Efficacy of relaxin for cisplatin-induced testicular dysfunction and epididymal spermatotoxicity

ConclusionsThis study clearly indicates that RLN exerts a protective effect against CP-induced testicular damage through attenuation of oxidative stress and suppression of apoptosis. Our findings suggest RLN as a potentially efficacious drug for use with cisplatin chemotherapy in order to ameliorate CP-induced side effects and testicular injury adversely affecting spermatogenesis, sperm quality, and oxidative-stress parameters.

http://link.springer.com/10.1186/s12610-020-0101-y

Source: Basic and Clinical Andrology - March 8, 2020 Category: Urology & Nephrology Source Type: research