systemic circulation after subcutaneous administration was investigated. Four PA molecules with different amino acid sequences were designed to understand the effect of nanofiber cohesion and charge on uptake. Solution small-angle X-ray scatte...
Source: Biomaterials - November 25, 2023 Category: Materials Science Authors: Mark H Barlek David C Gillis Simon A Egner Sophia L Maragos Mark R Karver Samuel I Stupp Nick D Tsihlis Melina R Kibbe Source Type: research
Elastic fibers define embryonic tissue stiffness to enable buckling morphogenesis of the small intestine
Biomaterials. 2023 Nov 17;303:122405. doi: 10.1016/j.biomaterials.2023.122405. Online ahead of print.ABSTRACTDuring embryonic development, tissues must possess precise material properties to ensure that cell-generated forces give rise to the stereotyped morphologies of developing organs. However, the question of how material properties are established and regulated during development remains understudied. Here, we aim to address these broader questions through the study of intestinal looping, a process by which the initially straight intestinal tube buckles into loops, permitting ordered packing within the body cavity. Loo...
Source: Biomaterials - November 24, 2023 Category: Materials Science Authors: Elise A Loffet John F Durel Jenny Gao Richard Kam Hyunjee Lim Nandan L Nerurkar Source Type: research
Elastic fibers define embryonic tissue stiffness to enable buckling morphogenesis of the small intestine
Biomaterials. 2023 Nov 17;303:122405. doi: 10.1016/j.biomaterials.2023.122405. Online ahead of print.ABSTRACTDuring embryonic development, tissues must possess precise material properties to ensure that cell-generated forces give rise to the stereotyped morphologies of developing organs. However, the question of how material properties are established and regulated during development remains understudied. Here, we aim to address these broader questions through the study of intestinal looping, a process by which the initially straight intestinal tube buckles into loops, permitting ordered packing within the body cavity. Loo...
Source: Biomaterials - November 24, 2023 Category: Materials Science Authors: Elise A Loffet John F Durel Jenny Gao Richard Kam Hyunjee Lim Nandan L Nerurkar Source Type: research
Optimized strategies of ROS-based nanodynamic therapies for tumor theranostics
Biomaterials. 2023 Nov 15;303:122391. doi: 10.1016/j.biomaterials.2023.122391. Online ahead of print.ABSTRACTReactive oxygen species (ROS) play a crucial role in regulating the metabolism of tumor growth, metastasis, death and other biological processes. ROS-based nanodynamic therapies (NDTs) are becoming attractive due to non-invasive, low side effects and tumor-specific advantages. NDTs have rapidly developed into numerous branches, such as photodynamic therapy, chemodynamic therapy, sonodynamic therapy and so on. However, the complexity of the tumor microenvironment and the limitations of existing sensitizers have great...
Source: Biomaterials - November 23, 2023 Category: Materials Science Authors: Yifan Di Ruizhu Deng Zhu Liu Yuling Mao Yikun Gao Qinfu Zhao Siling Wang Source Type: research
Optimized strategies of ROS-based nanodynamic therapies for tumor theranostics
Biomaterials. 2023 Nov 15;303:122391. doi: 10.1016/j.biomaterials.2023.122391. Online ahead of print.ABSTRACTReactive oxygen species (ROS) play a crucial role in regulating the metabolism of tumor growth, metastasis, death and other biological processes. ROS-based nanodynamic therapies (NDTs) are becoming attractive due to non-invasive, low side effects and tumor-specific advantages. NDTs have rapidly developed into numerous branches, such as photodynamic therapy, chemodynamic therapy, sonodynamic therapy and so on. However, the complexity of the tumor microenvironment and the limitations of existing sensitizers have great...
Source: Biomaterials - November 23, 2023 Category: Materials Science Authors: Yifan Di Ruizhu Deng Zhu Liu Yuling Mao Yikun Gao Qinfu Zhao Siling Wang Source Type: research
