Engineered human osteoarthritic cartilage organoids
Biomaterials. 2024 Mar 22;308:122549. doi: 10.1016/j.biomaterials.2024.122549. Online ahead of print.ABSTRACTThe availability of human cell-based models capturing molecular processes of cartilage degeneration can facilitate development of disease-modifying therapies for osteoarthritis [1], a currently unmet clinical need. Here, by imposing specific inflammatory challenges upon mesenchymal stromal cells at a defined stage of chondrogenesis, we engineered a human organotypic model which recapitulates main OA pathological traits such as chondrocyte hypertrophy, cartilage matrix mineralization, enhanced catabolism and mechanic...
Source: Biomaterials - March 30, 2024 Category: Materials Science Authors: Laura D önges Atharva Damle Andrea Mainardi Thomas Bock Monica Sch önenberger Ivan Martin Andrea Barbero Source Type: research
Design and development of novel self-assembled catechol-modified bile acid conjugates as pH-responsive apical sodium-dependent bile acid transporter targeting nanoparticles
This study underscores the therapeutic potential of the newly developed catechol-based, pH-responsive ASBT-inhibiting nanoparticles presenting a promising avenue for advancing therapy.PMID:38552366 | DOI:10.1016/j.biomaterials.2024.122539 (Source: Biomaterials)
Source: Biomaterials - March 29, 2024 Category: Materials Science Authors: Dong-Nyeong Lee Seong-Bin Yang Seho Kweon Jun-Hyuck Lee Kyeong-Ju Lee Yeonsu Ryu Dong Wook Shin Young Jun Kim Yong-Kyu Lee Jooho Park Source Type: research
A functional 3D full-thickness model for comprehending the interaction between airway epithelium and connective tissue in cystic fibrosis
Biomaterials. 2024 Mar 26;308:122546. doi: 10.1016/j.biomaterials.2024.122546. Online ahead of print.ABSTRACTPatients with cystic fibrosis (CF) experience severe lung disease, including persistent infections, inflammation, and irreversible fibrotic remodeling of the airways. Although therapy with transmembrane conductance regulator (CFTR) protein modulators reached optimal results in terms of CFTR rescue, lung transplant remains the best line of care for patients in an advanced stage of CF. Indeed, chronic inflammation and tissue remodeling still represent stumbling blocks during treatment, and underlying mechanisms are st...
Source: Biomaterials - March 29, 2024 Category: Materials Science Authors: Claudia Mazio Laura Sara Scognamiglio Costantino Casale Valeria Panzetta Francesco Urciuolo Luis J V Galietta Giorgia Imparato Paolo A Netti Source Type: research
Biomaterial-mediated intracellular control of macrophages for cell therapy in pro-inflammatory and pro-fibrotic conditions
We present a tunable biomaterial-based strategy to control macrophages intracellularly via small molecule-releasing microparticles. Poly(lactic-co-glycolic acid) microparticles encapsulating the anti-inflammatory and anti-fibrotic drug dexamethasone were administered to macrophages in vitro, with uptake rates controlled by different loading regimes. Microparticle dose and dexamethasone content directly affected macrophage phenotype and phagocytic capacity, independent of particle content per cell, leading to an overall pro-reparative, anti-inflammatory, anti-fibrotic phenotype with increased phagocytic and ECM degrading fu...
Source: Biomaterials - March 28, 2024 Category: Materials Science Authors: Tina Tylek Joanna Wong Andrew E Vaughan Kara L Spiller Source Type: research
Overcoming antibiotic resistance caused by genetic mutations of Helicobacter pylori with mucin adhesive polymer-based therapeutics
Biomaterials. 2024 Mar 25;308:122541. doi: 10.1016/j.biomaterials.2024.122541. Online ahead of print.ABSTRACTHerein, we describe the 3'-sialyllactose-polyethyleneimine-chlorine e6 conjugate (3PC), meticulously engineered to effectively target Helicobacter bacteria (H. pylori) within the gastric environment. The composition of 3PC comprises polyethyleneimine, a cationic polymer, 3'-sialyllactose, which exhibits a specific binding affinity for H. pylori surface proteins, and a photosensitizer capable of generating oxygen radicals in response to specific wavelengths. The distinctive feature of 3PC lies in its capacity to enha...
Source: Biomaterials - March 28, 2024 Category: Materials Science Authors: Byoungjun Lim Kyoung Sub Kim Ji Yong Ahn Kun Na Source Type: research
FAK, vinculin, and talin control mechanosensitive YAP nuclear localization
Biomaterials. 2024 Mar 20;308:122542. doi: 10.1016/j.biomaterials.2024.122542. Online ahead of print.ABSTRACTFocal adhesions (FAs) are nanoscale complexes containing clustered integrin receptors and intracellular structural and signaling proteins that function as principal sites of mechanotransduction in part via promoting the nuclear translocation and activation of the transcriptional coactivator yes-associated protein (YAP). Knockdown of FA proteins such as focal adhesion kinase (FAK), talin, and vinculin can prevent YAP nuclear localization. However, the mechanism(s) of action remain poorly understood. Herein, we invest...
