DNMT1-mediated PPAR α methylation aggravates damage of retinal tissues in diabetic retinopathy mice
Peroxisome proliferator-activated receptor alpha (PPAR α) is associated with diabetic retinopathy (DR), and the underlying mechanism is still unclear. Aim of this work was to investigate the mechanism of PPARα ... (Source: Biological Research)
Source: Biological Research - August 6, 2021 Category: Biomedical Science Authors: Ying Zhu, Xinru Wang, Xiaoyun Zhou, Lexi Ding, Dan Liu and Huizhuo Xu Tags: Research article Source Type: research
Molecules linked to Ras signaling as therapeutic targets in cardiac pathologies
The Ras family of small Guanosine Triphosphate (GTP)-binding proteins (G proteins) represents one of the main components of intracellular signal transduction required for normal cardiac growth, but is also cri... (Source: Biological Research)
Source: Biological Research - August 3, 2021 Category: Biomedical Science Authors: Manuel Ramos-Kuri, Sri Harika Meka, Fabio Salamanca-Buentello, Roger J. Hajjar, Larissa Lipskaia and Elie R. Chemaly Tags: Review Source Type: research
Cisplatin-induced hydroxyl radicals mediate pro-survival autophagy in human lung cancer H460 cells
Accumulated evidence demonstrates cisplatin, a recommended chemotherapy, modulating pro-survival autophagic response that contributes to treatment failure in lung cancer patients. However, distinct mechanisms ... (Source: Biological Research)
Source: Biological Research - July 28, 2021 Category: Biomedical Science Authors: Somruethai Sumkhemthong, Eakachai Prompetchara, Pithi Chanvorachote and Chatchai Chaotham Tags: Research article Source Type: research
Circulating miR-146a as a possible candidate biomarker in the indeterminate phase of Chagas disease
Chagas disease is considered important and presents intense inflammatory and fibrotic processes induced by the perpetuation of the parasite in the affected tissues and organs. Therefore, it is necessary to inq... (Source: Biological Research)
Source: Biological Research - July 21, 2021 Category: Biomedical Science Authors: Martha Alicia Ballinas-Verdugo, Rogelio Frank Jim énez-Ortega, Eduardo Martínez-Martínez, Nancy Rivas, Erick Abraham Contreras-López, Roxana Carbó, Fausto Sánchez, Rafael Bojalil, Ricardo Márquez-Velasco, Fausto Sánchez-Muñoz and Ricardo Alejandr Tags: Research article Source Type: research
Exploration of silicon functions to integrate with biotic stress tolerance and crop improvement
In the era of climate change, due to increased incidences of a wide range of various environmental stresses, especially biotic and abiotic stresses around the globe, the performance of plants can be affected b... (Source: Biological Research)
Source: Biological Research - July 8, 2021 Category: Biomedical Science Authors: Xiu-Peng Song, Krishan K. Verma, Dan-Dan Tian, Xiao-Qiu Zhang, Yong-Jian Liang, Xing Huang, Chang-Ning Li and Yang-Rui Li Tags: Review Source Type: research
OUTBREAK: a user-friendly georeferencing online tool for disease surveillance
The current COVID-19 pandemic has already claimed more than 3.7 million victims and it will cause more deaths in the coming months. Tools that track the number and locations of cases are critical for surveilla... (Source: Biological Research)
Source: Biological Research - July 8, 2021 Category: Biomedical Science Authors: Ra úl Arias-Carrasco, Jeevan Giddaluru, Lucas E. Cardozo, Felipe Martins, Vinicius Maracaja-Coutinho and Helder I. Nakaya Tags: Letter to the Editor Source Type: research
Identification of 5-methylcytosine-related signature for predicting prognosis in ovarian cancer
Ovarian cancer is one of the most common malignancies often resulting in a poor prognosis. 5-methylcytosine (m5C) is a common epigenetic modification with roles in eukaryotes. However, the expression and funct... (Source: Biological Research)
Source: Biological Research - June 29, 2021 Category: Biomedical Science Authors: Lei Wang and Song Gao Tags: Research article Source Type: research
Mvda is required for zebrafish early development
The MVD gene mutations are identified in porokeratosis, which is considered a skin-specific autoinflammatory keratinization disease. However, the biological function of MVD gene remains largely unknown. Therefore... (Source: Biological Research)
