Camptothesome-based combination nanotherapeutic regimen for improved colorectal cancer immunochemotherapy
Biomaterials. 2024 Jan 18;306:122477. doi: 10.1016/j.biomaterials.2024.122477. Online ahead of print.ABSTRACTCamptothesome is a sphingomyelin-conjugated camptothecin (SM-CSS-CPT) nanovesicle that fortified the therapeutic delivery of CPT in diverse cancer types. To mitigate the Camptothesome-induced IDO1 negative feedback mechanism, we had co-encapsulated, indoximod (IND, IDO1 inhibitor) into Camptothesome using doxorubicin-derived IND (DOX-IND). To maximize the therapeutic potential of DOX-IND/Camptothesome, herein, we first dissected the synergistic drug ratio (DOX-IND/SM-CSS-CPT) via systematical in vitro screening. DOX...
Source: Biomaterials - February 3, 2024 Category: Materials Science Authors: Zhiren Wang Wenpan Li Yanhao Jiang Tuyen Ba Tran Jinha Chung Minhyeok Kim Aaron James Scott Jianqin Lu Source Type: research

An injectable hydrogel microsphere-integrated training court to inspire tumor-infiltrating T lymphocyte potential
Biomaterials. 2024 Jan 25;306:122475. doi: 10.1016/j.biomaterials.2024.122475. Online ahead of print.ABSTRACTAlthough tumor-infiltrating T lymphocytes (TIL-Ts) play a crucial role in solid tumor immunotherapy, their clinical application has been limited because of the immunosuppressive microenvironment. Herein, we developed an injectable hydrogel microsphere-integrated training court (MS-ITC) to inspire the function of TIL-Ts and amplify TIL-Ts, through grafting with anti-CD3 and anti-CD28 antibodies and bovine serum albumin nanoparticles encapsulated with IL-7 and IL-15. MS-ITC provided the T-cell receptor and co-stimulat...
Source: Biomaterials - February 2, 2024 Category: Materials Science Authors: Jiachen He Junjie Niu Lin Wang Wen Zhang Xu He Xiongjinfu Zhang Wei Hu Yunkai Tang Huilin Yang Jie Sun Wenguo Cui Qin Shi Source Type: research

On-chip recapitulation of the tumor microenvironment: A decade of progress
Biomaterials. 2024 Jan 22;306:122482. doi: 10.1016/j.biomaterials.2024.122482. Online ahead of print.ABSTRACTOne of the hurdles to the development of new anticancer therapies is the lack of in vitro models which faithfully reproduce the in vivo tumor microenvironment (TME). Understanding the dynamic relationships between the components of the TME in a controllable, scalable, and reliable setting would indeed support the discovery of biological targets impacting cancer diagnosis and therapy. Cancer research is increasingly shifting from traditional two-dimensional (2D) cell culture toward three-dimensional (3D) culture mode...
Source: Biomaterials - February 1, 2024 Category: Materials Science Authors: S M Giannitelli V Peluzzi S Raniolo G Roscilli M Trombetta P Mozetic A Rainer Source Type: research

Gint4.T-siHDGF chimera-capped mesoporous silica nanoparticles encapsulating temozolomide for synergistic glioblastoma therapy
Biomaterials. 2024 Jan 20;306:122479. doi: 10.1016/j.biomaterials.2024.122479. Online ahead of print.ABSTRACTDue to glioblastoma (GBM) being the most intractable brain tumor, the continuous improvement of effective treatment methods is indispensable. The combination of siRNA-based gene therapy and chemotherapy for GBM treatment has now manifested great promise. Herein, Gint4.T-siHDGF chimera-capped mesoporous silica nanoparticles (MSN) encapsulating chemotherapy drug temozolomide (TMZ), termed as TMSN@siHDGF-Gint4.T, is developed to co-deliver gene-drug siHDGF and TMZ for synergistic GBM therapy. TMSN@siHDGF-Gint4.T posses...
Source: Biomaterials - January 31, 2024 Category: Materials Science Authors: Huaijun Fei Yang Jin Nan Jiang Yuhan Zhou Ningcheng Wei Yifan Liu Jiayi Miao Liying Zhang Rui Li Aixia Zhang Shuhu Du Source Type: research

