Hybrid interpenetrating network of polyester coronary stent with tunable biodegradation and mechanical properties
Biomaterials. 2023 Nov 29;304:122411. doi: 10.1016/j.biomaterials.2023.122411. Online ahead of print.ABSTRACTPoly(l-lactide) (PLLA) is an important candidate raw material of the next-generation biodegradable stent for percutaneous coronary intervention, yet how to make a polyester stent with sufficient mechanical strength and relatively fast biodegradation gets to be a dilemma. Herein, we put forward a hybrid interpenetrating network (H-IPN) strategy to resolve this dilemma. As such, we synthesize a multi-functional biodegradable macromer of star-like poly(d,l-lactide-co-ɛ-caprolactone) with six acrylate end groups, and p...
Source: Biomaterials - December 7, 2023 Category: Materials Science Authors: Daokun Shi Yahong Kang Zailai Jiang Xin Li Hongjie Zhang Qunsong Wang Jingzhen Guo Hongyan Jiang Qiyi Luo Jiandong Ding Source Type: research
DMSA-coated IONPs trigger oxidative stress, mitochondrial metabolic reprograming and changes in mitochondrial disposition, hindering cell cycle progression of cancer cells
Biomaterials. 2023 Nov 29;304:122409. doi: 10.1016/j.biomaterials.2023.122409. Online ahead of print.ABSTRACTThere is increasing interest in modulating the redox homeostasis of tumors since high levels of reactive oxygen species (ROS) make them more vulnerable to changes in these species. Nanomedicine offers promise in this context as such applications may provoke biological responses that induce ROS production. Indeed, iron oxide nanoparticles (IONPs) can induce ROS accumulation through the so-called Fenton reaction of iron, further augmenting the ROS in tumors and overloading the antioxidant system beyond its capacity, t...
Source: Biomaterials - December 5, 2023 Category: Materials Science Authors: Neus Daviu Yadileiny Portilla Marta G ómez de Cedrón Ana Ram írez de Molina Domingo F Barber Source Type: research
DMSA-coated IONPs trigger oxidative stress, mitochondrial metabolic reprograming and changes in mitochondrial disposition, hindering cell cycle progression of cancer cells
Biomaterials. 2023 Nov 29;304:122409. doi: 10.1016/j.biomaterials.2023.122409. Online ahead of print.ABSTRACTThere is increasing interest in modulating the redox homeostasis of tumors since high levels of reactive oxygen species (ROS) make them more vulnerable to changes in these species. Nanomedicine offers promise in this context as such applications may provoke biological responses that induce ROS production. Indeed, iron oxide nanoparticles (IONPs) can induce ROS accumulation through the so-called Fenton reaction of iron, further augmenting the ROS in tumors and overloading the antioxidant system beyond its capacity, t...
Source: Biomaterials - December 5, 2023 Category: Materials Science Authors: Neus Daviu Yadileiny Portilla Marta G ómez de Cedrón Ana Ram írez de Molina Domingo F Barber Source Type: research
An engineered lymph node comprising porous collagen scaffold with hybridized biological signals embedded in B cell membrane coatings
Biomaterials. 2023 Nov 30;304:122420. doi: 10.1016/j.biomaterials.2023.122420. Online ahead of print.ABSTRACTComplications can arise from damaging or removing lymph nodes after surgeries for malignant tumours. Our team has developed an innovative solution to recreate lymph nodes via an engineering approach. Using a Type II collagen scaffold coated with B cell membranes for the sake of attracting T cells in different regions, we could mimic the thymus-dependent and thymus-independent areas in vitro. This engineering strategy based on biophysical mimicry has a great potential for clinical applications. By further conjugating...
Source: Biomaterials - December 4, 2023 Category: Materials Science Authors: Bangheng Liu Min Jin Cheng Ma Zhen Zhang Liang Ma Yi Zhang Dong-An Wang Source Type: research
A telluroviologen-anchored tetraphenylporphyrin as sonosensitizer for periodontitis sonodynamic therapy
Biomaterials. 2023 Nov 23;304:122407. doi: 10.1016/j.biomaterials.2023.122407. Online ahead of print.ABSTRACTPeriodontitis is a chronic disease caused by bacteria (e.g. Porphyromonas gingivalis, P.gingivalis) that currently lacks effective non-invasive treatment options. Sonodynamic therapy (SDT) is an emerging non-invasive antimicrobial therapeutic strategy. Since ultrasonic tooth cleaning is widely used in dental treatments, SDT has significant potential for the facile implementation of treat periodontitis. However, hypoxia in periodontitis severely limits the effectiveness of traditional sonosensitizers. To address this...