Source: Biological Research - May 29, 2021 Category: Biomedical Science Authors: Wenghong Wong, Yike Huang, Zhuanbin Wu, Yu Kong, Jing Luan, Qiaoan Zhang, Jiewen Pan, Kexiang Yan and Zhenghua Zhang Tags: Research article Source Type: research
Manuka honey enhanced sensitivity of HepG2, hepatocellular carcinoma cells, for Doxorubicin and induced apoptosis through inhibition of Wnt/ β-catenin and ERK1/2
Recently, there is increasing awareness focused on the identification of naturally occurring anticancer agents derived from natural products. Manuka honey (MH) has been recognized for its biological properties... (Source: Biological Research)
Source: Biological Research - May 28, 2021 Category: Biomedical Science Authors: Heba R. Al Refaey, Al-Sayeda A. Newairy, Mayssaa M. Wahby, Chris Albanese, Mohamed Elkewedi, Muhammad Umer Choudhry and Ahmed S. Sultan Tags: Research article Source Type: research
Functional relationship between photosynthetic leaf gas exchange in response to silicon application and water stress mitigation in sugarcane
Water stress is one of the serious abiotic stresses that negatively influences the growth, development and production of sugarcane in arid and semi-arid regions. However, silicon (Si) has been applied as an al... (Source: Biological Research)
Source: Biological Research - May 1, 2021 Category: Biomedical Science Authors: Krishan K. Verma, Xiu-Peng Song, Chhedi Lal Verma, Zhong-Liang Chen, Vishnu D. Rajput, Kai-Chao Wu, Fen Liao, Gan-Lin Chen and Yang-Rui Li Tags: Research article Source Type: research
NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with cagPAI-positive H. pylori
Helicobacter pylori is detected by pathogen recognition receptors including toll-like receptors (TLR) and nucleotide-binding oligomerization domain (NOD)-like receptors, eliciting an innate immune response agains... (Source: Biological Research)
Source: Biological Research - April 20, 2021 Category: Biomedical Science Authors: Patricio Gonzalez-Hormazabal, Diana Pelaez, Maher Musleh, Marco Bustamante, Juan Stambuk, Raul Pisano, Hector Valladares, Enrique Lanzarini, Hector Chiong, Jose Suazo, Luis A. Qui ñones, Nelson M. Varela, V. Gonzalo Castro, Lilian Jara and Zoltan Berger Tags: Research article Source Type: research
The role of circular RNA circ_0008285 in gestational diabetes mellitus by regulating the biological functions of trophoblasts
In this study, we identified and investigated the potential circRNAs involved in gestational diabetes mellitus (GDM). (Source: Biological Research)
Source: Biological Research - April 20, 2021 Category: Biomedical Science Authors: Haitian Chen, Shaofeng Zhang, Yanxin Wu, Zhuyu Li, Dongyu Wang, Shiqin Cai and Zilian Wang Tags: Research article Source Type: research
Identification of blood-derived candidate gene markers and a new 7-gene diagnostic model for multiple sclerosis
Multiple sclerosis (MS) is a central nervous system disease with a high disability rate. Modern molecular biology techniques have identified a number of key genes and diagnostic markers to MS, but the etiology... (Source: Biological Research)
Source: Biological Research - April 1, 2021 Category: Biomedical Science Authors: Xin Chen, Huiqing Hou, Huimin Qiao, Haolong Fan, Tianyi Zhao and Mei Dong Tags: Research article Source Type: research
CircRNA RSF1 regulated ox-LDL induced vascular endothelial cells proliferation, apoptosis and inflammation through modulating miR-135b-5p/HDAC1 axis in atherosclerosis
Atherosclerosis (AS) is the most common type in cardiovascular disease. Due to its complex pathogenesis, the exact etiology of AS is unclear. circRNA has been shown to play an essential role in most diseases. ... (Source: Biological Research)
Source: Biological Research - March 23, 2021 Category: Biomedical Science Authors: Xiaohao Zhang, Junying Lu, Qinghua Zhang, Qiang Luo and Bin Liu Tags: Research article Source Type: research
Long non ‐coding RNA MALAT1 regulates cell proliferation and apoptosis via miR-135b-5p/GPNMB axis in Parkinson’s disease cell model
Parkinson ’s disease (PD) is a common age-related neurodegenerative disorder worldwide. This research aimed to investigate the effects and mechanism underlying long non-coding RNA metastasis-associated lung ade... (Source: Biological Research)
Source: Biological Research - March 16, 2021 Category: Biomedical Science Authors: Kefeng Lv, Yuhua Liu, Yanbing Zheng, Shaowen Dai, Peifeng Yin and Haifeng Miao Tags: Research article Source Type: research