Nanomedicines for reversing immunosuppressive microenvironment of hepatocellular carcinoma
Biomaterials. 2024 Jan 22;306:122481. doi: 10.1016/j.biomaterials.2024.122481. Online ahead of print.ABSTRACTAlthough immunotherapeutic strategies such as immune checkpoint inhibitors (ICIs) have gained promising advances, their limited efficacy and significant toxicity remain great challenges for hepatocellular carcinoma (HCC) immunotherapy. The tumor immunosuppressive microenvironment (TIME) with insufficient T-cell infiltration and low immunogenicity accounts for most HCC patients' poor response to ICIs. Worse still, the current immunotherapeutics without precise delivery may elicit enormous autoimmune side effects and ...
Source: Biomaterials - January 29, 2024 Category: Materials Science Authors: Xier Pan Shuting Ni Kaili Hu Source Type: research

Circulating immunotherapy strategy based on pyroptosis and STING pathway: Mn-loaded paclitaxel prodrug nanoplatform against tumor progression and metastasis
Biomaterials. 2024 Jan 23;306:122472. doi: 10.1016/j.biomaterials.2024.122472. Online ahead of print.ABSTRACTImmunotherapy has emerged as a promising strategy against tumors. However, its efficacy is limited by low immunogenicity, poor antigen presentation, and inadequate lymphocyte infiltration. Herein, we develop a nanoplatform (Mn-HSP) loaded with manganese ions (Mn2+) and paclitaxel (PTX) prodrug based on hyaluronic acid. PTX in Mn-HSP induces DNA damage and pyroptosis to release tumor-associated antigens (TAAs), enhancing tumor-specific adaptive immunity. Meanwhile, Mn2+ in Mn-HSP, together with PTX-induced DNA damage...
Source: Biomaterials - January 27, 2024 Category: Materials Science Authors: Bingjie Wang Teng Wang Tianze Jiang Shuang Li Lianxiao Zhang Xia Zhao Xiaojia Yang Xueyang Wang Source Type: research

Hypoxia-activated cascade nanovaccine for synergistic chemoembolization-immune therapy of hepatocellular carcinoma
Biomaterials. 2024 Jan 21;306:122480. doi: 10.1016/j.biomaterials.2024.122480. Online ahead of print.ABSTRACTIn this work, a promising treatment strategy for triggering robust antitumor immune responses in transarterial chemoembolization of hepatocellular carcinoma (HCC) is presented. The zeolitic imidazolate framework nanoparticles loaded with hypoxia-activated prodrug tirapazamine and immune adjuvant resiquimod facilitated in situ generation of nanovaccine via a facile approach. The nanovaccine can strengthen the ability of killing the liver cancer cells under hypoxic environment, while was capable of improving immunogen...
Source: Biomaterials - January 25, 2024 Category: Materials Science Authors: Qin Shi Wen Zhang Yongjie Zhou Songjiang Huang Jiaze Yu Minjie Yang Zihan Zhang Jingqin Ma Jianjun Luo Shengxiang Rao Daru Lu Shaojun Peng Yongbin Cao Lingxiao Liu Zhiping Yan Source Type: research

