Carbapenem-resistant hypervirulent ST23 Klebsiella pneumoniae with a highly transmissible dual-carbapenemase plasmid in Chile
The convergence of hypervirulence and carbapenem resistance in the bacterial pathogen Klebsiella pneumoniae represents a critical global health concern. Hypervirulent K. pneumoniae (hvKp) strains, frequently from... (Source: Biological Research)
Source: Biological Research - March 12, 2024 Category: Biomedical Science Authors: Mat ías Gálvez-Silva, Patricio Arros, Camilo Berríos-Pastén, Aura Villamil, Paula I. Rodas, Ingrid Araya, Rodrigo Iglesias, Pamela Araya, Juan C. Hormazábal, Constanza Bohle, Yahua Chen, Yunn-Hwen Gan, Francisco P. Chávez, Rosalba Lagos and Andrés Tags: Short report Source Type: research
Endometrial mesenchymal stromal/stem cells improve regeneration of injured endometrium in mice
The monthly regeneration of human endometrial tissue is maintained by the presence of human endometrial mesenchymal stromal/stem cells (eMSC), a cell population co-expressing the perivascular markers CD140b an... (Source: Biological Research)
Source: Biological Research - February 13, 2024 Category: Biomedical Science Authors: Tianqi Li, Rachel W.S. Chan, Raymond H.W. Li, Ernest H.Y. Ng, Songying Zhang and William S.B. Yeung Tags: Research article Source Type: research
Embryo development is impaired by sperm mitochondrial-derived ROS
Basal energetic metabolism in sperm, particularly oxidative phosphorylation, is known to condition not only their oocyte fertilising ability, but also the subsequent embryo development. While the molecular pat... (Source: Biological Research)
Source: Biological Research - January 30, 2024 Category: Biomedical Science Authors: Yentel Mateo-Otero, Marc Llavanera, Marc Torres-Garrido and Marc Yeste Tags: Research article Source Type: research
Fibroblasts inhibit osteogenesis by regulating nuclear-cytoplasmic shuttling of YAP in mesenchymal stem cells and secreting DKK1
Fibrous scars frequently form at the sites of bone nonunion when attempts to repair bone fractures have failed. However, the detailed mechanism by which fibroblasts, which are the main components of fibrous sc... (Source: Biological Research)
Source: Biological Research - January 20, 2024 Category: Biomedical Science Authors: Fei Huang, Guozhen Wei, Hai Wang, Ying Zhang, Wenbin Lan, Yun Xie and Gui Wu Tags: Research article Source Type: research
MSC-derived exosomes protect auditory hair cells from neomycin-induced damage via autophagy regulation
Sensorineural hearing loss (SNHL) poses a major threat to both physical and mental health; however, there is still a lack of effective drugs to treat the disease. Recently, novel biological therapies, such as ... (Source: Biological Research)
Source: Biological Research - January 13, 2024 Category: Biomedical Science Authors: Huan Liu, Huijuan Kuang, Yiru Wang, Lili Bao, Wanxin Cao, Lu Yu, Meihao Qi, Renfeng Wang, Xiaoshan Yang, Qingyuan Ye, Feng Ding, Lili Ren, Siying Liu, Furong Ma and Shiyu Liu Tags: Research article Source Type: research
Alpha-synuclein dynamics bridge Type-I Interferon response and SARS-CoV-2 replication in peripheral cells
Increasing evidence suggests a double-faceted role of alpha-synuclein ( α-syn) following infection by a variety of viruses, including SARS-CoV-2. Although α-syn accumulation is known to contribute to cell toxic... (Source: Biological Research)
Source: Biological Research - January 9, 2024 Category: Biomedical Science Authors: Fiona Limanaqi, Silvia Zecchini, Irma Saulle, Sergio Strizzi, Claudia Vanetti, Micaela Garziano, Gioia Cappelletti, Debora Parolin, Sonia Caccia, Daria Trabattoni, Claudio Fenizia, Mario Clerici and Mara Biasin Tags: Research article Source Type: research
Lactadherin immunoblockade in small extracellular vesicles inhibits sEV-mediated increase of pro-metastatic capacities
Tumor-derived small extracellular vesicles (sEVs) can promote tumorigenic and metastatic capacities in less aggressive recipient cells mainly through the biomolecules in their cargo. However, despite recent ad... (Source: Biological Research)
Source: Biological Research - January 3, 2024 Category: Biomedical Science Authors: Eduardo Dur án-Jara, Matías del Campo, Valentina Gutiérrez, Ignacio Wichmann, César Trigo, Marcelo Ezquer and Lorena Lobos-González Tags: Research article Source Type: research
Integration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndrome
Growing evidence has suggested that Type I Interferon (I-IFN) plays a potential role in the pathogenesis of Down Syndrome (DS). This work investigates the underlying function of MX1, an effector gene of I-IFN,... (Source: Biological Research)