Source: Biomaterials - December 4, 2023 Category: Materials Science Authors: Qi Sun Weijie Song Yujing Gao Rui Ding Shuai Shi Suxia Han Guoping Li Dandan Pei Ang Li Gang He Source Type: research
An engineered lymph node comprising porous collagen scaffold with hybridized biological signals embedded in B cell membrane coatings
Biomaterials. 2023 Nov 30;304:122420. doi: 10.1016/j.biomaterials.2023.122420. Online ahead of print.ABSTRACTComplications can arise from damaging or removing lymph nodes after surgeries for malignant tumours. Our team has developed an innovative solution to recreate lymph nodes via an engineering approach. Using a Type II collagen scaffold coated with B cell membranes for the sake of attracting T cells in different regions, we could mimic the thymus-dependent and thymus-independent areas in vitro. This engineering strategy based on biophysical mimicry has a great potential for clinical applications. By further conjugating...
Source: Biomaterials - December 4, 2023 Category: Materials Science Authors: Bangheng Liu Min Jin Cheng Ma Zhen Zhang Liang Ma Yi Zhang Dong-An Wang Source Type: research
A telluroviologen-anchored tetraphenylporphyrin as sonosensitizer for periodontitis sonodynamic therapy
Biomaterials. 2023 Nov 23;304:122407. doi: 10.1016/j.biomaterials.2023.122407. Online ahead of print.ABSTRACTPeriodontitis is a chronic disease caused by bacteria (e.g. Porphyromonas gingivalis, P.gingivalis) that currently lacks effective non-invasive treatment options. Sonodynamic therapy (SDT) is an emerging non-invasive antimicrobial therapeutic strategy. Since ultrasonic tooth cleaning is widely used in dental treatments, SDT has significant potential for the facile implementation of treat periodontitis. However, hypoxia in periodontitis severely limits the effectiveness of traditional sonosensitizers. To address this...
Source: Biomaterials - December 4, 2023 Category: Materials Science Authors: Qi Sun Weijie Song Yujing Gao Rui Ding Shuai Shi Suxia Han Guoping Li Dandan Pei Ang Li Gang He Source Type: research
Metal-polyphenol "prison" attenuated bacterial outer membrane vesicle for chemodynamics promoted in situ tumor vaccines
Biomaterials. 2023 Nov 23;304:122396. doi: 10.1016/j.biomaterials.2023.122396. Online ahead of print.ABSTRACTAs natural adjuvants, the bacterial outer membrane vesicles (OMV) hold great potential in cancer vaccines. However, the inherent immunotoxicity of OMV and the rarity of tumor-specific antigens seriously hamper the clinical translation of OMV-based cancer vaccines. Herein, metal-phenolic networks (MPNs) are used to attenuate the toxicity of OMV, meanwhile, provide tumor antigens via the chemodynamic effect induced immunogenic cell death (ICD). Specifically, MPNs are assembled on the OMV surface through the coordinati...
Source: Biomaterials - December 3, 2023 Category: Materials Science Authors: Weidong Nie Anqi Jiang Xu Ou Jiaxin Zhou Zijin Li Chao Liang Li-Li Huang Guanghao Wu Hai-Yan Xie Source Type: research
The effect of a bionic bone ionic environment on osteogenesis, osteoimmunology, and in situ bone tissue engineering
In this study, we extracted and isolated inorganic bone components (bone-derived monetite, BM) using a low-temperature method and, for the first time, investigated whether the BIE could actively affect cell differentiation and regulate osteoimmune reactions. It was evidenced that the BIE could foster the osteogenesis of human bone marrow stromal cells (hBMSCs) and promote hBMSCs mineralization without using osteogenic inductive agents. Interestingly, it was noted that BIE resulted in intracellular mineralization, evidenced by intracellular accumulation of carbonate hydroxyapatite similar to that oberved in osteoblasts cult...
Source: Biomaterials - December 3, 2023 Category: Materials Science Authors: Yuqing Mu Zhibin Du Wendong Gao Lan Xiao Ross Crawford Yin Xiao Source Type: research
Metal-polyphenol "prison" attenuated bacterial outer membrane vesicle for chemodynamics promoted in situ tumor vaccines
Biomaterials. 2023 Nov 23;304:122396. doi: 10.1016/j.biomaterials.2023.122396. Online ahead of print.ABSTRACTAs natural adjuvants, the bacterial outer membrane vesicles (OMV) hold great potential in cancer vaccines. However, the inherent immunotoxicity of OMV and the rarity of tumor-specific antigens seriously hamper the clinical translation of OMV-based cancer vaccines. Herein, metal-phenolic networks (MPNs) are used to attenuate the toxicity of OMV, meanwhile, provide tumor antigens via the chemodynamic effect induced immunogenic cell death (ICD). Specifically, MPNs are assembled on the OMV surface through the coordinati...
