Corrigendum to "Selective binding of C-6OH sulfated hyaluronic acid to the angiogenic isoform of VEGF < sub > 165 < /sub > " [Biomaterials 77(2016) 130-138]
Biomaterials. 2024 Feb 27:122501. doi: 10.1016/j.biomaterials.2024.122501. Online ahead of print.NO ABSTRACTPMID:38418279 | DOI:10.1016/j.biomaterials.2024.122501 (Source: Biomaterials)
Source: Biomaterials - February 28, 2024 Category: Materials Science Authors: Dong-Kwon Lim Ryan G Wylie Robert S Langer Daniel S Kohane Source Type: research
Honeycomb-inspired ZIF-sealed interface enhances osseointegration via anti-infection and osteoimmunomodulation
Biomaterials. 2024 Feb 21;307:122515. doi: 10.1016/j.biomaterials.2024.122515. Online ahead of print.ABSTRACTImplant-associated infections (IAIs) pose a significant threat to orthopedic surgeries. Bacteria colonizing the surface of implants disrupt bone formation-related cells and interfere with the osteoimmune system, resulting in an impaired immune microenvironment and osteogenesis disorders. Inspired by nature, a zeolitic imidazolate framework (ZIF)-sealed smart drug delivery system on Ti substrates (ZSTG) was developed for the "natural-artificial dual-enzyme intervention (NADEI)" strategy to address these challenges. T...
Source: Biomaterials - February 24, 2024 Category: Materials Science Authors: Jiale Dong Wei Zhou Xianli Hu Jiaxiang Bai Siming Zhang Xianzuo Zhang Lei Yu Peng Yang Lingtong Kong Mingkai Liu Xifu Shang Zheng Su Dechun Geng Chen Zhu Source Type: research
Smart composite scaffold to synchronize magnetic hyperthermia and chemotherapy for efficient breast cancer therapy
Biomaterials. 2024 Feb 20;307:122511. doi: 10.1016/j.biomaterials.2024.122511. Online ahead of print.ABSTRACTCombination of different therapies is an attractive approach for cancer therapy. However, it is a challenge to synchronize different therapies for maximization of therapeutic effects. In this work, a smart composite scaffold that could synchronize magnetic hyperthermia and chemotherapy was prepared by hybridization of magnetic Fe3O4 nanoparticles and doxorubicin (Dox)-loaded thermosensitive liposomes with biodegradable polymers. Irradiation of alternating magnetic field (AMF) could not only increase the scaffold tem...
Source: Biomaterials - February 24, 2024 Category: Materials Science Authors: Rui Sun Huajian Chen Man Wang Toru Yoshitomi Masaki Takeguchi Naoki Kawazoe Yingnan Yang Guoping Chen Source Type: research
Honeycomb-inspired ZIF-sealed interface enhances osseointegration via anti-infection and osteoimmunomodulation
Biomaterials. 2024 Feb 21;307:122515. doi: 10.1016/j.biomaterials.2024.122515. Online ahead of print.ABSTRACTImplant-associated infections (IAIs) pose a significant threat to orthopedic surgeries. Bacteria colonizing the surface of implants disrupt bone formation-related cells and interfere with the osteoimmune system, resulting in an impaired immune microenvironment and osteogenesis disorders. Inspired by nature, a zeolitic imidazolate framework (ZIF)-sealed smart drug delivery system on Ti substrates (ZSTG) was developed for the "natural-artificial dual-enzyme intervention (NADEI)" strategy to address these challenges. T...
Source: Biomaterials - February 24, 2024 Category: Materials Science Authors: Jiale Dong Wei Zhou Xianli Hu Jiaxiang Bai Siming Zhang Xianzuo Zhang Lei Yu Peng Yang Lingtong Kong Mingkai Liu Xifu Shang Zheng Su Dechun Geng Chen Zhu Source Type: research
Smart composite scaffold to synchronize magnetic hyperthermia and chemotherapy for efficient breast cancer therapy
Biomaterials. 2024 Feb 20;307:122511. doi: 10.1016/j.biomaterials.2024.122511. Online ahead of print.ABSTRACTCombination of different therapies is an attractive approach for cancer therapy. However, it is a challenge to synchronize different therapies for maximization of therapeutic effects. In this work, a smart composite scaffold that could synchronize magnetic hyperthermia and chemotherapy was prepared by hybridization of magnetic Fe3O4 nanoparticles and doxorubicin (Dox)-loaded thermosensitive liposomes with biodegradable polymers. Irradiation of alternating magnetic field (AMF) could not only increase the scaffold tem...