Source: Biomaterials - March 28, 2024 Category: Materials Science Authors: Elijah N Holland Marc A Fern ández-Yagüe Dennis W Zhou Eric B O'Neill Ayanna U Woodfolk Ana Mora-Boza Jianping Fu David D Schlaepfer Andr és J García Source Type: research
Planar amorphous silicon carbide microelectrode arrays for chronic recording in rat motor cortex
Biomaterials. 2024 Mar 21;308:122543. doi: 10.1016/j.biomaterials.2024.122543. Online ahead of print.ABSTRACTChronic implantation of intracortical microelectrode arrays (MEAs) capable of recording from individual neurons can be used for the development of brain-machine interfaces. However, these devices show reduced recording capabilities under chronic conditions due, at least in part, to the brain's foreign body response (FBR). This creates a need for MEAs that can minimize the FBR to possibly enable long-term recording. A potential approach to reduce the FBR is the use of MEAs with reduced cross-sectional geometries. Her...
Source: Biomaterials - March 28, 2024 Category: Materials Science Authors: Justin R Abbott Eleanor N Jeakle Pegah Haghighi Joshua O Usoro Brandon S Sturgill Yupeng Wu Negar Geramifard Rahul Radhakrishna Sourav Patnaik Shido Nakajima Jordan Hess Yusef Mehmood Veda Devata Gayathri Vijayakumar Armaan Sood Teresa Thuc Doan Thai Koma Source Type: research
Biomaterial-mediated intracellular control of macrophages for cell therapy in pro-inflammatory and pro-fibrotic conditions
We present a tunable biomaterial-based strategy to control macrophages intracellularly via small molecule-releasing microparticles. Poly(lactic-co-glycolic acid) microparticles encapsulating the anti-inflammatory and anti-fibrotic drug dexamethasone were administered to macrophages in vitro, with uptake rates controlled by different loading regimes. Microparticle dose and dexamethasone content directly affected macrophage phenotype and phagocytic capacity, independent of particle content per cell, leading to an overall pro-reparative, anti-inflammatory, anti-fibrotic phenotype with increased phagocytic and ECM degrading fu...
Source: Biomaterials - March 28, 2024 Category: Materials Science Authors: Tina Tylek Joanna Wong Andrew E Vaughan Kara L Spiller Source Type: research
Overcoming antibiotic resistance caused by genetic mutations of Helicobacter pylori with mucin adhesive polymer-based therapeutics
Biomaterials. 2024 Mar 25;308:122541. doi: 10.1016/j.biomaterials.2024.122541. Online ahead of print.ABSTRACTHerein, we describe the 3'-sialyllactose-polyethyleneimine-chlorine e6 conjugate (3PC), meticulously engineered to effectively target Helicobacter bacteria (H. pylori) within the gastric environment. The composition of 3PC comprises polyethyleneimine, a cationic polymer, 3'-sialyllactose, which exhibits a specific binding affinity for H. pylori surface proteins, and a photosensitizer capable of generating oxygen radicals in response to specific wavelengths. The distinctive feature of 3PC lies in its capacity to enha...
Source: Biomaterials - March 28, 2024 Category: Materials Science Authors: Byoungjun Lim Kyoung Sub Kim Ji Yong Ahn Kun Na Source Type: research
FAK, vinculin, and talin control mechanosensitive YAP nuclear localization
Biomaterials. 2024 Mar 20;308:122542. doi: 10.1016/j.biomaterials.2024.122542. Online ahead of print.ABSTRACTFocal adhesions (FAs) are nanoscale complexes containing clustered integrin receptors and intracellular structural and signaling proteins that function as principal sites of mechanotransduction in part via promoting the nuclear translocation and activation of the transcriptional coactivator yes-associated protein (YAP). Knockdown of FA proteins such as focal adhesion kinase (FAK), talin, and vinculin can prevent YAP nuclear localization. However, the mechanism(s) of action remain poorly understood. Herein, we invest...
Source: Biomaterials - March 28, 2024 Category: Materials Science Authors: Elijah N Holland Marc A Fern ández-Yagüe Dennis W Zhou Eric B O'Neill Ayanna U Woodfolk Ana Mora-Boza Jianping Fu David D Schlaepfer Andr és J García Source Type: research
Planar amorphous silicon carbide microelectrode arrays for chronic recording in rat motor cortex
Biomaterials. 2024 Mar 21;308:122543. doi: 10.1016/j.biomaterials.2024.122543. Online ahead of print.ABSTRACTChronic implantation of intracortical microelectrode arrays (MEAs) capable of recording from individual neurons can be used for the development of brain-machine interfaces. However, these devices show reduced recording capabilities under chronic conditions due, at least in part, to the brain's foreign body response (FBR). This creates a need for MEAs that can minimize the FBR to possibly enable long-term recording. A potential approach to reduce the FBR is the use of MEAs with reduced cross-sectional geometries. Her...
