iPSCs ameliorate hypoxia-induced autophagy and atrophy in C2C12 myotubes via the AMPK/ULK1 pathway
Duchenne muscular dystrophy (DMD) is an X-linked lethal genetic disorder for which there is no effective treatment. Previous studies have shown that stem cell transplantation into mdx mice can promote muscle r... (Source: Biological Research)
Source: Biological Research - June 3, 2023 Category: Biomedical Science Authors: Haimei Cen, Pin Fan, Yuting Ding, Bin Luo, Hong Luo, Menglong Chen and Yu Zhang Tags: Research article Source Type: research
Ursodeoxycholic acid induces sarcopenia associated with decreased protein synthesis and autophagic flux
Skeletal muscle generates force and movements and maintains posture. Under pathological conditions, muscle fibers suffer an imbalance in protein synthesis/degradation. This event causes muscle mass loss and de... (Source: Biological Research)
Source: Biological Research - May 27, 2023 Category: Biomedical Science Authors: Josu é Orozco-Aguilar, Franco Tacchi, Francisco Aguirre, Mayalen Valero-Breton, Mauricio Castro-Sepulveda, Felipe Simon and Claudio Cabello-Verrugio Tags: Research article Source Type: research
Neuroprotective effects of the PPAR β/δ antagonist GSK0660 in in vitro and in vivo Parkinson’s disease models
The underlying mechanism of Parkinson ’s disease are still unidentified, but excitotoxicity, oxidative stress, and neuroinflammation are considered key actors. Proliferator activated receptors (PPARs) are trans... (Source: Biological Research)
Source: Biological Research - May 25, 2023 Category: Biomedical Science Authors: Andrea Antonosante, Vanessa Castelli, Martina Sette, Margherita Alfonsetti, Mariano Catanesi, Elisabetta Benedetti, Matteo Ardini, Annamaria Cimini and Michele d ’Angelo Tags: Research article Source Type: research
Electroacupuncture inhibits dendritic spine remodeling through the srGAP3-Rac1 signaling pathway in rats with SNL
Previous studies have shown that peripheral nerve injury can lead to abnormal dendritic spine remodeling in spinal dorsal horn neurons. Inhibition of abnormal dendritic spine remodeling can relieve neuropathic... (Source: Biological Research)
Source: Biological Research - May 22, 2023 Category: Biomedical Science Authors: Qiaoyun Wu, Chenchen Cai, Xinwang Ying, Yujun Zheng, Jiaying Yu, Xiaoxue Gu, Wenzhan Tu, Xinfa Lou, Guanhu Yang, Ming Li and Songhe Jiang Tags: Research article Source Type: research
Activation of a hypothalamus-habenula circuit by mechanical stimulation inhibits cocaine addiction-like behaviors
Mechanoreceptor activation modulates GABA neuron firing and dopamine (DA) release in the mesolimbic DA system, an area implicated in reward and substance abuse. The lateral habenula (LHb), the lateral hypothal... (Source: Biological Research)
Source: Biological Research - May 17, 2023 Category: Biomedical Science Authors: Han Byeol Jang, DanBi Ahn, Suchan Chang, Hyung Kyu Kim, Bong Hyo Lee, Sang Chan Kim, Scott C. Steffensen, Kyle B. Bills, Hubert Lee and Hee Young Kim Tags: Research article Source Type: research
Correction: Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis
(Source: Biological Research)
Source: Biological Research - May 11, 2023 Category: Biomedical Science Authors: Ivanka Jim énez-Dinamarca, Yolanda Prado, Pablo Tapia, Sebastian Gatica, Clemens Alt, Charles P. Lin, Cristian Reyes-Martínez, Carmen G. Feijóo, Cristobal Aravena, Alejandra González-Canacer, Simón Correa, Diego Varela, Claudio Cabello-Verrugio and F Tags: Correction Source Type: research
Maintenance of chronicity signatures in fibroblasts isolated from recessive dystrophic epidermolysis bullosa chronic wound dressings under culture conditions
Recessive Dystrophic Epidermolysis Bullosa (RDEB) is a rare inherited skin disease caused by variants in the COL7A1 gene, coding for type VII collagen (C7), an important component of anchoring fibrils in the base... (Source: Biological Research)
Source: Biological Research - May 10, 2023 Category: Biomedical Science Authors: Cristian De Gregorio, Evelyng Catal án, Gabriel Garrido, Pilar Morandé, Jimena Castillo Bennett, Catalina Muñoz, Glenda Cofré, Ya-Lin Huang, Bárbara Cuadra, Paola Murgas, Margarita Calvo, Fernando Altermatt, María Joao Yubero, Francis Palisson, Andr Tags: Research article Source Type: research
Conformational characterization of the mammalian-expressed SARS-CoV-2 recombinant receptor binding domain, a COVID-19 vaccine
The COVID-19 pandemic has caused a large number of diseases worldwide. There are few vaccines to constrain this disease and the value of them is high. In this sense, the antigens of the vaccine platform Sobera... (Source: Biological Research)
