Deciphering the functional role of EGR1 in Prostaglandin F2 alpha induced luteal regression applying CRISPR in corpus luteum of buffalo
PGF2 α is essential for the induction of the corpus luteum regression which in turn reduces progesterone production. Early growth response (EGR) proteins are Cys2-His2-type zinc-finger transcription factor that... (Source: Biological Research)
Source: Biological Research - March 12, 2021 Category: Biomedical Science Authors: Meeti Punetha, Sai Kumar, Avishek Paul, Bosco Jose, Jaya Bharati, Arvind Sonwane, Jonathan A. Green, Kristin Whitworth and Mihir Sarkar Tags: Research article Source Type: research
LncRNA MALAT1 aggravates oxygen ‐glucose deprivation/reoxygenation-induced neuronal endoplasmic reticulum stress and apoptosis via the miR-195a-5p/HMGA1 axis
This study aimed to investigate the potential role and molecular mechanism of lncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) in cerebral ischemia/reperfusion injury. (Source: Biological Research)
Source: Biological Research - March 9, 2021 Category: Biomedical Science Authors: Ying Jia, Lian Yi, Qianqian Li, Tingjiao Liu and Shanshan Yang Tags: Research article Source Type: research
Lotus leaf flavonoids induce apoptosis of human lung cancer A549 cells through the ROS/p38 MAPK pathway
Leaves of the natural plant lotus are used in traditional Chinese medicine and tea production. They are rich in flavonoids. (Source: Biological Research)
Source: Biological Research - March 2, 2021 Category: Biomedical Science Authors: Xiang-Bo Jia, Quan Zhang, Lei Xu, Wen-Jian Yao and Li Wei Tags: Research article Source Type: research
Degradation of mitochondrial structure and deficiency of complex I were associated with the transgenic CMS of rice
Mitochondria play a significant role in plant cytoplasmic male sterility (CMS). In our previous study, mitochondrial complex I genes, nad4, nad5, and nad7 showed polymorphisms between the transgenic CMS line M2BS... (Source: Biological Research)
Source: Biological Research - February 22, 2021 Category: Biomedical Science Authors: Danfeng Tang, Fan Wei, Aziz Khan, Fazal Munsif and Ruiyang Zhou Tags: Research article Source Type: research
Exo70 intracellular redistribution after repeated mild traumatic brain injury
Exo70 is a subunit of the greater exocyst complex, a collection of proteins that oversees cellular membrane addition and polarized exocytosis by acting as a tethering intermediate between the plasma membrane a... (Source: Biological Research)
Source: Biological Research - February 16, 2021 Category: Biomedical Science Authors: Mat ías Lira, Pedro Zamorano and Waldo Cerpa Tags: Research article Source Type: research
Proteome profiling of different rat brain regions reveals the modulatory effect of prolonged maternal separation on proteins involved in cell death-related processes
Early-life stress in the form of maternal separation can be associated with alterations in offspring neurodevelopment and brain functioning. Here, we aimed to investigate the potential impact of prolonged mate... (Source: Biological Research)
Source: Biological Research - February 8, 2021 Category: Biomedical Science Authors: Zdenka Drastichova, Vladimir Rudajev, Gergely Pallag and Jiri Novotny Tags: Research article Source Type: research
Testosterone activates glucose metabolism through AMPK and androgen signaling in cardiomyocyte hypertrophy
Testosterone regulates nutrient and energy balance to maintain protein synthesis and metabolism in cardiomyocytes, but supraphysiological concentrations induce cardiac hypertrophy. Previously, we determined th... (Source: Biological Research)
Source: Biological Research - February 5, 2021 Category: Biomedical Science Authors: Mayarling Francisca Troncoso, Mario Pavez, Carlos Wilson, Daniel Lagos, Javier Duran, Sebasti án Ramos, Genaro Barrientos, Patricio Silva, Paola Llanos, Carla Basualto-Alarcón, B. Daan Westenbrink, Sergio Lavandero and Manuel Estrada Tags: Research article Source Type: research
Influence of kaolin application on most important fruit and leaf characteristics of two apple cultivars under sustained deficit irrigation
Apple is one of the oldest and most valuable fruits. Water restriction is one of the major problems in the production of this fruit in some planting areas. (Source: Biological Research)
