Associations of bedtime, sleep duration, and sleep quality with semen quality in males seeking fertility treatment: a preliminary study
ConclusionEarly bedtimes (< 10:30 PM) and conventional sleep duration (7.5–7.99 h) were associated with self-reported normal semen quality. The role of subjective sleep quality remains uncertain. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - April 22, 2020 Category: Urology & Nephrology Source Type: research
Efficacy of relaxin for cisplatin-induced testicular dysfunction and epididymal spermatotoxicity
ConclusionsThis study clearly indicates that RLN exerts a protective effect against CP-induced testicular damage through attenuation of oxidative stress and suppression of apoptosis. Our findings suggest RLN as a potentially efficacious drug for use with cisplatin chemotherapy in order to ameliorate CP-induced side effects and testicular injury adversely affecting spermatogenesis, sperm quality, and oxidative-stress parameters. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - March 8, 2020 Category: Urology & Nephrology Source Type: research
RISUG ® as a male contraceptive: journey from bench to bedside
AbstractEven after decades of research men still lack reliable and reversible contraceptive methods comparable to female methods of contraception. Traditional methods of male contraception present a high failure rate and also involve high risk both when used for contraception and for protection against sexually transmitted diseases. Various chemical, hormonal, immunological, vas based and herbal methods of contraception have been examined by scientists world over during the past four decades. Among the possible lead approaches, exogenous hormonal contraception, either alone or in combination with progesterone or antiandrog...
Source: Basic and Clinical Andrology - February 12, 2020 Category: Urology & Nephrology Source Type: research
Correction to: Gel electrophoresis of human sperm: a simple method for evaluating sperm protein quality
Following publication of the original article [1], the authors reported that the author given names and family names had been transposed. The author names in this correction article are presented correctly. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - February 12, 2020 Category: Urology & Nephrology Source Type: research
The detection of canine anti-sperm antibody following parenteral immunization of bitches against homogenized whole sperm
ConclusionsBased on the results obtained in this study, parenteral immunization with whole sperm can induce a high level of specific antibodies in the serum and genital secretions of female dogs and the response would be dose-dependent. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - January 22, 2020 Category: Urology & Nephrology Source Type: research
Testicular expression of long non –coding RNAs is affected by curative GnRHa treatment of cryptorchidism
ConclusionGiven that lncRNAs can cooperate with chromatin-modifying enzymes to promote epigenetic regulation of genes, GnRHa treatment may act as a surrogate for mini-puberty by triggering the differentiation of Ad spermatogonia via lncRNA-mediated epigenetic effects. Our work provides additional molecular evidence that infertility and azoospermia in cryptorchidism, resulting from defective mini-puberty cannot be cured with successful orchidopexy alone. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - December 26, 2019 Category: Urology & Nephrology Source Type: research
Can the SCD test and terminal uridine nick-end labeling by flow cytometry technique (TUNEL/FCM) be used interchangeably to measure sperm DNA damage in routine laboratory practice?
ConclusionsAndrology laboratories using the SCD test to measure sperm DNA damage need to know that it appears to give slightly underestimated measurements compared to TUNEL/FCM. However, this systematic underestimation is very small in amplitude. Both techniques give almost perfectly congruent results. Our study underlines the importance for each laboratory to validate its method to assess sperm DNA damage before implementing it in routine andrology lab practice. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - December 25, 2019 Category: Urology & Nephrology Source Type: research
Colibri ® insecticide induces male reproductive toxicity: alleviating effects of Lannea acida (Anacardiaceae) in rats
ConclusionPresent results indicate thatL. acida exerts curative effects against colibri ®-induced male reproductive toxicity. These results justify the use of this plant as fertility enhancer and suggest that it could be an alternative in the management of pesticide-derived male infertility. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - December 19, 2019 Category: Urology & Nephrology Source Type: research
Sleep related painful erection: an algorithm for evaluation and management
ConclusionBased on the limited number of treatment trials and reported cases, the low level of evidence and the lack of randomized clinical trials, no treatment consensus for SRPE can be reached. We suggested a useful tool for clinicians: an algorithm for the management of SRPE to facilitate their access to the literature without exhaustive return to case reports and series upon each case faced. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - December 3, 2019 Category: Urology & Nephrology Source Type: research
Oxidative-antioxidative status and hepatic and renal factors following melatonin administration in castrated and intact dogs
ConclusionsThe administration of melatonin in castrated dogs increased antioxidant activity and decreased oxidation products, compared with those of the castrated and untreated dogs, without adverse effects on liver enzymes and kidney function. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - November 14, 2019 Category: Urology & Nephrology Source Type: research
Post orgasmic illness syndrome: what do we know till now?
ConclusionPOIS is a rare condition that is underdiagnosed, most probably because of its unclear pathophysiology leading to a lack of treatment options. Further studies are warranted to investigate the prevalence, pathophysiology, and management of this debilitating condition. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - September 2, 2019 Category: Urology & Nephrology Source Type: research
Chemical sterilization with intratesticular administration of zinc gluconate in adult dogs: a preliminary report
ConclusionsTherefore, It is inferred that the injection of pH neutralized zinc gluconate into the adult dogs ’ testes resulted in the loss of sperm-producing tissue without affecting the production of testosterone and the general health of adult dogs. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - July 31, 2019 Category: Urology & Nephrology Source Type: research
Step-by-step loupes-mTESE in non-obstructive azoospermic men, a retrospective study
ConclusionsIn institutions where surgeons cannot afford an operating microscope, this modified mTESE technique using × 6 magnifying loupes is reliable, especially in patients with low testicular volumes and high FSH, in whom dilated tubules can be easily identified from the surrounding tissue. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - July 14, 2019 Category: Urology & Nephrology Source Type: research
Metabolic syndrome and smoking are independent risk factors of male idiopathic infertility
ConclusionsMetabolic syndrome and smoking should systematically be checked at the beginning of medical care in infertile males and personal and multifaceted coaching should be proposed to deal jointly with smoking and metabolic disorders.Trial registrationNCT01093378 ALIFERT. Registered: March 25, 2010. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - June 30, 2019 Category: Urology & Nephrology Source Type: research
Genes located in Y-chromosomal regions important for male fertility show altered transcript levels in cryptorchidism and respond to curative hormone treatment
ConclusionOur findings implicate Y-chromosomal genes, includingUSP9Y, UTY, TXLNGY, RBMY1B, RBMY1E, RBMY1J and TSPY4, some of which are known to be important for spermatogenesis, in the curative hormonal treatment of cryptorchidism-induced infertility. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - June 2, 2019 Category: Urology & Nephrology Source Type: research