Source: Biomaterials - March 28, 2024 Category: Materials Science Authors: Justin R Abbott Eleanor N Jeakle Pegah Haghighi Joshua O Usoro Brandon S Sturgill Yupeng Wu Negar Geramifard Rahul Radhakrishna Sourav Patnaik Shido Nakajima Jordan Hess Yusef Mehmood Veda Devata Gayathri Vijayakumar Armaan Sood Teresa Thuc Doan Thai Koma Source Type: research
An all-in-one therapeutic platform for the treatment of resistant Helicobacter pylori infection
Biomaterials. 2024 Mar 21;308:122540. doi: 10.1016/j.biomaterials.2024.122540. Online ahead of print.ABSTRACTHelicobacter pylori (H. pylori) infection is a major cause of gastric diseases. Currently, bismuth-based quadruple therapy is widely adopted for eradicating H. pylori infection. However, this first-line strategy faces several challenges such as drug resistance, intestinal dysbacteriosis, and patients' poor compliance. To overcome these problems, an all-in-one therapeutic platform (CLA-Bi-ZnO2@Lipo) that composed of liposomes loading clarithromycin (CLA), Bi, and ZnO2 hybrid nanoparticles was developed for eradicatin...
Source: Biomaterials - March 27, 2024 Category: Materials Science Authors: Chao Sun Jia Huang Xiaoqian Guo Chenli Zhang Li Wei Ka Ioi Wong Ziyun Yang Gang Zhao Min Lu Weiyan Yao Source Type: research
Multi-step strategies for synergistic treatment of urinary tract infections based on D-xylose-decorated antimicrobial peptide carbon dots
Biomaterials. 2024 Mar 22;308:122547. doi: 10.1016/j.biomaterials.2024.122547. Online ahead of print.ABSTRACTUrinary tract infections (UTIs) caused by Uropathogenic Escherichia coli (UPEC), often reoccur due to the formation of intracellular bacterial colonies (IBCs) and antibiotic resistance. Given the significance of YadC for UPEC infection in our previous study, we developed D-xylose-decorated ɛ-poly-L-lysine (εPL)-based carbon dots (D-xyl@εPLCDs) that can be traced, and employed multi-step approaches to elucidate the functional roles of D-xyl@εPLCDs in UPEC infection. Compared to undecorated particles, D-xyl@εPLCD...
Source: Biomaterials - March 27, 2024 Category: Materials Science Authors: Chunhui Miao Yajie Zhang Guowen Liu Jianming Yang Kaiyuan Yu Junqiang Lv Ran Liu Zhi Yao Yuanjie Niu Xiaojuan Wang Quan Wang Source Type: research
An all-in-one therapeutic platform for the treatment of resistant Helicobacter pylori infection
Biomaterials. 2024 Mar 21;308:122540. doi: 10.1016/j.biomaterials.2024.122540. Online ahead of print.ABSTRACTHelicobacter pylori (H. pylori) infection is a major cause of gastric diseases. Currently, bismuth-based quadruple therapy is widely adopted for eradicating H. pylori infection. However, this first-line strategy faces several challenges such as drug resistance, intestinal dysbacteriosis, and patients' poor compliance. To overcome these problems, an all-in-one therapeutic platform (CLA-Bi-ZnO2@Lipo) that composed of liposomes loading clarithromycin (CLA), Bi, and ZnO2 hybrid nanoparticles was developed for eradicatin...
Source: Biomaterials - March 27, 2024 Category: Materials Science Authors: Chao Sun Jia Huang Xiaoqian Guo Chenli Zhang Li Wei Ka Ioi Wong Ziyun Yang Gang Zhao Min Lu Weiyan Yao Source Type: research
Multi-step strategies for synergistic treatment of urinary tract infections based on D-xylose-decorated antimicrobial peptide carbon dots
Biomaterials. 2024 Mar 22;308:122547. doi: 10.1016/j.biomaterials.2024.122547. Online ahead of print.ABSTRACTUrinary tract infections (UTIs) caused by Uropathogenic Escherichia coli (UPEC), often reoccur due to the formation of intracellular bacterial colonies (IBCs) and antibiotic resistance. Given the significance of YadC for UPEC infection in our previous study, we developed D-xylose-decorated ɛ-poly-L-lysine (εPL)-based carbon dots (D-xyl@εPLCDs) that can be traced, and employed multi-step approaches to elucidate the functional roles of D-xyl@εPLCDs in UPEC infection. Compared to undecorated particles, D-xyl@εPLCD...
Source: Biomaterials - March 27, 2024 Category: Materials Science Authors: Chunhui Miao Yajie Zhang Guowen Liu Jianming Yang Kaiyuan Yu Junqiang Lv Ran Liu Zhi Yao Yuanjie Niu Xiaojuan Wang Quan Wang Source Type: research
