Glutathione depletion and dihydroorotate dehydrogenase inhibition actuated ferroptosis-augment to surmount triple-negative breast cancer
In this study, an albumin-based nanomedicine was developed to induce augmented ferroptosis in triple-negative breast cancer (TNBC) by depleting glutathione (GSH) and inhibiting DHODH activity. The nanomedicine (ATO/SRF@BSA) was developed by loading sorafenib (SRF) and atovaquone (ATO) into bovine serum albumin (BSA). SRF is an FDA-approved ferroptosis inducer and ATO is the only drug used in clinical that targets mitochondria. By combining the effects of SRF and ATO, ATO/SRF@BSA promoted the accumulation of lipid peroxides within mitochondria by inhibiting the glutathione peroxidase 4 (GPX4)-GSH pathway and downregulating ...
Source: Biomaterials - December 28, 2023 Category: Materials Science Authors: Tian-Jiao Zhou Meng-Meng Zhang Dan-Meng Liu Li-Ling Huang Hai-Qing Yu Yi Wang Lei Xing Hu-Lin Jiang Source Type: research
Selenium promotes immunogenic radiotherapy against cervical cancer metastasis through evoking P53 activation
Biomaterials. 2023 Dec 24;305:122452. doi: 10.1016/j.biomaterials.2023.122452. Online ahead of print.ABSTRACTRadiotherapy is still the recommended treatment for cervical cancer. However, radioresistance and radiation-induced side effects remain one of the biggest clinical problems. Selenium (Se) has been confirmed to exhibit radiation-enhancing effects for cancer treatment. However, Se species dominate the biological activities and which form of Se possesses better radiosensitizing properties and radiation safety remains elusive. Here, different Se species (the valence state of Se ranged from - 2, 0, +4 to + 6) synergy scr...
Source: Biomaterials - December 28, 2023 Category: Materials Science Authors: Yanchao Xu Haoqiang Lai Shuya Pan Liuliu Pan Ting Liu Ziyi Yang Tianfeng Chen Xueqiong Zhu Source Type: research
Glutathione depletion and dihydroorotate dehydrogenase inhibition actuated ferroptosis-augment to surmount triple-negative breast cancer
In this study, an albumin-based nanomedicine was developed to induce augmented ferroptosis in triple-negative breast cancer (TNBC) by depleting glutathione (GSH) and inhibiting DHODH activity. The nanomedicine (ATO/SRF@BSA) was developed by loading sorafenib (SRF) and atovaquone (ATO) into bovine serum albumin (BSA). SRF is an FDA-approved ferroptosis inducer and ATO is the only drug used in clinical that targets mitochondria. By combining the effects of SRF and ATO, ATO/SRF@BSA promoted the accumulation of lipid peroxides within mitochondria by inhibiting the glutathione peroxidase 4 (GPX4)-GSH pathway and downregulating ...
Source: Biomaterials - December 28, 2023 Category: Materials Science Authors: Tian-Jiao Zhou Meng-Meng Zhang Dan-Meng Liu Li-Ling Huang Hai-Qing Yu Yi Wang Lei Xing Hu-Lin Jiang Source Type: research
Selenium promotes immunogenic radiotherapy against cervical cancer metastasis through evoking P53 activation
Biomaterials. 2023 Dec 24;305:122452. doi: 10.1016/j.biomaterials.2023.122452. Online ahead of print.ABSTRACTRadiotherapy is still the recommended treatment for cervical cancer. However, radioresistance and radiation-induced side effects remain one of the biggest clinical problems. Selenium (Se) has been confirmed to exhibit radiation-enhancing effects for cancer treatment. However, Se species dominate the biological activities and which form of Se possesses better radiosensitizing properties and radiation safety remains elusive. Here, different Se species (the valence state of Se ranged from - 2, 0, +4 to + 6) synergy scr...
Source: Biomaterials - December 28, 2023 Category: Materials Science Authors: Yanchao Xu Haoqiang Lai Shuya Pan Liuliu Pan Ting Liu Ziyi Yang Tianfeng Chen Xueqiong Zhu Source Type: research
Glutathione depletion and dihydroorotate dehydrogenase inhibition actuated ferroptosis-augment to surmount triple-negative breast cancer
In this study, an albumin-based nanomedicine was developed to induce augmented ferroptosis in triple-negative breast cancer (TNBC) by depleting glutathione (GSH) and inhibiting DHODH activity. The nanomedicine (ATO/SRF@BSA) was developed by loading sorafenib (SRF) and atovaquone (ATO) into bovine serum albumin (BSA). SRF is an FDA-approved ferroptosis inducer and ATO is the only drug used in clinical that targets mitochondria. By combining the effects of SRF and ATO, ATO/SRF@BSA promoted the accumulation of lipid peroxides within mitochondria by inhibiting the glutathione peroxidase 4 (GPX4)-GSH pathway and downregulating ...
