A facile boronophenylalanine modified polydopamine dual drug-loaded nanoparticles for enhanced anti-tumor immune response in hepatocellular carcinoma comprehensive treatment
Biomaterials. 2023 Dec 21;305:122435. doi: 10.1016/j.biomaterials.2023.122435. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) has an insidious onset and high malignancy. Most patients have progressed to intermediate and advanced stages by the time of diagnosis, and the long-term efficacy of traditional treatments is not satisfactory. Immunotherapy has shown great promise in the treatment of HCC in recent years; however, the low immunogenicity and severe immunosuppressive tumor microenvironment result in a low response rate to immunotherapy in HCC patients. Therefore, it is of great significance to improve the...
Source: Biomaterials - December 27, 2023 Category: Materials Science Authors: Fan Yang Liqun Dai Kun Shi Qingya Liu Meng Pan Dong Mo Hanzhi Deng Liping Yuan Yi Lu Lili Pan Tingyu Yang Zhiyong Qian Source Type: research

Nitrogen vacancy-rich carbon nitride anchored with iron atoms for efficient redox dyshomeostasis under ultrasound actuation
Biomaterials. 2023 Dec 23;305:122446. doi: 10.1016/j.biomaterials.2023.122446. Online ahead of print.ABSTRACTTraditional Fe-based Fenton reaction for inducing oxidative stress is restricted by random charge transfer without oriental delivery, and the resultant generation of reactive oxygen species (ROS) is always too simplistic to realize a satisfactory therapeutic outcome. Herein, FeNv/CN nanosheets rich in nitrogen vacancies are developed for high-performance redox dyshomeostasis therapy after surface conjugation with polyethylene glycol (PEG) and cyclic Arg-Gly-Asp (cRGD). Surface defects in FeNv/CN serve as electron tr...
Source: Biomaterials - December 27, 2023 Category: Materials Science Authors: Mengting He Xiaoqin Wang Honglian Yu Yinmin Zhao Lei Zhang Zhigang Xu Yuejun Kang Peng Xue Source Type: research

Eyedrop delivery of therapeutic proteins with zwitterionic polymers to treat dry age-related macular degeneration
In this study, zwitterion-grafted chitosan (CS-ZW) was developed and then self-assembled with protein therapeutics including adalimumab (ADA) or catalase (CAT) for the treatment of dry age-related macular degeneration (dAMD) via topical eyedrops. Since CS-ZW can cross the mucus layer and open the tight junctions between epithelial cells, their delivered therapeutic proteins can be shuttled across the ocular barriers to reach the diseased site in the fundus. CS-ZW/ADA eyedrops delivering ADA to bind TNF-α in the fundus achieved a similar therapeutic effect to intravitreal ADA injection in a mouse dAMD model. In addition, t...
Source: Biomaterials - December 27, 2023 Category: Materials Science Authors: Yutong Jiang Xuehui Fu Ming Shao Wanwan Chang Han Zhang Zhuang Liu Source Type: research

A facile boronophenylalanine modified polydopamine dual drug-loaded nanoparticles for enhanced anti-tumor immune response in hepatocellular carcinoma comprehensive treatment
Biomaterials. 2023 Dec 21;305:122435. doi: 10.1016/j.biomaterials.2023.122435. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) has an insidious onset and high malignancy. Most patients have progressed to intermediate and advanced stages by the time of diagnosis, and the long-term efficacy of traditional treatments is not satisfactory. Immunotherapy has shown great promise in the treatment of HCC in recent years; however, the low immunogenicity and severe immunosuppressive tumor microenvironment result in a low response rate to immunotherapy in HCC patients. Therefore, it is of great significance to improve the...
Source: Biomaterials - December 27, 2023 Category: Materials Science Authors: Fan Yang Liqun Dai Kun Shi Qingya Liu Meng Pan Dong Mo Hanzhi Deng Liping Yuan Yi Lu Lili Pan Tingyu Yang Zhiyong Qian Source Type: research

Nitrogen vacancy-rich carbon nitride anchored with iron atoms for efficient redox dyshomeostasis under ultrasound actuation
Biomaterials. 2023 Dec 23;305:122446. doi: 10.1016/j.biomaterials.2023.122446. Online ahead of print.ABSTRACTTraditional Fe-based Fenton reaction for inducing oxidative stress is restricted by random charge transfer without oriental delivery, and the resultant generation of reactive oxygen species (ROS) is always too simplistic to realize a satisfactory therapeutic outcome. Herein, FeNv/CN nanosheets rich in nitrogen vacancies are developed for high-performance redox dyshomeostasis therapy after surface conjugation with polyethylene glycol (PEG) and cyclic Arg-Gly-Asp (cRGD). Surface defects in FeNv/CN serve as electron tr...
Source: Biomaterials - December 27, 2023 Category: Materials Science Authors: Mengting He Xiaoqin Wang Honglian Yu Yinmin Zhao Lei Zhang Zhigang Xu Yuejun Kang Peng Xue Source Type: research