Arginine-assembly as NO nano-donor prevents the negative feedback of macrophage repolarization by mitochondrial dysfunction for cancer immunotherapy
Biomaterials. 2024 Jan 17;306:122474. doi: 10.1016/j.biomaterials.2024.122474. Online ahead of print.ABSTRACTRepolarizing the tumor-associated macrophages (TAMs) towards the antitumoral M1-like phenotype has been a promising approach for cancer immunotherapy. However, the anti-cancer immune response is severely limited mainly by the repolarized M1-like macrophages belatedly returning to the M2-like phenotype (i.e., negative feedback). Inspired by nitric oxide (NO) effectively preventing repolarization of inflammatory macrophages in inflammatory diseases, herein, we develop an arginine assembly, as NO nano-donor for NO gene...
Source: Biomaterials - January 25, 2024 Category: Materials Science Authors: Xiao Zheng Ying Liu Yiqiong Liu Jie Zang Kun Wang Zichen Yang Nana Chen Jiuyuan Sun Li Huang Yan Li Liangyi Xue Hui Zhi Xiaoyou Zhang Min Yu Shiyu Chen Haiqing Dong Yongyong Li Source Type: research

Platelet-derived drug delivery systems: Pioneering treatment for cancer, cardiovascular diseases, infectious diseases, and beyond
This study aimed to provide a comprehensive overview of the potential value of these materials in clinical treatment, serving as a valuable reference for the advancement of novel platelet-derived DDSs and their broader utilization in the field of disease treatment.PMID:38266348 | DOI:10.1016/j.biomaterials.2024.122478 (Source: Biomaterials)
Source: Biomaterials - January 24, 2024 Category: Materials Science Authors: Yalan Zhu Lingling Xu Yong Kang Qinzhen Cheng Yiling He Xiaoyuan Ji Source Type: research

Immunosuppressive enzyme-responsive nanoparticles for enhanced accumulation in liver allograft to overcome acute rejection
Biomaterials. 2024 Jan 19;306:122476. doi: 10.1016/j.biomaterials.2024.122476. Online ahead of print.ABSTRACTAcute rejection is a life-threatening complication after liver transplantation. Immunosuppressants such as tacrolimus are used to inhibit acute rejection of liver grafts in clinic. However, inefficient intragraft accumulation may reduce the therapeutic outcomes of tacrolimus. Here, an enzyme-responsive nanoparticle is developed to selectively enhance the accumulation of tacrolimus in liver allograft through enzyme-induced aggregation to refine immunotherapeutic efficacy of tacrolimus. The nanoparticles are composed ...
Source: Biomaterials - January 24, 2024 Category: Materials Science Authors: Feixiang Luo Mingqian Li Yuguo Chen Shifei Song Haiyang Yu Peng Zhang Chunsheng Xiao Guoyue Lv Xuesi Chen Source Type: research

Bioengineered hydrogels enhance ex vivo preservation of patient-derived tumor explants for drug evaluation
Biomaterials. 2024 Mar;305:122460. doi: 10.1016/j.biomaterials.2023.122460. Epub 2024 Jan 2.ABSTRACTEx vivo patient-derived tumor slices (PDTS) are currently limited by short-term viability in culture. Here, we show how bioengineered hydrogels enable the identification of key matrix parameters that significantly enhance PDTS viability compared to conventional culture systems. As demonstrated using single-cell RNA sequencing and high-dimensional flow cytometry, hydrogel-embedded PDTS tightly preserved cancer, cancer-associated fibroblast, and various immune cell populations and subpopulations in the corresponding original t...
Source: Biomaterials - January 21, 2024 Category: Materials Science Authors: Christabella Adine Kanishka Fernando Nicholas Ching Wei Ho Hong Sheng Quah Samantha Shu Wen Ho Kenny Zhuoran Wu Karen Wei Weng Teng Camille Arcinas Ling Li Kelly Ha Joey Wei Ling Chew Chenhui Wang Nathaniel Sheng Hua Too Joe Poh Sheng Yeong Daniel Shao We Source Type: research