Source: Biological Research - January 6, 2021 Category: Biomedical Science Authors: Somayeh Faghih, Zabihollah Zamani, Reza Fatahi and Mohammad Omidi Tags: Research article Source Type: research
Low-temperature extracts of Purple blossoms of basil (Ocimum basilicum L.) intervened mitochondrial translocation contributes prompted apoptosis in human breast cancer cells
This study aimed to validate the impact of dark purple blossoms of basil (Ocimum basilicum L.) aqueous ex... (Source: Biological Research)
Source: Biological Research - January 6, 2021 Category: Biomedical Science Authors: Mariam Abdulaziz Alkhateeb, Wedad Refaiea Al-Otaibi, Qwait AlGabbani, Amena Ali Alsakran, Alaa Ahmed Alnafjan, Amani Mohammed Alotaibi and Wedad Saeed Al-Qahtani Tags: Research article Source Type: research
Tauroursodeoxycholic acid attenuates neuronal apoptosis via the TGR5/ SIRT3 pathway after subarachnoid hemorrhage in rats
This study investigated the roles of Tauroursodeoxycholic acid (TUDCA) in attenuate neur... (Source: Biological Research)
Source: Biological Research - December 1, 2020 Category: Biomedical Science Authors: Huihui Wu, Nini Yu, Xia Wang, Yina Yang and Hui Liang Tags: Research article Source Type: research
Actin filaments mediated root growth inhibition by changing their distribution under UV-B and hydrogen peroxide exposure in Arabidopsis
UV-B signaling in plants is mediated by UVR8, which interacts with transcriptional factors to induce root morphogenesis. However, research on the downstream molecules of UVR8 signaling in roots is still scarce... (Source: Biological Research)
Source: Biological Research - November 23, 2020 Category: Biomedical Science Authors: Meiting Du, Yanhong Wang, Huize Chen and Rong Han Tags: Research article Source Type: research
Improvement of endothelial function by Gunnera tinctoria extract with antioxidant properties
Gunnera tinctoria has been collected by Mapuche-Pewenche people for food and medicinal purposes. The high polyphenol content of methanolic extract from G. tinctoria leaves with chemical constituents such as ellag... (Source: Biological Research)
Source: Biological Research - November 23, 2020 Category: Biomedical Science Authors: Constanza Sabando, Mait é Rodríguez-Díaz, Walther Ide, Edgar Pastene, Marcia Avello, Mario Simirgiotis, Susana Rojas, Enrique Villarroel, Tiare Silva-Grecchi, Cristian Gutiérrez, Rebeca Bouza, Bárbara Cicchelli, Marcelo González and Saddys Rodrígue Tags: Research article Source Type: research
Knockdown of lncRNA TUG1 inhibits hippocampal neuronal apoptosis and participates in aerobic exercise-alleviated vascular cognitive impairment
Our previous study indicated that aerobic exercise relieves cognitive impairment in patients with vascular cognitive impairment (VCI) via regulating brain-derived neurotrophic factor (BDNF), but the mechanism ... (Source: Biological Research)
Source: Biological Research - November 19, 2020 Category: Biomedical Science Authors: Jing Wang, Yali Niu, Huaying Tao, Mina Xue and Chunxiao Wan Tags: Research article Source Type: research
Caspase-7 deficiency in Chinese hamster ovary cells reduces cell proliferation and viability
Chinese hamster ovary (CHO) cells are the most commonly used mammalian host cell in the commercial-scale production of biopharmaceutical proteins. Modification of genes involved in apoptosis may improve the pr... (Source: Biological Research)
Source: Biological Research - November 13, 2020 Category: Biomedical Science Authors: Fatemeh Safari, Safar Farajnia, Abbas Behzad Behbahani, Habib Zarredar, Mazyar Barekati-Mowahed and Hesam Dehghani Tags: Research article Source Type: research
Short-term perinatal oxygen exposure may impair lung development in adult mice
Hyperoxia at resuscitation increases oxidative stress, and even brief exposure to high oxygen concentrations during stabilization may trigger organ injury with adverse long-term outcomes in premature infants. ... (Source: Biological Research)
Source: Biological Research - November 10, 2020 Category: Biomedical Science Authors: Vasantha H. S. Kumar, Huamei Wang and Lori Nielsen Tags: Research article Source Type: research