Source: Biological Research - May 8, 2023 Category: Biomedical Science Authors: Leina Moro-P érez, Tammy Boggiano-Ayo, Sum Lai Lozada-Chang, Olga Lidia Fernández-Saiz, Kathya Rashida de la Luz and Jose Alberto Gómez-Pérez Tags: Research article Source Type: research
Propofol inhibits myocardial injury induced by microvesicles derived from hypoxia-reoxygenated endothelial cells via lncCCT4-2/CCT4 signaling
Ischemia-reperfusion (IR) induces increased release of extracellular vesicles in the heart and exacerbates myocardial IR injury. We have previously shown that propofol attenuates hypoxia/reoxygenation (HR)-ind... (Source: Biological Research)
Source: Biological Research - May 5, 2023 Category: Biomedical Science Authors: Xiaojun Zhang, Changsen Wang, Hao Xu, Shuyun Cai, Keyu Liu, Simeng Li, Linming Chen, Siman Shen, Xiaoxia Gu, Jing Tang, Zhengyuan Xia, Zhe Hu, Xiaotang Ma and Liangqing Zhang Tags: Research article Source Type: research
NEDD4-1 deficiency impairs satellite cell function during skeletal muscle regeneration
Satellite cells are tissue-specific stem cells primarily responsible for the regenerative capacity of skeletal muscle. Satellite cell function and maintenance are regulated by extrinsic and intrinsic mechanism... (Source: Biological Research)
Source: Biological Research - May 5, 2023 Category: Biomedical Science Authors: Felipe Cabezas, Claudio Cabello-Verrugio, Natalia Gonz ález, Jeremy Salas, Manuel J. Ramírez, Eduardo de la Vega and Hugo C. Olguín Tags: Research article Source Type: research
Zebrafish ambra1b knockout reveals a novel role for Ambra1 in primordial germ cells survival, sex differentiation and reproduction
AMBRA1 is an intrinsically disordered protein, working as a scaffold molecule to coordinate, by protein-protein interaction, many cellular processes, including autophagy, mitophagy, apoptosis and cell cycle pr... (Source: Biological Research)
Source: Biological Research - April 28, 2023 Category: Biomedical Science Authors: Camilla Maria Fontana, Francesca Terrin, Nicola Facchinello, Giacomo Meneghetti, Alberto Dinarello, Lisa Gambarotto, Annalisa Zuccarotto, Micol Caichiolo, Ginevra Brocca, Ranieri Verin, Francesca Nazio, Oliana Carnevali, Francesco Cecconi, Paolo Bonaldo a Tags: Research article Source Type: research
In situ isolation of nuclei or nuclear proteins from adherent cells: a simple, effective method with less cytoplasmic contamination
Isolation of nuclei or nuclear proteins is a prerequisite for western blot, nuclear proteome profiling, and other evaluations of nuclear proteins. Here, we developed a simple method for in situ isolation of nu... (Source: Biological Research)
Source: Biological Research - April 21, 2023 Category: Biomedical Science Authors: Ying Qin, Yun Zhou, Kun Wang, Jiaxuan Gu, Zhihao Xiong, Wendiao Zhang and Yong Chen Tags: Research article Source Type: research
Spontaneous spheroids from alveolar bone-derived mesenchymal stromal cells maintain pluripotency of stem cells by regulating hypoxia-inducible factors
The objectives of this study are to investigate the pluripotency and d... (Source: Biological Research)
Source: Biological Research - April 5, 2023 Category: Biomedical Science Authors: Ni Li, Xiaofeng Dai, Fei Yang, Yang Sun, Xingwen Wu, Qianrong Zhou, Kai Chen, Jian Sun, Wei Bi, Le Shi and Youcheng Yu Tags: Research article Source Type: research
Enrichment of miR-17-5p enhances the protective effects of EPC-EXs on vascular and skeletal muscle injury in a diabetic hind limb ischemia model
Diabetes mellitus (DM) is highly susceptible to diabetic hind limb ischemia (DHI). MicroRNA (MiR)-17-5p is downregulated in DM and plays a key role in vascular protection. Endothelial progenitor cell (EPC)-rel... (Source: Biological Research)
Source: Biological Research - April 1, 2023 Category: Biomedical Science Authors: Qunwen Pan, Xiaobing Xu, Wen He, Yan Wang, Zhi Xiang, Xiaojuan Jin, Qiong Tang, Ting Zhao and Xiaotang Ma Tags: Research article Source Type: research
Spleen regeneration after subcutaneous heterotopic autotransplantation in a mouse model
Splenectomy may lead to severe postoperative complications, including sepsis and cancers. A possible solution to this problem is heterotopic autotransplantation of the spleen. Splenic autografts rapidly restor... (Source: Biological Research)
Source: Biological Research - March 29, 2023 Category: Biomedical Science Authors: Andrey Elchaninov, Polina Vishnyakova, Anastasiya Lokhonina, Viktoria Kiseleva, Egor Menyailo, Maria Antonova, Aiaz Mamedov, Irina Arutyunyan, Galina Bolshakova, Dmitry Goldshtein, Xuhui Bao, Timur Fatkhudinov and Gennady Sukhikh Tags: Research article Source Type: research