Source: Biomaterials - February 24, 2024 Category: Materials Science Authors: Rui Sun Huajian Chen Man Wang Toru Yoshitomi Masaki Takeguchi Naoki Kawazoe Yingnan Yang Guoping Chen Source Type: research
Honeycomb-inspired ZIF-sealed interface enhances osseointegration via anti-infection and osteoimmunomodulation
Biomaterials. 2024 Feb 21;307:122515. doi: 10.1016/j.biomaterials.2024.122515. Online ahead of print.ABSTRACTImplant-associated infections (IAIs) pose a significant threat to orthopedic surgeries. Bacteria colonizing the surface of implants disrupt bone formation-related cells and interfere with the osteoimmune system, resulting in an impaired immune microenvironment and osteogenesis disorders. Inspired by nature, a zeolitic imidazolate framework (ZIF)-sealed smart drug delivery system on Ti substrates (ZSTG) was developed for the "natural-artificial dual-enzyme intervention (NADEI)" strategy to address these challenges. T...
Source: Biomaterials - February 24, 2024 Category: Materials Science Authors: Jiale Dong Wei Zhou Xianli Hu Jiaxiang Bai Siming Zhang Xianzuo Zhang Lei Yu Peng Yang Lingtong Kong Mingkai Liu Xifu Shang Zheng Su Dechun Geng Chen Zhu Source Type: research
Smart composite scaffold to synchronize magnetic hyperthermia and chemotherapy for efficient breast cancer therapy
Biomaterials. 2024 Feb 20;307:122511. doi: 10.1016/j.biomaterials.2024.122511. Online ahead of print.ABSTRACTCombination of different therapies is an attractive approach for cancer therapy. However, it is a challenge to synchronize different therapies for maximization of therapeutic effects. In this work, a smart composite scaffold that could synchronize magnetic hyperthermia and chemotherapy was prepared by hybridization of magnetic Fe3O4 nanoparticles and doxorubicin (Dox)-loaded thermosensitive liposomes with biodegradable polymers. Irradiation of alternating magnetic field (AMF) could not only increase the scaffold tem...
Source: Biomaterials - February 24, 2024 Category: Materials Science Authors: Rui Sun Huajian Chen Man Wang Toru Yoshitomi Masaki Takeguchi Naoki Kawazoe Yingnan Yang Guoping Chen Source Type: research
Honeycomb-inspired ZIF-sealed interface enhances osseointegration via anti-infection and osteoimmunomodulation
Biomaterials. 2024 Feb 21;307:122515. doi: 10.1016/j.biomaterials.2024.122515. Online ahead of print.ABSTRACTImplant-associated infections (IAIs) pose a significant threat to orthopedic surgeries. Bacteria colonizing the surface of implants disrupt bone formation-related cells and interfere with the osteoimmune system, resulting in an impaired immune microenvironment and osteogenesis disorders. Inspired by nature, a zeolitic imidazolate framework (ZIF)-sealed smart drug delivery system on Ti substrates (ZSTG) was developed for the "natural-artificial dual-enzyme intervention (NADEI)" strategy to address these challenges. T...
Source: Biomaterials - February 24, 2024 Category: Materials Science Authors: Jiale Dong Wei Zhou Xianli Hu Jiaxiang Bai Siming Zhang Xianzuo Zhang Lei Yu Peng Yang Lingtong Kong Mingkai Liu Xifu Shang Zheng Su Dechun Geng Chen Zhu Source Type: research
Smart composite scaffold to synchronize magnetic hyperthermia and chemotherapy for efficient breast cancer therapy
Biomaterials. 2024 Feb 20;307:122511. doi: 10.1016/j.biomaterials.2024.122511. Online ahead of print.ABSTRACTCombination of different therapies is an attractive approach for cancer therapy. However, it is a challenge to synchronize different therapies for maximization of therapeutic effects. In this work, a smart composite scaffold that could synchronize magnetic hyperthermia and chemotherapy was prepared by hybridization of magnetic Fe3O4 nanoparticles and doxorubicin (Dox)-loaded thermosensitive liposomes with biodegradable polymers. Irradiation of alternating magnetic field (AMF) could not only increase the scaffold tem...
Source: Biomaterials - February 24, 2024 Category: Materials Science Authors: Rui Sun Huajian Chen Man Wang Toru Yoshitomi Masaki Takeguchi Naoki Kawazoe Yingnan Yang Guoping Chen Source Type: research
Multi-functional dual-layer nanofibrous membrane for prevention of postoperative pancreatic leakage
In this study, we fabricated mitomycin-c and thrombin-loaded multifunctional dual-layer nanofibrous membrane with a combination of alginate, PCL, and gelatin to resolve the leakage due to suture line disruption, promote hemostasis, wound healing, and prevent postoperative tissue adhesion. Electrospinning was used to fabricate the dual-layer system. The study results demonstrated that high gelatin and alginate content in the inner layer decreased the fiber diameter and water contact angle, and crosslinking allowed the membrane to be more hydrophilic, making it highly biodegradable, and adhering firmly to the tissue surfaces...