Engineered 3D ex vivo models to recapitulate the complex stromal and immune interactions within the tumor microenvironment
Biomaterials. 2023 Dec 19;305:122428. doi: 10.1016/j.biomaterials.2023.122428. Online ahead of print.ABSTRACTCancer thrives in a complex environment where interactions between cellular and acellular components, surrounding the tumor, play a crucial role in disease development and progression. Despite significant progress in cancer research, the mechanism driving tumor growth and therapeutic outcomes remains elusive. Two-dimensional (2D) cell culture assays and in vivo animal models are commonly used in cancer research and therapeutic testing. However, these models suffer from numerous shortcomings including lack of key fea...
Source: Biomaterials - December 26, 2023 Category: Materials Science Authors: Kalpana Ravi Twinkle Jina Minette Manoharan Kuei-Chun Wang Barbara Pockaj Mehdi Nikkhah Source Type: research

Engineered 3D ex vivo models to recapitulate the complex stromal and immune interactions within the tumor microenvironment
Biomaterials. 2023 Dec 19;305:122428. doi: 10.1016/j.biomaterials.2023.122428. Online ahead of print.ABSTRACTCancer thrives in a complex environment where interactions between cellular and acellular components, surrounding the tumor, play a crucial role in disease development and progression. Despite significant progress in cancer research, the mechanism driving tumor growth and therapeutic outcomes remains elusive. Two-dimensional (2D) cell culture assays and in vivo animal models are commonly used in cancer research and therapeutic testing. However, these models suffer from numerous shortcomings including lack of key fea...
Source: Biomaterials - December 26, 2023 Category: Materials Science Authors: Kalpana Ravi Twinkle Jina Minette Manoharan Kuei-Chun Wang Barbara Pockaj Mehdi Nikkhah Source Type: research

Boosting the synergism between cancer ferroptosis and immunotherapy via targeted stimuli-responsive liposomes
Biomaterials. 2023 Dec 20;305:122442. doi: 10.1016/j.biomaterials.2023.122442. Online ahead of print.ABSTRACTBoth ferroptotic therapy and immunotherapy have been widely employed in cancer treatment. However, ferroptotic cell death fails to induce dendritic cells maturation, which limits the therapeutic outcome of ferroptotic cancer therapy. To address this, the current work reports a tailored liposome to establish a positive loop between ferroptotic therapy and immunotherapy. As the key component of liposome, a unique phospholipid is designed to bear two arachidonic acid tails. The liposome is further surface-engineered wi...
Source: Biomaterials - December 24, 2023 Category: Materials Science Authors: Zhuoya Gao Jiarong Zhang Yingchao Hou Jinjin Lu Jing Liang Yufeng Gao Boqi Li Shuai Gao Yanjun Zhao Min Gao Jinghua Chen Source Type: research

Passivation protein-adhesion platform promoting stent reendothelialization using two-electron-assisted oxidation of polyphenols
Biomaterials. 2023 Dec 16;305:122423. doi: 10.1016/j.biomaterials.2023.122423. Online ahead of print.ABSTRACTSuperhydrophilic surfaces play an important role in nature. Inspired by this, scientists have designed various superhydrophilic materials that are widely used in the field of biomaterials, such as PEG molecular brushes and zwitterionic materials. However, superhydrophilic coatings with only anti-fouling properties do not satisfy the requirements for rapid reendothelialization of cardiovascular stent surfaces. Herein, a novel polyphenol superhydrophilic surface with passivated protein-adsorption properties was develo...
Source: Biomaterials - December 24, 2023 Category: Materials Science Authors: Linhua Li Chunle Zhang Zhengjiang Cao Liang Ma Chang Liu Xiaorong Lan Chao Qu Ping Fu Rifang Luo Yunbing Wang Source Type: research

A programmable releasing versatile hydrogel platform boosts systemic immune responses via sculpting tumor immunogenicity and reversing tolerogenic dendritic cells
In conclusion, this study focuses on ICD-mediated tumor immunogenicity sculpture and nucleic acid endocytosis-involved tolerogenic DCs reversal, providing a novel paradigm for enhancing DCs-based antitumor immune responses.PMID:38142471 | DOI:10.1016/j.biomaterials.2023.122444 (Source: Biomaterials)
Source: Biomaterials - December 24, 2023 Category: Materials Science Authors: Wangxian Fu Xinchao Li Yingjie Li Rui Luo Chunqing Ou Dongxue Huang Xiuqi Liang Yanjie You Qinjie Wu Changyang Gong Source Type: research