Source: Biomaterials - December 3, 2023 Category: Materials Science Authors: Weidong Nie Anqi Jiang Xu Ou Jiaxin Zhou Zijin Li Chao Liang Li-Li Huang Guanghao Wu Hai-Yan Xie Source Type: research
The effect of a bionic bone ionic environment on osteogenesis, osteoimmunology, and in situ bone tissue engineering
In this study, we extracted and isolated inorganic bone components (bone-derived monetite, BM) using a low-temperature method and, for the first time, investigated whether the BIE could actively affect cell differentiation and regulate osteoimmune reactions. It was evidenced that the BIE could foster the osteogenesis of human bone marrow stromal cells (hBMSCs) and promote hBMSCs mineralization without using osteogenic inductive agents. Interestingly, it was noted that BIE resulted in intracellular mineralization, evidenced by intracellular accumulation of carbonate hydroxyapatite similar to that oberved in osteoblasts cult...
Source: Biomaterials - December 3, 2023 Category: Materials Science Authors: Yuqing Mu Zhibin Du Wendong Gao Lan Xiao Ross Crawford Yin Xiao Source Type: research
A comprehensive review on 3D tissue models: Biofabrication technologies and preclinical applications
Biomaterials. 2023 Nov 27;304:122408. doi: 10.1016/j.biomaterials.2023.122408. Online ahead of print.ABSTRACTThe limitations of traditional two-dimensional (2D) cultures and animal testing, when it comes to precisely foreseeing the toxicity and clinical effectiveness of potential drug candidates, have resulted in a notable increase in the rate of failure during the process of drug discovery and development. Three-dimensional (3D) in-vitro models have arisen as substitute platforms with the capacity to accurately depict in-vivo conditions and increasing the predictivity of clinical effects and toxicity of drug candidates. I...
Source: Biomaterials - December 2, 2023 Category: Materials Science Authors: Renjian Xie Vaibhav Pal Yanrong Yu Xiaolu Lu Mengwei Gao Shijie Liang Miao Huang Weijie Peng Ibrahim T Ozbolat Source Type: research
Pillar arene Se nanozyme therapeutic systems with dual drive power effectively penetrated mucus layer combined therapy acute lung injury
Biomaterials. 2023 Nov 2;304:122384. doi: 10.1016/j.biomaterials.2023.122384. Online ahead of print.ABSTRACTsiRNA has demonstrated a promising paradigm for therapy of acute lung injury(ALI). However, the pulmonary mucus layer barrier powerfully hinders the therapeutic efficacy. Herein, we proposed to use dual drive power to enhance the mucus permeation of siRNA by constructing the neutral and targeted selenium nanozymes therapeutic system. The multifunctional selenium nanozymes (CWP-Se@Man) were synthesized by modifying with cationic water-soluble pillar arene (CWP) and mannose (Man). After loading CCR2-siRNA, the CWP-Se@M...
Source: Biomaterials - November 28, 2023 Category: Materials Science Authors: Xu Chen Yonglan Yang Qiongmei Mai Gang Ye Yanan Liu Jie Liu Source Type: research
A novel capsid-XL32-derived adeno-associated virus serotype prompts retinal tropism and ameliorates choroidal neovascularization
Biomaterials. 2023 Nov 17;304:122403. doi: 10.1016/j.biomaterials.2023.122403. Online ahead of print.ABSTRACTGene therapy has been adapted, from the laboratory to the clinic, to treat retinopathies. In contrast to subretinal route, intravitreal delivery of AAV vectors displays the advantage of bypassing surgical injuries, but the viral particles are more prone to be nullified by the host neutralizing factors. To minimize such suppression of therapeutic effect, especially in terms of AAV2 and its derivatives, we introduced three serine-to-glycine mutations, based on the phosphorylation sites identified by mass spectrum anal...
Source: Biomaterials - November 28, 2023 Category: Materials Science Authors: Lin-Lin Luo Jie Xu Bing-Qiao Wang Chen Chen Xi Chen Qiu-Mei Hu Yu-Qiu Wang Wan-Yun Zhang Wan-Xiang Jiang Xin-Ting Li Hu Zhou Xiao Xiao Kai Zhao Sen Lin Source Type: research
Pillar arene Se nanozyme therapeutic systems with dual drive power effectively penetrated mucus layer combined therapy acute lung injury
Biomaterials. 2023 Nov 2;304:122384. doi: 10.1016/j.biomaterials.2023.122384. Online ahead of print.ABSTRACTsiRNA has demonstrated a promising paradigm for therapy of acute lung injury(ALI). However, the pulmonary mucus layer barrier powerfully hinders the therapeutic efficacy. Herein, we proposed to use dual drive power to enhance the mucus permeation of siRNA by constructing the neutral and targeted selenium nanozymes therapeutic system. The multifunctional selenium nanozymes (CWP-Se@Man) were synthesized by modifying with cationic water-soluble pillar arene (CWP) and mannose (Man). After loading CCR2-siRNA, the CWP-Se@M...
Source: Biomaterials - November 28, 2023 Category: Materials Science Authors: Xu Chen Yonglan Yang Qiongmei Mai Gang Ye Yanan Liu Jie Liu Source Type: research