Source: Biomaterials - February 23, 2024 Category: Materials Science Authors: Prayas Chakma Shanto Md Abdullah Al Fahad Hae Il Jung Myeongki Park Hyeyoung Kim Sang Ho Bae Byong-Taek Lee Source Type: research
Bone formation by human paediatric marrow stromal cells in a functional allogeneic immune system
In this study, we employed an immunodeficient animal model humanised with allogeneic immune cells to study the immune responses towards chondrogenically differentiated human pediatric MSCs (ch-pMSCs). We show that ch-differentiated pMSCs remained non-immunogenic to allogeneic CD4 and CD8 T cells in an in vitro co-culture model. After subcutaneous implantation in mice, ch-pMSC-derived grafts were able to initiate bone mineralisation in the presence of an allogeneic immune system for 3 weeks without the onset of immune responses. Re-exposing the splenocytes of the humanised animals to pMSCs did not trigger further T cell pro...
Source: Biomaterials - February 20, 2024 Category: Materials Science Authors: Virginia Palomares Cabeza Niamh Fahy Caoimhe H Kiernan Andrea Lolli Janneke Witte-Bouma Shorouk Fahmy Garcia Ana Merino Nicole Kops Yanto Ridwan Eppo B Wolvius Pieter A J Brama Martin J Hoogduijn Eric Farrell Source Type: research
Injectable pathological microenvironment-responsive anti-inflammatory hydrogels for ameliorating intervertebral disc degeneration
Biomaterials. 2024 Feb 13;306:122509. doi: 10.1016/j.biomaterials.2024.122509. Online ahead of print.ABSTRACTChronic local inflammation and resulting cellular dysfunction of nucleus pulposus (NP) cells are important pathogenic factors of intervertebral disc degeneration (IDD). Injectable pathological microenvironment-responsive hydrogels hold significant potential for treating IDD by adapting to dynamic microenvironment of IDD. Herein, we proposed an injectable gelatin-based hydrogel drug delivery system that could respond to the pathological microenvironment of IDD for controlled release of anti-inflammatory drug to promo...
Source: Biomaterials - February 20, 2024 Category: Materials Science Authors: Lei Liu Wantao Wang Lin Huang Yiwen Xian Wenzheng Ma Jinghao Fan Yixi Li Hongmei Liu Zhaomin Zheng Decheng Wu Source Type: research
Patient-derived tumor spheroid-induced angiogenesis preclinical platform for exploring therapeutic vulnerabilities in cancer
This study addresses the demand for research models that can support patient-treatment decisions and clarify the complexities of a tumor microenvironment by developing an advanced non-animal preclinical cancer model. Based on patient-derived tumor spheroids (PDTS), the proposed model reconstructs the tumor microenvironment with emphasis on tumor spheroid-driven angiogenesis. The resulting microfluidic chip system mirrors angiogenic responses elicited by PDTS, recapitulating patient-specific tumor conditions and providing robust, easily quantifiable outcomes. Vascularized PDTS exhibited marked angiogenesis and tumor prolife...
Source: Biomaterials - February 20, 2024 Category: Materials Science Authors: Jihoon Ko Sujin Hyung You Jeong Heo Sangmin Jung Seung Tae Kim Se Hoon Park Jung Yong Hong Sung Hee Lim Kyoung-Mee Kim Sanghee Yoo Noo Li Jeon Jeeyun Lee Source Type: research
Bone formation by human paediatric marrow stromal cells in a functional allogeneic immune system
In this study, we employed an immunodeficient animal model humanised with allogeneic immune cells to study the immune responses towards chondrogenically differentiated human pediatric MSCs (ch-pMSCs). We show that ch-differentiated pMSCs remained non-immunogenic to allogeneic CD4 and CD8 T cells in an in vitro co-culture model. After subcutaneous implantation in mice, ch-pMSC-derived grafts were able to initiate bone mineralisation in the presence of an allogeneic immune system for 3 weeks without the onset of immune responses. Re-exposing the splenocytes of the humanised animals to pMSCs did not trigger further T cell pro...
Source: Biomaterials - February 20, 2024 Category: Materials Science Authors: Virginia Palomares Cabeza Niamh Fahy Caoimhe H Kiernan Andrea Lolli Janneke Witte-Bouma Shorouk Fahmy Garcia Ana Merino Nicole Kops Yanto Ridwan Eppo B Wolvius Pieter A J Brama Martin J Hoogduijn Eric Farrell Source Type: research
Injectable pathological microenvironment-responsive anti-inflammatory hydrogels for ameliorating intervertebral disc degeneration
Biomaterials. 2024 Feb 13;306:122509. doi: 10.1016/j.biomaterials.2024.122509. Online ahead of print.ABSTRACTChronic local inflammation and resulting cellular dysfunction of nucleus pulposus (NP) cells are important pathogenic factors of intervertebral disc degeneration (IDD). Injectable pathological microenvironment-responsive hydrogels hold significant potential for treating IDD by adapting to dynamic microenvironment of IDD. Herein, we proposed an injectable gelatin-based hydrogel drug delivery system that could respond to the pathological microenvironment of IDD for controlled release of anti-inflammatory drug to promo...
Source: Biomaterials - February 20, 2024 Category: Materials Science Authors: Lei Liu Wantao Wang Lin Huang Yiwen Xian Wenzheng Ma Jinghao Fan Yixi Li Hongmei Liu Zhaomin Zheng Decheng Wu Source Type: research