Source: Biomaterials - December 28, 2023 Category: Materials Science Authors: Tian-Jiao Zhou Meng-Meng Zhang Dan-Meng Liu Li-Ling Huang Hai-Qing Yu Yi Wang Lei Xing Hu-Lin Jiang Source Type: research
Eyedrop delivery of therapeutic proteins with zwitterionic polymers to treat dry age-related macular degeneration
In this study, zwitterion-grafted chitosan (CS-ZW) was developed and then self-assembled with protein therapeutics including adalimumab (ADA) or catalase (CAT) for the treatment of dry age-related macular degeneration (dAMD) via topical eyedrops. Since CS-ZW can cross the mucus layer and open the tight junctions between epithelial cells, their delivered therapeutic proteins can be shuttled across the ocular barriers to reach the diseased site in the fundus. CS-ZW/ADA eyedrops delivering ADA to bind TNF-α in the fundus achieved a similar therapeutic effect to intravitreal ADA injection in a mouse dAMD model. In addition, t...
Source: Biomaterials - December 27, 2023 Category: Materials Science Authors: Yutong Jiang Xuehui Fu Ming Shao Wanwan Chang Han Zhang Zhuang Liu Source Type: research
A facile boronophenylalanine modified polydopamine dual drug-loaded nanoparticles for enhanced anti-tumor immune response in hepatocellular carcinoma comprehensive treatment
Biomaterials. 2023 Dec 21;305:122435. doi: 10.1016/j.biomaterials.2023.122435. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) has an insidious onset and high malignancy. Most patients have progressed to intermediate and advanced stages by the time of diagnosis, and the long-term efficacy of traditional treatments is not satisfactory. Immunotherapy has shown great promise in the treatment of HCC in recent years; however, the low immunogenicity and severe immunosuppressive tumor microenvironment result in a low response rate to immunotherapy in HCC patients. Therefore, it is of great significance to improve the...
Source: Biomaterials - December 27, 2023 Category: Materials Science Authors: Fan Yang Liqun Dai Kun Shi Qingya Liu Meng Pan Dong Mo Hanzhi Deng Liping Yuan Yi Lu Lili Pan Tingyu Yang Zhiyong Qian Source Type: research
Nitrogen vacancy-rich carbon nitride anchored with iron atoms for efficient redox dyshomeostasis under ultrasound actuation
Biomaterials. 2023 Dec 23;305:122446. doi: 10.1016/j.biomaterials.2023.122446. Online ahead of print.ABSTRACTTraditional Fe-based Fenton reaction for inducing oxidative stress is restricted by random charge transfer without oriental delivery, and the resultant generation of reactive oxygen species (ROS) is always too simplistic to realize a satisfactory therapeutic outcome. Herein, FeNv/CN nanosheets rich in nitrogen vacancies are developed for high-performance redox dyshomeostasis therapy after surface conjugation with polyethylene glycol (PEG) and cyclic Arg-Gly-Asp (cRGD). Surface defects in FeNv/CN serve as electron tr...
Source: Biomaterials - December 27, 2023 Category: Materials Science Authors: Mengting He Xiaoqin Wang Honglian Yu Yinmin Zhao Lei Zhang Zhigang Xu Yuejun Kang Peng Xue Source Type: research
Eyedrop delivery of therapeutic proteins with zwitterionic polymers to treat dry age-related macular degeneration
In this study, zwitterion-grafted chitosan (CS-ZW) was developed and then self-assembled with protein therapeutics including adalimumab (ADA) or catalase (CAT) for the treatment of dry age-related macular degeneration (dAMD) via topical eyedrops. Since CS-ZW can cross the mucus layer and open the tight junctions between epithelial cells, their delivered therapeutic proteins can be shuttled across the ocular barriers to reach the diseased site in the fundus. CS-ZW/ADA eyedrops delivering ADA to bind TNF-α in the fundus achieved a similar therapeutic effect to intravitreal ADA injection in a mouse dAMD model. In addition, t...
Source: Biomaterials - December 27, 2023 Category: Materials Science Authors: Yutong Jiang Xuehui Fu Ming Shao Wanwan Chang Han Zhang Zhuang Liu Source Type: research
A facile boronophenylalanine modified polydopamine dual drug-loaded nanoparticles for enhanced anti-tumor immune response in hepatocellular carcinoma comprehensive treatment
Biomaterials. 2023 Dec 21;305:122435. doi: 10.1016/j.biomaterials.2023.122435. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) has an insidious onset and high malignancy. Most patients have progressed to intermediate and advanced stages by the time of diagnosis, and the long-term efficacy of traditional treatments is not satisfactory. Immunotherapy has shown great promise in the treatment of HCC in recent years; however, the low immunogenicity and severe immunosuppressive tumor microenvironment result in a low response rate to immunotherapy in HCC patients. Therefore, it is of great significance to improve the...