Boosting the synergism between cancer ferroptosis and immunotherapy via targeted stimuli-responsive liposomes
Biomaterials. 2023 Dec 20;305:122442. doi: 10.1016/j.biomaterials.2023.122442. Online ahead of print.ABSTRACTBoth ferroptotic therapy and immunotherapy have been widely employed in cancer treatment. However, ferroptotic cell death fails to induce dendritic cells maturation, which limits the therapeutic outcome of ferroptotic cancer therapy. To address this, the current work reports a tailored liposome to establish a positive loop between ferroptotic therapy and immunotherapy. As the key component of liposome, a unique phospholipid is designed to bear two arachidonic acid tails. The liposome is further surface-engineered wi...
Source: Biomaterials - December 24, 2023 Category: Materials Science Authors: Zhuoya Gao Jiarong Zhang Yingchao Hou Jinjin Lu Jing Liang Yufeng Gao Boqi Li Shuai Gao Yanjun Zhao Min Gao Jinghua Chen Source Type: research

Passivation protein-adhesion platform promoting stent reendothelialization using two-electron-assisted oxidation of polyphenols
Biomaterials. 2023 Dec 16;305:122423. doi: 10.1016/j.biomaterials.2023.122423. Online ahead of print.ABSTRACTSuperhydrophilic surfaces play an important role in nature. Inspired by this, scientists have designed various superhydrophilic materials that are widely used in the field of biomaterials, such as PEG molecular brushes and zwitterionic materials. However, superhydrophilic coatings with only anti-fouling properties do not satisfy the requirements for rapid reendothelialization of cardiovascular stent surfaces. Herein, a novel polyphenol superhydrophilic surface with passivated protein-adsorption properties was develo...
Source: Biomaterials - December 24, 2023 Category: Materials Science Authors: Linhua Li Chunle Zhang Zhengjiang Cao Liang Ma Chang Liu Xiaorong Lan Chao Qu Ping Fu Rifang Luo Yunbing Wang Source Type: research

A programmable releasing versatile hydrogel platform boosts systemic immune responses via sculpting tumor immunogenicity and reversing tolerogenic dendritic cells
In conclusion, this study focuses on ICD-mediated tumor immunogenicity sculpture and nucleic acid endocytosis-involved tolerogenic DCs reversal, providing a novel paradigm for enhancing DCs-based antitumor immune responses.PMID:38142471 | DOI:10.1016/j.biomaterials.2023.122444 (Source: Biomaterials)
Source: Biomaterials - December 24, 2023 Category: Materials Science Authors: Wangxian Fu Xinchao Li Yingjie Li Rui Luo Chunqing Ou Dongxue Huang Xiuqi Liang Yanjie You Qinjie Wu Changyang Gong Source Type: research

Nanocodelivery of an NIR photothermal agent and an acid-responsive TLR7 agonist prodrug to enhance cancer photothermal immunotherapy and the abscopal effect
Biomaterials. 2023 Dec 17;305:122434. doi: 10.1016/j.biomaterials.2023.122434. Online ahead of print.ABSTRACTThe immunosuppressive tumor microenvironment (TME) greatly limits the actual outcome of immunotherapy. Therefore, it is urgent to develop appropriate strategies to reshape the TME and ultimately induce a strong immune response. Here, we developed a dual-functional liposome loaded with the photothermal agent IR808 near the infrared region (NIR) and Toll-like-receptor-7 (TLR7) agonist loxoribine prodrug (Lipo@IR808@Loxo) to achieve NIR light-triggered photothermal therapy (PTT) and the targeted delivery of immune adju...
Source: Biomaterials - December 23, 2023 Category: Materials Science Authors: Bo Chen Ruijie Huang Wei Zeng Wei Wang Yuanzeng Min Source Type: research

Nanocodelivery of an NIR photothermal agent and an acid-responsive TLR7 agonist prodrug to enhance cancer photothermal immunotherapy and the abscopal effect
Biomaterials. 2023 Dec 17;305:122434. doi: 10.1016/j.biomaterials.2023.122434. Online ahead of print.ABSTRACTThe immunosuppressive tumor microenvironment (TME) greatly limits the actual outcome of immunotherapy. Therefore, it is urgent to develop appropriate strategies to reshape the TME and ultimately induce a strong immune response. Here, we developed a dual-functional liposome loaded with the photothermal agent IR808 near the infrared region (NIR) and Toll-like-receptor-7 (TLR7) agonist loxoribine prodrug (Lipo@IR808@Loxo) to achieve NIR light-triggered photothermal therapy (PTT) and the targeted delivery of immune adju...
Source: Biomaterials - December 23, 2023 Category: Materials Science Authors: Bo Chen Ruijie Huang Wei Zeng Wei Wang Yuanzeng Min Source Type: research