Source: Biological Research - December 9, 2023 Category: Biomedical Science Authors: Zhenglong Guo, Yongchang Zhu, Hai Xiao, Ranran Dai, Wenke Yang, Wei Xue, Xueying Zhang, Bingtao Hao and Shixiu Liao Tags: Research article Source Type: research
The novel roles of YULINK in the migration, proliferation and glycolysis of pulmonary arterial smooth muscle cells: implications for pulmonary arterial hypertension
Abnormal remodeling of the pulmonary vasculature, characterized by the proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs) along with dysregulated glycolysis, is a pathognomonic feat... (Source: Biological Research)
Source: Biological Research - December 7, 2023 Category: Biomedical Science Authors: Yi-Chia Wu, Wei-Ting Wang, Ming-Chun Yang, Yu-Tsun Su, Jwu-Lai Yeh, Jong-Hau Hsu and Jiunn-Ren Wu Tags: Research article Source Type: research
Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3 α/ROS axis and interacting with apoptosis in Atherosclerosis progression
Atherosclerosis (AS), a significant contributor to cardiovascular disease (CVD), is steadily rising with the aging of the global population. Pyroptosis and apoptosis, both caspase-mediated cell death mechanism... (Source: Biological Research)
Source: Biological Research - December 2, 2023 Category: Biomedical Science Authors: Lin Cong, Xiankun Liu, Yiming Bai, Qin Qin, Lili Zhao, Ying Shi, Yunpeng Bai and Zhigang Guo Tags: Research article Source Type: research
Advances towards the use of gastrointestinal tumor patient-derived organoids as a therapeutic decision-making tool
In December 2022 the US Food and Drug Administration (FDA) removed the requirement that drugs in development must undergo animal testing before clinical evaluation, a declaration that now demands the establish... (Source: Biological Research)
Source: Biological Research - December 2, 2023 Category: Biomedical Science Authors: Javiera Obreque, Luis Vergara-G ómez, Nicolás Venegas, Helga Weber, Gareth I. Owen, Pablo Pérez-Moreno, Pamela Leal, Juan Carlos Roa and Carolina Bizama Tags: Review Source Type: research
Role of SYVN1 in the control of airway remodeling in asthma protection by promoting SIRT2 ubiquitination and degradation
Asthma is a heterogenous disease that characterized by airway remodeling. SYVN1 (Synoviolin 1) acts as an E3 ligase to mediate the suppression of endoplasmic reticulum (ER) stress through ubiquitination and de... (Source: Biological Research)
Source: Biological Research - December 2, 2023 Category: Biomedical Science Authors: Bing Dai, Si Liu, Wenxin Shen, Li Chen, Qianlan Zhou, Lina Han, Qinzhen Zhang and Lishen Shan Tags: Research article Source Type: research
Electroacupuncture promotes neurogenesis in the dentate gyrus and improves pattern separation in an early Alzheimer's disease mouse model
Impaired pattern separation occurs in the early stage of Alzheimer ’s disease (AD), and hippocampal dentate gyrus (DG) neurogenesis participates in pattern separation. Here, we investigated whether spatial memo... (Source: Biological Research)
Source: Biological Research - December 2, 2023 Category: Biomedical Science Authors: Yanyi Ding, Long Li, Sinuo Wang, Yajun Cao, Minguang Yang, Yaling Dai, Huawei Lin, Jianhong Li, Yulu Liu, Zhifu Wang, Weilin Liu and Jing Tao Tags: Research article Source Type: research
Autologous non-invasively derived stem cells mitochondria transfer shows therapeutic advantages in human embryo quality rescue
The decline in the quantity and quality of mitochondria are closely associated with infertility, particularly in advanced maternal age. Transferring autologous mitochondria into the oocytes of infertile female... (Source: Biological Research)
Source: Biological Research - November 17, 2023 Category: Biomedical Science Authors: Zhixin Jiang, Cheng Shi, Hongjing Han, Min Fu, Honglan Zhu, Tingting Han, Jia Fei, Yining Huang, Zhiping Jin, Jianan He, Yanbin Wang, Xi Chen and Huan Shen Tags: Research article Source Type: research
Prenatal ethanol exposure and changes in fetal neuroendocrine metabolic programming
Prenatal ethanol exposure (PEE) (mainly through maternal alcohol consumption) has become widespread. However, studies suggest that it can cause intrauterine growth retardation (IUGR) and multi-organ developmen... (Source: Biological Research)
Source: Biological Research - November 17, 2023 Category: Biomedical Science Authors: Liang Liu, Yinxian Wen, Qubo Ni, Liaobin Chen and Hui Wang Tags: Review Source Type: research