Source: Biomaterials - December 27, 2023 Category: Materials Science Authors: Fan Yang Liqun Dai Kun Shi Qingya Liu Meng Pan Dong Mo Hanzhi Deng Liping Yuan Yi Lu Lili Pan Tingyu Yang Zhiyong Qian Source Type: research
Nitrogen vacancy-rich carbon nitride anchored with iron atoms for efficient redox dyshomeostasis under ultrasound actuation
Biomaterials. 2023 Dec 23;305:122446. doi: 10.1016/j.biomaterials.2023.122446. Online ahead of print.ABSTRACTTraditional Fe-based Fenton reaction for inducing oxidative stress is restricted by random charge transfer without oriental delivery, and the resultant generation of reactive oxygen species (ROS) is always too simplistic to realize a satisfactory therapeutic outcome. Herein, FeNv/CN nanosheets rich in nitrogen vacancies are developed for high-performance redox dyshomeostasis therapy after surface conjugation with polyethylene glycol (PEG) and cyclic Arg-Gly-Asp (cRGD). Surface defects in FeNv/CN serve as electron tr...
Source: Biomaterials - December 27, 2023 Category: Materials Science Authors: Mengting He Xiaoqin Wang Honglian Yu Yinmin Zhao Lei Zhang Zhigang Xu Yuejun Kang Peng Xue Source Type: research
Engineered 3D ex vivo models to recapitulate the complex stromal and immune interactions within the tumor microenvironment
Biomaterials. 2023 Dec 19;305:122428. doi: 10.1016/j.biomaterials.2023.122428. Online ahead of print.ABSTRACTCancer thrives in a complex environment where interactions between cellular and acellular components, surrounding the tumor, play a crucial role in disease development and progression. Despite significant progress in cancer research, the mechanism driving tumor growth and therapeutic outcomes remains elusive. Two-dimensional (2D) cell culture assays and in vivo animal models are commonly used in cancer research and therapeutic testing. However, these models suffer from numerous shortcomings including lack of key fea...
Source: Biomaterials - December 26, 2023 Category: Materials Science Authors: Kalpana Ravi Twinkle Jina Minette Manoharan Kuei-Chun Wang Barbara Pockaj Mehdi Nikkhah Source Type: research
Engineered 3D ex vivo models to recapitulate the complex stromal and immune interactions within the tumor microenvironment
Biomaterials. 2023 Dec 19;305:122428. doi: 10.1016/j.biomaterials.2023.122428. Online ahead of print.ABSTRACTCancer thrives in a complex environment where interactions between cellular and acellular components, surrounding the tumor, play a crucial role in disease development and progression. Despite significant progress in cancer research, the mechanism driving tumor growth and therapeutic outcomes remains elusive. Two-dimensional (2D) cell culture assays and in vivo animal models are commonly used in cancer research and therapeutic testing. However, these models suffer from numerous shortcomings including lack of key fea...
Source: Biomaterials - December 26, 2023 Category: Materials Science Authors: Kalpana Ravi Twinkle Jina Minette Manoharan Kuei-Chun Wang Barbara Pockaj Mehdi Nikkhah Source Type: research
Boosting the synergism between cancer ferroptosis and immunotherapy via targeted stimuli-responsive liposomes
Biomaterials. 2023 Dec 20;305:122442. doi: 10.1016/j.biomaterials.2023.122442. Online ahead of print.ABSTRACTBoth ferroptotic therapy and immunotherapy have been widely employed in cancer treatment. However, ferroptotic cell death fails to induce dendritic cells maturation, which limits the therapeutic outcome of ferroptotic cancer therapy. To address this, the current work reports a tailored liposome to establish a positive loop between ferroptotic therapy and immunotherapy. As the key component of liposome, a unique phospholipid is designed to bear two arachidonic acid tails. The liposome is further surface-engineered wi...
Source: Biomaterials - December 24, 2023 Category: Materials Science Authors: Zhuoya Gao Jiarong Zhang Yingchao Hou Jinjin Lu Jing Liang Yufeng Gao Boqi Li Shuai Gao Yanjun Zhao Min Gao Jinghua Chen Source Type: research
Passivation protein-adhesion platform promoting stent reendothelialization using two-electron-assisted oxidation of polyphenols
Biomaterials. 2023 Dec 16;305:122423. doi: 10.1016/j.biomaterials.2023.122423. Online ahead of print.ABSTRACTSuperhydrophilic surfaces play an important role in nature. Inspired by this, scientists have designed various superhydrophilic materials that are widely used in the field of biomaterials, such as PEG molecular brushes and zwitterionic materials. However, superhydrophilic coatings with only anti-fouling properties do not satisfy the requirements for rapid reendothelialization of cardiovascular stent surfaces. Herein, a novel polyphenol superhydrophilic surface with passivated protein-adsorption properties was develo...
Source: Biomaterials - December 24, 2023 Category: Materials Science Authors: Linhua Li Chunle Zhang Zhengjiang Cao Liang Ma Chang Liu Xiaorong Lan Chao Qu Ping Fu Rifang Luo Yunbing Wang Source Type: research
