Development of synthetic modulator enabling long-term propagation and neurogenesis of human embryonic stem cell-derived neural progenitor cells
Neural progenitor cells (NPCs) are essential for in vitro drug screening and cell-based therapies for brain-related disorders, necessitating well-defined and reproducible culture systems. Current strategies em... (Source: Biological Research)
Source: Biological Research - November 11, 2023 Category: Biomedical Science Authors: Ceheng Liao, Ying Guan, Jihui Zheng, Xue Wang, Meixia Wang, Zhouhai Zhu, Qiyuan Peng, Hong-Hui Wang and Meng Li Tags: Research article Source Type: research
Heat-responsive microRNAs participate in regulating the pollen fertility stability of CMS-D2 restorer line under high-temperature stress
Anther development and pollen fertility of cytoplasmic male sterility (CMS) conditioned by Gossypium harknessii cytoplasm (CMS-D2) restorer lines are susceptible to continuous high-temperature (HT) stress in sum... (Source: Biological Research)
Source: Biological Research - November 9, 2023 Category: Biomedical Science Authors: Meng Zhang, Xuexian Zhang, Ruijie Wang, Rong Zang, Liping Guo, Tingxiang Qi, Huini Tang, Liangliang Chen, Hailin Wang, Xiuqin Qiao, Jianyong Wu and Chaozhu Xing Tags: Research article Source Type: research
Chemogenetic inhibition of NTS astrocytes normalizes cardiac autonomic control and ameliorate hypertension during chronic intermittent hypoxia
Obstructive sleep apnea (OSA) is characterized by recurrent episodes of chronic intermittent hypoxia (CIH), which has been linked to the development of sympathoexcitation and hypertension. Furthermore, it has ... (Source: Biological Research)
Source: Biological Research - November 6, 2023 Category: Biomedical Science Authors: Katherin Pereyra, Alexandra Las Heras, Camilo Toledo, Esteban D íaz-Jara, Rodrigo Iturriaga and Rodrigo Del Rio Tags: Short report Source Type: research
The effect of zofenopril on the cardiovascular system of spontaneously hypertensive rats treated with the ACE2 inhibitor MLN-4760
Angiotensin converting enzyme 2 (ACE2) plays a crucial role in the infection cycle of SARS-CoV-2 responsible for formation of COVID-19 pandemic. In the cardiovascular system, the virus enters the cells by bind... (Source: Biological Research)
Source: Biological Research - October 25, 2023 Category: Biomedical Science Authors: Sona Cacanyiova, Martina Cebova, Fedor Simko, Tomas Baka, Iveta Bernatova, Michal Kluknavsky, Stefan Zorad, Katarina Krskova, Ezgi Shaman, Anna Zemancikova, Andrej Barta, Basak G. Aydemir and Andrea Berenyiova Tags: Research article Source Type: research
SARS-CoV-2 spike protein S1 activates Cx43 hemichannels and disturbs intracellular Ca2+ dynamics
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the ongoing coronavirus disease 2019 (COVID-19). An aspect of high uncertainty is whether the SARS-CoV-2 per se or the systemic inflammation ... (Source: Biological Research)
Source: Biological Research - October 25, 2023 Category: Biomedical Science Authors: Juan Prieto-Villalobos, Claudia M. Lucero, Maximiliano Rovegno, Gonzalo I. G ómez, Mauricio A. Retamal and Juan A. Orellana Tags: Research article Source Type: research
An intracellular, non-oxidative factor activates in vitro chromatin fragmentation in pig sperm
In vitro incubation of epididymal and vas deferens sperm with Mn2+ induces Sperm Chromatin Fragmentation (SCF), a mechanism that causes double-stranded breaks in toroid-linker regions (TLRs). Whether this mechani... (Source: Biological Research)
Source: Biological Research - October 24, 2023 Category: Biomedical Science Authors: Estel Vi ñolas-Vergés, Marc Yeste, Ferran Garriga, Sergi Bonet, Yentel Mateo-Otero and Jordi Ribas-Maynou Tags: Research article Source Type: research
Two murine models of sepsis: immunopathological differences between the sexes —possible role of TGFβ1 in female resistance to endotoxemia
Endotoxic shock (ExSh) and cecal ligature and puncture (CLP) are models that induce sepsis. In this work, we investigated early immunologic and histopathologic changes induced by ExSh or CLP models in female a... (Source: Biological Research)
Source: Biological Research - October 24, 2023 Category: Biomedical Science Authors: Rafael Bojalil, Armando Ru íz-Hernández, Arturo Villanueva-Arias, Luis Manuel Amezcua-Guerra, Sergio Cásarez-Alvarado, Ana María Hernández-Dueñas, Verónica Rodríguez-Galicia, Lenin Pavón, Brenda Marquina, Enrique Becerril-Villanueva, Rogelio Hern Tags: Research article Source Type: research
Focal ischemic stroke modifies microglia-derived exosomal miRNAs: potential role of mir-212-5p in neuronal protection and functional recovery