Nanotherapeutics for prostate cancer treatment: A comprehensive review
Biomaterials. 2024 Mar;305:122469. doi: 10.1016/j.biomaterials.2024.122469. Epub 2024 Jan 16.ABSTRACTProstate cancer (PCa) is the most prevalent solid organ malignancy and seriously affects male health. The adverse effects of prostate cancer therapeutics can cause secondary damage to patients. Nanotherapeutics, which have special targeting abilities and controlled therapeutic release profiles, may serve as alternative agents for PCa treatment. At present, many nanotherapeutics have been developed to treat PCa and have shown better treatment effects in animals than traditional therapeutics. Although PCa nanotherapeutics are...
Source: Biomaterials - January 20, 2024 Category: Materials Science Authors: Ruimin Hu Jin Lan Dinglin Zhang Wenhao Shen Source Type: research

Nano-enhanced immunotherapy: Targeting the immunosuppressive tumor microenvironment
Biomaterials. 2024 Mar;305:122463. doi: 10.1016/j.biomaterials.2023.122463. Epub 2024 Jan 6.ABSTRACTThe tumor microenvironment (TME), which is mostly composed of tumor cells, immune cells, signaling molecules, stromal tissue, and the vascular system, is an integrated system that is conducive to the formation of tumors. TME heterogeneity makes the response to immunotherapy different in different tumors, such as "immune-cold" and "immune-hot" tumors. Tumor-associated macrophages, myeloid-derived suppressor cells, and regulatory T cells are the major suppressive immune cells and their different phenotypes interact and influen...
Source: Biomaterials - January 17, 2024 Category: Materials Science Authors: Yuzhi Jin Yangyue Huang Hui Ren Huanhuan Huang Chunyu Lai Wenjun Wang Zhou Tong Hangyu Zhang Wei Wu Chuan Liu Xuanwen Bao Weijia Fang Hongjun Li Peng Zhao Xiaomeng Dai Source Type: research

Gel-mediated recruitment of conventional type 1 dendritic cells potentiates the therapeutic effects of radiotherapy
Biomaterials. 2024 Mar;305:122470. doi: 10.1016/j.biomaterials.2024.122470. Epub 2024 Jan 11.ABSTRACTThe efficacy of radiotherapy has not yet achieved optimal results, partially due to insufficient priming and infiltration of effector immune cells within the tumor microenvironment (TME), which often exhibits suppressive phenotypes. In particular, the infiltration of X-C motif chemokine receptor 1 (XCR1)-expressing conventional type-1 dendritic cells (cDC1s), which are critical in priming CD8+ cytotoxic T cells, within the TME is noticeably restricted. Hence, we present a facile methodology for the efficient fabrication of ...
Source: Biomaterials - January 16, 2024 Category: Materials Science Authors: Yumin Wu Quguang Li Yifan Yan Yu Hao Chunjie Wang Bo Liu Yujie Zhu Zhuang Liu Liangzhu Feng Source Type: research

Near-infrared light-activatable, analgesic nanocomposite delivery system for comprehensive therapy of diabetic wounds in rats
Biomaterials. 2024 Mar;305:122467. doi: 10.1016/j.biomaterials.2024.122467. Epub 2024 Jan 7.ABSTRACTImpaired angiogenesis, bacterial infection, persistent severe pain, exacerbated inflammation, and oxidative stress injury are intractable problems in the treatment of chronic diabetic ulcer wounds. A strategy that effectively targets all these issues has proven challenging. Herein, an in-situ sprayable nanoparticle-gel composite comprising platinum clusters (Pt) loaded-mesoporous polydopamine (MPDA) nanoparticle and QX-314-loaded fibrin gel (Pt@MPDA/QX314@Fibrin) was developed for diabetic wound analgesia and therapy. The co...
Source: Biomaterials - January 15, 2024 Category: Materials Science Authors: Sufang Chen Haixia Wang Jingyi Du Zhendong Ding Tienan Wang Linan Zhang Jing Yang Yu Guan Chaojin Chen Mingqiang Li Ziqing Hei Yu Tao Weifeng Yao Source Type: research