Ischemic stroke is a severe type of stroke with high disability and mortality rates. In recent years, microglial exosome-derived miRNAs have been shown to be promising candidates for the treatment of ischemic ... (Source: Biological Research)
Source: Biological Research - October 3, 2023 Category: Biomedical Science Authors: Si-si Li, Jia-jia Wu, Xiang-xin Xing, Yu-lin Li, Jie Ma, Yu-jie Duan, Jun-peng Zhang, Chun-lei Shan, Xu-yun Hua, Mou-xiong Zheng and Jian-guang Xu Tags: Research article Source Type: research
S-Nitrosylation in endothelial cells contributes to tumor cell adhesion and extravasation during breast cancer metastasis
Nitric oxide is produced by different nitric oxide synthases isoforms. NO activates two signaling pathways, one dependent on soluble guanylate cyclase and protein kinase G, and other where NO post-translationa... (Source: Biological Research)
Source: Biological Research - September 29, 2023 Category: Biomedical Science Authors: T. Koning, F. Cordova, G. Aguilar, J. Sarmiento, G. A. Mardones, M. Boric, M. Varas-Godoy, A. Lladser, W. N. Duran, P. Ehrenfeld and F. A. Sanchez Tags: Research article Source Type: research
Identifying pyroptosis- and inflammation-related genes in intracranial aneurysms based on bioinformatics analysis
Intracranial aneurysm (IA) is the most common cerebrovascular disease, and subarachnoid hemorrhage caused by its rupture can seriously impede nerve function. Pyroptosis is an inflammatory mode of cell death wh... (Source: Biological Research)
Source: Biological Research - September 27, 2023 Category: Biomedical Science Authors: Donglin Zhou, Yimin Zhu, Peng Jiang, Tongfu Zhang, Jianfeng Zhuang, Tao Li, Linzeng Qi and Yunyan Wang Tags: Research article Source Type: research
Drosophila Atlastin regulates synaptic vesicle mobilization independent of bone morphogenetic protein signaling
The endoplasmic reticulum (ER) contacts endosomes in all parts of a motor neuron, including the axon and presynaptic terminal, to move structural proteins, proteins that send signals, and lipids over long dist... (Source: Biological Research)
Source: Biological Research - September 14, 2023 Category: Biomedical Science Authors: Francisca Bertin, Jorge Jara-Wilde, Benedikt Auer, Andr és Köhler-Solís, Carolina González-Silva, Ulrich Thomas and Jimena Sierralta Tags: Research article Source Type: research
Mucin1 induced trophoblast dysfunction in gestational diabetes mellitus via Wnt/ β-catenin pathway
To elucidate the role of Mucin1 (MUC1) in the trophoblast function (glucose uptake and apoptosis) of gestational diabetes mellitus (GDM) women through the Wnt/ β-catenin pathway. (Source: Biological Research)
Source: Biological Research - August 22, 2023 Category: Biomedical Science Authors: Shuang-Shuang Cui, Ping Zhang, Lu Sun, Yu-Lin-Lan Yuan, Jingyun Wang, Feng-Xiang Zhang and Ruiman Li Tags: Research article Source Type: research
Exploring the Neandertal legacy of pancreatic ductal adenocarcinoma risk in Eurasians
The genomes of present-day non-Africans are composed of 1 –3% of Neandertal-derived DNA as a consequence of admixture events between Neandertals and anatomically modern humans about 50–60 thousand years ago. Ne... (Source: Biological Research)
Source: Biological Research - August 13, 2023 Category: Biomedical Science Authors: Margherita Piccardi, Manuel Gentiluomo, Stefania Bertoncini, Raffaele Pezzilli, B álint Erőss, Stefania Bunduc, Faik G. Uzunoglu, Renata Talar-Wojnarowska, Tomas Vanagas, Cosimo Sperti, Martin Oliverius, Mateus Nóbrega Aoki, Stefano Ermini, Tamás Huss Tags: Research article Source Type: research
Human umbilical cord mesenchymal stem cells (hUC-MSCs) alleviate paclitaxel-induced spermatogenesis defects and maintain male fertility
Chemotherapeutic drugs can cause reproductive damage by affecting sperm quality and other aspects of male fertility. Stem cells are thought to alleviate the damage caused by chemotherapy drugs and to play role... (Source: Biological Research)
Source: Biological Research - August 13, 2023 Category: Biomedical Science Authors: YuSheng Zhang, YaNan Liu, Zi Teng, ZeLin Wang, Peng Zhu, ZhiXin Wang, FuJun Liu and XueXia Liu Tags: Research article Source Type: research
Identification and analysis of key hypoxia- and immune-related genes in hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM), an autosomal dominant genetic disease, is the main cause of sudden death in adolescents and athletes globally. Hypoxia and immune factors have been revealed to be related to ... (Source: Biological Research)
Source: Biological Research - August 9, 2023 Category: Biomedical Science Authors: Haozhen Yu, Lanxin Gu, Linfang Du, Zhao Dong, Zhuang Li, Mujun Yu, Yue Yin, Yishi Wang, Lu Yu and Heng Ma Tags: Research article Source Type: research
